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Research Output 2004 2019

Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging

Triest, F. J. J., Franssen, F. M. E., Reynaert, N., Gaffron, S., Spruit, M. A., Janssen, D. J. A., Rutten, E. P. A., Wouters, E. F. M. & Vanfleteren, L. E. G. W., Apr 2019, In : Journal of Clinical Medicine. 8, 4, p. 1-18 18 p., 511.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease

Piscaer, I., van den Ouweland, J. M. W., Vermeersch, K., Reynaert, N. L., Franssen, F. M. E., Keene, S., Wouters, E. F. M., Janssens, W., Vermeer, C. & Janssen, R., Aug 2019, In : Journal of Clinical Medicine. 8, 8, 14 p., 1116.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells

Perkins, T. N., Peeters, P. M., Albrecht, C., Schins, R. P. F., Dentener, M. A., Mossman, B. T., Wouters, E. F. M. & Reynaert, N. L., 1 Jun 2018, In : Toxicology and Applied Pharmacology. 348, p. 43-53 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease

Konings, G. F. J., Reynaert, N. L., Delvoux, B., Verhamme, F. M., Bracke, K. R., Brusselle, G. G., Romano, A. & Vernooy, J. H. J., 5 Mar 2017, In : Molecular and Cellular Endocrinology. 443, C, p. 23-31 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Involvement of c-Jun N-Terminal Kinase in TNF-alpha-Driven Remodeling

Eurlings, I. M. J., Reynaert, N. L., van de Wetering, C., Aesif, S. W., Mercken, E. M., de Cabo, R., van der Velden, J. L., Janssen-Heininger, Y. M., Wouters, E. F. M. & Dentener, M. A., Mar 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 3, p. 393-401 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
1 Citation (Scopus)

Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice

Hoffman, S. M., Qian, X., Nolin, J. D., Chapman, D. G., Chia, S. B., Lahue, K. G., Schneider, R., Ather, J. L., Randall, M. J., McMillan, D. H., Jones, J. T., Taatjes, D. J., Aliyeva, M., Daphtary, N., Abdalla, S., Lundblad, L. K. A., Ho, Y-S., Anathy, V., Irvin, C. G., Wouters, E. F. M. & 5 others, Reynaert, N. L., Dixon, A. E., van der Vliet, A., Poynter, M. E. & Janssen-Heininger, Y. M. W., 1 Sep 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 3, p. 377-386

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells

Perkins, T. N., Dentener, M. A., Stassen, F. R., Rohde, G. G., Mossman, B. T., Wouters, E. F. M. & Reynaert, N. L., 15 Jun 2016, In : Toxicology and Applied Pharmacology. 301, p. 61-70 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Selective IL-1α exposure to the fetal gut, lung, and chorioamnion/skin causes intestinal inflammatory and developmental changes in fetal sheep

Nikiforou, M., Kemp, M. W., van Gorp, R., Saito, M., Newnham, J. P., Reynaert, N. L., Janssen, L. E., Jobe, A. H., Kallapur, S. G., Kramer, B. & Wolfs, T., Jan 2016, In : Laboratory Investigation. 96, 1, p. 69-80 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Various Mechanistic Pathways Representing the Aging Process Are Altered in COPD

Rutten, E., Gopal, P., Wouters, E. F., Franssen, F. M., Hageman, G. J., Vanfleteren, L. E., Spruit, M. A. & Reynaert, N. L., 1 Jan 2016, In : Chest. 149, 1, p. 53-61 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015
5 Citations (Scopus)

Effect of chronic hypoxia on RAGE and its soluble forms in lungs and plasma of mice

Gopal, P., Gosker, H. R., de Theije, C. C., Eurlings, I., Sell, D. R., Monnier, V. M. & Reynaert, N. L., May 2015, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1852, 5, p. 992-1000 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed

Peeters, P. M., Wouters, E. F. & Reynaert, N. L., 1 Jan 2015, In : Journal of Immunology Research. 2015, 15 p., 828264.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells

Perkins, T. N., Peeters, P. M., Shukla, A., Arijs, I., Dragon, J., Wouters, E. F. M., Reynaert, N. L. & Mossman, B. T., 1 Mar 2015, In : Human Molecular Genetics. 24, 5, p. 1374-1389 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease

Vanhove, W., Peeters, P. M., Staelens, D., Schraenen, A., van der Goten, J., Cleynen, I., de Schepper, S., van Lommel, L., Reynaert, N. L., Schuit, F., van Assche, G., Ferrante, M., de Hertogh, G., Wouters, E. F. M., Rutgeerts, P., Vermeire, S., Nys, K. & Arijs, I., Nov 2015, In : Inflammatory Bowel Diseases. 21, 11, p. 2673-2682 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

The Effects of Dexamethasone and Oxygen in Ventilated Adult Sheep with Early Phase Acute Respiratory Distress Syndrome

Engel, M., Nowacki, R. M. E., Boden, P., Reiss, L. K., Uhlig, S., Reynaert, N. L., Gopal, P., Wouters, E. F. M., Willems, C. H. M. P., Kloosterboer, N., Wolfs, T. G. A. M., Zimmermann, L. J. I., Vos, G. & Kramer, B. W., Feb 2015, In : Lung. 193, 1, p. 97-103 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Thiol Redox Chemistry: Role of Protein Cysteine Oxidation and Altered Redox Homeostasis in Allergic Inflammation and Asthma

Hoffman, S., Nolin, J., McMillan, D., Wouters, E., Janssen-Heininger, Y. & Reynaert, N., Jun 2015, In : Journal of Cellular Biochemistry. 116, 6, p. 884-892 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
18 Citations (Scopus)

A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α

Eurlings, I. M. J., Dentener, M. A., Mercken, E. M., de Cabo, R., Bracke, K. R., Vernooy, J. H. J., Wouters, E. F. M. & Reynaert, N. L., 1 Oct 2014, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 307, 7, p. L557-L565 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Association of plasma sRAGE, but not esRAGE with lung function impairment in COPD

Gopal, P., Reynaert, N. L., Scheijen, J. L. J. M., Schalkwijk, C. G., Franssen, F. M. E., Wouters, E. F. M. & Rutten, E. P. A., 25 Feb 2014, In : Respiratory Research. 15, 1, 8 p., 24.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

Eurlings, I. M. J., Reynaert, N. L., van den Beucken, T., Gosker, H. R., de Theije, C. C., Verhamme, F. M., Bracke, K. R., Wouters, E. F. M. & Dentener, M. A., 16 Oct 2014, In : PLOS ONE. 9, 10, 11 p., e107757.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Efficacy of IFN-λ1 to protect human airway epithelial cells against human rhinovirus 1B infection.

Gulraiz, F., Bellinghausen, C., Dentener, M. A., Reynaert, N. L., Gaajetaan, G. R., Beuken, E. V., Rohde, G. G., Bruggeman, C. A. & Stassen, F. R., 21 Apr 2014, In : PLOS ONE. 9, 4, 10 p., e95134.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Plasma advanced glycation end-products and skin autofluorescence are increased in COPD

Gopal, P., Reynaert, N. L., Scheijen, J. L. J. M., Engelen, L., Schalkwijk, C. G., Franssen, F. M. E., Wouters, E. F. M. & Rutten, E. P. A., 1 Jan 2014, In : European Respiratory Journal. 43, 2, p. 430-438

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Research update for articles published in EJCI in 2012

Dullaart, R. P., Al-Daghri, N. M., Ashina, M., Bouzas-Mosquera, A., Brunetti, N. D., Buechler, C., Chen, H. S., Corrales, J. J., D'Archivio, M., Cas, A. D., Pino, G. G., Gomez-Abril, S. A., Gyori, D., Haslacher, H., Herder, C., Kerstens, M. N., Koutsilieris, M., Lupattelli, G., Mocsai, A., Msaouel, P. & 25 others, Orfao, A., Ormazabal, P., Pacher, R., Perkmann, T., Peteiro, J., Plischcke, M., Reynaert, N. L., Ricci, M. A., Robles, N. R., Rocha, M., Rutten, E. P., Sabico, S., Santamaria, F., Santoro, F., Schmid, A., Schmidt, M., Schytz, H. W., Shyu, K. G., Tada, H., Thorand, B., Valerio, G., Vesely, D. L., Wu, T. E., Yamagishi, M. & Yeh, Y. T., Oct 2014, In : European Journal of Clinical Investigation. 44, 10, p. 1010-1023 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

Peeters, P. M., Eurlings, I. M. J., Perkins, T. N., Wouters, E. F., Schins, R. P. F., Borm, P. J. A., Drommer, W., Reynaert, N. L. & Albrecht, C., 19 Nov 2014, In : Particle and Fibre Toxicology. 11, 1, 15 p., 58.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Similar matrix alterations in alveolar and small airway walls of COPD patients

Eurlings, I. M. J., Dentener, M. A., Cleutjens, J. P. M., Peutz, C. J., Rohde, G. G. U., Wouters, E. F. M. & Reynaert, N. L., 26 May 2014, In : BMC Pulmonary Medicine. 14, 1, 11 p., 90.

Research output: Contribution to journalArticleAcademicpeer-review

2013
11 Citations (Scopus)

Emerging mechanisms of glutathione-dependent chemistry in biology and disease.

Janssen-Heininger, Y. M., Nolin, J. D., Hoffman, S. M., van der Velden, A. L. J., Tully, J. E., Lahue, K. G., Abdalla, S. T., Chapman, D. G., Reynaert, N. L., van der Vliet, A. & Anathy, V., Sep 2013, In : Journal of Cellular Biochemistry. 114, 9, p. 1962-1968 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Increased glutaredoxin-1 and decreased protein S-glutathionylation in sputum of asthmatics

Kuipers, I., Louis, R., Manise, M., Dentener, M. A., Irvin, C. G., Janssen Heininger, Y. M., Brightling, C. E., Wouters, E. F. M. & Reynaert, N. L., Feb 2013, In : European Respiratory Journal. 41, 2, p. 469-472 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Interferon-beta induces a long-lasting antiviral state in human respiratory epithelial cells

Gaajetaan, G. R., Geelen, T. H., Vernooy, J. H. J., Dentener, M. A., Reynaert, N. L., Rohde, G. G., Beuken, E. V., Grauls, G. E., Bruggeman, C. A. M. V. A. & Stassen, F. R. M., Feb 2013, In : Journal of Infection. 66, 2, p. 163-169 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

Silica induces NLRP3 inflammasome activation in human lung epithelial cells

Peeters, P. M., Perkins, T. N., Wouters, E. F. M., Mossman, B. T. & Reynaert, N. L., 1 Jan 2013, In : Particle and Fibre Toxicology. 10, 1, 3.

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Systemic Soluble Receptor for Advanced Glycation Endproducts Is a Biomarker of Emphysema and Associated with AGER Genetic Variants in Patients with Chronic Obstructive Pulmonary Disease

Cheng, D. T., Kim, D. K., Cockayne, D. A., Belousov, A., Bitter, H., Cho, M. H., Duvoix, A., Edwards, L. D., Lomas, D. A., Miller, B. E., Reynaert, N., Tal-Singer, R., Wouters, E. F., Agusti, A., Fabbri, L. M., Rames, A., Visvanathan, S., Rennard, S. I., Jones, P., Parmar, H. & 5 others, MacNee, W., Wolff, G., Silverman, E. K., Mayer, R. J. & Pillai, S. G., 15 Oct 2013, In : American Journal of Respiratory and Critical Care Medicine. 188, 8, p. 948-957 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012
7 Citations (Scopus)

Altered cigarette smoke-induced lung inflammation due to ablation of grx1

Kuipers, I., Bracke, K. R., Brusselle, G. G., Aesif, S. W., Krijgsman, R., Arts, I. C., Wouters, E. F. M. & Reynaert, N. L., 1 Jan 2012, In : PLOS ONE. 7, 6, e38984.

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Decreased plasma sRAGE levels in COPD: influence of oxygen therapy

Gopal, P., Rutten, E. P. A., Dentener, M. A., Wouters, E. F. M. & Reynaert, N. L., Aug 2012, In : European Journal of Clinical Investigation. 42, 8, p. 807-814 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Differences in Gene Expression and Cytokine Production by Crystalline vs. Amorphous Silica in Human Lung Epithelial Cells

Perkins, T. N., Shukla, A., Peeters, P. M., Steinbacher, J. L., Landry, C. C., Lathrop, S. A., Steele, C., Reynaert, N. L., Wouters, E. F. M. & Mossman, B. T., 2 Feb 2012, In : Particle and Fibre Toxicology. 9, 1, p. 6 18 p., 6.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Smoke decreases reversible oxidations S-glutathionylation and S-nitrosylation in mice

Kuipers, I., Bracke, K. R., Brusselle, G. G., Wouters, E. F. M. & Reynaert, N. L., Feb 2012, In : Free Radical Research. 46, 2, p. 164-173 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2011
20 Citations (Scopus)

Activation of the glutaredoxin-1 gene by nuclear factor B enhances signaling.

Aesif, S. W., Kuipers, I., van der Velden, J., Tully, J. E., Guala, A. S., Anathy, V., Sheely, J. I., Reynaert, N. L., Wouters, E. F. M., van der Vliet, A. & Janssen-Heininger, Y. M. W., 1 Jan 2011, In : Free Radical Biology and Medicine. 51, 6, p. 1249-1257

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Cigarette Smoke Targets Glutaredoxin 1, Increasing S-glutathionylation and Epithelial Cell Death

Kuipers, I., Guala, A. S., Aesif, S. W., Konings, G. F. J., Bouwman, F. G., Mariman, E. C., Wouters, E. F. M., Janssen Heininger, Y. M. & Reynaert, N. L., Nov 2011, In : American Journal of Respiratory Cell and Molecular Biology. 45, 5, p. 931-937 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Glutathione biochemistry in asthma

Reynaert, N. L., Nov 2011, In : Biochimica et Biophysica Acta-general Subjects. 1810, 11, p. 1045-1051 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2010

Analytical validation of the screening for glutathionylated haemoglobin (HbX1d3) by MALDITOFS in order to monitor oxidatives stress.

de Boer, D., Rousseau, A. M., van Hedel-Bosch, D. M. M., Reynaert, N. L. & Wodzig, K., 1 Jan 2010, In : Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde. 35, 3, p. 175-177

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Protocols for the detection of s-glutathionylated and s-nitrosylated proteins in situ

Aesif, S. W., Janssen Heininger, Y. M. & Reynaert, N. L., 1 Jan 2010, In : Methods in Enzymology. 474, p. 289-96

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease

Janssen Heininger, Y. M., Aesif, S. W., van der Velden, J., Guala, A. S., Reiss, J. N., Roberson, E. C., Budd, R. C., Reynaert, N. L. & Anathy, V., 1 Jan 2010, In : Annals of the New York Academy of Sciences. 1203, p. 23-28 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2009
19 Citations (Scopus)

Association of glutathione-S-transferase omega haplotypes with susceptibility to chronic obstructive pulmonary disease.

Yanbaeva, D. G., Wouters, E. F., Dentener, M. A., Spruit, M. A. & Reynaert, N. L., 1 Jan 2009, In : Free Radical Research. 43, 8, p. 738-743

Research output: Contribution to journalArticleAcademicpeer-review

Nuclear Factor {kappa}B, Airway Epithelium, and Asthma: Avenues for Redox Control

Janssen-Heininger, Y. M., Poynter, M. E., Aesif, S. W., Pantano, C., Ather, J. L., Reynaert, N. L., Ckless, K., Anathy, V., van der Velden, J., Irvin, C. G. & van der Vliet, A., 1 Jan 2009, In : Proceedings of the American Thoracic Society : an official publication of the American Thoracic Society. 6, 3, p. 249-55

Research output: Contribution to journalArticleAcademic

61 Citations (Scopus)

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas

Anathy, V., Aesif, S. W., Guala, A. S., Havermans, M., Reynaert, N. L., Ho, Y. S., Budd, R. C. & Janssen Heininger, Y. M., 1 Jan 2009, In : Journal of Cell Biology. 184, 2, p. 241-52

Research output: Contribution to journalArticleAcademicpeer-review

2007
12 Citations (Scopus)

Catalase overexpression fails to attenuate allergic airways disease in the mouse

Reynaert, N. L., Aesif, S. W., McGovern, T., Brown, A., Wouters, E. F., Irvin, C. G. & Janssen-Heininger, Y. M. W., 1 Jan 2007, In : Journal of Immunology. 178, 6, p. 3814-3821

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)

Modulation of glutaredoxin-1 expression in a mouse model of allergic airway disease

Reynaert, N. L., Wouters, E. F. & Janssen-Heininger, Y. M., 1 Jan 2007, In : American Journal of Respiratory Cell and Molecular Biology. 36, 2, p. 147-151

Research output: Contribution to journalArticleAcademicpeer-review

2006
245 Citations (Scopus)

Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta

Reynaert, N. L., van der Vliet, A., Guala, A. S., McGovern, T., Hristova-Dijkstra, M. J., Pantano, C., Heintz, N. H., Heim, J., Ho, Y. S., Matthews, D. E., Wouters, E. F. & Janssen-Heininger, Y., 1 Jan 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 35, p. 13086-13091

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization

Reynaert, N. L., Ckless, K., Guala, A. S., Wouters, E. F., van der Vliet, A. & Janssen-Heininger, Y. M., 1 Jan 2006, In : Biochimica et Biophysica Acta-general Subjects. 1760, 3, p. 380-387

Research output: Contribution to journalArticleAcademicpeer-review

62 Downloads (Pure)

Redox redulation of inhibitory Kappa B kinase

Reynaert, N. L., 1 Jan 2006, Maastricht: Maastricht University.

Research output: ThesisDoctoral ThesisInternal

Open Access
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