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Research Output

Acidic cellular microenvironment modifies carcinogen-induced DNA damage and repair

Shi, Q., Maas, L., Veith, C., Van Schooten, F. J. & Godschalk, R. W., Jun 2017, In : Archives of Toxicology. 91, 6, p. 2425-2441 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compounds

Godschalk, R. W. L., van Schooten, F. J. & Bartsch, H., 1 Jan 2003, In : Journal of Biochemistry and Molecular Biology. 36, 1, p. 1-11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase

Gungor, N., Godschalk, R. W., Pachen, D. M., van Schooten, F. J. & Knaapen, A. M., 1 Jan 2007, In : Faseb Journal. 21, 10, p. 2359-2367

Research output: Contribution to journalArticleAcademicpeer-review

Adult-onset, short-term dietary restriction reduces cell senescence in mice

Wang, C., Maddick, M., Miwa, S., Jurk, D., Czapiewski, R., Saretzki, G., Langie, S. A., Godschalk, R. W. L., Cameron, K. & von Zglinicki, T., 1 Jan 2010, In : Aging. 2, 9, p. 555-566

Research output: Contribution to journalArticleAcademicpeer-review

Altered gene expression profiles in the lungs of benzo [a]pyrene-exposed mice in the presence of lipopolysaccharide-induced pulmonary inflammation

Shi, Q., Fijten, R. R., Spina, D., Vasquez, R. Y., Arlt, V. M., Godschalk, R. W. & Van Schooten, F. J., 1 Dec 2017, In : Toxicology and Applied Pharmacology. 336, p. 8-19 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

An ECVAG inter-laboratory validation study of the comet assay: inter-laboratory and intra-laboratory variations of DNA strand breaks and FPG-sensitive sites in human mononuclear cells.

Ersson, C., Moller, P., Forchhammer, L., Loft, S., Azqueta, A., Godschalk, R. W. L., van Schooten, F. J., Jones, G. D., Higgins, J. A., Cooke, M. S., Mistry, V., Karbaschi, M., Phillips, D. H., Sozeri, O., Routledge, M. N., Smith, K., Riso, P., Porrini, M., Matullo, G., Allione, A. & 10 others, Stepnik, M., Ferlinska, M., Teixeira, J. P., Costa, S., Corcuera, L. A., Lopez de Cerain, A., Laffon, B., Valdiglesias, V., Collins, A. R. & Moller, L., May 2013, In : Mutagenesis. 28, 3, p. 279-286 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

An ECVAG trial on assessment of oxidative damage to DNA measured by the comet assay.

Johansson, C., Moller, P., Forchhammer, L., Loft, S., Godschalk, R. W., Langie, S. A., Lumeij, S., Jones, G. D., Kwok, R. W., Azqueta, A., Phillips, D. H., Sozeri, O., Routledge, M. N., Charlton, A. J., Riso, P., Porrini, M., Allione, A., Matullo, G., Palus, J., Stepnik, M. & 2 others, Collins, A. R. & Moller, L., Mar 2010, In : Mutagenesis. 25, 2, p. 125-132 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

A profile of volatile organic compounds in breath discriminates COPD patients from controls.

van Berkel, J. J. B. N., Dallinga, J. W., Moller, G. M., Godschalk, R. W., Moonen, E. J., Wouters, E. F. & van Schooten, F. J., 1 Jan 2010, In : Respiratory Medicine. 104, 4, p. 557-563

Research output: Contribution to journalArticleAcademicpeer-review

Aromatic DNA adducts and number of lung cancer risk alleles in Map-Ta-Phut Industrial Estate workers and nearby residents.

Peluso, M., Srivatanakul, P., Jedpiyawongse, A., Sangrajrang, S., Munnia, A., Piro, S., Ceppi, M., Boffetta, P., Godschalk, R. W. L. & van Schooten, F. J., 1 Jan 2013, In : Mutagenesis. 28, 1, p. 57-63 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Aromatic DNA adducts in human white blood cells and skin after dermal application of coal tar.

Godschalk, R. W. L., Ostertag, J. U., Moonen, E. J. C., Neumann, H. A. M., Kleinjans, J. C. S. & van Schooten, F. J., 1 Jan 1998, In : Cancer Epidemiology Biomarkers & Prevention. 7, 9, p. 767-763 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Assessment and reduction of comet assay variation in relation to DNA damage: studies from the European Comet Assay Validation Group.

Moller, P., Moller, L., Godschalk, R. W. & Jones, G. D., Mar 2010, In : Mutagenesis. 25, 2, p. 109-111 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort.

de Vries, P. S., Gielen, M., Rizopoulos, D., Rump, P., Godschalk, R., Hornstra, G. & Zeegers, M. P., Sep 2014, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 91, 3, p. 81-85 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Association between prenatal and current exposure to selected LCPUFAs and school performance at age 7

van der Wurff, I. S. M., Bakker, E. C., Hornstra, G., Kirschner, P. A., Gielen, M., Godschalk, R. W. L., Kremers, S., Zeegers, M. P. & de Groot, R. H. M., May 2016, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 108, p. 22-29

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice

Verhofstad, N., Pennings, J. L., van Oostrom, C. T., van Benthem, J., van Schooten, F. J., van Steeg, H. & Godschalk, R. W., 26 May 2010, In : BMC Genomics. 11, 1, p. 333 12 p., 333.

Research output: Contribution to journalArticleAcademicpeer-review

Benzo[a]pyrene enhances lipid peroxidation induced DNA damage in aorta of apolipoprotein E knockout mice

Godschalk, R. W. L., Curfs, D. M. J., Bartsch, H., van Schooten, F. J. & Nair, J., 1 Jan 2003, In : Free Radical Research. 37, 12, p. 1299-1305 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: Toxicokinetics is essential for in vivo'in vitro comparisons.

van Kesteren, P. C., Zwart, P. E., Schaap, M. M., Pronk, T. E., van Herwijnen, M. H., Kleinjans, J. C., Bokkers, B. G., Godschalk, R. W. L., Zeilmaker, M. J., van Steeg, H. & Luijten, M., Mar 2013, In : Archives of Toxicology. 87, 3, p. 505-515 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Beta-carotene affects gene expression in lungs of male and female Bcmo1 (-/-) mice in opposite directions

van Helden, Y. G. J., Godschalk, R. W. L., Swarts, H. J. M., Hollman, P. C., van Schooten, F. J. & Keijer, J., 1 Jan 2011, In : Cellular and Molecular Life Sciences. 68, 3, p. 489-504 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

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Beta-carotene affects oxidative stress-related DNA damage in lung epithelial cells and in ferret lung.

van Helden, Y. G. J., Keijer, J., Heil, S. G., Pico, C., Palou, A., Oliver, P., Munnia, A., Briede, J. J., Peluso, M., Hal, N. F., van Schooten, F. J. & Godschalk, R. W., 1 Jan 2009, In : Carcinogenesis. 30, 12, p. 2070-2076

Research output: Contribution to journalArticleAcademicpeer-review

beta-Carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells.

van Helden, Y. G. J., Keijer, J., Knaapen, A. M., Heil, S. G., Briede, J. J., van Schooten, F. J. & Godschalk, R. W., 1 Jan 2009, In : Free Radical Biology and Medicine. 46, 2, p. 299-304

Research output: Contribution to journalArticleAcademicpeer-review

Biological markers for exposure to polycyclic aromatic hydrocarbons

Godschalk, R. W. L., 1 Jan 1999, [Maastricht: Universiteit Maastricht. 171 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
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236 Downloads (Pure)

Body mass index modulates aromatic DNA adduct levels and their persistence in smokers

Godschalk, R. W. L., Feldker, D. E. M., Borm, P. J. A., Wouters, E. F. M. & van Schooten, F. J., 1 Jan 2002, In : Cancer Epidemiology Biomarkers & Prevention. 11, 8, p. 790-793 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bulky DNA adduct levels in normal-appearing colon mucosa, and the prevalence of colorectal adenomas

Ho, V., Peacock, S., Massey, T. E., Godschalk, R. W., van Schooten, F. J., Ashbury, J. E., Vanner, S. J. & King, W. D., 17 Nov 2018, In : Biomarkers. 23, 8, p. 735-741 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bulky DNA Adducts in Cord Blood, Maternal Fruit-and-Vegetable Consumption, and Birth Weight in a European Mother-Child Study (NewGeneris)

Pedersen, M., Schoket, B., Godschalk, R. W. L., Wright, J., von Stedingk, H., Tornqvist, M., Sunyer, J., Nielsen, J. K., Merlo, D. F., Mendez, M. A., Meltzer, H. M., Lukacs, V., Landstrom, A., Kyrtopoulos, S. A., Kovacs, K., Knudsen, L. E., Haugen, M., Hardie, L. J., Gutzkow, K. B., Fleming, S. & 14 others, Fthenou, E., Farmer, P. B., Espinosa, A., Chatzi, L., Brunborg, G., Brady, N. J., Botsivali, M., Arab, K., Anna, L., Alexander, J., Agramunt, S., Kleinjans, J. C., Segerback, D. & Kogevinas, M., 1 Jan 2013, In : Environmental Health Perspectives. 121, 10, p. 1200-1206

Research output: Contribution to journalArticleAcademicpeer-review

Canonical autophagy does not contribute to cellular radioresistance

Schaaf, M. B., Jutten, B., Keulers, T. G., Savelkouls, K. G., Peeters, H. J., van den Beucken, T., van Schooten, F. J., Godschalk, R. W., Vooijs, M. & Rouschop, K. M., Mar 2015, In : Radiotherapy and Oncology. 114, 3, p. 406-412 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cigarette smoke-induced transgenerational alterations in genome stability in cord blood of human F1 offspring.

Laubenthal, J., Zlobinskaya, O., Poterlowicz, K., Baumgartner, A., Gdula, M. R., Fthenou, E., Keramarou, M., Hepworth, S. J., Kleinjans, J. C., van Schooten, F. J., Brunborg, G., Godschalk, R. W. L., Schmid, T. E. & Anderson, D., Oct 2012, In : Faseb Journal. 26, 10, p. 3946-3956 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Coal tar therapy. Is it carcinogenic?

van Schooten, F. J. & Godschalk, R. W. L., 1 Jan 1996, In : Drug Safety. 15, 6, p. 374-377

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking

Godschalk, R. W. L., Nair, J., van Schooten, F. J., Risch, A., Drings, P., Kayser, K., Dienemann, H. & Bartsch, H., 1 Jan 2002, In : Carcinogenesis. 23, 12, p. 2081-2086 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Corrigendum to "Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell Gene mutation assays) and integration with somatic cell testing" (vol 832, pg 7, 2018)

Marchetti, F., Aardema, M. J., Beevers, C., van Benthem, J., Godschalk, R., Williams, A., Yauk, C. L., Young, R. & Douglas, G. R., Aug 2019, In : Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 844, p. 70-71 2 p.

Research output: Contribution to journalErratum / corrigendumAcademic

Open Access

Corrigendum to "Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488" (vol 832, pg 19, 2018)

Marchetti, F., Aardema, M. J., Beevers, C., van Benthem, J., Douglas, G. R., Godschalk, R., Yauk, C. L., Young, R. & Williams, A., Aug 2019, In : Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 844, p. 69-69 1 p.

Research output: Contribution to journalErratum / corrigendumAcademic

Open Access

Decreased levels of lipid peroxidation-induced DNA damage in the onset of atherogenesis in apolipoprotein E deficient mice

Godschalk, R. W., Albrecht, C., Curfs, D. M., Schins, R. P., Bartsch, H., van Schooten, F. J. & Nair, J., 1 Jan 2007, In : Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 621, 1-2, p. 87-94

Research output: Contribution to journalArticleAcademicpeer-review

Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity.

Schults, M. A. C., Nagle, P. W., Rensen, S. S. M., Godschalk, R. W. L., Munnia, A., Peluso, M., Claessen, S. M., Greve, J. W., Driessen, A. L. C., Verdam, F. J., Buurman, W. A., van Schooten, F. J. & Chiu, R. K., 1 Aug 2012, In : Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 736, 1-2, p. 75-81 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

De Gezondheidsrisico's van Passief roken

van Schooten, F. J. & Godschalk, R. W. L., 1 Jan 2004, Tabaksgebruik: gevolgen en bestrijding. Knol, K., Hilvering, C., Wagener, T. & Willemsen, M. (eds.). Utrecht: Lemma, p. 23-246

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair

Langie, S. A. S., Knaapen, A. M., Brauers, K., van Berlo, D., van Schooten, F. J. & Godschalk, R. W., 1 Jan 2006, In : Mutagenesis. 21, 2, p. 153-158

Research output: Contribution to journalArticleAcademicpeer-review

Development of accurate classification method based on the analysis of volatile organic compounds from human exhaled air.

van Berkel, H. J. M., Dallinga, J. W., Moller, G. M., Godschalk, R. W., Moonen, E., Wouters, E. F. & van Schooten, F. J., 1 Jan 2008, In : Journal of Chromatography B. 861, 1, p. 101-107

Research output: Contribution to journalArticleAcademicpeer-review

Dietary flavonoids induce MLL translocations in primary human CD34+ cells

van Waalwijk van Doorn-Khosrovani, S. B., Janssen, J., Maas, L. M., Godschalk, R. W., Nijhuis, J. G. & van Schooten, F. J., 1 Jan 2007, In : Carcinogenesis. 28, 8, p. 1703-1709

Research output: Contribution to journalArticleAcademicpeer-review

Dietary supplement intake during pregnancy; better safe than sorry?

de Boer, A., Bast, A. & Godschalk, R., Jun 2018, In : Regulatory Toxicology and Pharmacology. 95, p. 442-447 6 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Differences in aromatic-DNA adduct levels between alveolar macrophages and subpopulations of white blood cells from smokers.

Godschalk, R. W. L., Maas, L. M., van Zandwijk, N., van 't Veer, C., Borm, P. J. A., Verhaert, J., Kleinjans, J. C. S. & van Schooten, F. J., 1 Jan 1998, In : Carcinogenesis. 19, 5, p. 819-825 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability.

Schults, M. A. C., Timmermans, L., Godschalk, R. W. L., Theys, J., Wouters, B. G., van Schooten, F. J. & Chiu, R. K., 1 Jan 2010, In : Journal of Biological Chemistry. 285, 19, p. 14558-14564

Research output: Contribution to journalArticleAcademicpeer-review

DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo(a)pyrene.

Verhofstad, N., van Oostrom, C. T., van Benthem, J., van Schooten, F. J., van Steeg, H. & Godschalk, R. W., Mar 2010, In : Environmental and Molecular Mutagenesis. 51, 2, p. 123-129 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

DNA adducts and combinations of multiple lung cancer at-risk alleles in environmentally exposed and smoking subjects

Peluso, M. E., Munnia, A., Srivatanakul, P., Jedpiyawongse, A., Sangrajrang, S., Ceppi, M., Godschalk, R. W. L., van Schooten, F. J. & Boffetta, P., Jul 2013, In : Environmental and Molecular Mutagenesis. 54, 6, p. 375-383 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

DNA adducts in skin biopsies and 1-hydroxypyrene in urine of psoriasis patients and healthy volunteers following treatment with coal tar.

Roelofzen, J. H., van der Valk, P. G., Godschalk, R. W. L., Dettbarn, G., Seidel, A., Golsteijn, L., Anzion, R., Aben, K. K., van Schooten, F. J., Kiemeney, L. A. & Scheepers, P. T., 13 Aug 2012, In : Toxicology Letters. 213, 1, p. 39-44 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

DNA from Nails for Genetic Analyses in Large-Scale Epidemiologic Studies

Hogervorst, J. G. F., Godschalk, R. W. L., van den Brandt, P. A., Weijenberg, M. P., Verhage, B. A. J., Jonkers, L., Goessens, J., Simons, C. C. J. M., Vermeesch, J. R., van Schooten, F. J. & Schouten, L. J., Dec 2014, In : Cancer Epidemiology Biomarkers & Prevention. 23, 12, p. 2703-2712 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

DNA repair as a human biomonitoring tool: Comet assay approaches

Azqueta, A., Langie, S. A. S., Boutet-Robinet, E., Duthie, S., Ladeira, C., Moller, P., Collins, A. R., Godschalk, R. W. L. & Grp 5 hCOMET Project CA15132, 2019, In : Mutation Research-Reviews in Mutation Research. 781, 2019, p. 71-87 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

DNA-repair measurements by use of the modified comet assay: An inter-laboratory comparison within the European Comet Assay Validation Group (ECVAG)

Godschalk, R. W. L., Ersson, C., Riso, P., Porrini, M., Langie, S. A., van Schooten, F. J., Azqueta, A., Collins, A. R., Jones, G. D., Kwok, R. W., Phillips, D. H., Sozeri, O., Allione, A., Matullo, G., Moller, L., Forchhammer, L., Loft, S. & Moller, P., 18 Sep 2013, In : Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 757, 1, p. 60-67 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Does Ataxia Telangiectasia Mutated (ATM) protect testicular and germ cell DNA integrity by regulating the redox status?

Godschalk, R. W. L., Vanhees, K., Maas, L., Drittij - Reijnders, M. J., Pachen, D., van Doorn-Khosrovani, S. V. W., van Schooten, F. J. & Haenen, G. R. M. M., Aug 2016, In : Reproductive Toxicology. 63, p. 169-173

Research output: Contribution to journalArticleAcademicpeer-review

Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice.

van Helden, Y. G., Godschalk, R. W., Heil, S. G., Bunschoten, A., Hessel, S., Amengual, J., Bonet, M. L., von Lintig, J., van Schooten, F. J. & Keijer, J., Aug 2010, In : Carcinogenesis. 31, 8, p. 1329-1337 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells

Shi, Q., Boots, A. W., Maas, L., Veith, C., van Kuijk, K., Haenen, G. R., Godschalk, R. W. & Van Schooten, F. J., 15 Apr 2017, In : Toxicology. 381, p. 64-74 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access