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Research Output 2010 2019

2019

Quantification of epicardial adipose tissue in patients undergoing hybrid ablation for atrial fibrillation

Vroomen, M., Olsthoorn, J. R., Maesen, B., L'Espoir, V., La Meir, M., Das, M., Maessen, J. G., Crijns, H. J. G. M., Verheule, S. & Pison, L., Jul 2019, In : European Journal of Cardio-Thoracic Surgery. 56, 1, p. 79-86 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Arterial hypertension drives arrhythmia progression via specific structural remodeling in a porcine model of atrial fibrillation

Manninger, M., Zweiker, D., van Hunnik, A., Alogna, A., Prassl, A. J., Schipke, J., Zeemering, S., Zirngast, B., Schonleitner, P., Schwarzl, M., Herbst, V., Thon-Gutschi, E., Huber, S., Rohrer, U., Ebner, J., Brussee, H., Pieske, B. M., Heinzel, F. R., Verheule, S., Antoons, G. & 6 others, Lueger, A., Muhlfeld, C., Plank, G., Schotten, U., Post, H. & Scherr, D., 1 Sep 2018, In : Heart Rhythm. 15, 9, p. 1328-1336 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardioversion of persistent atrial fibrillation is associated with a 24-hour relapse gap: Observations from prolonged postcardioversion rhythm monitoring

Weijs, B., Limantoro, I., Delhaas, T., de Vos, C. B., Blaauw, Y., Houben, R. P. M., Verheule, S., Pisters, R. & Crijns, H. J. G. M., 1 Mar 2018, In : Clinical Cardiology. 41, 3, p. 366-371 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of Na+-channel blockade on the three-dimensional substrate of atrial fibrillation in a model of endo-epicardial dissociation and transmural conduction

Gharaviri, A., Verheule, S., Eckstein, J., Potse, M., Krause, R., Auricchio, A., Kuijpers, N. H. L. & Schotten, U., 1 Nov 2018, In : EP Europace. 20, Suppl. 3, p. iii69-iii76 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Loss of Side-to-Side Connections Affects the Relative Contributions of the Sodium and Calcium Current to Transverse Propagation Between Strands of Atrial Myocytes

Zhao, J., Schotten, U., Smaill, B. & Verheule, S., 4 Sep 2018, In : Frontiers in physiology. 9, 10 p., 1212.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Stationary Atrial Fibrillation Properties in the Goat Do Not Entail Stable or Recurrent Conduction Patterns

van Hunnik, A., Zeemering, S., Podziemski, P., Simons, J., Gatta, G., Hannink, L., Maesen, B., Kuiper, M., Verheule, S. & Schotten, U., 27 Jul 2018, In : Frontiers in physiology. 9, 16 p., 947.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
23 Downloads (Pure)

Vernakalant does not alter early repolarization or contractility in normal and electrically remodelled atria

van Hunnik, A., Nasrallah, H., Lau, D. H., Kuiper, M., Verheule, S. & Schotten, U., 1 Jan 2018, In : EP Europace. 20, 1, p. 140-148 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2017
22 Downloads (Pure)

How disruption of endo-epicardial electrical connections enhances endo-epicardial conduction during atrial fibrillation

Gharaviri, A., Verheule, S., Eckstein, J., Potse, M., Kuklik, P., Kuijpers, N. H. L. & Schotten, U., Feb 2017, In : EP Europace. 19, 2, p. 308-318 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
23 Downloads (Pure)

Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation

Spronk, H. M. H., De Jong, A. M., Verheule, S., De Boer, H. C., Maass, A. H., Lau, D. H., Rienstra, M., van Hunnik, A., Kuiper, M., Lumeij, S., Zeemering, S., Linz, D., Kamphuisen, P. W., ten Cate, H., Crijns, H. J., Van Gelder, I. C., van Zonneveld, A. J. & Schotten, U., 1 Jan 2017, In : European Heart Journal. 38, 1, p. 38-50 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models

Ji, Y., Varkevisser, R., Opacic, D., Bossu, A., Kuiper, M., Beekman, J. D. M., Yang, S., Khan, A. P., Dobrev, D., Voigt, N., Wang, M. Z., Verheule, S., Vos, M. A. & van der Heyden, M. A. G., Aug 2017, In : British Journal of Pharmacology. 174, 15, p. 2576-2590 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
1 Citation (Scopus)
3 Citations (Scopus)

Atrial metabolism and tissue perfusion as determinants of electrical and structural remodelling in atrial fibrillation

Opacic, D., van Bragt, K. A., Nasrallah, H. M., Schotten, U. & Verheule, S., 1 Apr 2016, In : Cardiovascular Research. 109, 4, p. 527-541

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats

Linz, D., Hohl, M., Dhein, S., Ruf, S., Reil, J-C., Kabiri, M., Wohlfart, P., Verheule, S., Boehm, M., Sadowski, T. & Schotten, U., 1 Jun 2016, In : Cardiovascular Research. 110, 3, p. 371-380

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-gamma/Adiponectin Signalling

Antonopoulos, A. S., Margaritis, M., Verheule, S., Recalde, A., Sanna, F., Herdman, L., Psarros, C., Nasrallah, H., Coutinho, P., Akoumianakis, I., Brewer, A. C., Sayeed, R., Krasopoulos, G., Petrou, M., Tarun, A., Tousoulis, D., Shah, A. M., Casadei, B., Channon, K. M. & Antoniades, C., 4 Mar 2016, In : Circulation Research. 118, 5, p. 842-855

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

Reilly, S. N., Liu, X., Carnicer, R., Recalde, A., Muszkiewicz, A., Jayaram, R., Carena, M. C., Wijesurendra, R., Stefanini, M., Surdo, N. C., Lomas, O., Ratnatunga, C., Sayeed, R., Krasopoulos, G., Rajakumar, T., Bueno-Orovio, A., Verheule, S., Fulga, T. A., Rodriguez, B., Schotten, U. & 1 others, Casadei, B., 25 May 2016, In : Science Translational Medicine. 8, 340, 340ra74.

Research output: Contribution to journalArticleAcademicpeer-review

2015
16 Citations (Scopus)

Atrial fibrillation and rapid acute pacing regulate adipocyte/adipositas-related gene expression in the atria

Chilukoti, R. K., Giese, A., Malenke, W., Homuth, G., Bukowska, A., Goette, A., Felix, S. B., Kanaan, J., Wollert, H. -G., Evert, K., Verheule, S., Jais, P., Hatem, S. N., Lendeckel, U. & Wolke, C., 6 May 2015, In : International Journal of Cardiology. 187, p. 604-613

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Catheter-Based Renal Denervation Reduces Atrial Nerve Sprouting and Complexity of Atrial Fibrillation in Goats

Linz, D., van Hunnik, A., Hohl, M., Mahfoud, F., Wolf, M., Neuberger, H-R., Casadei, B., Reilly, S. N., Verheule, S., Boehm, M. & Schotten, U., Apr 2015, In : Circulation-Arrhythmia and Electrophysiology. 8, 2, p. 466-U294

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Dynamic regulation of atrial coronary blood flow in healthy adult pigs

van Bragt, K. A., Nasrallah, H. M., Kuiper, M., van Hunnik, A., Kuijpers, N. H. L., Schotten, U. & Verheule, S., May 2015, In : Heart Rhythm. 12, 5, p. 991-1000

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Indices of bipolar complex fractionated atrial electrograms correlate poorly with each other and atrial fibrillation substrate complexity

Lau, D. H., Maesen, B., Zeemering, S., Kuklik, P., van Hunnik, A., Lankveld, T. A. R., Bidar, E., Verheule, S., Nijs, J., Maessen, J., Crijns, H., Sanders, P. & Schotten, U., Jul 2015, In : Heart Rhythm. 12, 7, p. 1415-1423

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
1 Citation (Scopus)

The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results

Schotten, U., Hatem, S., Ravens, U., Jais, P., Mueller, F-U., Goette, A., Rohr, S., Antoons, G., Pieske, B., Scherr, D., Oto, A., Casadei, B., Verheule, S., Cartlidge, D., Steinmeyer, K., Goetsche, T., Dobrev, D., Kockskaemper, J., Lendeckel, U., Fabritz, L. & 2 others, Kirchhof, P. & Camm, A. J., Oct 2015, In : EP Europace. 17, 10, p. 1457-1466

Research output: Contribution to journalArticleAcademicpeer-review

2014
10 Citations (Scopus)

A prospective randomized controlled trial on the incidence and predictors of late-phase postoperative atrial fibrillation up to 30 days and the preventive value of biatrial pacing

Bidar, E., Maesen, B., Nieman, F., Verheule, S., Schotten, U. & Maessen, J. G., 1 Jan 2014, In : Heart Rhythm. 11, 7, p. 1156-1162

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Atrial supplydemand balance in healthy adult pigs: coronary blood flow, oxygen extraction, and lactate production during acute atrial fibrillation

van Bragt, K. A., Nasrallah, H. M., Kuiper, M., Luiken, J. J., Schotten, U. & Verheule, S., 1 Jan 2014, In : Cardiovascular Research. 101, 1, p. 9-19

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Effects of renal denervation on atrial arrhythmogenesis

Linz, D., Hunnik, A. V., Ukena, C., Mahfoud, F., Ewen, S., Verheule, S., Böhm, M. & Schotten, U., Nov 2014, In : Future Cardiology. 10, 6, p. 813-22 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Role of endo-epicardial dissociation of electrical activity and transmural conduction in the development of persistent atrial fibrillation

Verheule, S., Eckstein, J., Linz, D., Maesen, B., Bidar, E., Gharaviri, A. & Schotten, U., Aug 2014, In : Progress in Biophysics & Molecular Biology. 115, 2-3, p. 173-185

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes

Greiser, M., Kerfant, B-G., Williams, G. S. B., Voigt, N., Harks, E., Dibb, K. M., Giese, A., Meszaros, J., Verheule, S., Ravens, U., Allessie, M. A., Gammie, J. S., van der Velden, J., Lederer, W. J., Dobrev, D. & Schotten, U., Nov 2014, In : Journal of Clinical Investigation. 124, 11, p. 4759-4772

Research output: Contribution to journalArticleAcademicpeer-review

2013

Loss of Continuity in the Thin Epicardial Layer Because of Endomysial Fibrosis Increases the Complexity of Atrial Fibrillatory Conduction

Verheule, S., Tuyls, E., Gharaviri, A., Hulsmans, S., van Hunnik, A., Kuiper, M., Serroyen, J., Zeemering, S., Kuijpers, N. H. L. & Schotten, U., Feb 2013, In : Circulation-Arrhythmia and Electrophysiology. 6, 1, p. 202-211

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice

Kirchhof, P., Marijon, E., Fabritz, L., Li, N., Wang, W., Wang, T., Schulte, K., Hanstein, J., Schulte, J. S., Vogel, M., Mougenot, N., Laakmann, S., Fortmueller, L., Eckstein, J., Verheule, S., Kaese, S., Staab, A., Grote-Wessels, S., Schotten, U., Moubarak, G. & 4 others, Wehrens, X. H. T., Schmitz, W., Hatem, S. & Mueller, F. U., 20 Jun 2013, In : International Journal of Cardiology. 166, 2, p. 366-374

Research output: Contribution to journalArticleAcademicpeer-review

Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation

Maesen, B., Zeemering, S., Afonso, C., Eckstein, J., Burton, R. A. B., van Hunnik, A., Stuckey, D. J., Tyler, D., Maessen, J., Grau, V., Verheule, S., Kohl, P. & Schotten, U., Oct 2013, In : Circulation-Arrhythmia and Electrophysiology. 6, 5, p. 967-975

Research output: Contribution to journalArticleAcademicpeer-review

2012
16 Citations (Scopus)

A computer model of endo-epicardial electrical dissociation and transmural conduction during atrial fibrillation

Gharaviri, A., Verheule, S., Eckstein, J., Potse, M., Kuijpers, N. H. L. & Schotten, U., Nov 2012, In : EP Europace. 14, p. V10-V16

Research output: Contribution to journalArticleAcademicpeer-review

Stability of Complex Fractionated Atrial Electrograms: A Systematic Review

Lau, D. H., Maesen, B., Zeemering, S., Verheule, S., Crijns, H. J. & Schotten, U., Sep 2012, In : Journal of Cardiovascular Electrophysiology. 23, 9, p. 980-987

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Stimulation of the intra-cardiac vagal nerves innervating the AV-node to control ventricular rate during AF: specificity, parameter optimization and chronic use up to 3 months

Kornet, L., van Hunnik, A., Michels, K., Verheule, S., Della Scala, A., West, T., Kessels, R. & Cornelussen, R., Jan 2012, In : Journal of Interventional Cardiac Electrophysiology. 33, 1, p. 7-18

Research output: Contribution to journalArticleAcademicpeer-review

2011

Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation Implications for the Antiarrhythmic Effect of Statins

Reilly, S. N., Jayaram, R., Nahar, K., Antoniades, C., Verheule, S., Channon, K. M., Alp, N. J., Schotten, U. & Casadei, B., 6 Sep 2011, In : Circulation. 124, 10, p. 1107-U91

Research output: Contribution to journalArticleAcademicpeer-review

Mechanoelectrical coupling enhances initiation and affects perpetuation of atrial fibrillation during acute atrial dilation

Kuijpers, N. H. L., Potse, M., van Dam, P. M., ten Eikelder, H. M. M., Verheule, S., Prinzen, F. W. & Schotten, U., Mar 2011, In : Heart Rhythm. 8, 3, p. 429-436

Research output: Contribution to journalArticleAcademicpeer-review

Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal

Schotten, U., Verheule, S., Kirchhof, P. & Goette, A., Jan 2011, In : Physiological Reviews. 91, 1, p. 265-325

Research output: Contribution to journalArticleAcademicpeer-review

PITX2c Is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene Expression

Kirchhof, P., Kahr, P. C., Kaese, S., Piccini, I., Vokshi, I., Scheld, H-H., Rotering, H., Fortmueller, L., Laakmann, S., Verheule, S., Schotten, U., Fabritz, L. & Brown, N. A., Apr 2011, In : Circulation : Cardiovascular Genetics. 4, 2, p. 123-U84

Research output: Contribution to journalArticleAcademicpeer-review

Time course and mechanisms of endo-epicardial electrical dissociation during atrial fibrillation in the goat

Eckstein, J., Maesen, B., Linz, D., Zeemering, S., van Hunnik, A., Verheule, S., Allessie, M. & Schotten, U., Mar 2011, In : Cardiovascular Research. 89, 4, p. 816-824

Research output: Contribution to journalArticleAcademicpeer-review

2010

Fibrillatory Conduction in the Atrial Free Walls of Goats in Persistent and Permanent Atrial Fibrillation

Verheule, S., Tuyls, E., van Hunnik, A., Kuiper, M., Schotten, U. & Allessie, M., Dec 2010, In : Circulation-Arrhythmia and Electrophysiology. 3, 6, p. 590-U64

Research output: Contribution to journalArticleAcademicpeer-review

Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability

Blana, A., Kaese, S., Fortmueller, L., Laakmann, S., Damke, D., van Bragt, K., Eckstein, J., Piccini, I., Kirchhefer, U., Nattel, S., Breithardt, G., Carmeliet, P., Carmeliet, E., Schotten, U., Verheule, S., Kirchhof, P. & Fabritz, L., Dec 2010, In : Heart Rhythm. 7, 12, p. 1862-1869

Research output: Contribution to journalArticleAcademicpeer-review