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Research Output 2004 2019

2019

d-amino Acids in Health and Disease: A Focus on Cancer

Bastings, J. J. A. J., van Eijk, H. M., Damink, S. W. O. & Rensen, S. S., Sep 2019, In : Nutrients. 11, 9, 18 p., 2205.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Diet-Induced Alteration of Microbiota and Development of Obesity, Nonalcoholic Fatty Liver Disease, and Diabetes: Study Protocol of a Prospective Study

Uittenbogaart, M., Leclercq, W. K. G., Bonouvrie, D., Romeijn, M. M., Luijten, A. A. P. M., Damink, S. W. M. O., van Dielen, F. M. H. & Rensen, S. S., Jun 2019, In : JMIR Research Protocols. 8, 6, p. 1-6 6 p., 11553.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Distal versus proximal intestinal short-chain fatty acid release in man

Neis, E. P. J. G., van Eijk, H. M. H., Lenaerts, K., Damink, S. W. M. O., Blaak, E. E., Dejong, C. H. C. & Rensen, S. S., Apr 2019, In : Gut. 68, 4, p. 764-765 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Duodenal-jejunal lining increases postprandial unconjugated bile acid responses and disrupts the bile acid-FXR-FGF19 axis in humans

van Nierop, F. S., de Jonge, C., Kulik, W., Bouvy, N., Schaap, F. G., Damink, S. W. O., Rensen, S., Romijn, J. A., Greve, J. W. M. & Soeters, M. R., Apr 2019, In : Metabolism-Clinical and Experimental. 93, p. 25-32 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Host phenotype is associated with reduced survival independent of tumour biology in patients with colorectal liver metastases

van Dijk, D. P. J., Krill, M., Farshidfar, F., Li, T., Rensen, S. S., Damink, S. W. M. O., Dixon, E., Sutherland, F. R., Ball, C. G., Mazurak, V. C., Baracos, V. E. & Bathe, O. F., Feb 2019, In : Journal of cachexia, sarcopenia and muscle. 10, 1, p. 123-130 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery

West, M. A., van Dijk, D. P. J., Gleadowe, F., Reeves, T., Primrose, J. N., Abu Hilal, M., Edwards, M. R., Jack, S., Rensen, S. S. S., Grocott, M. P. W., Levett, D. Z. H. & Damink, S. W. M. O., Aug 2019, In : Journal of cachexia, sarcopenia and muscle. 10, 4, p. 860-871 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Clinical Link between Human Intestinal Microbiota and Systemic Cancer Therapy

Aarnoutse, R., Ziemons, J., Penders, J., Rensen, S. S., de Vos-Geelen, J. & Smidt, M. L., 1 Sep 2019, In : International journal of molecular sciences. 20, 17, 34 p., 4145.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice

Bijnen, M., Josefs, T., Cuijpers, I., Maalsen, C. J., van de Gaar, J., Vroomen, M., Wijnands, E., Rensen, S. S., Greve, J. W. M., Hofker, M. H., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G. & Wouters, K., Jul 2018, In : Gut. 67, 7, p. 1317-1327 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Impact of chemotherapy-associated liver injury on tumour regression grade and survival in patients with colorectal liver metastases

Zhao, J., Sawo, P., Rensen, S. S., Rouflart, M. M. J., Winstanley, A., Vreuls, C. P. H., Verheij, J., van Mierlo, K. M. C., Lodewick, T. M., van Woerden, V., van Tiel, F. H., van Dam, R. M., Dejong, C. H. C. & Damink, S. W. M. O., Feb 2018, In : HPB. 20, 2, p. 147-154 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80(+)Clec4f(+)Vsig4(+)Ly6C(-) Kupffer Cell Subsets

van der Tuin, S. J. L., Li, Z., Berbee, J. F. P., Verkouter, I., Ringnalda, L. E., Neele, A. E., van Klinken, J. B., Rensen, S. S., Fu, J., de Winther, M. P. J., Groen, A. K., Rensen, P. C. N., van Dijk, K. W. & Wang, Y., 20 Mar 2018, In : Journal of the American Heart Association. 7, 6, p. 1-21 21 p., 008105.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Metabolic liver inflammation in obesity does not robustly decrease hepatic and circulating CETP

Blauw, L. L., Li, Z., Rensen, S. S., Greve, J. W. M., Verhoeven, A., Derks, R. J., Giera, M., Wang, Y. & Rensen, P. C. N., 1 Aug 2018, In : Atherosclerosis. 275, p. 149-155 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression

Peng, K-Y., Watt, M. J., Rensen, S., Greve, J. W., Huynh, K., Jayawardana, K. S., Meikle, P. J. & Meex, R. C. R., Oct 2018, In : Journal of Lipid Research. 59, 10, p. 1977-1986 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity

Scupakova, K., Soons, Z., Ertaylan, G., Pierzchalski, K. A., Eijkel, G. B., Ellis, S. R., Greve, J. W., Driessen, A., Verheij, J., De Kok, T. M., Damink, S. W. M. O., Rensen, S. S. & Heeren, R. M. A., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5130-5138 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

TUB gene expression in hypothalamus and adipose tissue and its association with obesity in humans

Nies, V. J. M., Struik, D., Wolfs, M. G. M., Rensen, S. S., Szalowska, E., Unmehopa, U. A., Fluiter, K., van der Meer, T. P., Hajmousa, G., Buurman, W. A., Greve, J. W., Rezaee, F., Shiri-Sverdlov, R., Vonk, R. J., Swaab, D. F., Wolffenbuttel, B. H. R., Jonker, J. W. & van Vliet-Ostaptchouk, J. V., Mar 2018, In : International Journal of Obesity. 42, 3, p. 376-383 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

A Liver-Specific Long Noncoding RNA With a Role in Cell Viability Is Elevated in Human Nonalcoholic Steatohepatitis

Atanasovska, B., Rensen, S. S., van der Sijde, M. R., Marsman, G., Kumar, V., Jonkers, I., Withoff, S., Shiri-Sverdlov, R., Greve, J. W. M., Faber, K. N., Moshage, H., Wijmenga, C., van de Sluis, B., Hofker, M. H. & Fu, J., Sep 2017, In : Hepatology. 66, 3, p. 794-808 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Erratum to: Human splanchnic amino-acid metabolism (vol 49, pg 161, 2017)

Neis, E. P. J. G., Sabrkhany, S., Hundscheid, I., Schellekens, D., Lenaerts, K., Damink, S. W. O., Blaak, E. E., Dejong, C. H. C. & Rensen, S. S., Jun 2017, In : Amino Acids. 49, 6, 1 p.

Research output: Contribution to journalErratum / corrigendumAcademic

Open Access

Human splanchnic amino-acid metabolism

Neis, E. P. J. G., Sabrkhany, S., Hundscheid, I., Schellekens, D., Lenaerts, K., Damink, S. W. O., Blaak, E. E., Dejong, C. H. C. & Rensen, S. S., Jan 2017, In : Amino Acids. 49, 1, p. 161-172 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Study protocol on the role of intestinal microbiota in colorectal cancer treatment: a pathway to personalized medicine 2.0

Aarnoutse, R., de Vos-Geelen, J. M. P. G. M., Penders, J., Boerma, E. G., Warmerdam, F. A. R. M., Goorts, B., Damink, S. W. M. O., Soons, Z., Rensen, S. S. M. & Smidt, M. L., Jul 2017, In : International Journal of Colorectal Disease. 32, 7, p. 1077-1084 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systematic review of the influence of chemotherapy-associated liver injury on outcome after partial hepatectomy for colorectal liver metastases

Zhao, J., van Mierlo, K. M. C., Gómez-Ramírez, J., Kim, H., Pilgrim, C. H. C., Pessaux, P., Rensen, S. S., van der Stok, E. P., Schaap, F. G., Soubrane, O., Takamoto, T., Viganò, L., Winkens, B., Dejong, C. H. C. & Olde Damink, S. W. M., Jul 2017, In : British Journal of Surgery. 104, 8, p. 990-1002 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

Effects of Liver Resection on Hepatic Short-Chain Fatty Acid Metabolism in Humans

Neis, E. P. J. G., Bloemen, J. G., Rensen, S. S., van der Vorst, J. R., van den Broek, M. A., Venema, K., Buurman, W. & Dejong, C. H. C., 11 Nov 2016, In : PLOS ONE. 11, 11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Inter-Tissue Gene Co-Expression Networks between Metabolically Healthy and Unhealthy Obese Individuals

Kogelman, L. J. A., Fu, J., Franke, L., Greve, J. W., Hofker, M., Rensen, S. S. & Kadarmideen, H. N., 1 Dec 2016, In : PLOS ONE. 11, 12, e0167519.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention

Walenbergh, S. M. A., Houben, T., Rensen, S. S., Bieghs, V., Hendrikx, T., van Gorp, P. J., Oligschläger, Y., Jeurissen, M. L. J., Gijbels, M. J. J., Buurman, W. A., Vreugdenhil, A. C. E., Greve, J. W. M., Plat, J., Hofker, M. H., Kalhan, S., Pihlajamaki, J., Lindsey, P., Koek, G. H. & Shiri-Sverdlov, R., 6 Dec 2016, In : Scientific Reports. 6, 38278.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
11 Citations (Scopus)

Colonic metaproteomic signatures of active bacteria and the host in obesity

Kolmeder, C. A., Ritari, J., Verdam, F. J., Muth, T., Keskitalo, S., Varjosalo, M., Fuentes, S., Greve, J. W., Buurman, W. A., Reichl, U., Rapp, E., Martens, L., Palva, A., Salonen, A., Rensen, S. S. & de Vos, W. M., Oct 2015, In : Proteomics. 15, 20, p. 3544-3552 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity

Wolfs, M. G., Gruben, N., Rensen, S. S., Verdam, F. J., Greve, J., Driessen, A., Wijmenga, C., Buurman, W., Franke, L., Scheja, L., Koonen, D. P., Shiri-Sverdlov, R., van Haeften, T. W., Hofker, M. H. & Fu, J., Feb 2015, In : Nutrition & Diabetes. 5, 7 p., e146.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of oral meal feeding on whole body protein breakdown and protein synthesis in cachectic pancreatic cancer patients

van Dijk, DP., van de Poll, M. C., Moses, A. G., Preston, T., Olde Damink, S. W. M., Rensen, S. S., Deutz, N. E., Soeters, P. B., Ross, J. A., Fearon, K. & Dejong, C. H., 1 Jan 2015, In : Journal of cachexia, sarcopenia and muscle. 6, 3, p. 212-221

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, J. C., Burke, M., Goode, R. J., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., Greve, J. W., Rensen, S. S., Molloy, M. P., Lancaster, G. I., Bruce, C. R. & Watt, M. J., 1 Jan 2015, In : Cell Metabolism. 22, 6, p. 1078-1089

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Navigating through metaproteomics data: a logbook of database searching

Muth, T., Kolmeder, C. A., Salojarvi, J., Keskitalo, S., Varjosalo, M., Verdam, F. J., Rensen, S. S., Reichl, U., de Vos, W. M., Rapp, E. & Martens, L., Oct 2015, In : Proteomics. 15, 20, p. 3439-3453 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells

Wang, Y., van der Tuin, S., Tjeerdema, N., van Dam, A. D., Rensen, S. S., Hendrikx, T., Berbée, J. F. P., Atanasovska, B., Fu, J., Hoekstra, M., Bekkering, S., Riksen, N. P., Buurman, W. A., Greve, J. W., Hofker, M. H., Shiri-Sverdlov, R., Meijer, O. C., Smit, J. W. A., Havekes, L. M., van Dijk, K. W. & 1 others, Rensen, P. C. N., Dec 2015, In : Hepatology. 62, 6, p. 1710-1722 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation

van Best, N., Jansen, P. L. M. & Rensen, S. S., Jul 2015, In : Hepatology International. 9, 3, p. 406-415 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

The Role of Microbial Amino Acid Metabolism in Host Metabolism

Neis, E. P. J. G., Dejong, C. H. & Rensen, S. S., Apr 2015, In : Nutrients. 7, 4, p. 2930-2946 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
3 Citations (Scopus)

Complement alternative pathway activation in human nonalcoholic steatohepatitis

Segers, F. M. E., Verdam, F. J., de Jonge, C., Boonen, B. T. C., Driessen, A., Shiri-Sverdlov, R., Bouvy, N. D., Greve, J., Buurman, W. A. & Rensen, S. S., 9 Oct 2014, In : PLOS ONE. 9, 10, 9 p., e110053.

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Genetic and epigenetic regulation of gene expression in fetal and adult human livers

Bonder, M. J., Kasela, S., Kals, M., Tamm, R., Lokk, K., Barragan, I., Buurman, W., Deelen, P., Greve, J., Ivanov, M., Rensen, S. S., van Vliet-Ostaptchouk, J. V., Wolfs, M. G., Fu, J., Hofker, M. H., Wijmenga, C., Zhernakova, A., Ingelman-Sundberg, M., Franke, L. & Milani, L., 4 Oct 2014, In : BMC Genomics. 15, 1, 13 p., 860.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans

Plat, J., Hendrikx, T., Bieghs, V., Jeurissen, M. L. J., Walenbergh, S. M., van Gorp, P. J., de Smet, E., Konings, M., Vreugdenhil, A. C., Guichot, Y. D., Rensen, S. S., Buurman, W., Greve, J., Lutjohann, D., Mensink, R. P. & Shiri-Sverdlov, R., 1 Jan 2014, In : PLOS ONE. 9, 10, e110758.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Six Months of Treatment with the Endoscopic Duodenal-Jejunal Bypass Liner Does Not Lead to Decreased Systemic Inflammation in Obese Patients with Type 2 Diabetes

de Jonge, C., Rensen, S. S., D'Agnolo, H. M., Bouvy, N. D., Buurman, W. A. & Greve, J. W., Feb 2014, In : Obesity Surgery. 24, 2, p. 337-341 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013
70 Citations (Scopus)

De novo lipogenesis in human fat and liver is linked to ChREBP-beta and metabolic health

Eissing, L., Scherer, T., Todter, K., Knippschild, U., Greve, J. W., Buurman, W. A., Pinnschmidt, H. O., Rensen, S. S., Wolf, A. M., Bartelt, A., Heeren, J., Buettner, C. & Scheja, L., Feb 2013, In : Nature Communications. 4, 11 p., 1528.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Endoscopic duodenal-jejunal bypass liner rapidly improves plasma parameters of nonalcoholic fatty liver disease

de Jonge, C., Rensen, S. S., Koek, G. H., Joosten, M. F., Buurman, W. A., Bouvy, N. & Greve, J. W., Nov 2013, In : Clinical gastroenterology and hepatology. 11, 11, p. 1517-1520 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

69 Citations (Scopus)

Endoscopic duodenal-jejunal bypass liner rapidly improves type 2 diabetes.

de Jonge, C., Rensen, S. S. M., Verdam, F. J., Vincent, R. P., Bloom, S. R., Buurman, W. A., le Roux, C. W., Schaper, N. C., Bouvy, N. D. & Greve, J. W., Sep 2013, In : Obesity Surgery. 23, 9, p. 1354-1360 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

80 Citations (Scopus)

Human intestinal microbiota composition is associated with local and systemic inflammation in obesity.

Verdam, F. J., Fuentes, S., de Jonge, C., Zoetendal, E. G., Erbil, R., Greve, J. W., Buurman, W. A., de Vos, W. M. & Rensen, S. S. M., 1 Jan 2013, In : Obesity. 21, 12, p. E607-E615

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Liver manipulation during liver surgery in humans is associated with hepatocellular damage and hepatic inflammation.

van den Broek, M. A., Shiri-Sverdlov, R., Schreurs, J. J., Bloemen, J. G., Bieghs, V., Rensen, S. S. M., Dejong, C. H. C. & Olde Damink, S., 1 Jan 2013, In : Liver International. 33, 4, p. 633-641

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Nicotine effect on inflammatory and growth factor responses in murine cutaneous wound healing

Xanthoulea, S., Deliaert, A., Romano, A., Rensen, S. S., Buurman, W. A. & van der Hulst, R. R., Dec 2013, In : International Immunopharmacology. 17, 4, p. 1155-1164 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Non-alcoholic steatohepatitis: A non-invasive diagnosis by analysis of exhaled breath.

Verdam, F. J., Dallinga, J. W., Driessen, A. L. C., de Jonge, C., Moonen, E. J., van Berkel, J. B., Luijk, J., Bouvy, N. D., Buurman, W. A., Rensen, S. S. M., Greve, J. W. & van Schooten, F. J., Mar 2013, In : Journal of Hepatology. 58, 3, p. 543-548 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)

The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice.

Bieghs, V., Hendrikx, T., van Gorp, P. J. J., Verheyen, F., Guichot, Y. D., Walenbergh, S. M., Gijbels, M. J. J., Rensen, S. S. M., Bast, A., Plat, J., Kalhan, S. C., Leitersdorf, E., Hofker, M. H., Lutjohann, D. & Shiri-Sverdlov, R., 1 Jan 2013, In : Gastroenterology. 144, 1, p. 167-178.e1

Research output: Contribution to journalArticleAcademicpeer-review

2012
6 Citations (Scopus)

Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity.

Schults, M. A. C., Nagle, P. W., Rensen, S. S. M., Godschalk, R. W. L., Munnia, A., Peluso, M., Claessen, S. M., Greve, J. W., Driessen, A. L. C., Verdam, F. J., Buurman, W. A., van Schooten, F. J. & Chiu, R. K., 1 Aug 2012, In : Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 736, 1-2, p. 75-81 7 p.

Research output: Contribution to journalArticleAcademicpeer-review