19972019

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Article
2019

4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue

Grandoch, M., Floegel, U., Virtue, S., Maier, J. K., Jelenik, T., Kohlmorgen, C., Feldmann, K., Ostendorf, Y., Castaneda, T. R., Zhou, Z., Yamaguchi, Y., Nascimento, E. B. M., Sunkari, V. G., Goy, C., Kinzig, M., Soergel, F., Bollyky, P. L., Schrauwen, P., Al-Hasani, H., Roden, M. & 5 others, Keipert, S., Vidal-Puig, A., Jastroch, M., Haendeler, J. & Fischer, J. W., May 2019, In : Nature Metabolism. 1, 5, p. 546-559 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion

Phielix, E., Begovatz, P., Gancheva, S., Bierwagen, A., Kornips, E., Schaart, G., Hesselink, M. K. C., Schrauwen, P. & Roden, M., 1 Nov 2019, In : JCI INSIGHT. 4, 21, 12 p., 127928.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Wefers, J., van Moorsel, D., Hansen, J., Connell, N. J., Havekes, B., Hoeks, J., Lichtenbelt, W. D. V. M., Duez, H., Phielix, E., Kalsbeek, A., Boekschoten, M. V., Hooiveld, G. J., Hesselink, M. K. C., Kersten, S., Staels, B., Scheer, F. A. J. L. & Schrauwen, P., 24 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. 7789-7794 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Clemmensen, C., Jail, S., Kleinert, M., Quarta, C., Gruber, T., Reber, J., Sachs, S., Fischer, K., Feuchtinger, A., Karlas, A., Simonds, S. E., Grandl, G., Loher, D., Sanchez-Quant, E., Keipert, S., Jastroch, M., Hofmann, S. M., Nascimento, E. B. M., Schrauwen, P., Ntziachristos, V. & 4 others, Cowley, M. A., Finan, B., Mueller, T. D. & Tschoep, M. H., 23 Oct 2018, In : Nature Communications. 9, 13 p., 4304.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

Gemmink, A., Daemen, S., Brouwers, B., Huntjens, P. R., Schaart, G., Moonen-Kornips, E., Jorgensen, J., Hoeks, J., Schrauwen, P. & Hesselink, M. K. C., 1 Mar 2018, In : Journal of Physiology. 596, 5, p. 857-868 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox

Daemen, S., Gemmink, A., Brouwers, B., Meex, R. C. R., Huntjens, P. R., Schaart, G., Moonen-Komips, E., Jorgensen, J., Hoeks, J., Schrauwen, P. & Hesselink, M. K. C., Nov 2018, In : Molecular Metabolism. 17, p. 71-81 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity

Lancel, S., Hesselink, M. K. C., Woldt, E., Rouille, Y., Dorchies, E., Delhaye, S., Duhem, C., Thorel, Q., Mayeuf-Louchart, A., Pourcet, B., Montel, V., Schaart, G., Beton, N., Picquet, F., Briand, O., Salles, J. P., Duez, H., Schrauwen, P., Bastide, B., Bailleul, B. & 2 others, Staels, B. & Sebti, Y., 3 May 2018, In : JCI INSIGHT. 3, 9, p. 1-13 13 p., e98081.

Research output: Contribution to journalArticleAcademicpeer-review

Exercise counteracts lipotoxicity by improving lipid turnover and lipid droplet quality

Zacharewicz, E., Hesselink, M. K. C. & Schrauwen, P., Nov 2018, In : Journal of Internal Medicine. 284, 5, p. 505-518 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity

Stinkens, R., Brouwers, B., Jocken, J. W., Blaak, E. E., Teunissen-Beekman, M. F., Hesselink, M. K., van Baak, M. A., Schrauwen, P. & Goossens, G. H., Nov 2018, In : Journal of Applied Physiology. 125, 5, p. 1585-1593 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver

Brouwers, B., Schrauwen-Hinderling, V. B., Jelenik, T., Gemmink, A., Sparks, L. M., Havekes, B., Bruls, Y., Dahlmans, D., Roden, M., Hesselink, M. K. C. & Schrauwen, P., Feb 2018, In : American Journal of Physiology : Endocrinology and Metabolism. 314, 2, p. E165-E173 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans

Nascimento, E. B. M., Sparks, L. M., Divoux, A., van Gisbergen, M. W., Broeders, E. P. M., Jorgensen, J. A., Schaart, G., Bouvy, N. D., Lichtenbelt, W. D. V. M. & Schrauwen, P., 1 Jan 2018, In : Obesity. 26, 1, p. 135-140 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Peroxisome Proliferator-Activated Receptor alpha is dispensable for cold-induced adipose tissue browning in mice

Defour, M., Dijk, W., Ruppert, P., Nascimento, E. B. M., Schrauwen, P. & Kersten, S., Apr 2018, In : Molecular Metabolism. 10, p. 39-54 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism

Dahlmans, D., Houzelle, A., Andreux, P., Jorgensen, J. A., Wang, X., de Windt, L. J., Schrauwen, P., Auwerx, J. & Hoeks, J., Nov 2017, In : Molecular Metabolism. 6, 11, p. 1429-1442 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Benefits of Substitution Sitting with Standing and Walking in Free-living Conditions for Cardiometabolic Risk Markers, cognition and Mood in Overweight Adults

Duvivier, B. M. F. M., Schaper, N. C., Koster, A., van Kan, L., Peters, H. P. F., Adam, J. J., Giesbrecht, T., Kornips, E., Hulsbosch, M., Willems, P., Hesselink, M. K. C., Schrauwen, P. & Savelberg, H. H. C. M., 8 Jun 2017, In : Frontiers in physiology. 8, 9 p., 353.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue

Schreiber, R., Diwoky, C., Schoiswohl, G., Feiler, U., Wongsiriroj, N., Abdellatif, M., Kolb, D., Hoeks, J., Kershaw, E. E., Sedej, S., Schrauwen, P., Haemmerle, G. & Zechner, R., 7 Nov 2017, In : Cell Metabolism. 26, 5, p. 753-763.e7 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups

Dahlmans, D., Houzelle, A., Jorgensen, J. A., Phielix, E., Lindeboom, L., Hesselink, M. K. C., Schrauwen, P. & Hoeks, J., 21 Sep 2017, In : Frontiers in physiology. 8, 10 p., 711.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intramyocellular lipid droplets and insulin sensitivity, the human perspective

Gemmink, A., Goodpaster, B. H., Schrauwen, P. & Hesselink, M. K. C., Oct 2017, In : Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1862, 10, p. 1242-1249 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Longitudinal relaxation time editing for acetylcarnitine detection with H-MRS

Lindeboom, L., Bruls, Y. M. H., van Ewijk, P. A., Hesselink, M. K. C., Wildberger, J. E., Schrauwen, P. & Schrauwen-Hinderling, V. B., Feb 2017, In : Magnetic Resonance in Medicine. 77, 2, p. 505–510 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes

Brouwers, B., Schrauwen-Hinderling, V. B., Jelenik, T., Gemmink, A., Havekes, B., Bruls, Y., Dahlmans, D., Roden, M., Hesselink, M. K. C. & Schrauwen, P., 1 Aug 2017, In : Clinical Science. 131, 15, p. 1905-1917 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats

van Bree, B. W. J., Lenaers, E., Nabben, M., Briede, J. J., Jorgensen, J. A., Schaart, G., Schrauwen, P., Hoeks, J. & Hesselink, M. K. C., 14 Mar 2016, In : Scientific Reports. 6, 22854.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Combatting type 2 diabetes by turning up the heat

Schrauwen, P. & van Marken Lichtenbelt, W., Nov 2016, In : Diabetologia. 59, 11, p. 2269-2279

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial

Most, J., Timmers, S., Warnke, I., Jocken, J. W. E., van Boekschoten, M., de Groot, P., Bendik, I., Schrauwen, P., Goossens, G. H. & Blaak, E. E., Jul 2016, In : American Journal of Clinical Nutrition. 104, 1, p. 215-227

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity

van Moorsel, D., Hansen, J., Havekes, B., Scheer, F. A. J. L., Jorgensen, J. A., Hoeks, J., Schrauwen-Hinderling, V. B., Duez, H., Lefebvre, P., Schaper, N. C., Hesselink, M. K. C., Staels, B. & Schrauwen, P., Aug 2016, In : Molecular Metabolism. 5, 8, p. 635-645

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Effects of exercise training on intrahepatic lipid content in humans

Brouwers, B., Hesselink, M. K. C., Schrauwen, P. & Schrauwen-Hinderling, V. B., Oct 2016, In : Diabetologia. 59, 10, p. 2068-2079

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease

Dahlmans, D., Houzelle, A., Schrauwen, P. & Hoeks, J., 1 Jun 2016, In : Clinical Science. 130, 11, p. 843-852

Research output: Contribution to journalArticleAcademicpeer-review

Quantum coherence spectroscopy to measure dietary fat retention in the liver

Lindeboom, L., de Graaf, R. A., Nabuurs, C. I., van Ewijk, E., Hesselink, M. K. C., Wildberger, J. E., Schrauwen, P. & Schrauwen-Hinderling, V. B., 18 Aug 2016, In : JCI INSIGHT. 1, 13, e84671.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial

Timmers, S., de Ligt, M., Phielix, E., van de Weijer, T., Hansen, J., Moonen-Kornips, E., Schaart, G., Kunz, I., Hesselink, M. K. C., Schrauwen-Hinderling, V. B. & Schrauwen, P., Dec 2016, In : Diabetes Care. 39, 12, p. 2211-2217

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

Hesselink, M. K. C., Schrauwen-Hinderling, V. & Schrauwen, P., Nov 2016, In : Nature Reviews Endocrinology. 12, 11, p. 633-645

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes

Hansen, J., Timmers, S., Moonen-Kornips, E., Duez, H., Staels, B., Hesselink, M. K. C. & Schrauwen, P., 19 Oct 2016, In : Scientific Reports. 6, 35047.

Research output: Contribution to journalArticleAcademicpeer-review

Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis - A Cohort Study in a Group of Thyroid Carcinoma Patients

Broeders, E., Vijgen, G., Havekes, B., Bouvy, N. D., Mottaghy, F. M., Kars, M., Schaper, N. C., Schrauwen, P., Brans, B. & van Marken Lichtenbelt, W., 19 Jan 2016, In : PLOS ONE. 11, 1, 15 p., e0145049.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015

Acute exercise does not decrease liver fat in men with overweight or NAFLD

Bilet, L., Brouwers, B., van Ewijk, P. A., Hesselink, M. K., Kooi, M. E., Schrauwen, P. & Schrauwen-Hinderling, V. B., 13 Apr 2015, In : Scientific Reports. 5, 7 p., 9709.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise

Seiler, S. E., Koves, T. R., Gooding, J. R., Wong, K. E., Stevens, R. D., Ilkayeva, O. R., Wittmann, A. H., Debalsi, K. L., Davies, M. N., Lindeboom, L., Schrauwen, P., Schrauwen-Hinderling, V. B. & Muoio, D. M., 7 Jul 2015, In : Cell Metabolism. 22, 1, p. 65-76 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Diet and glycaemia: the markers and their meaning. A report of the Unilever Nutrition Workshop

Alssema, M., Boers, H. M., Ceriello, A., Kilpatrick, E. S., Mela, D. J., Priebe, M. G., Schrauwen, P., Wolffenbuttel, B. H. & Pfeiffer, A. F., 28 Jan 2015, In : British Journal of Nutrition. 113, 2, p. 239-248 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring

van Ewijk, P. A., Paglialunga, S. A., Kooi, M. E., Nunes, P. M., Gemmink, A., Slenter, J., Moonen Kornips, E., Jorgensen, J. A., Hoeks, J., Wildberger, J. E., Hesselink, M. K., Glatz, J. F., Heerschap, A., Kersten, S., Schrauwen, P. & Schrauwen-Hinderling, V. B., 1 Jan 2015, In : Obesity. 23, 11, p. 2242-2250

Research output: Contribution to journalArticleAcademicpeer-review

Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans

van de Weijer, T., Phielix, E., Bilet, L., Williams, E. G., Ropelle, E. R., Bierwagen, A., Livingstone, R., Nowotny, P., Sparks, L. M., Paglialunga, S. A., Szendroedi, J., Havekes, B., Moullan, N., Pirinen, E., Hwang, J. H., Schrauwen-Hinderling, V. B., Hesselink, M. K., Auwerx, J., Roden, M. & Schrauwen, P., Apr 2015, In : Diabetes. 64, 4, p. 1193-1201 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Genomic and transcriptomic predictors of triglyceride response to regular exercise

Sarzynski, M. A., Davidsen, P. K., Sung, Y. J., Hesselink, M., Schrauwen, P., Rice, T. K., Rao, D. C., Falciani, F. & Bouchard, C., Dec 2015, In : British Journal of Sports Medicine. 49, 23, p. 1524-1531 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance.

Hanssen, M. J., Wierts, R., Hoeks, J., Gemmink, A., Brans, B., Mottaghy, F. M., Schrauwen, P. & van Marken Lichtenbelt, W. D., Mar 2015, In : Diabetologia. 58, 3, p. 586-595 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Low brown adipose tissue activity in endurance-trained compared with lean sedentary men

Vosselman, M. J., Hoeks, J., Brans, B., Pallubinsky, H., Nascimento, E. B. M., van der Lans, A. A. J., Broeders, E. P., Mottaghy, F. M., Schrauwen, P. & van Marken Lichtenbelt, W. D., Dec 2015, In : International Journal of Obesity. 39, 12, p. 1696-1702 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter

Gnaiger, E., Boushel, R., Sondergaard, H., Munch-Andersen, T., Damsgaard, R., Hagen, C., Diez-Sanchez, C., Ara, I., Wright-Paradis, C., Schrauwen, P., Hesselink, M., Calbet, J. A., Christiansen, M., Helge, J. W. & Saltin, B., Dec 2015, In : Scandinavian Journal of Medicine & Science in Sports. 25, Suppl 4, p. 126-134 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging

Billecke, N., Bosma, M., Rock, W., Fleissner, F., Best, G., Schrauwen, P., Kersten, S., Bonn, M., Hesselink, M. & Parekh, S. H., Apr 2015, In : Integrative Biology. 7, 4, p. 467-476 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Resveratrol and obesity: Can resveratrol relieve metabolic disturbances?

de Ligt, M., Timmers, S. & Schrauwen, P., Jun 2015, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1852, 6, p. 1137-1144 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Serum FGF21 levels are associated with brown adipose tissue activity in humans

Hanssen, M., Broeders, E., Samms, R. J., Vosselman, M. J., van der Lans, A. A., Cheng, C. C., Adams, A. C., van Marken Lichtenbelt, W. D. & Schrauwen, P., 1 Jan 2015, In : Scientific Reports. 5, 10275.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
20 Citations (Scopus)

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., Jorgensen, J. A., Boekschoten, M. V., Hesselink, M. K., Havekes, B., Kersten, S., Mottaghy, F. M., van Marken Lichtenbelt, W. D. & Schrauwen, P., Aug 2015, In : Nature Medicine. 21, 8, p. 863-865 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

Broeders, E. P., Nascimento, E. B. M., Havekes, B., Brans, B., Roumans, K. H. M., Tailleux, A., Schaart, G., Kouach, M., Charton, J., Deprez, B., Bouvy, N. D., Mottaghy, F., Staels, B., van Marken Lichtenbelt, W. & Schrauwen, P., 1 Sep 2015, In : Cell Metabolism. 22, 3, p. 418-426 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)
2014

Can resveratrol help to maintain metabolic health?

Schrauwen, P. & Timmers, S., 1 Jan 2014, In : Proceedings of the Nutrition Society. 73, 2, p. 271-277

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Chemical imaging of lipid droplets in muscle tissues using hyperspectral coherent Raman microscopy

Billecke, N., Rago, G., Bosma, M., Eijkel, G., Gemmink, A., Leproux, P., Huss, G., Schrauwen, P., Hesselink, M. K., Bonn, M. & Parekh, S. H., 1 Jan 2014, In : Histochemistry and Cell Biology. 141, 3, p. 263-273

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)