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Research Output 1999 2014

2014
6 Citations (Scopus)

Interventricular Differences in beta-Adrenergic Responses in the Canine Heart: Role of Phosphodiesterases

Molina, C. E., Johnson, D. M., Mehel, H., Spätjens, R., Mika, D., Algalarrondo, V., Slimane, Z. H., Lechene, P., Abi-Gerges, N., van der Linde, H. J., Leroy, J., Volders, P. G. A., Fischmeister, R. & Vandecasteele, G., Jun 2014, In : Journal of the American Heart Association. 3, 3, e000858.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of I-Ks, but preserved cAMP-dependent up-regulation

Spätjens, R., Bebarova, M., Seyen, S. R. M., Lentink, V., Jongbloed, R. J., Arens, Y. H. J. M., Heijman, J. & Volders, P. G. A., 1 Oct 2014, In : Cardiovascular Research. 104, 1, p. 216-225

Research output: Contribution to journalArticleAcademicpeer-review

2012
34 Citations (Scopus)

Dominant-Negative Control of cAMP-Dependent I-Ks Upregulation in Human Long-QT Syndrome Type 1

Heijman, J., Spätjens, R., Seyen, S. R. M., Lentink, V., Kuijpers, H. J. H., Boulet, I. R., de Windt, L. J., David, M. & Volders, P. G. A., 20 Jan 2012, In : Circulation Research. 110, 2, p. 211-+

Research output: Contribution to journalArticleAcademicpeer-review

2007

Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium

Donker, D. W., Maessen, J. G., Verheyen, F., Ramaekers, F., Spatjens, R. L. H. M. G., Kuijpers, R., Rarnakers, C., Schiffers, P. M. H., Vos, M. A., Crijns, H. J. G. M. & Volders, P. G. A., May 2007, In : American Journal of Physiology-heart and Circulatory Physiology. 292, 5, p. H2324-H2332

Research output: Contribution to journalArticleAcademicpeer-review

Serial left-ventricular biopsy sampling using a minimally invasive trans-thoracic approach in adult dogs

Donker, D. W., Maessen, J. G., Spatjens, R. L. H. M. G., van der Nagel, T., de Jong, M. M., Ramaekers, F. C., Crijns, H. J. G. M., Vos, M. A. & Volders, P. G. A., Sep 2007, In : Pflugers Archiv-European Journal of Physiology. 454, 6, p. 1043-1051

Research output: Contribution to journalArticleAcademicpeer-review

2006

Temporal patterns of electrical remodeling in canine ventricular hypertrophy: Focus on I-Ks downregulation and blunted beta-adrenergic activation

Stengl, M., Ramakers, C., Donker, D. W., Nabar, A., Rybin, A. V., Spatjens, R. L. H. M. G., van der Nagel, T., Wodzig, W., Sipido, K. R., Antoons, G., Moorman, A. F. M., Vos, M. A. & Volders, P. G. A., 1 Oct 2006, In : Cardiovascular Research. 72, 1, p. 90-100

Research output: Contribution to journalArticleAcademicpeer-review

2005

End-diastolic myofiber stress and ejection strain increase with ventricular volume overload

Donker, D. W., Volders, PGA., Arts, T., Bekkers, BBACM., Hofstra, L., Spatjens, RLHMG., Beekman, J. D. M., Borgers, M., Crijns, HJGM. & Vos, MA., Jul 2005, In : Basic Research in Cardiology. 100, 4, p. 372-382

Research output: Contribution to journalArticleAcademicpeer-review

Molecular and electrical characterization of the canine cardiac ventricular septum

Ramakers, C., Stengl, M., Spätjens, R., Moorman, A. F. M. & Vos, MA., Jan 2005, In : Journal of Molecular and Cellular Cardiology. 38, 1, p. 153-161

Research output: Contribution to journalArticleAcademicpeer-review

2004

Electrophysiological and proarrhythmic parameters in transmural canine left-ventricular needle biopsies

Verduijn, S., Jungschleger, JGM., Stengl, M., Spatjens, RLHMG., Beekman, J. D. M. & Vos, MA., Oct 2004, In : Pflugers Archiv-European Journal of Physiology. 449, 1, p. 115-122

Research output: Contribution to journalArticleAcademicpeer-review

2003

Accumulation of slowly activating delayed rectifier potassium current(I-Ks) canine ventricular myocytes

Stengl, M., Volders, PGA., Thomsen, M. B., Spatjens, RLHMG., Sipido, K. R. & Vos, MA., 15 Sep 2003, In : Journal of Physiology. 551, 3, p. 777-786

Research output: Contribution to journalArticleAcademicpeer-review

Electrophysiological safety of sertindole in dogs with normal and remodeled hearts

Thomsen, M. B., Volders, PGA., Stengl, M., Spatjens, RLHMG., Beekman, J. D. M., Bischoff, U., Kall, MA., Frederiksen, K., Matz, J. & Vos, MA., Nov 2003, In : Journal of Pharmacology and Experimental Therapeutics. 307, 2, p. 776-784

Research output: Contribution to journalArticleAcademicpeer-review

Probing the contribution of I-Ks to canine ventricular repolarization - Key role for beta-adrenergic receptor stimulation

Volders, PGA., Stengl, M., van Opstal, JM., Gerlach, U., Spatjens, RLHMG., Beekman, J. D. M., Sipido, K. R. & Vos, MA., 3 Jun 2003, In : Circulation. 107, 21, p. 2753-2760

Research output: Contribution to journalArticleAcademicpeer-review

1999

Downregulation of delayed rectifier K+ currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes

Volders, PGA., Sipido, K. R., Vos, MA., Spatjens, RLHMG., Leunissen, JDM., Carmeliet, E. & Wellens, HJJ., 14 Dec 1999, In : Circulation. 100, 24, p. 2455-2461

Research output: Contribution to journalArticleAcademicpeer-review

Repolarizing K+ currents I-TO1 and I-Ks are larger in right than left canine ventricular midmyocardium

Volders, PGA., Sipido, K. R., Carmeliet, E., Spatjens, RLHMG., Wellens, HJJ. & Vos, MA., 19 Jan 1999, In : Circulation. 99, 2, p. 206-210

Research output: Contribution to journalArticleAcademicpeer-review