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Research Output 2005 2019

2019

Chemokines as Therapeutic Targets in Cardiovascular Disease The Road Behind, The Road Ahead

Noels, H., Weber, C. & Koenen, R. R., Apr 2019, In : Arteriosclerosis Thrombosis and Vascular Biology. 39, 4, p. 583-592 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lysophosphatidylcholine in Platelet Microvesicles: The Grease for Cardiovascular Disease

Koenen, R. R., Aug 2019, In : Thrombosis and Haemostasis. 119, 8, p. 1202-1204 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

No hearty reception: infusion of CXCL4 impedes tissue repair by macrophages after myocardial infarction

Koenen, R. R., 1 Feb 2019, In : Cardiovascular Research. 115, 2, p. 264-265 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2

Denisov, S. S., Ippel, J. H., Heinzmann, A. C. A., Koenen, R. R., Ortega-Gomez, M., Soehnlein, O., Hackeng, T. M. & Dijkgraaf, I., 16 Aug 2019, In : Journal of Biological Chemistry. 294, 33, p. 12370-12379 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis

Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., Ruf, W., van Gorp, R. H., Koenen, R. R., Vajen, T., Alshaikh, N. A., Wolberg, A. S., Macrae, F. L., Asquith, N. & 43 others, Heemskerk, J., Heinzmann, A., Moorlag, M., Mackman, N., van der Meijden, P., Meijers, J. C. M., Heestermans, M., Renne, T., Dolleman, S., Chayoua, W., Ariens, R. A. S., Baaten, C. C., Nagy, M., Kuliopulos, A., Posma, J. J., Harrison, P., Vries, M. J., Crijns, H. J. G. M., Dudink, E. A. M. P., Buller, H. R., Henskens, Y. M. C., Sjalander, A., Zwaveling, S., Erkuner, O., Eikelboom, J. W., Gulpen, A., Peeters, F. E. C. M., Douxfils, J., Olie, R. H., Baglin, T., Leader, A., Schotten, U., Scaf, B., van Beusekom, H. M. M., Mosnier, L. O., van der Vorm, L., Declerck, P., Visser, M., Dippel, D. W. J., Strijbis, V. J., Pertiwi, K., ten Cate-Hoek, A. J. & ten Cate, H., 1 Feb 2018, In : Thrombosis and Haemostasis. 118, 2, p. 229-250 22 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis

Vajen, T., Koenen, R. R., Werner, I., Staudt, M., Projahn, D., Curaj, A., Sonmez, T. T., Simsekyilmaz, S., Schumacher, D., Mollmann, J., Hackeng, T. M., von Hundelshausen, P., Weber, C. & Liehn, E. A., 13 Jul 2018, In : Scientific Reports. 8, 11 p., 10647.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases

Koenen, R. R. & Aikawa, E., 19 Sep 2018, In : Frontiers in cardiovascular medicine. 5, 2 p., 133.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks

Dickhout, A. & Koenen, R. R., 22 Aug 2018, In : Frontiers in cardiovascular medicine. 5, 9 p., 113.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access

Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets

Vajen, T., Heinzmann, A. C. A., Dickhout, A., Zhao, Z., Nagy, M., Heemskerk, J. W. M. & Koenen, R. R., 1 Apr 2018, In : Journal of visualized experiment. 134, 6 p., e57009.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation

Curaj, A., Wu, Z., Rix, A., Gresch, O., Sternkopf, M., Alampour-Rajabi, S., Lammers, T., van Zandvoort, M., Weber, C., Koenen, R. R., Liehn, E. A. & Kiessling, F., 1 Jan 2018, In : Arteriosclerosis Thrombosis and Vascular Biology. 38, 1, p. 40-48 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

A trip across the vast endothelial cell surface

Koenen, R. R., 2017, MAYA SIMIONESCU - RIGOAREA STIINTEI & BUNATATEA INTELIGENTEI. Manduteanu, I., Sima, A. & Papov, D. (eds.). Fundaţia Naţională pentru Ştiinţă şi Artă, p. 43-45 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation

von Hundelshausen, P., Agten, S. M., Eckardt, V., Blanchet, X., Schmitt, M. M., Ippel, H., Neideck, C., Bidzhekov, K., Leberzammer, J., Wichapong, K., Faussner, A., Drechsler, M., Grommes, J., van Geffen, J. P., Li, H., Ortega-Gomez, A., Megens, R. T. A., Naumann, R., Dijkgraaf, I., Nicolaes, G. A. F. & 8 others, Doering, Y., Soehnlein, O., Lutgens, E., Heemskerk, J. W. M., Koenen, R. R., Mayo, K. H., Hackeng, T. M. & Weber, C., 5 Apr 2017, In : Science Translational Medicine. 9, 384, 14 p., eaah6650.

Research output: Contribution to journalArticleAcademicpeer-review

Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice

Zhao, Z., Vajen, T., Karshovska, E., Dickhout, A., Schmitt, M. M., Megens, R. T. A., von Hundelshausen, P., Koeppel, T. A., Hackeng, T. M., Weber, C. & Koenen, R. R., Aug 2017, In : Journal of Cellular and Molecular Medicine. 21, 8, p. 1523-1531 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Extrazelluläre Vesikel im Blut: Der verlängerte Arm der Blutplättchen

Koenen, R., 2017, In : Trillium Diagnostik. 15, 4, p. 256-258 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype

Vajen, T., Benedikter, B. J., Heinzmann, A. C. A., Vasina, E. M., Henskens, Y., Parsons, M., Maguire, P. B., Stassen, F. R., Heemskerk, J. W. M., Schurgers, L. J. & Koenen, R. R., 16 May 2017, In : Journal of Extracellular Vesicles . 6, 1, 14 p., 1322454.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Deletion of junctional adhesion molecule a from platelets increases early stage neointima formation after wire injury in hyperlipidemic mice

Zhao, Z., Karshovska, E., Schmitt, M., Megens, R., Von Hundelshausen, P., Koeppel, T. A., Hackeng, T. M., Weber, C. & Koenen, R., 1 Jul 2016, p. S55-S55.

Research output: Contribution to conferenceAbstractAcademic

1 Citation (Scopus)

Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium

Regn, M., Laggerbauer, B., Jentzsch, C., Ramanujam, D., Ahles, A., Sichler, S., Calzada-Wack, J., Koenen, R. R., Braun, A., Nieswandt, B. & Engelhardt, S., Oct 2016, In : Journal of Molecular and Cellular Cardiology. 99, p. 57-64

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Probing Functional Heteromeric Chemokine Protein-Protein Interactions through Conformation-Assisted Oxime Ligation

Agten, S. M., Koenen, R. R., Ippel, H., Eckardt, V., von Hundelshausen, P., Mayo, K. H., Weber, C. & Hackeng, T. M., 21 Nov 2016, In : Angewandte Chemie-International Edition. 55, 48, p. 14963-14966

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

The prowess of platelets in immunity and inflammation

Koenen, R. R., Oct 2016, In : Thrombosis and Haemostasis. 116, 4, p. 605-612

Research output: Contribution to journalArticleAcademicpeer-review

2015
3 Citations (Scopus)

Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility

Medina, I., Cougoule, C., Drechsler, M., Bermudez, B., Koenen, R. R., Sluimer, J., Wolfs, I., Doering, Y., Herias, V., Gijbels, M., Bot, I., de Jager, S. C. A., Weber, C., Cleutjens, J., van Berkel, T. J. C., Sikkink, K-J., Mocsai, A., Maridonneau-Parini, I., Soehnlein, O. & Biessen, E. A. L., 11 Aug 2015, In : Circulation. 132, 6, p. 490-501

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Hyperreactivity of Junctional Adhesion Molecule A-Deficient Platelets Accelerates Atherosclerosis in Hyperlipidemic Mice

Karshovska, E., Zhao, Z., Blanchet, X., Schmitt, M. M. N., Bidzhekov, K., Soehnlein, O., von Hundelshausen, P., Mattheij, N. J., Cosemans, J. M. E. M., Megens, R. T. A., Koeppel, T. A., Schober, A., Hackeng, T. M., Weber, C. & Koenen, R. R., 13 Feb 2015, In : Circulation Research. 116, 4, p. 587-599

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Microvesicles from platelets: novel drivers of vascular inflammation

Vajen, T., Mause, S. F. & Koenen, R. R., Aug 2015, In : Thrombosis and Haemostasis. 114, 2, p. 228-236

Research output: Contribution to journalArticleAcademicpeer-review

2014
26 Citations (Scopus)

Activation of CXCR7 Limits Atherosclerosis and Improves Hyperlipidemia by Increasing Cholesterol Uptake in Adipose Tissue

Li, X., Zhu, M., Penfold, M. E., Koenen, R. R., Thiemann, A., Heyll, K., Akhtar, S., Koyadan, S., Wu, Z., Gremse, F., Kiessling, F., van Zandvoort, M., Schall, T. J., Weber, C. & Schober, A., 18 Mar 2014, In : Circulation. 129, 11, p. 1244-1253

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution

Schmitt, M. M. N., Fraemohs, L., Hackeng, T. M., Weber, C. & Koenen, R. R., Jun 2014, In : Atherosclerosis. 234, 2, p. 254-264

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Bone Marrow-Specific Knock-In of a Non-Activatable Ikk alpha Kinase Mutant Influences Haematopoiesis but Not Atherosclerosis in Apoe-Deficient Mice

Tilstam, P. V., Gijbels, M. J., Habbeddine, M., Cudejko, C., Asare, Y., Theelen, W., Zhou, B., Doering, Y., Drechsler, M., Pawig, L., Simsekyilmaz, S., Koenen, R. R., de Winther, M. P. J., Lawrence, T., Bernhagen, J., Zernecke, A., Weber, C. & Noels, H., 3 Feb 2014, In : PLOS ONE. 9, 2, e87452.

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction

Projahn, D., Simsekyilmaz, S., Singh, S., Kanzler, I., Kramp, B. K., Langer, M., Burlacu, A., Bernhagen, J., Klee, D., Zernecke, A., Hackeng, T. M., Groll, J., Weber, C., Liehn, E. A. & Koenen, R. R., May 2014, In : Journal of Cellular and Molecular Medicine. 18, 5, p. 790-800

Research output: Contribution to journalArticleAcademicpeer-review

CX(3)CL1, a special deputy at the intersection of platelets and the vessel wall

Koenen, R. R., Apr 2014, In : Thrombosis and Haemostasis. 111, 4, p. 567-567

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

CXCR4 blockade induces atherosclerosis by affecting neutrophil function

Bot, I., Daissormont, I. T. M. N., Zernecke, A., van Puijvelde, G. H. M., Kramp, B., de Jager, S. C. A., Sluimer, J. C., Manca, M., Herias, V., Westra, M. M., Bot, M., van Santbrink, P. J., van Berkel, T. J. C., Su, L., Skjelland, M., Gullestad, L., Kuiper, J., Halvorsen, B., Aukrust, P., Koenen, R. R. & 2 others, Weber, C. & Biessen, E. A. L., Sep 2014, In : Journal of Molecular and Cellular Cardiology. 74, p. 44-52

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis

Schmitt, M. M. N., Megens, R. T. A., Zernecke, A., Bidzhekov, K., van den Akker, N. M., Rademakers, T., van Zandvoort, M. A., Hackeng, T. M., Koenen, R. R. & Weber, C., 7 Jan 2014, In : Circulation. 129, 1, p. 66-+

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome

Blanchet, X., Cesarek, K., Brandt, J., Herwald, H., Teupser, D., Kuechenhoff, H., Karshovska, E., Mause, S. F., Siess, W., Wasmuth, H., Soehnlein, O., Koenen, R. R., Weber, C. & von Hundelshausen, P., Dec 2014, In : Thrombosis and Haemostasis. 112, 6, p. 1277-1287

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

TNF-alpha and IFN-gamma promote lymphocyte adhesion to endothelial junctional regions facilitating transendothelial migration

Jaczewska, J., Abdulreda, M. H., Yau, C. Y., Schmitt, M. M., Schubert, I., Berggren, P-O., Weber, C., Koenen, R. R., Moy, V. T. & Wojcikiewicz, E. P., Feb 2014, In : Journal of Leukocyte Biology. 95, 2, p. 265-274

Research output: Contribution to journalArticleAcademicpeer-review

2013
4 Citations (Scopus)

Chemoselective Oxime Reactions in Proteins and Peptides by Using an Optimized Oxime Strategy: The Demise of Levulinic Acid

Agten, S. M., Suylen, D., Ippel, H., Kokozidou, M., Tans, G., van de Vijver, P., Koenen, R. R. & Hackeng, T. M., 16 Dec 2013, In : Chembiochem. 14, 18, p. 2431-2434

Research output: Contribution to journalArticleAcademicpeer-review

75 Citations (Scopus)

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

Soehnlein, O., Drechsler, M., Doering, Y., Lievens, D., Hartwig, H., Kemmerich, K., Ortega-Gomez, A., Mandl, M., Vijayan, S., Projahn, D., Garlichs, C. D., Koenen, R. R., Hristov, M., Lutgens, E., Zernecke, A. & Weber, C., Mar 2013, In : EMBO Molecular Medicine. 5, 3, p. 471-481

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment

Kramp, B. K., Megens, R. T. A., Sarabi, A., Winkler, S., Projahn, D., Weber, C., Koenen, R. R. & von Hundelshausen, P., Oct 2013, In : Thrombosis and Haemostasis. 110, 4, p. 795-806

Research output: Contribution to journalArticleAcademicpeer-review

2012

Anti-Inflammatory Therapeutic Approaches to Reduce Acute Atherosclerotic Complications

Kanzler, I., Liehn, E. A., Koenen, R. R. & Weber, C., Jan 2012, In : Current Pharmaceutical Biotechnology. 13, 1, p. 37-45

Research output: Contribution to journalArticleAcademicpeer-review

123 Citations (Scopus)

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

Doering, Y., Manthey, H. D., Drechsler, M., Lievens, D., Megens, R. T. A., Soehnlein, O., Busch, M., Manca, M., Koenen, R. R., Pelisek, J., Daemen, M. J., Lutgens, E., Zenke, M., Binder, C. J., Weber, C. & Zernecke, A., 3 Apr 2012, In : Circulation. 125, 13, p. 1673-U190

Research output: Contribution to journalArticleAcademicpeer-review

Contribution of Platelet CX(3)CR1 to Platelet-Monocyte Complex Formation and Vascular Recruitment During Hyperlipidemia

Postea, O., Vasina, E. M., Cauwenberghs, S., Projahn, D., Liehn, E. A., Lievens, D., Theelen, W., Kramp, B. K., Butoi, E. D., Soehnlein, O., Heemskerk, J. W. M., Ludwig, A., Weber, C. & Koenen, R. R., May 2012, In : Arteriosclerosis Thrombosis and Vascular Biology. 32, 5, p. 1186-+

Research output: Contribution to journalArticleAcademicpeer-review

67 Citations (Scopus)

Disruption of Platelet-derived Chemokine Heteromers Prevents Neutrophil Extravasation in Acute Lung Injury

Grommes, J., Alard, J-E., Drechsler, M., Wantha, S., Morgelin, M., Kuebler, W. M., Jacobs, M., von Hundelshausen, P., Markart, P., Wygrecka, M., Preissner, K. T., Hackeng, T. M., Koenen, R. R., Weber, C. & Soehnlein, O., 15 Mar 2012, In : American Journal of Respiratory and Critical Care Medicine. 185, 6, p. 628-636

Research output: Contribution to journalArticleAcademicpeer-review

Hematopoietic Interferon Regulatory Factor 8-Deficiency Accelerates Atherosclerosis in Mice

Doering, Y., Soehnlein, O., Drechsler, M., Shagdarsuren, E., Chaudhari, S. M., Meiler, S., Hartwig, H., Hristov, M., Koenen, R. R., Hieronymus, T., Zenke, M., Weber, C. & Zernecke, A., Jul 2012, In : Arteriosclerosis Thrombosis and Vascular Biology. 32, 7, p. 1613-1623

Research output: Contribution to journalArticleAcademicpeer-review

Incorporation of Disulfide Containing Protein Modules into Multivalent Antigenic Conjugates: Generation of Antibodies against the Thrombin-Sensitive Region of Murine Protein S

Van de Vijver, P., Schmitt, M., Suylen, D., Scheer, L., Thomassen, M. C. L. G. D., Schurgers, L. J., Griffin, J. H., Koenen, R. R. & Hackeng, T. M., 28 Nov 2012, In : Journal of the American Chemical Society. 134, 47, p. 19318-19321

Research output: Contribution to journalArticleAcademicpeer-review

183 Citations (Scopus)

MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages

Nazari-Jahantigh, M., Wei, Y., Noels, H., Akhtar, S., Zhou, Z., Koenen, R. R., Heyll, K., Gremse, F., Kiessling, F., Grommes, J., Weber, C. & Schober, A., Nov 2012, In : Journal of Clinical Investigation. 122, 11, p. 4190-4202

Research output: Contribution to journalArticleAcademicpeer-review

Platelets: key players in vascular inflammation

Projahn, D. & Koenen, R. R., Dec 2012, In : Journal of Leukocyte Biology. 92, 6, p. 1167-1175

Research output: Contribution to journalArticleAcademicpeer-review

2011

Chemokines: established and novel targets in atherosclerosis

Koenen, R. R. & Weber, C., Dec 2011, In : EMBO Molecular Medicine. 3, 12, p. 713-725

Research output: Contribution to journalArticleAcademicpeer-review

Cross talk between smooth muscle cells and monocytes/activated monocytes via CX3CL1/CX3CR1 axis augments expression of pro-atherogenic molecules

Butoi, E. D., Gan, A. M., Manduteanu, I., Stan, D., Calin, M., Pirvulescu, M., Koenen, R. R., Weber, C. & Simionescu, M., Dec 2011, In : Biochimica et Biophysica Acta-Molecular Cell Research. 1813, 12, p. 2026-2035

Research output: Contribution to journalArticleAcademicpeer-review

CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment

Sarabi, A., Kramp, B. K., Drechsler, M., Hackeng, T. M., Soehnlein, O., Weber, C., Koenen, R. R. & von Hundelshausen, P., Jan 2011, In : Journal of Thrombosis and Haemostasis. 9, 1, p. 209-219

Research output: Contribution to journalArticleAcademicpeer-review

Double-Edged Role of the CXCL12/CXCR4 Axis in Experimental Myocardial Infarction

Liehn, E. A., Tuchscheerer, N., Kanzler, I., Drechsler, M., Fraemohs, L., Schuh, A., Koenen, R. R., Zander, S., Soehnlein, O., Hristov, M., Grigorescu, G., Urs, A. O., Leabu, M., Bucur, I., Merx, M. W., Zernecke, A., Ehling, J., Gremse, F., Lammers, T., Kiessling, F. & 3 others, Bernhagen, J., Schober, A. & Weber, C., 29 Nov 2011, In : Journal of the American College of Cardiology. 58, 23, p. 2415-2423

Research output: Contribution to journalArticleAcademicpeer-review

Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis

de Jager, S. C. A., Bermudez, B., Bot, I., Koenen, R. R., Bot, M., Kavelaars, A., de Waard, V., Heijnen, C. J., Muriana, F. J. G., Weber, C., van Berkel, T. J. C., Kuiper, J., Lee, S-J., Abia, R. & Biessen, E. A. L., 14 Feb 2011, In : Journal of Experimental Medicine. 208, 2, p. 217-225

Research output: Contribution to journalArticleAcademicpeer-review