20142019

Research output per year

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Research Output

2017

Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

Ellis, S. R., Soltwisch, J., Paine, M. R. L., Dreisewerd, K. & Heeren, R. M. A., 7 Jul 2017, In : Chemical Communications. 53, 53, p. 7246-7249 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Mass spectrometry imaging for clinical research - latest developments, applications, and current limitations

Vaysse, P-M., Heeren, R. M. A., Porta, T. & Balluff, B., 7 Aug 2017, In : Analyst. 142, 15, p. 2690-2712 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Mass Spectrometry Imaging for the Investigation of Intratumor Heterogeneity

Balluff, B., Hanselmann, M. & Heeren, R. M. A., 2017, APPLICATIONS OF MASS SPECTROMETRY IMAGING TO CANCER. Drake, RR. & McDonnell, LA. (eds.). Elsevier Science, p. 201-230 30 p. (Advances in Cancer Research, Vol. 134).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Mass Spectrometry Imaging in Nanomedicine: Unraveling the Potential of MSI for the Detection of Nanoparticles in Neuroscience

Barre, F. P. Y., Heeren, R. M. A. & Potocnik, N. O., 2017, In : Current Pharmaceutical Design. 23, 13, p. 1974-1984 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
68 Downloads (Pure)

Optimization of Sample Preparation and Instrumental Parameters for the Rapid Analysis of Drugs of Abuse in Hair samples by MALDI-MS/MS Imaging

Flinders, B., Beasley, E., Verlaan, R. M., Cuypers, E., Francese, S., Bassindale, T., Clench, M. R. & Heeren, R. M. A., Nov 2017, In : Journal of the American Society for Mass Spectrometry. 28, 11, p. 2462-2468 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI

Bakker, B., Eijkel, G. B., Heeren, R. M. A., Karperien, M., Post, J. N. & Cillero-Pastor, B., 5 Sep 2017, In : Analytical Chemistry. 89, 17, p. 9438-9444 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sequencing and Identification of Endogenous Neuropeptides with Matrix-Enhanced Secondary Ion Mass Spectrometry Tandem Mass Spectrometry

Potocnik, N. O., Fisher, G. L., Prop, A. & Heeren, R. M. A., 15 Aug 2017, In : Analytical Chemistry. 89, 16, p. 8223-8227 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Composition of Poly(Ethylene Terephthalate) (PET) Surface Precipitates Determined at High Resolving Power by Tandem Mass Spectrometry Imaging

Fisher, G. L., Hammond, J. S., Bryan, S. R., Larson, P. E. & Heeren, R. M. A., Aug 2017, In : Microscopy and Microanalysis. 23, 4, p. 843-848 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development

Gussenhoven, R., Ophelders, D. R. M. G., Kemp, M. W., Payne, M. S., Spiller, O. B., Beeton, M. L., Stock, S. J., Cillero-Pastor, B., Barre, F. P. Y., Heeren, R. M. A., Kessels, L., Stevens, B., Rutten, B. P., Kallapur, S. G., Jobe, A. H., Kramer, B. W. & Wolfs, T. G. A. M., 2017, In : Developmental Neuroscience. 39, 6, p. 472-486 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Visualizing hepatocellular amino acid kinetics through mass spectrometry imaging of stable isotopes

Arts, M., Soons, Z., Dubois, L. J., Pierzchalski, K. A., Ellis, S. R., Balluff, B., Eijkel, G. B., Cramer, T., Lieuwes, N., Agten, S. M., Hackeng, T. M., Van Loon, L. J., Heeren, R. M. & Damink, S. W. O., 2017, In : Journal of Hepatology. 66, 1, p. S43-S44 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Visualizing molecular distributions for biomaterials applications with mass spectrometry imaging: a review

Paine, M. R. L., Kooijman, P. C., Fisher, G. L., Heeren, R. M. A., Fernandez, F. M. & Ellis, S. R., 28 Sep 2017, In : Journal of Materials Chemistry. B, Materials for Biology and Medicine. 5, 36, p. 7444-7460 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

An ambient detection system for visualization of charged particles generated with ionization methods at atmospheric pressure

Hommersom, B., Syed, S. U. A. H., Eijkel, G. B., Kilgour, D. P. A., Goodlett, D. R. & Heeren, R. M. A., 15 Feb 2016, In : Rapid Communications in Mass Spectrometry. 30, 3, p. 352-358

Research output: Contribution to journalArticleAcademicpeer-review

A New Method and Mass Spectrometer Design for TOF-SIMS Parallel Imaging MS/MS

Fisher, G. L., Bruinen, A. L., Potocnik, N. O., Hammond, J. S., Bryan, S. R., Larson, P. E. & Heeren, R. M. A., 21 Jun 2016, In : Analytical Chemistry. 88, 12, p. 6433-6440

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Consequences of Decontamination Procedures in Forensic Hair Analysis Using Metal-Assisted Secondary Ion Mass Spectrometry Analysis

Cuypers, E., Flinders, B., Boone, C. M., Bosman, I. J., Lusthof, K. J., Van Asten, A. C., Tytgat, J. & Heeren, R. M. A., 15 Mar 2016, In : Analytical Chemistry. 88, 6, p. 3091-3097

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Derivatization Strategies for the Detection of Triamcinolone Acetonide in Cartilage by Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Barre, F. P. Y., Flinders, B., Garcia, J. P., Jansen, I., Huizing, L. R. S., Porta, T., Creemers, L. B., Heeren, R. M. A. & Cillero-Pastor, B., 20 Dec 2016, In : Analytical Chemistry. 88, 24, p. 12051-12059

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
54 Downloads (Pure)

Direct Analysis and Quantification of Metaldehyde in Water using Reactive Paper Spray Mass Spectrometry

Maher, S., Jjunju, F. P. M., Damon, D. E., Gorton, H., Maher, Y. S., Syed, S. U., Heeren, R. M. A., Young, I. S., Taylor, S. & Badu-Tawiah, A. K., 21 Oct 2016, In : Scientific Reports. 6, 35643.

Research output: Contribution to journalArticleAcademicpeer-review

Enhanced capabilities for imaging gangliosides in murine brain with matrix-assisted laser desorption/ionization and desorption electrospray ionization mass spectrometry coupled to ion mobility separation

Skraskova, K., Claude, E., Jones, E. A., Towers, M., Ellis, S. R. & Heeren, R. M. A., 15 Jul 2016, In : Methods. 104, p. 69-78

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Mass Spectrometry Imaging of Drug Related Crystal-Like Structures in Formalin-Fixed Frozen and Paraffin-Embedded Rabbit Kidney Tissue Sections

Bruinen, A. L., van Oevelen, C., Eijkel, G. B., Van Heerden, M., Cuyckens, F. & Heeren, R. M. A., Jan 2016, In : Journal of the American Society for Mass Spectrometry. 27, 1, p. 117-123

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Mass Spectrometry Imaging of the Hypoxia Marker Pimonidazole in a Breast Tumor Model

Mascini, N. E., Cheng, M., Jiang, L., Rizwan, A., Podmore, H., Bhandari, D. R., Roempp, A., Glunde, K. & Heeren, R. M. A., 15 Mar 2016, In : Analytical Chemistry. 88, 6, p. 3107-3114

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

More from less: high-throughput dual polarity lipid imaging of biological tissues

Ellis, S. R., Cappell, J., Potocnik, N. O., Balluff, B., Hamaide, J., Van der Linden, A. & Heeren, R. M. A., 2016, In : Analyst. 141, 12, p. 3832-3841

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Multimodal Spectroscopic Study of Amyloid Fibril Polymorphism

VandenAkker, C. C., Schleeger, M., Bruinen, A. L., Deckert-Gaudig, T., Velikov, K. P., Heeren, R. M. A., Deckert, V., Bonn, M. & Koenderink, G. H., 1 Sep 2016, In : Journal of Physical Chemistry B. 120, 34, p. 8809-8817

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Norharmane matrix enhances detection of endotoxin by MALDI-MS for simultaneous profiling of pathogen, host and vector systems

Scott, A. J., Flinders, B., Cappell, J., Liang, T., Pelc, R. S., Tran, B., Kilgour, D. P. A., Heeren, R. M. A., Goodlett, D. R. & Ernst, R. K., Nov 2016, In : Pathogens and Disease. 74, 8, ftw097.

Research output: Contribution to journalArticleAcademicpeer-review

OXYGEN REGULATES LIPID PROFILES IN HUMAN PRIMARY CHONDROCYTE CULTURES

Bakker, B., Eijkel, G. B., Heeren, R. M., Karperien, M., Post, J. N. & Cillero-Pastor, B., Apr 2016, In : Osteoarthritis and Cartilage. 24, p. S456-S457 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Open Access

Parallel imaging MS/MS TOF-SIMS instrument

Fisher, G. L., Hammond, J. S., Larson, P. E., Bryan, S. R. & Heeren, R. M. A., 2016, In : Journal of Vacuum Science & Technology B. 34, 3, 03H126.

Research output: Contribution to journalArticleAcademicpeer-review

Screening and Quantification of Aliphatic Primary Alkyl Corrosion Inhibitor Amines in Water Samples by Paper Spray Mass Spectrometry

Jjunju, F. P. M., Maher, S., Damon, D. E., Barrett, R. M., Syed, S. U., Heeren, R. M. A., Taylor, S. & Badu-Tawiah, A. K., 19 Jan 2016, In : Analytical Chemistry. 88, 2, p. 1391-1400

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Spatial Autocorrelation in Mass Spectrometry Imaging

Cassese, A., Ellis, S. R., Ogrinc Potocnik, N., Burgermeister, E., Ebert, M., Walch, A., Van Den Maagdenberg, A. M. J. M., McDonnell, L. A., Heeren, R. M. A. & Balluff, B., 7 Jun 2016, In : Analytical Chemistry. 88, 11, p. 5871-5878 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Spectroscopic data handling at petabyte scale

Davies, A. N., Ellis, S., Balluff, B. & Heeren, R., 2016, In : Spectroscopy Europe. 28, 1, p. 15-17

Research output: Contribution to journalArticleProfessional

Sub-Micron Resolution Imaging with Bio-Molecular Identification by TOF-SIMS Parallel Imaging MS/MS

Fisher, G. L., Ogrinc Potocnik, N., Bruinen, A., Hammond, J. S., Bryan, S. R. & Heeren, R., 2016, In : Proceedings of Microscopy & Microanalysis 2016. 22, S3, p. 350 351 p.

Research output: Contribution to journalConference article in journalAcademicpeer-review

The Impact of N-terminal Acetylation of alpha-Synuclein on Phospholipid Membrane Binding and Fibril Structure

Iyer, A., Roeters, S. J., Schilderink, N., Hommersom, B., Heeren, R. M. A., Woutersen, S., Claessens, M. M. A. E. & Subramaniam, V., 30 Sep 2016, In : Journal of Biological Chemistry. 291, 40, p. 21110-21122

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2015

A micropixelated ion-imaging detector for mass resolution enhancement of a QMS instrument

Syed, S. U. A. H., Eijkel, G. B., Maher, S., Kistemaker, P., Taylor, S. & Heeren, R. M. A., Mar 2015, In : Analytical and Bioanalytical Chemistry. 407, 8, p. 2055-2062

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Characterization of lipidic markers of chondrogenic differentiation using mass spectrometry imaging

Rocha, B., Cillero-Pastor, B., Eijkel, G., Bruinen, A. L., Ruiz-Romero, C., Heeren, R. M. A. & Blanco, F. J., Feb 2015, In : Proteomics. 15, 4, p. 702-13 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Complexiteit in beeld : samen naar de moleculaire ‘selfie’

Heeren, R. M. A., 19 Jun 2015, Maastricht: Maastricht University.

Research output: Book/ReportInaugural speechPopular

Differentiation of Mesenchymal Stem Cells under Hypoxia and Normoxia: Lipid Profiles Revealed by Time-of-Flight Secondary Ion Mass Spectrometry and Multivariate Analysis

Georgi, N., Cillero-Pastor, B., Eijkel, G. B., Periyasamy, P. C., Kiss, A., van Blitterswijk, C., Post, J. N., Heeren, R. M. A. & Karperien, M., 7 Apr 2015, In : Analytical Chemistry. 87, 7, p. 3981-3988

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Direct Ion Imaging Approach for Investigation of Ion Dynamics in Multipole Ion Guides

Syed, S. U. A. H., Maher, S., Eijkel, G. B., Ellis, S. R., Jjunju, F., Taylor, S. & Heeren, R. M. A., 7 Apr 2015, In : Analytical Chemistry. 87, 7, p. 3714-3720

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Discussion point: reporting guidelines for mass spectrometry imaging

McDonnell, L. A., Roempp, A., Balluff, B., Heeren, R. M. A., Albar, J. P., Andren, P. E., Corthals, G. L., Walch, A. & Stoeckli, M., Mar 2015, In : Analytical and Bioanalytical Chemistry. 407, 8, p. 2035-2045

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Distributed computing strategies for processing of FT-ICR MS imaging datasets for continuous mode data visualization

Smith, D. F., Schulz, C., Konijnenburg, M., Kilic, M. & Heeren, R. M. A., Mar 2015, In : Analytical and Bioanalytical Chemistry. 407, 8, p. 2321-2327

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Fast image-charge calculations for multi-particle simulations in FT-ICR analyzer cells of arbitrary geometry

Driver, J. A., Kharchenko, A., Heeren, R. M. A. & Amster, I. J., 1 Feb 2015, In : International Journal of Mass Spectrometry. 377, p. 432-439

Research output: Contribution to journalArticleAcademicpeer-review

Getting the picture: The coming of age of imaging MS

Heeren, R. M. A., 1 Feb 2015, In : International Journal of Mass Spectrometry. 377, p. 672-680

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Hand-Held Portable Desorption Atmospheric Pressure Chemical Ionization Ion Source for in Situ Analysis of Nitroaromatic Explosives

Jjunju, F. P. M., Maher, S., Li, A., Syed, S. U., Smith, B., Heeren, R. M. A., Taylor, S. & Cooks, R. G., 6 Oct 2015, In : Analytical Chemistry. 87, 19, p. 10047-10055

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

MALDI-Mass Spectrometric Imaging Revealing Hypoxia-Driven Lipids and Proteins in a Breast Tumor Model

Jiang, L., Chughtai, K., Purvine, S. O., Bhujwalla, Z. M., Raman, V., Pasa-Tolic, L., Heeren, R. M. A. & Glunde, K., 16 Jun 2015, In : Analytical Chemistry. 87, 12, p. 5947-5956

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Mass spectrometry imaging of biological tissue: an approach for multicenter studies

Römpp, A., Both, J-P., Brunelle, A., Heeren, R. M. A., Laprévote, O., Prideaux, B., Seyer, A., Spengler, B., Stoeckli, M. & Smith, D. F., Mar 2015, In : Analytical and Bioanalytical Chemistry. 407, 8, p. 2329-35 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

MultiModal Molecular Imaging

Heeren, R., 2015, In : The Analytical Scientist. 25, p. 32-34

Research output: Contribution to journalArticleProfessional

Precise Anatomic Localization of Accumulated Lipids in Mfp2 Deficient Murine Brains Through Automated Registration of SIMS Images to the Allen Brain Atlas

Skraskova, K., Khmelinskii, A., Abdelmoula, W. M., De Munter, S., Baes, M., McDonnell, L., Dijkstra, J. & Heeren, R. M. A., Jun 2015, In : Journal of the American Society for Mass Spectrometry. 26, 6, p. 948-957

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Preparation of longitudinal sections of hair samples for the analysis of cocaine by MALDI-MS/MS and TOF-SIMS imaging

Flinders, B., Cuypers, E., Zeijlemaker, H., Tytgat, J. & Heeren, R. M. A., Oct 2015, In : Drug Testing and Analysis. 7, 10, p. 859-865

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Protein classification and distribution in osteoarthritic human synovial tissue by matrix-assisted laser desorption ionization mass spectrometry imaging

Cillero-Pastor, B., Eijkel, G. B., Blanco, F. J. & Heeren, R. M. A., Mar 2015, In : Analytical and Bioanalytical Chemistry. 407, 8, p. 2213-2222

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

The Use of Mass Spectrometry Imaging to Predict Treatment Response of Patient-Derived Xenograft Models of Triple-Negative Breast Cancer

Mascini, N. E., Eijkel, G. B., ter Brugge, P., Jonkers, J., Wesseling, J. & Heeren, R. M. A., Feb 2015, In : Journal of Proteome Research. 14, 2, p. 1069-1075

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
20 Citations (Scopus)
2014

A critical evaluation of the current state-of-the-art in quantitative imaging mass spectrometry

Ellis, S. R., Bruinen, A. L. & Heeren, R. M. A., Feb 2014, In : Analytical and Bioanalytical Chemistry. 406, 5, p. 1275-1289

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

"Afterlife Experiment": Use of MALDI-MS and SIMS Imaging for the Study of the Nitrogen Cycle within Plants

Seaman, C., Flinders, B., Eijkel, G., Heeren, R. M. A., Bricklebank, N. & Clench, M. R., 21 Oct 2014, In : Analytical Chemistry. 86, 20, p. 10071-10077

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Automatic Generic Registration of Mass Spectrometry Imaging Data to Histology Using Nonlinear Stochastic Embedding

Abdelmoula, W. M., Skraskova, K., Balluff, B., Carreira, R. J., Tolner, E. A., Lelieveldt, B. P. F., van der Maaten, L., Morreau, H., van den Maagdenberg, A. M. J. M., Heeren, R. M. A., McDonnell, L. A. & Dijkstra, J., 16 Sep 2014, In : Analytical Chemistry. 86, 18, p. 9204-9211

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)