20102019
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Research Output 2010 2019

2019

New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility

ter Beek, O., Pavlenko, D., Suck, M., Helfrich, S., Bolhuis-Versteeg, L., Snisarenko, D., Causserand, C., Bacchin, P., Aimar, P., van Oerle, R., Wetzels, R., Verhezen, P., Henskens, Y. & Stamatialis, D., 15 Oct 2019, In : Separation and Purification Technology. 225, p. 60-73 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes

Posthuma, J. J., Posma, J. J. N., Schep, G., Bender, M. M. H., van Oerle, R., van der Wal, A. C., Ten Cate, H. & Spronk, H. M. H., Apr 2019, In : Journal of Vascular Surgery. 69, 4, p. 1243-1250 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Searching for a Common Thrombo-Inflammatory Basis in Patients With Deep Vein Thrombosis or Peripheral Artery Disease

Kremers, B. M. M., Birocchi, S., van Oerle, R., Zeerleder, S., Spronk, H. M. H., Mees, B. M. E., Luken, B. M., ten Cate, H. & ten Cate-Hoek, A. J., 2 Apr 2019, In : Frontiers in cardiovascular medicine. 6, p. 1-11 11 p., 33.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice

Posthuma, J. J., Posma, J. J. N., van Oerle, R., Leenders, P., van Gorp, R. H., Jaminon, A. M. G., Mackman, N., Heitmeier, S., Schurgers, L. J., ten Cate, H. & Spronk, H. M. H., 7 Mar 2019, In : Scientific Reports. 9, 9 p., 3909.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access
2018

Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study

Panova-Noeva, M., Schulz, A., Spronk, H. M., Beicht, A., Laubert-Reh, D., van Oerle, R., Arnold, N., Prochaska, J. H., Blettner, M., Beutel, M., Pfeiffer, N., Munzel, T., Lackner, K. J., ten Cate, H. & Wild, P. S., 1 May 2018, In : Thrombosis and Haemostasis. 118, 5, p. 873-882 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Preoperative screening for bleeding disorders: A comprehensive laboratory assessment of clinical practice

Vries, M. J., van der Meijden, P. E., Kuiper, G. J., Nelemans, P. J., Wetzels, R. J., van Oerle, R. G., Lance, M. D., ten Cate, H. & Henskens, Y. M., Oct 2018, In : Research and practice in thrombosis and haemostasis. 2, 4, p. 767-777 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function

Kuiper, G. J. A. J. M., Houben, R., Wetzels, R. J. H., Verhezen, P. W. M., van Oerle, R., ten Cate, H., Henskens, Y. M. C. & Lance, M. D., 2017, In : Platelets. 28, 7, p. 668-675 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Biomarkers for Prediction of Central Venous Catheter Related-Thrombosis in Patients With Hematological Malignancies

Boersma, R. S., Hamulyak, K., van Oerle, R., Tuinenburg, A., Ten Cate - Hoek, A. & Schouten, H. C., Nov 2016, In : Clinical and Applied Thrombosis-Hemostasis. 22, 8, p. 779-784

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Early platelet recovery following cardiac surgery with cardiopulmonary bypass

van Poucke, S., Stevens, K., Wetzels, R., Kicken, C., Verhezen, P., Theunissen, M., Kuiper, G-J., van Oerle, R., Henskens, Y. & Lance, M., 2016, In : Platelets. 27, 8, p. 751-757 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Factor XIa and Thrombin Generation Are Elevated in Patients with Acute Coronary Syndrome and Predict Recurrent Cardiovascular Events

Loeffen, R. A., van Oerle, R., Leers, M. P. G., Kragten, J. A., Crijns, H., Spronk, H. M. H. & ten Cate, H., 15 Jul 2016, In : PLOS ONE. 11, 7, 16 p., e0158355.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Increased coagulation and fibrinolytic potential of solvent-detergent plasma: a comparative study between Omniplasma and fresh frozen plasma

van Beers, J. J. B. C., van Egmond, L. T., Wetzels, R. J. H., Verhezen, P. W. M., Beckers, E. A. M., van Oerle, R., Spronk, H. M. H., Straat, R. J. M. H. E. & Henskens, Y. M. C., Jul 2016, In : Vox Sanguinis. 111, 1, p. 33-42

Research output: Contribution to journalArticleAcademicpeer-review

Uitdagingen bij het screenen en diagnosticeren van milde bloedingsziekten

Moenen, F. C., Vries, M. C., Henskens, Y., ten Cate, H., Wetzels, R. J., Verhezen, P. W., van Oerle, R. & Beckers, E., 2016, In : Nederlands Tijdschrift voor Hematologie. 13, 5, p. 182-189

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Validation of a modified thromboelastometry approach to detect changes in fibrinolytic activity

Kuiper, G-J., Kleinegris, M-C., van Oerle, R., Spronk, H., Lance, M., ten Cate, H. & Henskens, Y., 14 Jan 2016, In : Thrombosis Journal. 14, 13 p., 1.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
4 Citations (Scopus)

Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding

Swieringa, F., Lance, M. D., Fuchs, B., Feijge, M. A. H., Solecka, B. A., Verheijen, L. P. J., Hughes, K. R., Van Oerle, R., Deckmyn, H., Kannicht, C., Heemskerk, J. W. M. & Van der Meijden, P. E. J., Aug 2015, In : Journal of Thrombosis and Haemostasis. 13, 8, p. 1503-1513

Research output: Contribution to journalArticleAcademicpeer-review

Recombinant Factor VIIa Reduces Bleeding after Blunt Liver Injury in a Pig Model of Dilutional Coagulopathy under Severe Hypothermia

Spronk, H. M. H., Braunschweig, T., Rossaint, R., Wuest, D. C., van Oerle, R., Lauritzen, B., Tolba, R. & Grottke, O., 22 Jun 2015, In : PLOS ONE. 10, 6, e0113979.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

The hypercoagulable profile of patients with stent thrombosis

Loeffen, R., Godschalk, T. C., van Oerle, R., Spronk, H. M. H., Hackeng, C. M., ten Berg, J. M. & ten Cate, H., 15 Jul 2015, In : Heart. 101, 14, p. 1126-1132

Research output: Contribution to journalArticleAcademicpeer-review

2014

Effects of Ultrapure Hemodialysis and Low Molecular Weight Heparin on the Endothelial Surface Layer

Cornelis, T., Broers, N. J. H., Titulaer, D. C. L. M., Henskens, Y. M., van Oerle, R., van der Sande, F. M., Spronk, H. M., Vink, H., Leunissen, K. M., ten Cate, H. & Kooman, J. P., 2014, In : Blood Purification. 38, 3-4, p. 203-210 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Increased factor XIa levels in patients with a first acute myocardial infarction: The introduction of a new thrombin generation based factor XIa assay

Loeffen, R., van Oerle, R., de Groot, P. G., Waltenberger, J., Crijns, H. J., Spronk, H. M. H. & ten Cate, H., Dec 2014, In : Thrombosis Research. 134, 6, p. 1328-1334

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Long-term strenuous exercise induces a hypercoagulable state through contact activation

Posthuma, J. J., Loeffen, R., van Oerle, R., Henskens, Y. M. C., ten Cate, H., Spronk, H. M. H. & van der Meijden, P. E. J., Jun 2014, In : Thrombosis and Haemostasis. 111, 6, p. 1197-1199

Research output: Contribution to journalArticleAcademicpeer-review

2013
9 Citations (Scopus)

Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project

Strak, M., Hoek, G., Steenhof, M., Kilinc, E., Godri, K. J., Gosens, I., Mudway, I. S., van Oerle, R., Spronk, H. M. H., Cassee, F. R., Kelly, F. J., Harrison, R. M., Brunekreef, B., Lebret, E. & Janssen, N. A. H., May 2013, In : Occupational and Environmental Medicine. 70, 5, p. 332-340

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Composition of PM Affects Acute Vascular Inflammatory and Coagulative Markers - The RAPTES Project

Strak, M., Hoek, G., Godri, K. J., Gosens, I., Mudway, I. S., van Oerle, R., Spronk, H. M. H., Cassee, F. R., Lebret, E., Kelly, F. J., Harrison, R. M., Brunekreef, B., Steenhof, M. & Janssen, N. A. H., 13 Mar 2013, In : PLOS ONE. 8, 3, e58944.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Development of novel membranes for blood purification therapies based on copolymers of N-vinylpyrrolidone and n-butylmethacrylate

Tijink, M., Janssen, J., Timmer, M., Austen, J., Aldenhoff, Y., Kooman, J., Koole, L., Damoiseaux, J., van Oerle, R., Henskens, Y. & Stamatialis, D., 2013, In : Journal of Materials Chemistry. B, Materials for Biology and Medicine. 1, 44, p. 6066-6077

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Do blood collection methods influence whole-blood platelet function analysis?

Lance, M. D., Henskens, Y., Nelemans, P., Theunissen, M. H. S., Van Oerle, R., Spronk, H. M. & Marcus, M. A. E., 2013, In : Platelets. 24, 4, p. 275-281

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner

Borissoff, J. I., Otten, J. J. T., Heeneman, S., Leenders, P., van Oerle, R., Soehnlein, O., Loubele, S. T. B. G., Hamulyak, K., Hackeng, T. M., Daemen, M. J. A. P., Degen, J. L., Weiler, H., Esmon, C. T., van Ryn, J., Biessen, E. A. L., Spronk, H. M. H. & ten Cate, H., 7 Feb 2013, In : PLOS ONE. 8, 2, e55784.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Patients with Antineutrophil Cytoplasmic Antibodies Associated Vasculitis in Remission Are Hypercoagulable

Hilhorst, M., Winckers, K., Wilde, B., van Oerle, R., ten Cate, H. & Tervaert, J. W. C., Dec 2013, In : Journal of Rheumatology. 40, 12, p. 2042-2046

Research output: Contribution to journalArticleAcademicpeer-review

Platelet Dysfunction in Thrombosis Patients Treated with Vitamin K Antagonists and Recurrent Bleeding

van der Meijden, P. E. J., Bouman, A. C., Feijge, M. A. H., van Oerle, R., Spronk, H. M. H., Hamulyak, K., ten Cate-Hoek, A. J., ten Cate, H. & Heemskerk, J. W. M., 28 May 2013, In : PLOS ONE. 8, 5

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Thrombin Generation Capacity of Prothrombin Complex Concentrate in an In Vitro Dilutional Model

Grottke, O., Rossaint, R., Henskens, Y., van Oerle, R., ten Cate, H. & Spronk, H. H., 17 May 2013, In : PLOS ONE. 8, 5, e64100.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Thrombin Generation in the Glasgow Myocardial Infarction Study

Smid, M., Dielis, A. W. J. H., Spronk, H. M. H., Rumley, A., van Oerle, R., Woodward, M., ten Cate, H. & Lowe, G., 24 Jun 2013, In : PLOS ONE. 8, 6, e66977.

Research output: Contribution to journalArticleAcademicpeer-review

2012
12 Citations (Scopus)

ATP-gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation

Lecut, C., Faccinetto, C., Delierneux, C., Van Oerle, R., Spronk, H. M. H., Evans, R. J., El Benna, J., Bours, V. & Oury, C., Mar 2012, In : Journal of Thrombosis and Haemostasis. 10, 3, p. 453-465

Research output: Contribution to journalArticleAcademicpeer-review

Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa

van der Meijden, P. E. J., van Schilfgaarde, M., van Oerle, R., Renne, T., ten Cate, H. & Spronk, H. M. H., Jul 2012, In : Journal of Thrombosis and Haemostasis. 10, 7, p. 1355-1362

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Platelet concentrate transport in pneumatic tube systems - does it work?

Lance, M. D., Marcus, M. A. E., van Oerle, R., Theunissen, H. M. S. & Henskens, Y. M. C., Jul 2012, In : Vox Sanguinis. 103, 1, p. 79-82

Research output: Contribution to journalArticleAcademicpeer-review

Preanalytic variables of thrombin generation: towards a standard procedure and validation of the method

Loeffen, R., Kleinegris, M. -C. F., Loubele, S. T. B. G., Pluijmen, P. H. M., Fens, D., van Oerle, R., ten Cate, H. & Spronk, H. M. H., Dec 2012, In : Journal of Thrombosis and Haemostasis. 10, 12, p. 2544-2554

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

The effects of pneumatic tube system transport on ROTEM analysis and contact activation assessed by thrombin generation test

Lance, M. D., Kuiper, G. J. A. J. M., Sloep, M., Spronk, H. M. H., van Oerle, R., ten Cate, H., Marcus, M. A. E. & Henskens, Y. M. C., Sep 2012, In : Thrombosis Research. 130, 3, p. E147-E150

Research output: Contribution to journalArticleAcademicpeer-review

2011

Factor XII activation is essential to sustain the procoagulant effects of particulate matter

Kilinc, E., Van Oerle, R., Borissoff, J. I., Oschatz, C., Gerlofs Nijland, M. E., Janssen, N. A., Cassee, F. R., Sandstrom, T., Renne, T., Ten Cate, H. & Spronk, H. M. H., Jul 2011, In : Journal of Thrombosis and Haemostasis. 9, 7, p. 1359-1367

Research output: Contribution to journalArticleAcademicpeer-review

Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury

Grottke, O., Braunschweig, T., Spronk, H. M. H., Esch, S., Rieg, A. D., van Oerle, R., ten Cate, H., Fitzner, C., Tolba, R. & Rossaint, R., 18 Aug 2011, In : Blood. 118, 7, p. 1943-1951

Research output: Contribution to journalArticleAcademicpeer-review

Prothrombin complex concentrate reduces blood loss and enhances thrombin generation in a pig model with blunt liver injury under severe hypothermia

Honickel, M., Rieg, A. D., Rossaint, R., Braunschweig, T., Spronk, H. M. H., ten Cate, H., van Oerle, R., Tolba, R. & Grottke, O., Oct 2011, In : Thrombosis and Haemostasis. 106, 4, p. 724-733

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A

Ninivaggi, M., Dargaud, Y., Van Oerle, R., De Laat, B., Hemker, H. C. & Lindhout, T., Aug 2011, In : Journal of Thrombosis and Haemostasis. 9, 8, p. 1549-1555

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin generation in patients with a first acute myocardial infarction

Smid, M., Dielis, A. W. J. H., Winkens, M. H. M., Spronk, H. M. H., van Oerle, R., Hamulyak, K., Prins, M. H., Rosing, J., Waltenberger, J. L. & ten Cate, H., Mar 2011, In : Journal of Thrombosis and Haemostasis. 9, 3, p. 450-456

Research output: Contribution to journalArticleAcademicpeer-review

2010

Early Atherosclerosis Exhibits an Enhanced Procoagulant State

Borissoff, J. I., Heeneman, S., Kilinc, E., Kassak, P., Van Oerle, R., Winckers, K., Govers-Riemslag, J. W. P., Hamulyak, K., Hackeng, T. M., Daemen, M. J. A. P., Ten Cate, H. & Spronk, H. M. H., 24 Aug 2010, In : Circulation. 122, 8, p. 821-U145

Research output: Contribution to journalArticleAcademicpeer-review

Endothelial Activation in Lacunar Stroke Subtypes

Knottnerus, I. L. H., Govers-Riemslag, J. W. P., Hamulyak, K., Rouhl, R. P. W., Staals, J., Spronk, H. M. H., van Oerle, R., van Raak, E. P. M., Lodder, J., ten Cate, H. & van Oostenbrugge, R. J., Aug 2010, In : Stroke. 41, 8, p. 1617-1622

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin generation as an intermediate phenotype for venous thrombosis A proof-of-concept study

Segers, O., van Oerle, R., ten Cate, H., Rosing, J. & Castoldi, E., Jan 2010, In : Thrombosis and Haemostasis. 103, 1, p. 114-122

Research output: Contribution to journalArticleAcademicpeer-review