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Research Output 1999 2019

2019

Incidence and predictors of implantable cardioverter-defibrillator therapy and its complications in idiopathic ventricular fibrillation patients

Blom, L. J., Visser, M., Christiaans, I., Scholten, M. F., Bootsma, M., van den Berg, M. P., Yap, S-C., van der Heijden, J. F., Doevendans, P. A., Loh, P., Postema, P. G., Barge-Schaapsveld, D. Q., Hofman, N., Volders, P. G. A., Wilde, A. A. & Hassink, R. J., Oct 2019, In : EP Europace. 21, 10, p. 1519-1526 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1

ter Bekke, R. M. A., Moers, A. M. E., de Jong, M. M. J., Johnson, D. M., Schwartz, P. J., Vanoli, E. & Volders, P. G. A., 1 Jul 2019, In : International Journal of Cardiology. 286, p. 66-72 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update

Bosman, L. P., Verstraelen, T. E., van Lint, F. H. M., Cox, M. G. P. J., Groeneweg, J. A., Mast, T. P., van der Zwaag, P. A., Volders, P. G. A., Evertz, R., Wong, L., de Groot, N. M. S., Zeppenfeld, K., van der Heijden, J. F., van den Berg, M. P., Wilde, A. A. M., Asselbergs, F. W., Hauer, R. N. W., te Riele, A. S. J. M., van Tintelen, J. P., Baas, A. E. & 15 others, Barge-Schaapveld, D. Q. C. M., Boekholdt, S. M., Cramer, M. J. M., Dooijes, D., Jongbloed, J. D. H., Loh, P., Planken, R. N., Prakken, N. H. J., van der Smagt, J. J., van der Wal, A. C., Teske, A. J., van Veen, T. A. B., Velthuis, B. K., Vink, A. & Yap, S. C., Oct 2019, In : Netherlands Heart Journal. 27, 10, p. 480-486 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

To the Editor-Interpretation of electrograms is key to understand the clinical potential of ECGI

Cluitmans, M. J. M., Stoks, J. & Volders, P. G. A., Jun 2019, In : Heart Rhythm. 16, 6, p. E51-E52 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

2018

Beauty and the beat: A complicated case of multifocal ectopic Purkinje-related premature contractions

Ter Bekke, R. M. A., David, M., Krapels, I. P. C., Crijns, H. J. G. M. & Volders, P. G. A., Sep 2018, In : HeartRhythm Case Reports. 4, 9, p. 429-433 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation

Conte, G., Caputo, M. L., Volders, P. G. A., Luca, A., Mainardi, L., Schotten, U., Corino, V. D. A., Regoli, F., Zeemering, S., Zink, M., Yazdani, S., Kappenberger, L., Moccetti, T., Vesin, J-M. & Auricchio, A., 15 Feb 2018, In : International Journal of Cardiology. 253, p. 66-70 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Late complications of an atrial septal occluder provoked by anticoagulant therapy

Nguyen, U., Weijs, B., Luyten, P., Blokzijl, C., Witsenburg, M., Volders, P. & Bekkers, B., 2018, In : Journal of Cardiology Cases. 17, 2, p. 68-71 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Life-long tailoring of diagnosis and management of patients with idiopathic ventricular fibrillation-future perspectives in research

Blom, L. J., Volders, P. G. A., Wilde, A. A. & Hassink, R. J., 1 Aug 2018, In : Netherlands Heart Journal. 26, 7-8, p. 367-374 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Predicting changes to I-Na from missense mutations in human SCN5A

Clerx, M., Heijman, J., Collins, P. & Volders, P. G. A., 24 Aug 2018, In : Scientific Reports. 8, 1, 13 p., 12797.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Wavelet-promoted sparsity for non-invasive reconstruction of electrical activity of the heart

Cluitmans, M., Karel, J., Bonizzi, P., Volders, P., Westra, R. & Peeters, R., Nov 2018, In : Medical & Biological Engineering & Computing. 56, 11, p. 2039-2050 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Heritability in a SCN5A-mutation founder population with increased female susceptibility to non-nocturnal ventricular tachyarrhythmia and sudden cardiac death

ter Bekke, R. M. A., Isaacs, A., Barysenka, A., Hoos, M. B., Jongbloed, J. D. H., Hoorntje, J. C. A., Patelski, A. S. M., Helderman-van den Enden, A. T. J. M., van den Wijngaard, A., Stoll, M. & Volders, P. G. A., Dec 2017, In : Heart Rhythm. 14, 12, p. 1873-1881 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

In Vivo Validation of Electrocardiographic Imaging

Cluitmans, M. J. M., Bonizzi, P., Karel, J. M. H., Das, M., Kietselaer, B. L. J. H., Jong, M. M. J. D., Prinzen, F. W., Peeters, R. L. M., Westra, R. L. & Volders, P. G. A., 2017, In : JACC: Clinical Electrophysiology. 3, 3, p. 232 - 242

Research output: Contribution to journalArticleAcademicpeer-review

Lamin A/C-Related Cardiac Disease Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation

Hoorntje, E. T., Bollen, I. A., Barge-Schaapveld, D. Q., van Tienen, F. H., te Meerman, G. J., Jansweijer, J. A., van Essen, A. J., Volders, P. G., Constantinescu, A. A., van den Akker, P. C., van Spaendonck-Zwarts, K. Y., Oldenburg, R. A., Marcelis, C. L., van der Smagt, J. J., Hennekam, E. A., Vink, A., Bootsma, M., Aten, E., Wilde, A. A., van den Wijngaard, A. & 5 others, Broers, J. L., Jongbloed, J. D., van der Velden, J., van den Berg, M. P. & van Tintelen, J. P., Aug 2017, In : Circulation : Cardiovascular Genetics. 10, 4, 36 p., 001631.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Physiology-based regularization of the electrocardiographic inverse problem

Cluitmans, M. J. M., Clerx, M., Vandersickel, N., Peeters, R. L. M., Volders, P. G. A. & Westra, R. L., Aug 2017, In : Medical & Biological Engineering & Computing. 55, 8, p. 1353-1365 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
2 Citations (Scopus)

Detailed characterization of familial idiopathic ventricular fibrillation linked to the DPP6 locus

ten Sande, J. N., Postema, P. G., Boekholdt, S. M., Tan, H. L., van der Heijden, J. F., de Groot, N. M. S., Volders, P. G. A., Zeppenfeld, K., Boersma, L. V. A., Nannenberg, E. A., Christiaans, I. & Wilde, A. A. M., Apr 2016, In : Heart Rhythm. 13, 4, p. 905-912

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Hypertrophic remodelling in cardiac regulatory myosin light chain (MYL2) founder mutation carriers

Claes, G. R. F., van Tienen, F. H. J., Lindsey, P., Krapels, I. P. C., van den Enden, A., Hoos, M., Barrois, Y. E. G., Janssen, J., Paulussen, A. D. C., Sels, J-W. E. M., Kuijpers, S. H. H., van Tintelen, J. P., van den Berg, M. P., Heesen, W. F., Garcia-Pavia, P., Perrot, A., Christiaans, I., Salemink, S., Marcelis, C. L. M., Smeets, B. & 3 others, Brunner, H. G., Volders, P. G. A. & van den Wijngaard, A., 14 Jun 2016, In : European Heart Journal. 37, 23, p. 1815-1822

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Improving survival after out-of-hospital cardiac arrest requires new tools

Wellens, H., Lindemans, F. W., Houben, R. P., Gorgels, A., Volders, P. G., ter Bekke, R. M. A. & Crijns, H. J., 14 May 2016, In : European Heart Journal. 37, 19, p. 1499-1503

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Myokit: A simple interface to cardiac cellular electrophysiology

Clerx, M., Collins, P., de lange, E. & Volders, P. G. A., Jan 2016, In : Progress in Biophysics & Molecular Biology. 120, 1-3, p. 100-114

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology

Baumert, M., Porta, A., Vos, M. A., Malik, M., Couderc, J-P., Laguna, P., Piccirillo, G., Smith, G. L., Tereshchenko, L. G. & Volders, P. G. A., Jun 2016, In : EP Europace. 18, 6, p. 925-944

Research output: Contribution to journalArticleAcademicpeer-review

Spatiotemporal Activation Time Estimation Improves Noninvasive Localization of Cardiac Electrical Activity

Cluitmans, M., Coll-Font, J., Brooks, D., Erem, B., Bonizzi, P., Karel, J., Volders, P., Peeters, R. & Westra, R., 1 Sep 2016, Computing in Cardiology. Vancouver, Canada

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

2015
49 Citations (Scopus)

Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family Members

Groeneweg, J. A., Bhonsale, A., James, C. A., te Riele, A. S., Dooijes, D., Tichnell, C., Murray, B., Wiesfeld, A. C. P., Sawant, A. C., Kassamali, B., Atsma, D. E., Volders, P. G., de Groot, N. M., de Boer, K., Zimmerman, S. L., Kamel, I. R., van der Heijden, J. F., Russell, S. D., Cramer, M. J., Tedford, R. J. & 8 others, Doevendans, P. A., van Veen, T. A., Tandri, H., Wilde, A. A., Judge, D. P., van Tintelen, J. P., Hauer, R. N. & Calkins, H., Jun 2015, In : Circulation : Cardiovascular Genetics. 8, 3, p. 437-446

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Electromechanical window negativity in genotyped long-QT syndrome patients: relation to arrhythmia risk

ter Bekke, R. M. A., Haugaa, K. H., van den Wijngaard, A., Bos, J. M., Ackerman, M. J., Edvardsen, T. & Volders, P. G. A., 14 Jan 2015, In : European Heart Journal. 36, 3, p. 179-186

Research output: Contribution to journalArticleAcademicpeer-review

High-resolution validation of localization of electrocardiographic imaging shows a centimeter-accuracy

Cluitmans, M., de Jong, M., Karel, J., Bonizzi, P., Prinzen, F., Peeters, R., Westra, R. & Volders, P., 2015, International Society for Computerized Electrocardiology (ISCE). Dolce Hayes Mansion, San Jose, CA, USA

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademic

10 Citations (Scopus)
6 Citations (Scopus)

Opportunities and challenges of current electrophysiology research: a plea to establish 'translational electrophysiology' curricula

Lau, D. H., Volders, P. G. A., Kohl, P., Prinzen, F. W., Zaza, A., Kaeaeb, S., Oto, A. & Schotten, U., 1 May 2015, In : EP Europace. 17, 5, p. 825-833

Research output: Contribution to journalArticleAcademicpeer-review

Spatiotemporal Activation Time Estimation Improves Noninvasive Localization of Cardiac Electrical Activity

Cluitmans, M., Karel, J., Bonizzi, P., de Jong, M., Volders, P., Peeters, R. & Westra, R., 1 Sep 2015, Computing in Cardiology. Nice, France

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademic

3 Citations (Scopus)

The role of the SCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders

Verstraelen, T. E., Ter Bekke, R. M., Volders, P. G., Masclee, A. A. M. & Kruimel, J. W., Jul 2015, In : Neurogastroenterology and Motility. 27, 7, p. 906-913 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Whole heart simulations improve localization of origin of a heart beat in noninvasive electrocardiographic imaging

Cluitmans, M., Clerx, M., Karel, J., Bonizzi, P., Peeters, R., Volders, P. & Westra, R., 1 Sep 2015, International conference on basic clinical multimodal imaging. Utrecht - The Netherlands, 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Abstract/Poster in proceedingAcademic

2014
6 Citations (Scopus)

Interventricular Differences in beta-Adrenergic Responses in the Canine Heart: Role of Phosphodiesterases

Molina, C. E., Johnson, D. M., Mehel, H., Spätjens, R., Mika, D., Algalarrondo, V., Slimane, Z. H., Lechene, P., Abi-Gerges, N., van der Linde, H. J., Leroy, J., Volders, P. G. A., Fischmeister, R. & Vandecasteele, G., Jun 2014, In : Journal of the American Heart Association. 3, 3, e000858.

Research output: Contribution to journalArticleAcademicpeer-review

Inverse reconstruction of epicardial potentials is improved by novel regularization methods and extensive validaton

Cluitmans, M., Bonizzi, P., Karel, J., Peeters, R., Volders, P. & Westra, R., 2014, Mathematical Biosciences Institute (MBI), Workshop 3: Integrating Modalities and Scales in Life Science Imaging. Ohio, USA

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademic

2 Citations (Scopus)

Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of I-Ks, but preserved cAMP-dependent up-regulation

Spätjens, R., Bebarova, M., Seyen, S. R. M., Lentink, V., Jongbloed, R. J., Arens, Y. H. J. M., Heijman, J. & Volders, P. G. A., 1 Oct 2014, In : Cardiovascular Research. 104, 1, p. 216-225

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Successful treatment of a patient with symptomatic long QT syndrome type 3 using ranolazine combined with a beta-blocker

van den Berg, M. P., van den Heuvel, F., van Tintelen, J. P., Volders, P. G. A. & van Gelder, I. C., 15 Jan 2014, In : International Journal of Cardiology. 171, 1, p. 90-92

Research output: Contribution to journalArticleAcademicpeer-review

2013
38 Citations (Scopus)
34 Citations (Scopus)

Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After beta-Adrenergic Stimulation

Johnson, D. M., Heijman, J., Bode, E. F., Greensmith, D. J., van der Linde, H., Abi-Gerges, N., Eisner, D. A., Trafford, A. W. & Volders, P. G. A., 18 Jan 2013, In : Circulation Research. 112, 2, p. 246-+

Research output: Contribution to journalArticleAcademicpeer-review

Inverse Reconstruction of Epicardial Potentials Improves by Vectorcardiography and Realistic Potentials

Cluitmans, M., Bonizzi, P., Karel, J., Volders, P., Peeters, R. & Westra, R., 2013, Computing in Cardiology. Zaragoza, Spain

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademic

48 Citations (Scopus)

Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure

Dirkx, E., Gladka, M. M., Philippen, L. E., Armand, A-S., Kinet, V., Leptidis, S., el Azzouzi, H., Salic, K., Bourajjaj, M., da Silva, G. J. J., Olieslagers, S., van der Nagel, R., de Weger, R., Bitsch, N., Kisters, N., Seyen, S., Morikawa, Y., Chanoine, C., Heymans, S., Volders, P. G. A. & 6 others, Thum, T., Dimmeler, S., Cserjesi, P., Eschenhagen, T., Martins, P. A. D. C. & De Windt, L. J., Nov 2013, In : Nature Cell Biology. 15, 11, p. 1282-1293

Research output: Contribution to journalArticleAcademicpeer-review

Right-Ventricular Enlargement in Arrhythmogenic Right-Ventricular Cardiomyopathy Is Associated with Decreased QRS Amplitudes and T-Wave Negativity

Zusterzeel, R., ter Bekke, R. M. A., Volders, P. G. A., Leijten, F. M. M., van den Wijngaard, A., Serroyen, J. & Gorgels, A. P. M., Nov 2013, In : Annals of Noninvasive Electrocardiology. 18, 6, p. 555-563

Research output: Contribution to journalArticleAcademicpeer-review

Wavelet-sparsity based regularization over time in the inverse problem of electrocardiography

Cluitmans, M. J. M., Karel, J. M. H., Bonizzi, P., Volders, P. G. A., Westra, R. L. & Peeters, R. L. M., Aug 2013, 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). p. 3781-3784 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

2012

Arrhythmogenic mechano-electric heterogeneity in the long-QT syndrome

ter Bekke, R. M. A. & Volders, P. G. A., 2012, In : Progress in Biophysics & Molecular Biology. 110, 2-3, p. 347-358

Research output: Contribution to journalArticleAcademicpeer-review

Assay-specific pitfalls of catecholamine hplc assays

Bons, J. A., Havekes, B., Volders, P. G., de Zwaan, C., Kema, I. P., Wodzig, W. K. & Menheere, P. P., 1 Jan 2012, In : Clinical Chemistry and Laboratory Medicine. 50, 10, p. 1853-6

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

34 Citations (Scopus)

Dominant-Negative Control of cAMP-Dependent I-Ks Upregulation in Human Long-QT Syndrome Type 1

Heijman, J., Spätjens, R., Seyen, S. R. M., Lentink, V., Kuijpers, H. J. H., Boulet, I. R., de Windt, L. J., David, M. & Volders, P. G. A., 20 Jan 2012, In : Circulation Research. 110, 2, p. 211-+

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
2011

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Pathogenic Desmosome Mutations in Index-Patients Predict Outcome of Family Screening: Dutch Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Genotype-Phenotype Follow-Up Study

Cox, M. G. P. J., van der Zwaag, P. A., van der Werf, C., van der Smagt, J. J., Noorman, M., Bhuiyan, Z. A., Wiesfeld, A. C. P., Volders, P. G. A., van Langen, I. M., Atsma, D. E., Dooijes, D., van den Wijngaard, A., Houweling, A. C., Jongbloed, J. D. H., Jordaens, L. J. L. M., Cramer, M. J., Doevendans, P. A., de Bakker, J. M. T., Wilde, A. A. M., van Tintelen, J. P. & 1 others, Hauer, R. N. W., 14 Jun 2011, In : Circulation. 123, 23, p. 2690-2700

Research output: Contribution to journalArticleAcademicpeer-review

Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6

Postema, P. G., Christiaans, I., Hofman, N., Alders, M., Koopmann, T. T., Bezzina, C. R., Loh, P., Zeppenfeld, K., Volders, P. G. A. & Wilde, A. A. M., Jun 2011, In : Netherlands Heart Journal. 19, 6, p. 290-296

Research output: Contribution to journalArticleAcademicpeer-review

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

Laverty, H. G., Benson, C., Cartwright, E. J., Cross, M. J., Garland, C., Hammond, T. R., Holloway, C., McMahon, N., Milligan, J., Park, B. K., Pirmohamed, M., Pollard, C., Radford, J., Roome, N., Sager, P., Singh, S., Suter, T., Suter, W., Trafford, A. W., Volders, P. G. A. & 4 others, Wallis, R., Weaver, R., York, M. & Valentin, J. P., Jun 2011, In : British Journal of Pharmacology. 163, 4, p. 675-693

Research output: Contribution to journalArticleAcademicpeer-review

Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient

Heijman, J., Volders, P. G. A., Westra, R. L. & Rudy, Y., May 2011, In : Journal of Molecular and Cellular Cardiology. 50, 5, p. 863-871 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Manifest disease, risk factors for sudden cardiac death, and cardiac events in a large nationwide cohort of predictively tested hypertrophic cardiomyopathy mutation carriers: determining the best cardiological screening strategy

Christiaans, I., Birnie, E., Bonsel, G. J., Mannens, M. M. A. M., Michels, M., Majoor-Krakauer, D., Dooijes, D., van Tintelen, J. P., Van den Berg, M. P., Volders, P. G. A., Arens, Y. H., van den Wijngaard, A., Atsma, D. E., Helderman-van den Enden, A. T. J. M., Houweling, A. C., de Boer, K., van der Smagt, J. J., Hauer, R. N. W., Marcelis, C. L. M., Timmermans, J. & 2 others, van Langen, I. M. & Wilde, A. A. M., May 2011, In : European Heart Journal. 32, 9, p. 1161-1170

Research output: Contribution to journalArticleAcademicpeer-review

Recurrent and founder mutations in the Netherlands: cardiac Troponin I (TNNI3) gene mutations as a cause of severe forms of hypertrophic and restrictive cardiomyopathy

van den Wijngaard, A., Volders, P., van Tintelen, J. P., Jongbloed, J. D. H., van den Berg, M. P., Deprez, R. H. L., Mannens, M. M. A. M., Hofmann, N., van Slegtenhorst, M., Dooijes, D., Michels, M., Arens, Y., Jongbloed, R. & Smeets, B. J. M., Aug 2011, In : Netherlands Heart Journal. 19, 7-8, p. 344-351

Research output: Contribution to journalArticleAcademicpeer-review