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Research Output 2010 2019

2019

Assessing cost-effectiveness of early intervention in Alzheimer's disease: An open-source modeling framework

Green, C., Handels, R., Gustavsson, A., Wimo, A., Winblad, B., Skoldunger, A. & Jonsson, L., Oct 2019, In : Alzheimer's & Dementia. 15, 10, p. 1309-1321 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Challenges and recommendations for the health-economic evaluation of primary prevention programmes for dementia

Handels, R. & Wimo, A., 2 Jan 2019, In : Aging & Mental Health. 23, 1, p. 53-59 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

Vermunt, L., Sikkes, S. A. M., van den Hout, A., Handels, R., Bos, I., van der Flier, W. M., Kern, S., Ousset, P-J., Maruff, P., Skoog, I., Verhey, F. R. J., Freund-Levi, Y., Tsolaki, M., Wallin, A. K., Rikkert, M. O., Soininen, H., Spiru, L., Zetterberg, H., Blennow, K., Scheltens, P. & 30 others, Muniz-Terrera, G., Visser, P. J., Vellas, B., Reynish, E., Ousset, P. J., Andrieu, S., Burns, A., Pasquier, F., Frisoni, G., Salmon, E., Michel, J. P., Zekry, D. S., Boada, M., Dartigues, J. F., Olde-Rikkert, M. G. M., Rigaud, A. S., Winblad, B., Malick, A., Sinclair, A., Froelich, L., Scheltens, P., Ribera, C., Touchon, J., Robert, P., Salva, A., Waldemar, G., Bullock, R., Tsolaki, M., Rodriguez, G. & Spiru, L., Jul 2019, In : Alzheimer's & Dementia. 15, 7, p. 888-898 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Necessidades de Cuidados e Recurso aos Serviços na Demência: Avaliação Inicial da Coorte Portuguesa no Estudo Actifcare

Goncalves-Pereira, M., Marques, M. J., Balsinha, C., Fernandes, A., Machado, A. S., Verdelho, A., Barahona-Correa, B., Barrios, H., Guimaraes, J., Grave, J., Alves, L., de Almeida, M. C., Reis, T., Orrell, M., Woods, B., De Vugt, M., Verhey, F., Wolfs, C., Handels, R., Kerpershoek, L. & 19 others, Meyer, G., Stephan, A., Bieber, A., Broda, A., Bartoszek, G., Jelley, H., Wimo, A., Skoldunger, A., Sjolund, B-M., Engedal, K., Selbaek, G., Michalet, M., Rosvik, J., Eriksen, S., Irving, K., Hopper, L., Joyce, R., Zanetti, O. & Portolani, E., May 2019, In : Acta Medica Portuguesa. 32, 5, p. 355-367 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

Lewczuk, P., Riederer, P., O'Bryant, S. E., Verbeek, M. M., Dubois, B., Visser, P. J., Jellinger, K. A., Engelborghs, S., Ramirez, A., Parnetti, L., Jack, C. R., Teunissen, C. E., Hampel, H., Lleo, A., Jessen, F., Glodzik, L., de Leon, M. J., Fagan, A. M., Molinuevo, J., Jansen, W. J. & 30 others, Winblad, B., Shaw, L. M., Andreasson, U., Otto, M., Mollenhauer, B., Wiltfang, J., Turner, M. R., Zerr, I., Handels, R., Thompson, A. G., Johansson, G., Ermann, N., Trojanowski, J. Q., Karaca, I., Wagner, H., Oeckl, P., van Doorn, L. V. W., Bjerke, M., Kapogiannis, D., Kuiperij, H. B., Farotti, L., Li, Y., Gordon, B. A., Epelbaum, S., Vos, S. J. B., Klijn, C. J. M., Van Nostrand, W. E., Minguillon, C., Schmitz, M. & Gallo, C., Jun 2018, In : World Journal of Biological Psychiatry. 19, 4, p. 244-328 85 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Impact of Untimely Access to Formal Care on Costs and Quality of Life in Community Dwelling People with Dementia

Janssen, N., Handels, R. L., Skoldunger, A., Woods, B., Jelley, H., Edwards, R. T., Orrell, M., Selbaek, G., Rosvik, J., Goncalves-Pereira, M., Marques, M. J., Zanetti, O., Portolani, E., Irving, K., Hopper, L., Meyer, G., Bieber, A., Stephan, A., Kerpershoek, L., Wolfs, C. A. G. & 3 others, de Vugt, M. E., Verhey, F. R. J. & Wimo, A., 1 Jan 2018, In : Journal of Alzheimer's Disease. 66, 3, p. 1165-1174 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Measuring quality of life of people with predementia and dementia and their caregivers: a systematic review protocol

Landeiro, F., Walsh, K., Ghinai, I., Mughal, S., Nye, E., Wace, H., Roberts, N., Lecomte, P., Wittenberg, R., Wolstenholme, J., Handels, R., Roncancio-Diaz, E., Potashman, M. H., Tockhorn-Heidenreich, A. & Gray, A. M., 1 Mar 2018, In : BMJ Open. 8, 3, 5 p., e019082.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Needs and quality of life of people with middle-stage dementia and their family carers from the European Actifcare study. When informal care alone may not suffice

Kerpershoek, L., de Vugt, M., Wolfs, C., Woods, B., Jelley, H., Orrell, M., Stephan, A., Bieber, A., Meyer, G., Selbaek, G., Handels, R., Wimo, A., Hopper, L., Irving, K., Marques, M., Goncalves-Pereira, M., Portolani, E., Zanetti, O. & Verhey, F., 1 Jan 2018, In : Aging & Mental Health. 22, 7, p. 897-902 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Quality of Life, Care Resource Use, and Costs of Dementia in 8 European Countries in a Cross-Sectional Cohort of the Actifcare Study

Handels, R. L. H., Skoldunger, A., Bieber, A., Edwards, R. T., Goncalves-Pereire, M., Hopper, L., Irving, K., Jelley, H., Kerpershoek, L., Marques, M. J., Meyer, G., Michelet, M., Portolani, E., Rosvik, J., Selbaek, G., Stephan, A., de Vugt, M., Wolfs, C., Woods, B., Zanetti, O. & 2 others, Verhey, F. & Wimo, A., 1 Jan 2018, In : Journal of Alzheimer's Disease. 66, 3, p. 1027-1040 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Resource utilisation and costs in predementia and dementia: a systematic review protocol

Landeiro, F., Wace, H., Ghinai, I., Nye, E., Mughal, S., Walsh, K., Roberts, N., Lecomte, P., Wittenberg, R., Wolstenholme, J., Handels, R., Roncancio-Diaz, E., Potashman, M. H., Tockhorn-Heidenreich, A. & Gray, A. M., 23 Jan 2018, In : BMJ Open. 8, 1, 5 p., e019060.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Systematic literature review of methodologies and data sources of existing economic models across the full spectrum of Alzheimer's disease and dementia from apparently healthy through disease progression to end of life care: a systematic review protocol

Karagiannidou, M., Wittenberg, R., Landeiro, F. I. T., Park, A-L., Fry, A., Knapp, M., Gray, A. M., Tockhorn-Heidenreich, A., Sanchez, A. Y. C., Ghinai, I., Handels, R., Lecomte, P. & Wolstenholme, J., 1 Jun 2018, In : BMJ Open. 8, 6, 5 p., e020638.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2017

Caregiver profiles in dementia related to quality of life, depression and perseverance time in the European Actifcare study: the importance of social health

Janssen, E. P. C. J., de Vugt, M., Kohler, S., Wolfs, C., Kerpershoek, L., Handels, R. L. H., Orrell, M., Woods, B., Jelley, H., Stephan, A., Bieber, A., Meyer, G., Engedal, K., Selbaek, G., Wimo, A., Irving, K., Hopper, L., Marques, M., Goncalves-Pereira, M., Portolani, E. & 2 others, Zanetti, O. & Verhey, F. R., 2017, In : Aging & Mental Health. 21, 1, p. 49-57 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cost-Utility of Using Alzheimer's Disease Biomarkers in Cerebrospinal Fluid to Predict Progression from Mild Cognitive Impairment to Dementia

Handels, R. L. H., Wimo, A., Dodel, R., Kramberger, M. G., Visser, P. J., Luis Molinuevo, J., Verhey, F. R. J. & Winblad, B., 7 Nov 2017, In : Journal of Alzheimer's Disease. 60, 4, p. 1477-1487 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers

Handels, R. L. H., Vos, S. J. B., Kramberger, M. G., Jelic, V., Blennow, K., van Buchem, M., van der Flier, W., Freund-Levi, Y., Hampel, H., Rikkert, M. O., Oleksik, A., Pirtosek, Z., Scheltens, P., Soininen, H., Teunissen, C., Tsolaki, M., Wallin, A. K., Winblad, B., Verhey, F. R. J. & Visser, P. J., Aug 2017, In : Alzheimer's & Dementia. 13, 8, p. 903-912 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment

Herukka, S-K., Simonsen, A. H., Andreasen, N., Baldeiras, I., Bjerke, M., Blennow, K., Engelborghs, S., Frisoni, G. B., Gabryelewicz, T., Galluzzi, S., Handels, R., Kramberger, M. G., Kulczynska, A., Luis Molinuevo, J., Mroczko, B., Nordberg, A., Oliveira, C. R., Otto, M., Rinne, J. O., Rot, U. & 8 others, Saka, E., Soininen, H., Struyfs, H., Suardi, S., Visser, P. J., Winblad, B., Zetterberg, H. & Waldemar, G., Mar 2017, In : Alzheimer's & Dementia. 13, 3, p. 285-295 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia

Simonsen, A. H., Herukka, S-K., Andreasen, N., Baldeiras, I., Bjerke, M., Blennow, K., Engelborghs, S., Frisoni, G. B., Gabryelewicz, T., Galluzzi, S., Handels, R., Kramberger, M. G., Kulczynska, A., Luis Molinuevo, J., Mroczko, B., Nordberg, A., Oliveira, C. R., Otto, M., Rinne, J. O., Rot, U. & 8 others, Saka, E., Soininen, H., Struyfs, H., Suardi, S., Visser, P. J., Winblad, B., Zetterberg, H. & Waldemar, G., Mar 2017, In : Alzheimer's & Dementia. 13, 3, p. 274-284 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Diagnostic and Prognostic Value of Neuropsychological Assessment in Memory Clinic Patients

Jansen, W. J., Handels, R. L. H., Visser, P. J., Aalten, P., Bouwman, F., Claassen, J., van Domburg, P., Hoff, E., Hoogmoed, J., Leentjens, A. F. G., Rikkert, M. O., Oleksik, A. M., Smid, M., Scheltens, P., Wolfs, C., Verhey, F. & Ramakers, I. H. G. B., 2017, In : Journal of Alzheimer's Disease. 55, 2, p. 679-689 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016
1 Citation (Scopus)

Access to timely formal dementia care in Europe: protocol of the Actifcare (ACcess to Timely Formal Care) study

Kerpershoek, L., de Vugt, M., Wolfs, C., Jelley, H., Orrel, M., Woods, B., Stephan, A., Bieber, A., Meyer, G., Engedal, K., Selbaek, G., Handels, R., Wimo, A., Hopper, L., Irving, K., Marques, M., Goncalves-Pereira, M., Portolani, E., Zanetti, O. & Verhey, F., 23 Aug 2016, In : BMC Health Services Research. 16, 423.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Added Prognostic Value of Cerebrospinal Fluid Biomarkers in Predicting Decline in Memory Clinic Patients in a Prospective Cohort

Handels, R. L. H., Joore, M. A., Vos, S. J. B., Aalten, P., Ramakers, I. H. G. B., Rikkert, M. O., Scheltens, P., Jansen, W. J., Visser, P-J., van Berckel, B. M. N., van Domburg, P., Smid, M., Hoff, E., Hoogmoed, J., Bouwman, F., Claassen, J., Leentjens, A. F. G., Wolfs, C. A. G., Severens, J. L. & Verhey, F. R. J., 2016, In : Journal of Alzheimer's Disease. 52, 3, p. 875-885

Research output: Contribution to journalArticleAcademicpeer-review

Combinations of Service Use Types of People With Early Cognitive Disorders

Janssen, N., Handels, R. L. H., Koehler, S., Ramakers, I. H. G. B., Hamel - de Bakker, R., Rikkert, M. G. M. O., Scheltens, P., Bouwman, F. H., van der Flier, W. M., Wolfs, C. A. G., de Vugt, M. E., Evers, S. M. A. A. & Verhey, F. R. J., 1 Jul 2016, In : Journal of the American Medical Directors Association. 17, 7, p. 620-625

Research output: Contribution to journalArticleAcademicpeer-review

2015
3 Citations (Scopus)
2014
91 Downloads (Pure)

Diagnosing Alzheimer's disease: A systematic review of economic evaluations

Handels, R. L. H., Wolfs, C. A. G., Aalten, P., Joore, M., Verhey, F. R. J. & Severens, J. L., Mar 2014, In : Alzheimer's & Dementia. 10, 2, p. 225-237 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
21 Citations (Scopus)

Health economic evaluation of treatments for Alzheimer's disease: impact of new diagnostic criteria

Wimo, A., Ballard, C., Brayne, C., Gauthier, S., Handels, R., Jones, R. W., Jonsson, L., Khachaturian, A. S. & Kramberger, M., 1 Jan 2014, In : Journal of Internal Medicine. 275, 3, p. 304-316

Research output: Contribution to journalArticleAcademicpeer-review

379 Downloads (Pure)

Health technology assessment of diagnostic strategies for Alzheimer’s disease

Handels, R. L. H., 1 Jan 2014, 's-Hertogenbosch: BOXPress. 192 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
File
2013
17 Citations (Scopus)

Determinants of Care Costs of Patients With Dementia or Cognitive Impairment

Handels, R. L. H., Wolfs, C. A. G., Aalten, P., Verhey, F. R. J. & Severens, J. L., 2013, In : Alzheimer Disease & Associated Disorders. 27, 1, p. 30-36

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Scopus)

Impact of molecular imaging on the diagnostic process in a memory clinic

Ossenkoppele, R., Prins, N. D., Pijnenburg, Y. A. L., Lemstra, A. W., van der Flier, W. M., Adriaanse, S. F., Windhorst, A. D., Handels, R. L. H., Wolfs, C. A. G., Aalten, P., Verhey, F. R. J., Verbeek, M. M., van Buchem, M. A., Hoekstra, O. S., Lammertsma, A. A., Scheltens, P. & van Berckel, B. N. M., Jul 2013, In : Alzheimer's & Dementia. 9, 4, p. 414-421

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Natural Progression Model of Cognition and Physical Functioning among People with Mild Cognitive Impairment and Alzheimer's Disease

Handels, R. L. H., Xu, W., Rizzuto, D., Caracciolo, B., Wang, R., Winblad, B., Verhey, F. R. J., Severens, J. L., Fratiglioni, L., Joore, M. A. & Wimo, A., 2013, In : Journal of Alzheimer's Disease. 37, 2, p. 357-365

Research output: Contribution to journalArticleAcademicpeer-review

2012

Diagnostic and economic evaluation of new biomarkers for Alzheimer's disease: the research protocol of a prospective cohort study

Handels, R. L. H., Aalten, P., Wolfs, C. A. G., OldeRikkert, M., Scheltens, P., Visser, P. J., Joore, M. A., Severens, J. L. & Verhey, F. R. J., 10 Aug 2012, In : BMC Neurology. 12

Research output: Contribution to journalArticleAcademicpeer-review

Test sequence of CSF and MRI biomarkers for prediction of AD in subjects with MCI

Vos, S., van Rossum, I. A., Burns, L., Knol, D., Scheltens, P., Soininen, H., Wahlund, L-O., Hampel, H., Tsolaki, M., Minthon, L., Handels, R., L'Italien, G., van der Flier, W. M., Aalten, P., Teunissen, C., Barkhof, F., Blennow, K., Wolz, R., Rueckert, D., Verhey, F. & 1 others, Visser, P. J., Oct 2012, In : Neurobiology of Aging. 33, 10, p. 2272-2281

Research output: Contribution to journalArticleAcademicpeer-review

2010

Biomarkers as Predictors for Conversion from Mild Cognitive Impairment to Alzheimer-Type Dementia: Implications for Trial Design

van Rossum, I. A., Vos, S., Handels, R. & Visser, P. J., 2010, In : Journal of Alzheimer's Disease. 20, 3, p. 881-891

Research output: Contribution to journalArticleAcademicpeer-review