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Research Output 2005 2017

2017

Limited additive value of the Ki-67 proliferative index on patient survival in World Health Organization-classified pulmonary carcinoids

Swarts, D. R. A., Rudelius, M., Claessen, S. M. H., Cleutjens, J. P., Seidl, S., Volante, M., Ramaekers, F. C. S. & Speel, E. J. M., Feb 2017, In : Histopathology. 70, 3, p. 412-422 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

Jiang, J., Mathijs, K., Timmermans, L., Claessen, S. M., Hecka, A., Weusten, J., Peters, R., van Delft, J. H., Kleinjans, J. C. S., Jennen, D. G. J. & de Kok, T. M., 1 Oct 2017, In : Toxicology and Applied Pharmacology. 332, p. 100-108 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The idiosyncratic drug-induced gene expression changes in HepG2 cells

Jiang, J., Mathijs, K., Timmermans, L., Claessen, S. M., Hecka, A., Weusten, J., Peters, R., van Delft, J. H., Kleinjans, J. C. S., Jennen, D. G. J. & de Kok, T. M., Oct 2017, In : Data in brief. 14, p. 462-468 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)
1 Citation (Scopus)

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes

Jetten, M. J. A., Ruiz-Aracama, A., Coonen, M. L. J., Claessen, S. M., van Herwijnen, M. H. M., Lommen, A., van Delft, J., Peijnenburg, A. A. C. M. & Kleinjans, J. C. S., May 2016, In : Archives of Toxicology. 90, 5, p. 1103-1115

Research output: Contribution to journalArticleAcademicpeer-review

2015
23 Citations (Scopus)

Application of High-Throughput Sequencing to Circulating microRNAs Reveals Novel Biomarkers for Drug-Induced Liver Injury

Krauskopf, J., Caiment, F., Claessen, S. M., Johnson, K. J., Warner, R. L., Schomaker, S. J., Burt, D. A., Aubrecht, J. & Kleinjans, J., Feb 2015, In : Toxicological Sciences. 143, 2, p. 268-276

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
6 Citations (Scopus)

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

van Breda, S. G. J., Claessen, S. M. H., Lo, K., van Herwijnen, M., Brauers, K. J. J., Lisanti, S., Theunissen, D. H. J., Jennen, D. G. J., Gaj, S., de Kok, T. & Kleinjans, J. C. S., Nov 2015, In : Archives of Toxicology. 89, 11, p. 1959-1969

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
11 Citations (Scopus)

High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity

Caiment, F., Gaj, S., Claessen, S. & Kleinjans, J., 11 Mar 2015, In : Nucleic Acids Research. 43, 5, p. 2525-2534

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens

Deferme, L., Wolters, J., Claessen, S., Briede, J. & Kleinjans, J., Aug 2015, In : Chemical Research in Toxicology. 28, 8, p. 1636-1646

Research output: Contribution to journalArticleAcademicpeer-review

2014
8 Citations (Scopus)

Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices

Jetten, M. J. A., Claessen, S. M., Dejong, C. H., Lahoz, A., Castell, J. V., van Delft, J. H. M. & Kleinjans, J. C. S., 2 Sep 2014, In : Toxicology. 323C, p. 61-69

Research output: Contribution to journalArticleAcademicpeer-review

2013
19 Citations (Scopus)

Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes

Jetten, M. J. A., Kleinjans, J. C. S., Claessen, S. M., Chesne, C. & van Delft, J. H. M., Oct 2013, In : Toxicology in Vitro. 27, 7, p. 2031-2040

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis

Mooren, J. J., Kremer, B., Claessen, S. M. H., Voogd, A. C., Bot, F. J., Klussmann, J. P., Huebbers, C. U., Hopman, A. H. N., Ramaekers, F. C. S. & Speel, E-J. M., 15 Apr 2013, In : International Journal of Cancer. 132, 8, p. 1781-1789

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Time series analysis of oxidative stress response patterns in HepG2: A toxicogenomics approach

Deferme, L., Briede, J. J., Claessen, S. M. H., Jennen, D. G. J., Cavil, R. & Kleinjans, J. C. S., 5 Apr 2013, In : Toxicology. 306, p. 24-34

Research output: Contribution to journalArticleAcademicpeer-review

2012
28 Citations (Scopus)

A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo

Magkoufopoulou, C., Claessen, S. M. H., Tsamou, M., Jennen, D. G. J., Kleinjans, J. C. S. & van Delft, J. H. M., Jul 2012, In : Carcinogenesis. 33, 7, p. 1421-1429

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans

Jetten, M. J. A., Gaj, S., Ruiz-Aracama, A., de Kok, T. M., van Delft, J. H. M., Lommen, A., van Someren, E. P., Jennen, D. G. J., Claessen, S. M., Peijnenburg, A. A. C. M., Stierum, R. H. & Kleinjans, J. C. S., 15 Mar 2012, In : Toxicology and Applied Pharmacology. 259, 3, p. 320-328

Research output: Contribution to journalArticleAcademicpeer-review

Performance of in vitro gamma H2AX assay in HepG2 cells to predict in vivo genotoxicity

Tsamou, M., Jennen, D. G. J., Claessen, S. M. H., Magkoufopoulou, C., Kleinjans, J. C. S. & van Delft, J. H. M., Nov 2012, In : Mutagenesis. 27, 6, p. 645-652

Research output: Contribution to journalArticleAcademicpeer-review

RNA-Seq Provides New Insights in the Transcriptome Responses Induced by the Carcinogen Benzo[a]pyrene

van Delft, J., Gaj, S., Lienhard, M., Albrecht, M. W., Kirpiy, A., Brauers, K., Claessen, S., Lizarraga, D., Lehrach, H., Herwig, R. & Kleinjans, J., Dec 2012, In : Toxicological Sciences. 130, 2, p. 427-439

Research output: Contribution to journalArticleAcademicpeer-review

Transcriptomic Concentration-Response Evaluation of Valproic Acid, Cyproconazole, and Hexaconazole in the Neural Embryonic Stem Cell Test (ESTn)

Theunissen, P. T., Robinson, J. F., Pennings, J. L. A., de Jong, E., Claessen, S. M. H., Kleinjans, J. C. S. & Piersma, A. H., Feb 2012, In : Toxicological Sciences. 125, 2, p. 430-438

Research output: Contribution to journalArticleAcademicpeer-review

2011

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells

Magkoufopoulou, C., Claessen, S. M. H., Jennen, D. G. J., Kleinjans, J. C. S. & van Delft, J. H. M., Sep 2011, In : Mutagenesis. 26, 5, p. 593-604

Research output: Contribution to journalArticleAcademicpeer-review

Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures

van Dartel, D. A. M., Pennings, J. L. A., de la Fonteyne-Blankestijn, L. J., Brauers, K. J. J., Claessen, S., van Delft, J. H., Kleinjans, J. C. S. & Piersma, A. H., 1 Mar 2011, In : Toxicology and Applied Pharmacology. 251, 2, p. 110-118

Research output: Contribution to journalArticleAcademicpeer-review

Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and poor clinical outcome

Swarts, D. R. A., Claessen, S. M. H., Jonkers, Y. M. H., van Suylen, R-J., Dingemans, A-M. C., de Herder, W. W., de Krijger, R. R., Smit, E. F., Thunnissen, F. B. J. M., Seldenrijk, C. A., Vink, A., Perren, A., Ramaekers, F. C. S. & Speel, E-J. M., Sep 2011, In : American Journal of Pathology. 179, 3, p. 1129-1137 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of Developmental Toxicant Identification Using Gene Expression Profiling in Embryonic Stem Cell Differentiation Cultures

van Dartel, D. A. M., Pennings, J. L. A., de la Fonteyne-Blankestijn, L. J., Brauers, K. J. J., Claessen, S., van Delft, J. H., Kleinjans, J. C. S. & Piersma, A. H., Jan 2011, In : Toxicological Sciences. 119, 1, p. 126-134

Research output: Contribution to journalArticleAcademicpeer-review

Time-Response Evaluation by Transcriptomics of Methylmercury Effects on Neural Differentiation of Murine Embryonic Stem Cells

Theunissen, P. T., Pennings, J. L. A., Robinson, J. F., Claessen, S. M. H., Kleinjans, J. C. S. & Piersma, A. H., Aug 2011, In : Toxicological Sciences. 122, 2, p. 437-447

Research output: Contribution to journalArticleAcademicpeer-review

2010

Spectral Karyotypic and Comparative Genomic Analysis of the Endocrine Pancreatic Tumor Cell Line BON-1

Lopez, J. R., Claessen, S. M. H., Macville, M. V. E., Albrechts, J. C. M., Skogseid, B. & Speel, E-J. M., 2010, In : Neuroendocrinology. 91, 2, p. 131-141

Research output: Contribution to journalArticleAcademicpeer-review

2007
20 Citations (Scopus)

DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients

Jonkers, Y. M., Claessen, S. M. H., Perren, A., Schmitt, A. M., Hofland, L. J., de Herder, W. W., de Krijger, R. R., Verhofstad, A. A., Hermus, A. R., Kummer, J. A., Skogseid, B., Volante, M., Voogd, A. C., Ramaekers, F. C. S. & Speel, E. J. M., 1 Jan 2007, In : Endocrine-Related Cancer. 14, 3, p. 769-79

Research output: Contribution to journalArticleAcademicpeer-review

2005
53 Citations (Scopus)
126 Downloads (Pure)

Chromosomal instability predicts metastatic disease in patients with insulinomas.

Jonkers, Y. M. H., Claessen, S. M. H., Perren, A., Schmid, S., Komminoth, P., Verhofstad, A. A., Hofland, L. J., de Krijger, R. R., Slootweg, P. J., Ramaekers, F. C. S. & Speel, E. J. M., 1 Jan 2005, In : Endocrine-Related Cancer. 12, p. 435-447

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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