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Research Output 2010 2019

Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum beta-lactamase-producing Enterobacteriaceae in Dutch hospitals: a cluster-randomised, crossover, non-inferiority study

Kluytmans-van den Bergh, M. F. Q., Bruijning-Verhagen, P. C. J., Vandenbroucke-Grauls, C. M. J. E., de Brauwer, E. I. G. B., Buiting, A. G. M., Diederen, B. M., van Elzakker, E. P. M., Friedrich, A. W., Hopman, J., al Naiemi, N., Rossen, J. W. A., Ruijs, G. J. H. M., Savelkoul, P. H. M., Verhulst, C., Vos, M. C., Voss, A., Bonten, M. J. M. & Kluytmans, J. A. J. W., Oct 2019, In : Lancet Infectious Diseases. 19, 10, p. 1069-1079 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Corrigendum. The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study

Koedooder, R., Singer, M., Schoenmakers, S., Savelkoul, P. H. M., Morre, S. A., de Jonge, J. D., Poort, L., Cuypers, W. J. S. S., Beckers, N. G. M., Broekmans, F. J. M., Cohlen, B. J., den Hartog, J. E., Fleischer, K., Lambalk, C. B., Smeenk, J. M. J. S., Budding, A. E. & Laven, J. S. E., Oct 2019, In : Human Reproduction. 34, 10, p. 2091-2092 2 p.

Research output: Contribution to journalErratum / corrigendumAcademic

Improving peak concentrations of a single dose regime of gentamicin in patients with sepsis in the emergency department

Cobussen, M., Stassen, P. M., Posthouwer, D., van Tiel, F. H., Savelkoul, P. H. M., Havenith, T. & Haeseker, M. B., 22 Jan 2019, In : PLOS ONE. 14, 1, 10 p., 0210012.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Microbiome on the Bone-Anchored Hearing System: A Prospective Study

Calon, T. G. A., Trobos, M., Johansson, M. L., van Tongeren, J., van der Lugt-Degen, M., Janssen, A. M. L., Savelkoul, P. H. M., Stokroos, R. J. & Budding, A. E., 26 Apr 2019, In : Frontiers in microbiology. 10, p. 1-11 11 p., 799.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis

van de Groep, K., Bos, M. P., Varkila, M. R. J., Savelkoul, P. H. M., Ong, D. S. Y., Derde, L. P. G., Juffermans, N. P., van der Poll, T., Bonten, M. J. M., Cremer, O. L., de Beer, F. M., Bos, L. D. J., Glas, G. J., Hoogendijk, A. J., van Hooijdonk, R. T. M., Horn, J., Huson, M. A., Juffermans, N. P., van der Poll, T., Schouten, L. R. A. & 15 others, Scicluna, B., Schultz, M. J., Straat, M., van Vught, L. A., Wieske, L., Wiewel, M. A., Witteveen, E., Bonten, M. J. M., Cremer, O. L., Frencken, J. F., Klouwenberg, P. M. C. K., Koster-Brouwer, M. E., Ong, D. S. Y., Varkila, M. R. J. & Verboom, D. M., Oct 2019, In : European Journal of Clinical Microbiology & Infectious Diseases. 38, 10, p. 1829-1836 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effect of surgical fecal stream diversion of the healthy colon on the colonic microbiota

van der Sluis, W. B., Bouman, M-B., Mullender, M. G., Degen, M. C., Savelkoul, P. H. M., Meijerink, W. J. H. J., de Boer, N. K. H., van Bodegraven, A. A. & Budding, A. E., Apr 2019, In : European Journal of Gastroenterology & Hepatology. 31, 4, p. 451-457 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The fecal and mucosal microbiome in acute appendicitis patients: an observational study

Peeters, T., Penders, J., Smeekens, S. P., Galazzo, G., Houben, B., Netea, M. G., Savelkoul, P. H. M. & Gyssens, I. C., Jan 2019, In : Future Microbiology. 14, 2, p. 111-127 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Skin Microbiota in Patients Hospitalized for Cellulitis and Association With Outcome

Cranendonk, D. R., Hugenholtz, F., Prins, J. M., Savelkoul, P. H. M., Budding, A. E., Wiersinga, W. J., Cranendonk, D. R., Prins, J. M., Wiersinga, W. J., Hoepelman, A. I. M., Oosterheert, J. J., van Agtmael, M. A., Branger, J., Brinkman, K., Lauw, F. N., Pijlman, A. H., Sankatsing, S. U. C., Soetekouw, R., Veenstra, J. & de Vries, P. J., 15 Apr 2019, In : Clinical Infectious Diseases. 68, 8, p. 1292-1299 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study

Koedooder, R., Singer, M., Schoenmakers, S., Savelkoul, P. H. M., Morre, S. A., de Jonge, J. D., Poort, L., Cuypers, W. J. S. S., Beckers, N. G. M., Broekmans, F. J. M., Cohlen, B. J., den Hartog, J. E., Fleischer, K., Lambalk, C. B., Smeenk, J. M. J. S., Budding, A. E. & Laven, J. S. E., Jun 2019, In : Human Reproduction. 34, 6, p. 1042-1054 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Development and first evaluation of a novel multiplex real-time PCR on whole blood samples for rapid pathogen identification in critically ill patients with sepsis

van de Groep, K., Bos, M. P., Savelkoul, P. H. M., Rubenjan, A., Gazenbeek, C., Melchers, W. J. G., van der Poll, T., Juffermans, N. P., Ong, D. S. Y., Bonten, M. J. M. & Cremer, O. L., 1 Jul 2018, In : European Journal of Clinical Microbiology & Infectious Diseases. 37, 7, p. 1333-1344 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of a real-time PCR assay for detection and quantification of bacterial DNA directly in blood of preterm neonates with suspected late-onset sepsis

van den Brand, M., van den Dungen, F. A. M., Bos, M. P., van Weissenbruch, M. M., van Furth, A. M., de Lange, A., Rubenjan, A., Peters, R. P. H. & Savelkoul, P. H. M., 22 Apr 2018, In : Critical Care. 22, 10 p., 105.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) isolated from bean sprouts in the Netherlands

Huizinga, P., Schrauwen, E., Garcia-Cobos, S., Willemsen, I., Verhulst, C., Friedrich, A. W., Savelkoul, P. H. M., Rossen, J. W. & Kluytmans, J., 30 Aug 2018, In : PLOS ONE. 13, 8, 13 p., e0203338.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Gram-negative bacterial membrane vesicle release in response to the host-environment: different threats, same trick?

Volgers, C., Savelkoul, P. H. M. & Stassen, F. R. M., 1 Jan 2018, In : Critical Reviews in Microbiology. 44, 3, p. 258-273 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Gut Microbiota and Body Weight in School-Aged Children: The KOALA Birth Cohort Study

Mbakwa, C. A., Hermes, G. D. A., Penders, J., Savelkoul, P. H. M., Thijs, C., Dagnelie, P. C., Mommers, M., Zoetendal, E. G., Smidt, H. & Arts, I. C. W., Nov 2018, In : Obesity. 26, 11, p. 1767-1776 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Quantifying Hospital-Acquired Carriage of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Among Patients in Dutch Hospitals

Kluytmans-van den Bergh, M. F. Q., van Mens, S. P., Haverkate, M. R., Bootsma, M. C. J., Kluytmans, J. A. J. W., Bonten, M. J. M., Oudhuis, G. & Savelkoul, P., 1 Jan 2018, In : Infection Control and Hospital Epidemiology. 39, 1, p. 32-39 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Redox-dependent thiol modifications: implications for the release of extracellular vesicles

Benedikter, B. J., Weseler, A. R., Wouters, E. F. M., Savelkoul, P. H. M., Rohde, G. G. U. & Stassen, F. R. M., Jul 2018, In : Cellular and Molecular Life Sciences. 75, 13, p. 2321-2337 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Safety and immunogenicity of HBAI20 Hepatitis B vaccine in healthy naive and nonresponding adults

Koc, O. M., Savelkoul, P. H. M., van Loo, I. H. M., Peeters, A. & Lashof, A. M. L. O., Sep 2018, In : Journal of Viral Hepatitis. 25, 9, p. 1048-1056 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The ReceptIVFity cohort study protocol to validate the urogenital microbiome as predictor for IVF or IVF/ICSI outcome

Koedooder, R., Singer, M., Schoenmakers, S., Savelkoul, P. H. M., Morre, S. A., de Jonge, J. D., Poort, L., Cuypers, W-J. S. S., Budding, A. E. & Laven, J. S. E., 7 Dec 2018, In : Reproductive Health. 15, 7 p., 202.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Variability of core microbiota in newly diagnosed treatment-naive paediatric inflammatory bowel disease patients

de Meij, T. G. J., de Groot, E. F. J., Peeters, C. F. W., de Boer, N. K. H., Kneepkens, C. M. F., Eck, A., Benninga, M. A., Savelkoul, P. H. M., van Bodegraven, A. A. & Budding, A. E., 13 Aug 2018, In : PLOS ONE. 13, 8, 20 p., 0197649.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Volatile metabolites in breath strongly correlate with gut microbiome in CD patients

Smolinska, A., Tedjo, D. I., Blanchet, L., Bodelier, A., Pierik, M. J., Masclee, A. A. M., Dallinga, J., Savelkoul, P. H. M., Jonkers, D. M. A. E., Penders, J. & van Schooten, F-J., 26 Sep 2018, In : Analytica Chimica Acta. 1025, p. 1-11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Bead-based flow-cytometry for semi-quantitative analysis of complex membrane vesicle populations released by bacteria and host cells

Volgers, C., Benedikter, B. J., Grauls, G. E., Savelkoul, P. H. M. & Stassen, F. R. M., 2017, In : Microbiological Research. 200, p. 25-32 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection

Volgers, C., Grauls, G. E., Hellebrand, P. H. M., Savelkoul, P. H. M. & Stassen, F. R. M., Dec 2017, In : Inflammopharmacology. 25, 6, p. 643-651 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Correction for Eck et al., Robust Microbiota-Based Diagnostics for Inflammatory Bowel Disease

Eck, A., de Groot, E. F. J., de Meij, T. G. J., Welling, M., Savelkoul, P. H. M. & Budding, A. E., Sep 2017, In : Journal of Clinical Microbiology. 55, 9, p. 2871-2871 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Effects of N-acetyl-L-cysteine on the membrane vesicle release and growth of respiratory pathogens

Volgers, C., Benedikter, B. J., Grauls, G. E., Hellebrand, P. H. M., Savelkoul, P. H. M. & Stassen, F. R. M., May 2017, In : Fems Microbiology Letters. 364, 9, 8 p., 087.

Research output: Contribution to journalArticleAcademicpeer-review

Gut Colonization by Methanogenic Archaea Is Associated with Organic Dairy Consumption in Children

van de Pol, J. A. A., van Best, N., Mbakwa, C. A., Thijs, C., Savelkoul, P. H., Arts, I. C. W., Hornef, M. W., Mommers, M. & Penders, J., 10 Mar 2017, In : Frontiers in microbiology. 8, 10 p., 355.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Immunomodulatory role for membrane vesicles released by THP-1 macrophages and respiratory pathogens during macrophage infection

Volgers, C., Benedikter, B. J., Grauls, G. E., Savelkoul, P. H. M. & Stassen, F. R. M., 13 Nov 2017, In : BMC Microbiology. 17, 14 p., 216.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Interpretation of microbiota-based diagnostics by explaining individual classifier decisions

Eck, A., Zintgraf, L. M., de Groot, E. F. J., de Meij, T. G. J., Cohen, T. S., Savelkoul, P. H. M., Welling, M. & Budding, A. E., 4 Oct 2017, In : BMC Bioinformatics. 18, 13 p., 441.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Robust Microbiota-Based Diagnostics for Inflammatory Bowel Disease

Eck, A., de Groot, E. F. J., de Meij, T. G. J., Welling, M., Savelkoul, P. H. M. & Budding, A. E., Jun 2017, In : Journal of Clinical Microbiology. 55, 6, p. 1720-1732 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
1 Citation (Scopus)

A novel quantitative PCR assay for the detection of Streptococcus pneumoniae using the competence regulator gene target comX

Habets, M. N., Cremers, A. J., Bos, M. P., Savelkoul, P. H., Eleveld, M. J., Meis, J. F., Hermans, P. W., Melchers, W. J., de Jonge, M. I. & Diavatopoulos, D. A., 2016, In : Journal of Medical Microbiology. 65, Part 2, p. 129–136 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

A prospective multicenter evaluation of direct molecular detection of blood stream infection from a clinical perspective

Nieman, A. E., Savelkoul, P. H. M., Beishuizen, A., Henrich, B., Lamik, B., MacKenzie, C. R., Kindgen-Milles, D., Helmers, A., Diaz, C., Sakka, S. G. & Schade, R. P., 30 Jun 2016, In : BMC Infectious Diseases. 16, 314.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Automated broad range molecular detection of bacteria in clinical samples

Budding, A. E., Hoogewerf, M., Vandenbroucke-Grauls, C. M. & Savelkoul, P. H. M., Apr 2016, In : Journal of Clinical Microbiology. 54, 4, p. 934–943 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Characterization of Microbiota in Children with Chronic Functional Constipation

de Meij, T. G. J., de Groot, E. F. J., Eck, A., Budding, A. E., Kneepkens, C. M. F., Benninga, M. A., van Bodegraven, A. A. & Savelkoul, P. H. M., 19 Oct 2016, In : PLOS ONE. 11, 10, e0164731.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Composition and stability of intestinal microbiota of healthy children within a Dutch population

de Meij, T. G., Budding, A. E., de Groot, E. F., Jansen, F. M., Kneepkens, C. M., Benninga, M. A., Penders, J., van Bodegraven, A. A. & Savelkoul, P. H., Apr 2016, In : Faseb Journal. 30, 4, p. 1512-1522 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Diet drives quick changes in the metabolic activity and composition of human gut microbiota in a validated in vitro gut model

Aguirre Morales, M., Eck, A., Koenen, M. E., Savelkoul, P. H. M., Budding, A. E. & Venema, K., 2016, In : Research in Microbiology. 167, 2, p. 114-125

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer

von Wintersdorff, C., Penders, J., van Niekerk, J., Mills, N. D., Majumder, S., van Alphen, L., Savelkoul, P. H. M. & Wolffs, P. F. G., 19 Feb 2016, In : Frontiers in microbiology. 7, 10 p., 173.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Exposure to common respiratory bacteria alters the airway epithelial response to subsequent viral infection

Bellinghausen, C., Gulraiz, F., Heinzmann, A. C. A., Dentener, M. A., Savelkoul, P. H. M., Wouters, E. F., Rohde, G. G. & Stassen, F. R., 3 Jun 2016, In : Respiratory Research. 17, 68.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
Open Access
1 Citation (Scopus)

Long-Term Green Tea Supplementation Does Not Change the Human Gut Microbiota

Janssens, P. L. H. R., Penders, J., Hursel, R., Budding, A. E., Savelkoul, P. H. M. & Westerterp-Plantenga, M. S., 7 Apr 2016, In : PLOS ONE. 11, 4, 15 p., e0153134.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Presence of mcr-1-positive Enterobacteriaceae in retail chicken meat but not in humans in the Netherlands since 2009

Kluytmans-van den Bergh, M. F., Huizinga, P., Bonten, M. J., Bos, M., De Bruyne, K., Friedrich, A. W., Rossen, J. W., Savelkoul, P. H. & Kluytmans, J. A., 3 Mar 2016, In : Eurosurveillance. 21, 9, p. 12-18

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Prevalence and risk factors for carriage of ESBL-producing Enterobacteriaceae in Amsterdam

Reuland, E. A., al Naiemi, N., Kaiser, A. M., Heck, M., Kluytmans, J. A., Savelkoul, P. H., Elders, P. J. & Vandenbroucke-Grauls, C. M., 1 Apr 2016, In : Journal of Antimicrobial Chemotherapy. 71, 4, p. 1076-1082 7 p.

Research output: Contribution to journalArticleAcademicpeer-review