Pim Heckman

Research output

Research output per year 2014 2015 2017 2018 2019 2024

• 20 Article
• 3 Chapter
• 3 (Systematic) Review article
• 1 Abstract
• 2 More
  • 1 Conference Abstract/Poster in journal
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults

  Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Smit, S., Tsai, M., Lahu, G., Uz, T., Blokland, A. & Prickaerts, J., 15 Mar 2018, In: Neuropharmacology. 131, p. 31-38 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial

  Heckman, P. R. A., Van Duinen, M. A., Blokland, A., Uz, T., Prickaerts, J. & Sambeth, A., Jan 2018, In: Psychopharmacology. 235, 1, p. 301–308 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Acute sleep loss impairs object but not spatial pattern separation in humans

  Blokland, A., Jackson, M., Puustinen, K., Soeterboek, J. & Heckman, P. R. A., 1 Jan 2024, In: Neuroscience Letters. 818, 5 p., 137535.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study

  Blokland, A., Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Tsai, M., Lahu, G., Uz, T. & Prickaerts, J., May 2019, In: Neurobiology of Aging. 77, p. 37-43 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• From Age-Related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential Role for Phosphodiesterases

  Heckman, P. R. A., Blokland, A. & Prickaerts, J., 2017, Phosphodiesterases: CNS Functions and Diseases. Zhang, H-T., Xu, Y. & O'Donnell, J. M. (eds.). Berlin: Springer Verlag, p. 135-168 34 p. (Advances in Neurobiology, Vol. 17).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

  Open Access

  File
  117 Downloads (Pure)

• Glutamate Signalling in Object Novelty Recognition Memory Tests

  Argyrousi, E. K., Heckman, P. R. A. & Prickaerts, J., 2018, Handbook of Object Novelty Recognition. Ennaceur, A. & de Souza Silva, M. A. (eds.). Elsevier, Vol. 27. p. 541-551 11 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

• Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease

  Prickaerts, J., Heckman, P. R. A. & Blokland, A., 9 Aug 2017, In: Expert Opinion on Investigational Drugs. 26, 9, p. 1033-1048 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Memory and mood during MDMA intoxication, with and without memantine pretreatment

  de Sousa Fernandes Perna, E. B., Theunissen, E. L., Kuypers, K. P. C., Heckman, P., de la Torre, R., Farre, M. & Ramaekers, J. G., Dec 2014, In: Neuropharmacology. 87, p. 198-205 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• No interaction between rivastigmine and citalopram on memory and novelty processing in healthy human volunteers

  Heckman, P. R. A., Blokland, A. & Sambeth, A., Feb 2019, In: Journal of Psychopharmacology. 33, 2, p. 210-218 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• PDE and cognitive processing : beyond the memory domain

  Heckman, P., Blokland, A., Ramaekers, J. & Prickaerts, J., Mar 2015, In: Neurobiology of Learning and Memory. 119, p. 108-122 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Phosphodiesterase 2A inhibition and impulsivity

  Heckman, P. R. A., Van Duinen, M., Blokland, A., Ramaekers, J. & Prickaerts, J., Mar 2015, p. S31-S31.

  Research output: Contribution to conference › Abstract › Academic

• Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata

  Heckman, P. R. A., Schweimer, J. V., Sharp, T., Prickaerts, J. & Blokland, A., Mar 2018, In: Brain Structure & Function. 223, 2, p. 739-748 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations

  Heckman, P. R. A., Blokland, A., Bollen, E. P. P. & Prickaerts, J., Apr 2018, In: Neuroscience and Biobehavioral Reviews. 87, p. 233-254 22 p.

  Research output: Contribution to journal › (Systematic) Review article › peer-review

  Open Access

• Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications

  Heckman, P. R. A., van Duinen, M. A., Bollen, E. P. P., Nishi, A., Wennogle, L. P., Blokland, A. & Prickaerts, J., Oct 2016, In: International Journal of Neuropsychopharmacology. 19, 10, 16 p., pyw030.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  278 Downloads (Pure)

• Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer's Disease: A Translational Overview

  Heckman, P. R. A., Wouters, C. & Prickaerts, J., 2015, In: Current Pharmaceutical Design. 21, 3, p. 317-331

  Research output: Contribution to journal › Article › Academic › peer-review

• Phosphodiesterase Inhibitors in Object Recognition and Object Location Memory Tests

  Heckman, P. R. A., Argyrousi, E. K. & Prickaerts, J., 2018, Handbook of Object Novelty Recognition. Ennaceur, A. & de Souza Silva, M. A. (eds.). Elsevier, Vol. 27. p. 567-574 8 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

• Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation

  Heckman, P. R. A., Roig Kuhn, F., Raven, F., Bolsius, Y. G., Prickaerts, J., Meerlo, P. & Havekes, R., Jun 2020, In: Synapse. 74, 6, 6 p., 22150.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Phosphodiesterase Type 4 Inhibition in CNS Diseases

  Blokland, A., Heckman, P., Vanmierlo, T., Schreiber, R., Paes, D. & Prickaerts, J., Dec 2019, In: Trends in Pharmacological Sciences. 40, 12, p. 971-985 15 p.

  Research output: Contribution to journal › (Systematic) Review article › peer-review

  Open Access

  File
  224 Downloads (Pure)

• Pro-cognitive effect of upregulating cyclic guanosine monophosphate signalling during memory acquisition or early consolidation is mediated by increased AMPA receptor trafficking

  Argyrousi, E. K., Heckman, P. R. A., van Hagen, B. T. J., Muysers, H., van Goethem, N. P. & Prickaerts, J., Jan 2020, In: Journal of Psychopharmacology. 34, 1, p. 103-114 12 p., 0269881119885262.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Recovering object-location memories after sleep deprivation-induced amnesia

  Bolsius, Y. G., Heckman, P. R. A., Paraciani, C., Wilhelm, S., Raven, F., Meijer, E. L., Kas, M. J. H., Ramirez, S., Meerlo, P. & Havekes, R., 23 Jan 2023, In: Current Biology. 33, 2, p. 298-308.e5 17 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans

  Theunissen, E. L., Heckman, P., de Sousa Fernandes Perna, E. B., Kuypers, K. P. C., Sambeth, A., Blokland, A., Prickaerts, J., Toennes, S. W. & Ramaekers, J. G., 1 Jan 2015, In: Psychopharmacology. 232, 2, p. 343-353 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  94 Downloads (Pure)

• Role of cyclic nucleotides and their downstream signaling cascades in memory function: Being at the right time at the right spot

  Argyrousi, E. K., Heckman, P. R. A. & Prickaerts, J., Jun 2020, In: Neuroscience and Biobehavioral Reviews. 113, p. 12-38 27 p.

  Research output: Contribution to journal › (Systematic) Review article › peer-review

  Open Access

• Soluble guanylate cyclase stimulator riociguat improves spatial memory in mice via peripheral mechanisms

  Nelissen, E., van Hagen, B. T. J., Argyrousi, E. K., van Goethem, N. P., Heckman, P. R. A., Paes, D., Mulder-Jongen, D. A. J., Ramaekers, J. G., Blokland, A., Schmidt, H. H. H. W. & Prickaerts, J., 25 Sept 2022, In: Neuroscience Letters. 788, 8 p., 136840.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Targeting phosphodiesterase type 4 for improving cognitive fronto-striatal functioning: a translational approach

  Heckman, P. R. A., 2017, Maastricht: Maastricht University.

  Research output: Thesis › Doctoral Thesis › Internal

  Open Access

  File
  2253 Downloads (Pure)

• The mediating role of phosphodiesterase type 4 in the dopaminergic modulation of motor impulsivity

  Heckman, P. R. A., Blokland, A., Van Goethem, N. P., Van Hagen, B. T. J. & Prickaerts, J., 17 Sept 2018, In: Behavioural Brain Research. 350, p. 16-22 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The PDE4-inhibitor roflumilast improves memory: findings from a translational perspective

  Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Tsai, M., Lahu, G., Uz, T., Blokland, A. & Prickaerts, J., Oct 2017, In: European Neuropsychopharmacology. 27, Suppl 4, p. S1024-S1025

  Research output: Contribution to journal › Conference Abstract/Poster in journal › Academic

• Translational issues with the development of cognition enhancing drugs

  Blokland, A., van Goethem, N., Heckman, P., Schreiber, R. & Prickaerts, J., 1 Jan 2014, In: Frontiers in Neurology. 5, 190.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Treatment with the selective PDE4B inhibitor A-33 or PDE4D inhibitor zatolmilast prevents sleep deprivation-induced deficits in spatial pattern separation

  Zhao, H., Blokland, A., Prickaerts, J., Havekes, R. & Heckman, P. R. A., 28 Feb 2024, In: Behavioural Brain Research. 459, 6 p., 114798.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats

  Nelissen, E., van Goethem, N. P., Bonassoli, V. T., Heckman, P. R. A., van Hagen, B. T. J., Suay, D., Wouters, C. & Prickaerts, J., 23 Apr 2019, In: Neuroscience Letters. 699, p. 41-46 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access