19962019

Research output per year

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Research Output

2009

Beta-carotene affects oxidative stress-related DNA damage in lung epithelial cells and in ferret lung.

van Helden, Y. G. J., Keijer, J., Heil, S. G., Pico, C., Palou, A., Oliver, P., Munnia, A., Briede, J. J., Peluso, M., Hal, N. F., van Schooten, F. J. & Godschalk, R. W., 1 Jan 2009, In : Carcinogenesis. 30, 12, p. 2070-2076

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

beta-Carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells.

van Helden, Y. G. J., Keijer, J., Knaapen, A. M., Heil, S. G., Briede, J. J., van Schooten, F. J. & Godschalk, R. W., 1 Jan 2009, In : Free Radical Biology and Medicine. 46, 2, p. 299-304

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

Introducing a true internal standard for the Comet assay to minimize intra- and inter-experiment variability in measures of DNA damage and repair

Zainol, M., Stoute, J., Almeida, G. M., Rapp, A., Bowman, K. J., Jones, G. D. & ECVAG (Godschalk R.), R., 1 Jan 2009, In : Nucleic Acids Research. 37, 22, e150.

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Potential role of cytochrome P450-1B1 in the metabolic activation of 4-aminobiphenyl in humans.

Ketelslegers, H. B., Godschalk, R. W., Eskens, B. J. M., Dallinga, J. W., Gottschalk, R. W., van Schooten, F. J., van Delft, J. H. & Kleinjans, J. C., 1 Jan 2009, In : Molecular Carcinogenesis. 48, 8, p. 685-691

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Use of spermatozoal mRNA profiles to study gene-environment interactions in human germ cells

Linschooten, J. O., van Schooten, F. J., Baumgartner, A., Cemeli, E., van Delft, J., Anderson, D. & Godschalk, R. W., 1 Jan 2009, In : Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 667, 1-2, p. 70-6

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)
2008

Development of accurate classification method based on the analysis of volatile organic compounds from human exhaled air.

van Berkel, H. J. M., Dallinga, J. W., Moller, G. M., Godschalk, R. W., Moonen, E., Wouters, E. F. & van Schooten, F. J., 1 Jan 2008, In : Journal of Chromatography B. 861, 1, p. 101-107

Research output: Contribution to journalArticleAcademicpeer-review

83 Citations (Scopus)

Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location

Yauk, C., Polyzos, A., Rowan Carroll, A., Somers, C. M., Godschalk, R. W., van Schooten, F. J., Berndt, M. L., Pogribny, I. P., Koturbash, I., Williams, A., Douglas, G. R. & Kovalchuk, O., 1 Jan 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 2, p. 605-10

Research output: Contribution to journalArticleAcademicpeer-review

152 Citations (Scopus)

New methods for assessing male germ line mutations in humans and genetic risks in their offspring.

Verhofstad, N., Linschooten, J. O., van Benthem, J., Dubrova, Y. E., van Steeg, H., van Schooten, F. J. & Godschalk, R. W., 1 Jan 2008, In : Mutagenesis. 23, 4, p. 241-247

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

State of the art of genotype vs. phenotype studies

Hirvonen, A., Godschalk, R. W. L., Kirsch-Volders, M. & van Schooten, F. J., 1 Jan 2008, ECNIS.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2007

Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase

Gungor, N., Godschalk, R. W., Pachen, D. M., van Schooten, F. J. & Knaapen, A. M., 1 Jan 2007, In : Faseb Journal. 21, 10, p. 2359-2367

Research output: Contribution to journalArticleAcademicpeer-review

52 Citations (Scopus)

Decreased levels of lipid peroxidation-induced DNA damage in the onset of atherogenesis in apolipoprotein E deficient mice

Godschalk, R. W., Albrecht, C., Curfs, D. M., Schins, R. P., Bartsch, H., van Schooten, F. J. & Nair, J., 1 Jan 2007, In : Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 621, 1-2, p. 87-94

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Dietary flavonoids induce MLL translocations in primary human CD34+ cells

van Waalwijk van Doorn-Khosrovani, S. B., Janssen, J., Maas, L. M., Godschalk, R. W., Nijhuis, J. G. & van Schooten, F. J., 1 Jan 2007, In : Carcinogenesis. 28, 8, p. 1703-1709

Research output: Contribution to journalArticleAcademicpeer-review

57 Citations (Scopus)

Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity

Langie, S. A., Knaapen, A. M., Ramaekers, C. H. M. A., Theys, J., Brun, J., Godschalk, R. W., van Schooten, F. J., Lambin, P., Gray, D. A., Wouters, B. G. & Chiu, R. K., 1 Jan 2007, In : Dna Repair. 6, 6, p. 852-862

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers

Wilms, L. C., Boots, A. W., de Boer, V. C., Maas, L. M., Pachen, D. M., Gottschalk, R. W., Ketelslegers, H., Godschalk, R. W., Haenen, G. R., van Schooten, F. J. & Kleinjans, J. C., 1 Jan 2007, In : Carcinogenesis. 28, 8, p. 1800-1806

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

The role of glutathione in the regulation of nucleotide excision repair during oxidative stress

Langie, S. A. S., Knaapen, A. M., Houben, J. M. J., van Kempen, F. C., de Hoon, J. P., Gottschalk, R. W., Godschalk, R. W. & van Schooten, F. J., 1 Jan 2007, In : Toxicology Letters. 168, 3, p. 302-309

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)
2006

Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair

Langie, S. A. S., Knaapen, A. M., Brauers, K., van Berlo, D., van Schooten, F. J. & Godschalk, R. W., 1 Jan 2006, In : Mutagenesis. 21, 2, p. 153-158

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Scopus)

Interindividual variations in DNA adduct levels assessed by analysis of multiple genetic polymorphisms in smokers

Ketelslegers, H., Gottschalk, R. W., Godschalk, R. W., Knaapen, A. M., van Schooten, F. J., Vlietinck, R. F., Kleinjans, J. C. & van Delft, J. H. M., 1 Jan 2006, In : Cancer Epidemiology Biomarkers & Prevention. 15, 4, p. 624-629

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)
2005

Interaction between cadmium and aromatic DNA adducts in hprt mutagenesis during foetal development

Godschalk, R., Hogervorst, J., Albering, H., Mercelina Roumans, P., van Schooten, F. J., de Haan, J. & Kleinjans, J., 1 Jan 2005, In : Mutagenesis. 20, 3, p. 181-185

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)
2004

De Gezondheidsrisico's van Passief roken

van Schooten, F. J. & Godschalk, R. W. L., 1 Jan 2004, Tabaksgebruik: gevolgen en bestrijding. Knol, K., Hilvering, C., Wagener, T. & Willemsen, M. (eds.). Utrecht: Lemma, p. 23-246

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

In vitro and in vivo studies on oxygen free radical and DNA adduct formation in rat lung and liver during benzo[a]pyrene metabolism

Briedé, J. J., Godschalk, R. W., Emans, M. T., de Kok, T. M., van Agen, E., van Maanen, J. M. S., van Schooten, F. J. & Kleinjans, J. C., 1 Jan 2004, In : Free Radical Research. 38, 9, p. 995-1002

Research output: Contribution to journalArticleAcademicpeer-review

54 Citations (Scopus)

Myeloperoxidase (MPO)-463G -> A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers

van Schooten, F. J., Boots, A. W., Knaapen, A. M., Godschalk, R. W., Maas, L. M., Borm, P. J. A., Drent, M. & Jacobs, J. A., 1 Jan 2004, In : Cancer Epidemiology Biomarkers & Prevention. 13, 5, p. 828-833

Research output: Contribution to journalArticleAcademicpeer-review

Simultaneous genotyping of nine polymorphisms in xenobiotic-metabolizing enzymes by multiplex PCR amplification and single base extension

Knaapen, A. M., Ketelslegers, H., Gottschalk, R. W., Janssen, R. G. J. H., Paulussen, A. D., Smeets, H. J. M., Godschalk, R. W., van Schooten, F. J., Kleinjans, J. C. & van Delft, J. H., 1 Jan 2004, In : Clinical Chemistry. 50, 9, p. 1664-1668

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)
2003

A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compounds

Godschalk, R. W. L., van Schooten, F. J. & Bartsch, H., 1 Jan 2003, In : Journal of Biochemistry and Molecular Biology. 36, 1, p. 1-11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

92 Citations (Scopus)

Benzo[a]pyrene enhances lipid peroxidation induced DNA damage in aorta of apolipoprotein E knockout mice

Godschalk, R. W. L., Curfs, D. M. J., Bartsch, H., van Schooten, F. J. & Nair, J., 1 Jan 2003, In : Free Radical Research. 37, 12, p. 1299-1305 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Gevolgen en bestrijding van roken

van Schooten, F. J. & Godschalk, R. W. L., 1 Jan 2003, Gezondheidsrisico's van roken.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Modulation of plasma lipid levels affects benzo[a]pyrene-induced DNA damage in tissues of two hyperlipidemic mouse models

Curfs, D. M. J., Beckers, L., Godschalk, R. W. L., Gijbels, M. J. J. & van Schooten, F. J., 1 Jan 2003, In : Environmental and Molecular Mutagenesis. 42, 4, p. 243-249 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
2002

Body mass index modulates aromatic DNA adduct levels and their persistence in smokers

Godschalk, R. W. L., Feldker, D. E. M., Borm, P. J. A., Wouters, E. F. M. & van Schooten, F. J., 1 Jan 2002, In : Cancer Epidemiology Biomarkers & Prevention. 11, 8, p. 790-793 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking

Godschalk, R. W. L., Nair, J., van Schooten, F. J., Risch, A., Drings, P., Kayser, K., Dienemann, H. & Bartsch, H., 1 Jan 2002, In : Carcinogenesis. 23, 12, p. 2081-2086 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

73 Citations (Scopus)

Modified immunoenriched (32)P-HPLC assay for the detection of O(4)-ethylthymidine in human biomonitoring studies

Godschalk, R. W. L., Nair, J., Kliem, C., Wiessler, M., Bouvier, G. & Bartsch, H., 1 Jan 2002, In : Chemical Research in Toxicology. 15, 3, p. 433-437 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)
2001

Impact of GSTM1 on aromatic-DNA adducts and p53 accumulation in human skin and lymphocytes.

Godschalk, R. W. L., Ostertag, J. U., Zandsteeg, A., Agen van, B., Neumann, H. A. M., van Straaten, H. W. M. & van Schooten, F. J., 1 Jan 2001, In : Pharmacogenetics. 11, p. 537-543 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1,GSTT1, NAT1 and NAT2.

Godschalk, R. W. L., Dallinga, J. W., Wikman, H., Risch, A., Kleinjans, J. C. S., Bartsch, H. & van Schooten, F. J., 1 Jan 2001, In : Pharmacogenetics. 11, p. 389-398 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Myeloperoxidase--463A variant reduces benzo[a]pyrene diol epoxide DNA adducts in skin of coal tar treated patients.

Rojas, W., Godschalk, R. W. L., Alexandrov, K., Cascorbi, I., Kriek, E., Ostertag, J. U., van Schooten, F. J. & Bartsch, H., 1 Jan 2001, In : Carcinogenesis. 22, p. 1015-1018 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)
2000

Exposure-route-dependent DNA adduct formation by polycyclic aromatic hydrocarbons

Godschalk, R. W. L., Moonen, E. J. C., Schilderman-Houba, P. A. E. L., Broekman, W. M., Kleinjans, J. C. S. & van Schooten, F. J., 1 Jan 2000, In : Carcinogenesis. 21, p. 87-92 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)

Immunoperoxidase detection of polycyclic aromatic hydrocarbon-DNA adducts in mouth floor and buccal mucosa cells of smokers and nonsmokers

Besarati Nia, A., van Straaten, H. W. M., Godschalk, R. W. L., van Zandwijk, N., Balm, A. J. M., Kleinjans, J. C. S. & van Schooten, F. J., 1 Jan 2000, In : Environmental and Molecular Mutagenesis. 36, p. 127-133 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)
1999

Biological markers for exposure to polycyclic aromatic hydrocarbons

Godschalk, R. W. L., 1 Jan 1999, [Maastricht: Universiteit Maastricht. 171 p.

Research output: ThesisDoctoral ThesisInternal

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195 Downloads (Pure)
1998

Aromatic DNA adducts in human white blood cells and skin after dermal application of coal tar.

Godschalk, R. W. L., Ostertag, J. U., Moonen, E. J. C., Neumann, H. A. M., Kleinjans, J. C. S. & van Schooten, F. J., 1 Jan 1998, In : Cancer Epidemiology Biomarkers & Prevention. 7, 9, p. 767-763 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Differences in aromatic-DNA adduct levels between alveolar macrophages and subpopulations of white blood cells from smokers.

Godschalk, R. W. L., Maas, L. M., van Zandwijk, N., van 't Veer, C., Borm, P. J. A., Verhaert, J., Kleinjans, J. C. S. & van Schooten, F. J., 1 Jan 1998, In : Carcinogenesis. 19, 5, p. 819-825 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

75 Citations (Scopus)
14 Citations (Scopus)
1997

Neutrophils amplify the formation of DNA adducts by benzo[a]pyrene in lung target cells

Borm, P. J. A., Knaapen, A. M., Schins, R. P. F., Godschalk, R. W. L. & van Schooten, F. J., 1 Jan 1997, In : Environmental Health Perspectives. 105, suppl 5, p. 1089-1093

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)
1996

Coal tar therapy. Is it carcinogenic?

van Schooten, F. J. & Godschalk, R. W. L., 1 Jan 1996, In : Drug Safety. 15, 6, p. 374-377

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)