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Research Output 2008 2019

2019

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

Yin, C., Ackermann, S., Ma, Z., Mohanta, S. K., Zhang, C., Li, Y., Nietzsche, S., Westermann, M., Peng, L., Hu, D., Bontha, S. V., Srikakulapu, P., Beer, M., Megens, R. T. A., Steffens, S., Hildner, M., Halder, L. D., Eckstein, H-H., Pelisek, J., Herms, J. & 9 others, Roeber, S., Arzberger, T., Borodovsky, A., Habenicht, L., Binder, C. J., Weber, C., Zipfel, P. F., Skerka, C. & Habenicht, A. J. R., Mar 2019, In : Nature Medicine. 25, 3, p. 496-506 23 p.

Research output: Contribution to journalArticleAcademicpeer-review

CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis

Pfeiler, S., Thakur, M., Gruenauer, P., Megens, R. T. A., Joshi, U., Coletti, R., Samara, V., Mueller-Stoy, G., Ishikawa-Ankerhold, H., Stark, K., Klingl, A., Froehlich, T., Arnold, G. J., Woermann, S., Bruns, C. J., Alguel, H., Weber, C., Massberg, S. & Engelmann, B., Feb 2019, In : Faseb Journal. 33, 2, p. 1860-1872 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

Silvestre-Roig, C., Braster, Q., Wichapong, K., Lee, E. Y., Marie Teulon, J., Berrebeh, N., Winter, J., Adrover, J. M., Santos, G. S., Froese, A., Lemnitzer, P., Ortega-Gomez, A., Chevre, R., Marschner, J., Schumski, A., Winter, C., Perez-Olivares, L., Pan, C., Paulin, N., Schoufour, T. & 19 others, Hartwig, H., Gonzalez-Ramos, S., Kamp, F., Megens, R. T. A., Mowen, K. A., Gunzer, M., Maegdefessel, L., Hackeng, T., Lutgens, E., Daemen, M., von Blume, J., Anders, H-J., Nikolaev, V. O., Pellequer, J-L., Weber, C., Hidalgo, A., Nicolaes, G. A. F., Wong, G. C. L. & Soehnlein, O., 9 May 2019, In : Nature. 569, 7755, p. 236-+ 25 p.

Research output: Contribution to journalArticleAcademicpeer-review

PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function

Bianchini, M., Duchene, J., Santovito, D., Schloss, M. J., Evrard, M., Winkels, H., Aslani, M., Mohanta, S. K., Horckmans, M., Blanchet, X., Lacy, M., von Hundelshausen, P., Atzler, D., Habenicht, A., Gerdes, N., Pelisek, J., Ng, L. G., Steffens, S., Weber, C. & Megens, R. T. A., Jun 2019, In : Science Immunology. 4, 36, 14 p., 3054.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis

Rami, M., Guillamat-Prats, R., Rinne, P., Salvermoser, M., Ring, L., Bianchini, M., Blanchet, X., Megens, R. T. A., Doring, Y., Walzog, B., Soehnlein, O., Weber, C., Faussner, A. & Steffens, S., 1 May 2018, In : Arteriosclerosis Thrombosis and Vascular Biology. 38, 5, p. 1007-1019 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Dimeric Glycoprotein VI Binds to Collagen but Not to Fibrin

Ebrahim, M., Jamasbi, J., Adler, K., Megens, R. T. A., M'Bengue, Y., Blanchet, X., Uhland, K., Ungerer, M., Brandl, R., Weber, C., Elia, N., Lorenz, R., Muench, G. & Siess, W., Feb 2018, In : Thrombosis and Haemostasis. 118, 2, p. 351-361 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis

Schmitz, C., Noels, H., El Bounkari, O., Straussfeld, E., Megens, R. T. A., Sternkopf, M., Alampour-Rajabi, S., Krammer, C., Tilstam, P. V., Gerdes, N., Burger, C., Kapurniotu, A., Bucala, R., Jankowski, J., Weber, C. & Bernhagen, J., 1 Aug 2018, In : Faseb Journal. 32, 8, p. 4428-4443 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pericardial Adipose Tissue Regulates Granulopoiesis, Fibrosis, and Cardiac Function After Myocardial Infarction

Horckmans, M., Bianchini, M., Santovito, D., Megens, R. T. A., Springael, J-Y., Negri, I., Vacca, M., Di Eusanio, M., Moschetta, A., Weber, C., Duchene, J. & Steffens, S., 27 Feb 2018, In : Circulation. 137, 9, p. 948-960 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Seijkens, T. T. P., van Tiel, C. M., Kusters, P. J. H., Atzler, D., Soehnlein, O., Zarzycka, B., Aarts, S. A. B. M., Lameijer, M., Gijbels, M. J., Beckers, L., den Toom, M., Slutter, B., Kuiper, J., Duchene, J., Aslani, M., Megens, R. T. A., van 't Veer, C., Kooij, G., Schrijver, R., Hoeksema, M. A. & 16 others, Boon, L., Fay, F., Tang, J., Baxter, S., Jongejan, A., Moerland, P. D., Vriend, G., Bleijlevens, B., Fisher, E. A., Duivenvoorden, R., Gerdes, N., de Winther, M. P. J., Nicolaes, G. A., Mulder, W. J. M., Weber, C. & Lutgens, E., 6 Feb 2018, In : Journal of the American College of Cardiology. 71, 5, p. 527-542 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Actin Regulator Coronin-1A Modulates Platelet Shape Change and Consolidates Arterial Thrombosis

Stocker, T. J., Pircher, J., Skenderi, A., Ehrlich, A., Eberle, C., Megens, R. T. A., Petzold, T., Zhang, Z., Walzog, B., Mueller-Taubenberger, A., Weber, C., Massberg, S., Ishikawa-Ankerhold, H. & Schulz, C., Dec 2018, In : Thrombosis and Haemostasis. 118, 12, p. 2098-2111 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Recombinant GPVI-Fc added to single or dual antiplatelet therapy in vitro prevents plaque-induced platelet thrombus formation

Munoz, A-K. M., Jamasbi, J., Uhland, K., Degen, H., Muench, G., Ungerer, M., Brandl, R., Megens, R., Weber, C., Lorenz, R. & Siess, W., Aug 2017, In : Thrombosis and Haemostasis. 117, 8, p. 1651-1659 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment

Ortega-Gomez, A., Salvermoser, M., Rossaint, J., Pick, R., Brauner, J., Lemnitzer, P., Tilgner, J., de Jong, R. J., Megens, R. T. A., Jamasbi, J., Doering, Y., Pham, C. T., Scheiermann, C., Siess, W., Drechsler, M., Weber, C., Grommes, J., Zarbock, A., Walzog, B. & Soehnlein, O., 18 Oct 2016, In : Circulation. 134, 16, p. 1176-1188

Research output: Contribution to journalArticleAcademicpeer-review

Deletion of junctional adhesion molecule a from platelets increases early stage neointima formation after wire injury in hyperlipidemic mice

Zhao, Z., Karshovska, E., Schmitt, M., Megens, R., Von Hundelshausen, P., Koeppel, T. A., Hackeng, T. M., Weber, C. & Koenen, R., 1 Jul 2016, p. S55-S55.

Research output: Contribution to conferenceAbstractAcademic

Rac signal adaptation controls neutrophil mobilization from the bone marrow

Campa, C. C., Germena, G., Ciraolo, E., Copperi, F., Sapienza, A., Franco, I., Ghigo, A., Camporeale, A., Di Savino, A., Martini, M., Perino, A., Megens, R. T. A., Kurz, A. R. M., Scheiermann, C., Sperandio, M., Gamba, A. & Hirsch, E., 20 Dec 2016, In : Science Signaling. 9, 459, ra124.

Research output: Contribution to journalArticleAcademicpeer-review

RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/beta-catenin signaling in human mesenchymal stem cells

Mahl, C., Egea, V., Megens, R. T. A., Pitsch, T., Santovito, D., Weber, C. & Ries, C., Apr 2016, In : Cellular and Molecular Life Sciences. 73, 7, p. 1489-1501

Research output: Contribution to journalArticleAcademicpeer-review

2015
4 Citations (Scopus)

Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies Functional and Imaging Studies

Jamasbi, J., Megens, R. T. A., Bianchini, M., Muench, G., Ungerer, M., Faussner, A., Sherman, S., Walker, A., Goyal, P., Jung, S., Brandl, R., Weber, C., Lorenz, R., Farndale, R., Elia, N. & Siess, W., 9 Jun 2015, In : Journal of the American College of Cardiology. 65, 22, p. 2404-2415

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Hyperreactivity of Junctional Adhesion Molecule A-Deficient Platelets Accelerates Atherosclerosis in Hyperlipidemic Mice

Karshovska, E., Zhao, Z., Blanchet, X., Schmitt, M. M. N., Bidzhekov, K., Soehnlein, O., von Hundelshausen, P., Mattheij, N. J., Cosemans, J. M. E. M., Megens, R. T. A., Koeppel, T. A., Schober, A., Hackeng, T. M., Weber, C. & Koenen, R. R., 13 Feb 2015, In : Circulation Research. 116, 4, p. 587-599

Research output: Contribution to journalArticleAcademicpeer-review

Intravital Microscopy for Atherosclerosis Research

Megens, R. T. A. & Soehnlein, O., 2015, In : Methods in molecular biology. 1339, p. 41-60 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Optical Imaging Innovations for Atherosclerosis Research Multiphoton Microscopy and Optical Nanoscopy

Megens, R. T. A., Bianchini, M., Schmitt, M. M. N. & Weber, C., Jun 2015, In : Arteriosclerosis Thrombosis and Vascular Biology. 35, 6, p. 1339-1346

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5

Alard, J-E., Ortega-Gomez, A., Wichapong, K., Bongiovanni, D., Horckmans, M., Megens, R. T. A., Leoni, G., Ferraro, B., Rossaint, J., Paulin, N., Ng, J., Ippel, H., Suylen, D., Hinkel, R., Blanchet, X., Gaillard, F., D'Amico, M., von Hundelshausen, P., Zarbock, A., Scheiermann, C. & 6 others, Hackeng, T. M., Steffens, S., Kupatt, C., Nicolaes, G. A. F., Weber, C. & Soehnlein, O., 9 Dec 2015, In : Science Translational Medicine. 7, 317, 317ra196.

Research output: Contribution to journalArticleAcademicpeer-review

2014
14 Citations (Scopus)

Deficiency of the Sialyltransferase St3Gal4 Reduces-Ccl5Mediated Myeloid Cell Recruitment and Arrest

Doering, Y., Noels, H., Mandl, M., Kramp, B., Neideck, C., Lievens, D., Drechsler, M., Megens, R. T. A., Tilstam, P. V., Langer, M., Hartwig, H., Theelen, W., Marth, J. D., Sperandio, M., Soehnlein, O. & Weber, C., 14 Mar 2014, In : Circulation Research. 114, 6, p. 976-981

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis

Schmitt, M. M. N., Megens, R. T. A., Zernecke, A., Bidzhekov, K., van den Akker, N. M., Rademakers, T., van Zandvoort, M. A., Hackeng, T. M., Koenen, R. R. & Weber, C., 7 Jan 2014, In : Circulation. 129, 1, p. 66-+

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice

Chevre, R., Maria Gonzalez-Granado, J., Megens, R. T. A., Sreeramkumar, V., Silvestre-Roig, C., Molina-Sanchez, P., Weber, C., Soehnlein, O., Hidalgo, A. & Andres, V., 28 Feb 2014, In : Circulation Research. 114, 5, p. 770-779

Research output: Contribution to journalArticleAcademicpeer-review

141 Citations (Scopus)

MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1

Schober, A., Nazari-Jahantigh, M., Wei, Y., Bidzhekov, K., Gremse, F., Grommes, J., Megens, R. T. A., Heyll, K., Noels, H., Hristov, M., Wang, S., Kiessling, F., Olson, E. N. & Weber, C., Apr 2014, In : Nature Medicine. 20, 4, p. 368-+

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet

Aoqui, C., Chmielewski, S., Scherer, E., Eissler, R., Sollinger, D., Heid, I., Braren, R., Schmaderer, C., Megens, R. T. A., Weber, C., Heemann, U., Tschoep, M. & Baumann, M., 3 Feb 2014, In : Cardiovascular Diabetology. 13, 31.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Two-Photon Laser Scanning Microscopy as a Useful Tool for Imaging and Evaluating Macrophage-, IL-4 Activated Macrophage-and Osteoclast-based In Vitro Degradation of Beta-Tricalcium Phosphate Bone Substitute Material

Campos, D. F. D., Vogt, M., Lindner, M., Kirsten, A., Weber, M., Megens, R. T. A., Pyta, J., Zenke, M., Van Zandvoort, M. & Fischer, H., Feb 2014, In : Microscopy Research and Technique. 77, 2, p. 143-152

Research output: Contribution to journalArticleAcademicpeer-review

2013
3 Citations (Scopus)

Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment

Kramp, B. K., Megens, R. T. A., Sarabi, A., Winkler, S., Projahn, D., Weber, C., Koenen, R. R. & von Hundelshausen, P., Oct 2013, In : Thrombosis and Haemostasis. 110, 4, p. 795-806

Research output: Contribution to journalArticleAcademicpeer-review

Neutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes

Wantha, S., Alard, J-E., Megens, R. T. A., van der Does, A. M., Doering, Y., Drechsler, M., Pham, C. T. N., Wang, M-W., Wang, J-M., Gallo, R. L., von Hundelshausen, P., Lindbom, L., Hackeng, T., Weber, C. & Soehnlein, O., 1 Mar 2013, In : Circulation Research. 112, 5, p. 792-801

Research output: Contribution to journalArticleAcademicpeer-review

2012
123 Citations (Scopus)

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

Doering, Y., Manthey, H. D., Drechsler, M., Lievens, D., Megens, R. T. A., Soehnlein, O., Busch, M., Manca, M., Koenen, R. R., Pelisek, J., Daemen, M. J., Lutgens, E., Zenke, M., Binder, C. J., Weber, C. & Zernecke, A., 3 Apr 2012, In : Circulation. 125, 13, p. 1673-U190

Research output: Contribution to journalArticleAcademicpeer-review

Presence of luminal neutrophil extracellular traps in atherosclerosis

Megens, R. T. A., Vijayan, S., Lievens, D., Doering, Y., van Zandvoort, M. A. M. J., Grommes, J., Weber, C. & Soehnlein, O., Mar 2012, In : Thrombosis and Haemostasis. 107, 3, p. 597-598

Research output: Contribution to journalArticleAcademicpeer-review

2011

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

Weber, C., Meiler, S., Doering, Y., Koch, M., Drechsler, M., Megens, R. T. A., Rowinska, Z., Bidzhekov, K., Fecher, C., Ribechini, E., van Zandvoort, M. A. M. J., Binder, C. J., Jelinek, I., Hristov, M., Boon, L., Jung, S., Korn, T., Lutz, M. B., Foerster, I., Zenke, M. & 3 others, Hieronymus, T., Junt, T. & Zernecke, A., Jul 2011, In : Journal of Clinical Investigation. 121, 7, p. 2898-2910

Research output: Contribution to journalArticleAcademicpeer-review

Endothelial glycocalyx thickness and platelet-vessel wall interactions during atherogenesis

Reitsma, S., Egbrink, M. G. A. O., Heijnen, V. V. T., Megens, R. T. A., Engels, W., Vink, H., Slaaf, D. W. & van Zandvoort, M. A. M. J., Nov 2011, In : Thrombosis and Haemostasis. 106, 5, p. 939-946

Research output: Contribution to journalArticleAcademicpeer-review

Intravital imaging of phagocyte recruitment

Megens, R. T. A., Kemmerich, K., Pyta, J., Weber, C. & Soehnlein, O., May 2011, In : Thrombosis and Haemostasis. 105, 5, p. 802-810

Research output: Contribution to journalArticleAcademicpeer-review

Lipoprotein-Derived Lysophosphatidic Acid Promotes Atherosclerosis by Releasing CXCL1 from the Endothelium

Zhou, Z., Subramanian, P., Sevilmis, G., Globke, B., Soehnlein, O., Karshovska, E., Megens, R., Heyll, K., Chun, J., Saulnier-Blache, J. S., Reinholz, M., van Zandvoort, M., Weber, C. & Schobert, A., 4 May 2011, In : Cell Metabolism. 13, 5, p. 592-600

Research output: Contribution to journalArticleAcademicpeer-review

Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia

Soehnlein, O., Wantha, S., Simsekyilmaz, S., Doering, Y., Megens, R. T. A., Mause, S. F., Drechsler, M., Smeets, R., Weinandy, S., Schreiber, F., Gries, T., Jockenhoevel, S., Moeller, M., Vijayan, S., van Zandvoort, M. A. M. J., Agerberth, B., Pham, C. C. T. N., Gallo, R. L., Hackeng, T. M., Liehn, E. A. & 3 others, Zernecke, A., Klee, D. & Weber, C., 5 Oct 2011, In : Science Translational Medicine. 3, 103, p. 10

Research output: Contribution to journalArticleAcademicpeer-review

Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y(12) antagonist ticagrelor

Kuijpers, M. J. E., Megens, R. T. A., Nikookhesal, E., Feijge, M. A. H., De Mey, J. G. R., Egbrink, M. G. A. O., van Giezen, J. J. J. & Heemskerk, J. W. M., Dec 2011, In : Thrombosis and Haemostasis. 106, 6, p. 1179-1188

Research output: Contribution to journalArticleAcademicpeer-review

2010

Arterial radius estimation from microscopic data using a new algorithm for circle parameter estimation

van Triest, H. J. W., Megens, R. T. A., van Assen, H. C., Romeny, B. M. T. H. & van Zandvoort, M. A. M. J., 2010, In : Journal of Biomedical Optics. 15, 2, p. 8

Research output: Contribution to journalArticleAcademicpeer-review

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

Drechsler, M., Megens, R. T. A., van Zandvoort, M., Weber, C. & Soehnlein, O., 2 Nov 2010, In : Circulation. 122, 18, p. 1837-+

Research output: Contribution to journalArticleAcademicpeer-review

In vivo high-resolution structural imaging of large arteries in small rodents using two-photon laser scanning microscopy

Megens, R. T. A., Reitsma, S., Prinzen, L., Egbrink, M. G. A. O., Engels, W., Leenders, P. J. A., Brunenberg, E. J. L., Reesink, K. D., Janssen, B. J. A., Romeny, B. M. T. H., Slaaf, D. W. & van Zandvoort, M. A. M. J., 2010, In : Journal of Biomedical Optics. 15, 1, p. 10

Research output: Contribution to journalArticleAcademicpeer-review

Lysophosphatidic Acid Receptors LPA1 and LPA3 Promote CXCL12-Mediated Smooth Muscle Progenitor Cell Recruitment in Neointima Formation

Subramanian, P., Karshovska, E., Reinhard, P., Megens, R. T. A., Zhou, Z., Akhtar, S., Schumann, U., Li, X., van Zandvoort, M., Ludin, C., Weber, C. & Schober, A., 9 Jul 2010, In : Circulation Research. 107, 1, p. 96-U197

Research output: Contribution to journalArticleAcademicpeer-review

2008
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