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2019

Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse

Kneppers, A., Leermakers, P., Pansters, N., Backx, E., Gosker, H., van Loon, L., Schols, A., Langen, R. & Verdijk, L., Jan 2019, In : Faseb Journal. 33, 1, p. 1288-1298 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis

Fenton, C. G., Webster, J. M., Martin, C. S., Fareed, S., Wehmeyer, C., Mackie, H., Jones, R., Seabright, A. P., Lewis, J. W., Lai, Y. C., Goodyear, C. S., Jones, S. W., Cooper, M. S., Lavery, G. G., Langen, R., Raza, K. & Hardy, R. S., 1 Aug 2019, In : Arthritis Research & Therapy. 21, p. 1-12 12 p., 182.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia

Brzeszczynska, J., Meyer, A., McGregor, R., Schilb, A., Degen, S., Tadini, V., Johns, N., Langen, R., Schols, A., Glass, D. J., Roubenoff, R., Ross, J. A., Fearon, K. C. H., Greig, C. A. & Jacobi, C., Feb 2018, In : Journal of cachexia, sarcopenia and muscle. 9, 1, p. 93-105 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Altered protein turnover signaling and myogenesis during impaired recovery of inflammation-induced muscle atrophy in emphysematous mice

Ceelen, J. J. M., Schols, A. M. W. J., Kneppers, A. E. M., Rosenbrand, R. P. H. A., Drozdz, M. M., van Hoof, S. J., de Theije, C. C., Kelders, M. C. J. M., Verhaegen, F. & Langen, R. C. J., 17 Jul 2018, In : Scientific Reports. 8, 12 p., 10761.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A novel in vitro model for the assessment of postnatal myonuclear accretion

Kneppers, A., Verdijk, L., de Theije, C., Corten, M., Gielen, E., van Loon, L., Schols, A. & Langen, R., 14 Feb 2018, In : Skeletal Muscle. 8, 13 p., 4.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice

Theije, C. C., Schols, A. M. W. J., Lamers, W. H., Ceelen, J. J. M., van Gorp, R. H., Hermans, J. J. R., Kohler, S. E. & Langen, R. C. J., 1 Jan 2018, In : Endocrinology. 159, 1, p. 519-534 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy

de Theije, C. C., Schols, A. M. W. J., Lamers, W. H., Neumann, D., Kohler, S. E. & Langen, R. C. J., 13 Sep 2018, In : PLOS ONE. 13, 9, 18 p., 0203630.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

Ceelen, J. J. M., Schols, A. M. W. J., Thielen, N. G. M., Haegens, A., Gray, D. A., Kelders, M. C. J. M., de Theije, C. C. & Langen, R. C. J., 2 May 2018, In : Respiratory Research. 19, 11 p., 80.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation

Ceelen, J. J. M., Schols, A. M. W. J., van Hoof, S. J., de Theije, C. C., Verhaegen, F. & Langen, R. C. J., 2 May 2017, In : Respiratory Research. 18, 10 p., 75.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Inactivation of glycogen synthase kinase-3 beta (GSK-3 beta) enhances skeletal muscle oxidative metabolism

Theeuwes, W. F., Gosker, H. R., Langen, R. C. J., Verhees, K. J. P., Pansters, N. A. M., Schols, A. M. W. J. & Remels, A. H. V., Dec 2017, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1863, 12, p. 3075-3086 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

98 Downloads (Pure)
2016
9 Citations (Scopus)

Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly

Brzeszczynska, J., Johns, N., Schilb, A., Degen, S., Degen, M., Langen, R., Schols, A., Glass, D. J., Roubenoff, R., Greig, C. A., Jacobi, C., Fearon, K. C. H. & Ross, J. A., Aug 2016, In : Aging. 8, 8, p. 1690-1702

Research output: Contribution to journalArticleAcademicpeer-review

2015

Differential sensitivity of oxidative and glycolytic muscles to hypoxia-induced muscle atrophy

de Theije, C. C., Langen, R. C., Lamers, W. H., Gosker, H. R., Schols, A. M. & Koehler, S. E., 15 Jan 2015, In : Journal of Applied Physiology. 118, 2, p. 200-211 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Muscle-specific GSK-3beta ablation accelerates regeneration of disuse-atrophied skeletal muscle

Pansters, N. A. M., Schols, A. M., Verhees, K. J., de Theije, C. C., Snepvangers, F., Kelders, M. C. J. M., Ubags, N. D. J., Haegens, A. & Langen, R. C., 1 Jan 2015, In : Biochimica et Biophysica Acta. Mucoproteins and Mucopolysaccharides. 1852, 3, p. 490-506

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Preserved muscle oxidative metabolic phenotype in newly diagnosed non-small cell lung cancer cachexia

Op den Kamp, C. M., Gosker, H. R., Lagarde, S., Tan, D. Y., Snepvangers, F. J., Dingemans, A-M. C., Langen, R. C. J. & Schols, A. M. W. J., Jun 2015, In : Journal of cachexia, sarcopenia and muscle. 6, 2, p. 164-173

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

TNF-alpha-Induced NF-kappa B Activation Stimulates Skeletal Muscle Glycolytic Metabolism Through Activation of HIF-1 alpha

Remels, A., Gosker, H., Koen Verhees, K. J. P., Langen, R. & Schols, A., 2015, In : Endocrinology. 156, 5, p. 1770-1781

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
2014

Activation of alternative NF-κB signaling during recovery of disuse-induced loss of muscle oxidative phenotype.

Remels, A. H., Pansters, N. A. M., Gosker, H. R., Schols, A. M. & Langen, R. C., Mar 2014, In : American Journal of Physiology : Endocrinology and Metabolism. 306, 6, p. E615-E626 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Early body weight loss during concurrent chemo-radiotherapy for non-small cell lung cancer

Op den Kamp, C. M. H., de Ruysscher, D. K. M., van den Heuvel, M., Elferink, M., Houben, R. M. A., Oberije, C. J. G., Bootsma, G. P., Geraedts, W. H., Pitz, C. C. M., Langen, R. C., Wouters, E. F. M., Schols, A. M. W. J. & Dingemans, A. M. C., 1 Jan 2014, In : Journal of cachexia, sarcopenia and muscle. 5, 2, p. 127-137

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Phase II drugs that are currently in development for the treatment of cachexia

Dingemans, A-M. C., de Vos-Geelen, J., Langen, R. & Schols, A. M. W., Dec 2014, In : Expert Opinion on Investigational Drugs. 23, 12, p. 1655-1669

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
3 Citations (Scopus)
2013
13 Citations (Scopus)

Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia.

Op den Kamp, C. M. H., Langen, R. C. J., Snepvangers, F. J., de Theije, C. C., Schellekens, J. M., Laugs, F., Dingemans, A. M. & Schols, A. M. W. J., Sep 2013, In : American Journal of Clinical Nutrition. 98, 3, p. 738-748 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology

Baarsma, H. A., Bos, S., Meurs, H., Visser, K. H., Smit, M., Schols, A. M., Langen, R. C., Kerstjens, H. A. & Gosens, R., 23 Oct 2013, In : Respiratory Research. 14, 1, 10 p., 113.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy

Verhees, K. J., Pansters, N. A. M., Baarsma, H. A., Remels, A. H., Haegens, A., de Theije, G. C., Schols, A. M., Gosens, R. & Langen, R. C., 1 Jan 2013, In : Respiratory Research. 14, p. 117

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Regulation of skeletal muscle oxidative phenotype by classical NF-κB signalling.

Remels, A. H. V., Gosker, H. R., de Bakker, J., Guttridge, D. C., Schols, A. M. W. J. & Langen, R. C. J., Aug 2013, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1832, 8, p. 1313-1325 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Regulation of skeletal muscle plasticity by glycogen synthase kinase-3β: a potential target for the treatment of muscle wasting

Verhees, K. J. P., Pansters, N. A. M., Schols, A. M. W. J. & Langen, R. C. J., Jun 2013, In : Current Pharmaceutical Design. 19, 18, p. 3276-3298

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Synergistic stimulation of myogenesis by glucocorticoid and IGF-I signaling

Pansters, N. A. M., Langen, R. C. J., Wouters, E. F. M. & Schols, A. M. W. J., May 2013, In : Journal of Applied Physiology. 114, 9, p. 1329-1339 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

The mechanisms of cachexia underlying muscle dysfunction in COPD.

Remels, A. H. V., Gosker, H. R., Langen, R. C. J. & Schols, A. M. W. J., May 2013, In : Journal of Applied Physiology. 114, 9, p. 1253-1262 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)
42 Citations (Scopus)
2012
20 Citations (Scopus)

NF-kappa B Activation Is Required for the Transition of Pulmonary Inflammation to Muscle Atrophy

Langen, R. C. J., Haegens, A., Vernooy, J. H. J., Wouters, E. F. M., de Winther, M. P. J., Carlsen, H., Steele, C., Shoelson, S. E. & Schols, A. M. W. J., 1 Jan 2012, In : American Journal of Respiratory Cell and Molecular Biology. 47, 3, p. 288-297

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

NF-kB activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy.

Haegens, A., Schols, A. M. W. J., Gorissen, S. H., van Essen, A. L., Snepvangers, F., Gray, D. A., Shoelson, S. E. & Langen, R. C. J., 1 Jan 2012, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 302, 1, p. L103-L110 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)
29 Citations (Scopus)
2011

Decreased Exercise-Induced Expression of Nuclear Factor-{kappa}B-Regulated Genes in Muscle of Patients With COPD.

Mercken, E. M., Hageman, G. J., Langen, R. C. J., Wouters, E. F. M. & Schols, A. M. W. J., 1 Jan 2011, In : Chest. 139, 2, p. 337-346

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Glycogen synthase kinase-3ß is required for the induction of skeletal muscle atrophy.

Koen Verhees, K. J. P., Schols, A. M. W. J., Kelders, M. C., Op den Kamp, C. M. H., van der Velden, J. & Langen, R. C. J., Nov 2011, In : American Journal of Physiology-Cell Physiology. 301, 5, p. C995-C1007 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

Hypoxia and muscle maintenance regulation: implications for chronic respiratory disease

de Theije, C., Costes, F., Langen, R. C., Pison, C. & Gosker, H. R., Nov 2011, In : Current Opinion in Clinical Nutrition and Metabolic Care. 14, 6, p. 548-553 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Palmitate-induced skeletal muscle insulin resistance does not require NF-κB activation

Hommelberg, P. P., Plat, J., Sparks, L. M., Schols, A. M. W. J., van Essen, A. L., Kelders, M. C., Van Beurden, D., Mensink, R. P. & Langen, R. C. J., Apr 2011, In : Cellular and Molecular Life Sciences. 68, 7, p. 1215-1225 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)

Segregation of myoblast fusion and muscle-specific gene expression by distinct ligand-dependent inactivation of GSK-3ß.

Pansters, N. A. M., van der Velden, A. L. J., Kelders, M. C. J. M., Laeremans, H., Schols, A. M. W. J. & Langen, R. C. J., Feb 2011, In : Cellular and Molecular Life Sciences. 68, 3, p. 523-535 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)
2010
9 Citations (Scopus)

Regulation of mitochondrial biogenesis during myogenesis

Remels, A. H., Langen, R. C., Schrauwen, P., Schaart, G., Schols, A. M. & Gosker, H. R., 5 Feb 2010, In : Molecular and Cellular Endocrinology. 315, 1-2, p. 113-120 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?

Remels, A. H. V., Gosker, H. R., Schrauwen, P., Hommelberg, P. P., Sliwinski, P., Polkey, M., Galdiz, J., Wouters, E. F. M., Langen, R. C. J. & Schols, A. M. W. J., Dec 2010, In : Faseb Journal. 24, 12, p. 5052-5062 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Scopus)

Trans-10, cis-12 conjugated linoleic acid inhibits skeletal muscle differentiation and GLUT4 expression independently from NF-'B activation.

Hommelberg, P. P., Plat, J., Remels, A. H. V., van Essen, A. L., Kelders, M. C., Mensink, R. P., Schols, A. M. W. J. & Langen, R. C. J., Dec 2010, In : Molecular Nutrition & Food Research. 54, 12, p. 1763-1772 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Trans Fatty Acid-Induced NF-kappaB Activation Does Not Induce Insulin Resistance in Cultured Murine Skeletal Muscle Cells

Hommelberg, P. P., Langen, R. C. J., Schols, A. M. W. J., van Essen, A. L., Snepvangers, F. J., Mensink, R. P. & Plat, J., 1 Jan 2010, In : Lipids. 45, 3, p. 285-290

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
2009

Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure.

Gosker, H. R., Langen, R. C., Bracke, K. R., Joos, G. F., Brusselle, G. G., Steele, C., Ward, K. A., Wouters, E. F. & Schols, A. M., 1 Jan 2009, In : American Journal of Respiratory Cell and Molecular Biology. 40, 6, p. 710-716

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

Fatty acid-induced NF-{kappa}B activation and insulin resistance in skeletal muscle are chain length dependent.

Hommelberg, P. P. H., Plat, J., Langen, R., Schols, A. M. & Mensink, R. P., 1 Jan 2009, In : American Journal of Physiology : Endocrinology and Metabolism. 296, 1, p. E114-E120

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Muscle atrophy in cachexia: can dietary protein tip the balance?

Op den Kamp, C. M. H., Langen, R. C., Haegens, A. & Schols, A. M., 1 Jan 2009, In : Current Opinion in Clinical Nutrition and Metabolic Care. 12, 6, p. 611-616

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)