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Research Output 2010 2019

  • 26 Article
  • 1 Conference Abstract/Poster in journal
2019

An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms

Iglesias, V. S., van Hoof, S. J., Vaniqui, A., Schyns, L. E., Lieuwes, N., Yaromina, A., Spiegelberg, L., Groot, A. J., Verhaegen, F., Theys, J., Dubois, L. & Vooijs, M., 2019, In : British Journal of Radiology. 92, 1095, 10 p., 20180476.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure

Konings, G. F. J., Saarinen, N., Delvoux, B., Kooreman, L., Koskimies, P., Krakstad, C., Fasmer, K. E., Haldorsen, I. S., Zaffagnini, A., Hakkinen, M. R., Auriola, S., Dubois, L., Lieuwes, N., Verhaegen, F., Schyns, L. E. J. R., Kruitwagen, R. F. P. M., Xanthoulea, S. & Romano, A., Sep 2018, In : International journal of molecular sciences. 19, 9, 16 p., 2547.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses

Rekers, N. H., Pimentel, V. O., Yaromina, A., Lieuwes, N. G., Biemans, R., Zegers, C. M. L., Germeraad, W. T. V., Van Limbergen, E. J., Neri, D., Dubois, L. J. & Lambin, P., 1 Jan 2018, In : OncoImmunology . 7, 4, 15 p., e1414119.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A novel concept for tumour targeting with radiation: Inverse dose-painting or targeting the "Low Drug Uptake Volume"

Yaromina, A., Granzier, M., Biemans, R., Lieuwes, N., van Elmpt, W., Shakirin, G., Dubois, L. & Lambin, P., Sep 2017, In : Radiotherapy and Oncology. 124, 3, p. 513-520 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Visualizing hepatocellular amino acid kinetics through mass spectrometry imaging of stable isotopes

Arts, M., Soons, Z., Dubois, L. J., Pierzchalski, K. A., Ellis, S. R., Balluff, B., Eijkel, G. B., Cramer, T., Lieuwes, N., Agten, S. M., Hackeng, T. M., Van Loon, L. J., Heeren, R. M. & Damink, S. W. O., 2017, In : Journal of Hepatology. 66, 1, p. S43-S44 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

2016
4 Citations (Scopus)

Synthesis and in Vivo Biological Evaluation of Ga-68-Labeled Carbonic Anhydrase IX Targeting Small Molecules for Positron Emission Tomography

Sneddon, D., Niemans, R., Bauwens, M., Yaromina, A., van Kuijk, S. J. A., Lieuwes, N. G., Biemans, R., Pooters, I., Pellegrini, P. A., Lengkeek, N. A., Greguric, I., Tonissen, K. F., Supuran, C. T., Lambin, P., Dubois, L. & Poulsen, S-A., 14 Jul 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6431-6443

Research output: Contribution to journalArticleAcademicpeer-review

The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy

van Kuijk, S. J. A., Gieling, R. G., Niemans, R., Lieuwes, N. G., Biemans, R., Telfer, B. A., Haenen, G. R. M. M., Yaromina, A., Lambin, P., Dubois, L. J. & Williams, K. J., 11 Aug 2016, In : PLOS ONE. 11, 8, e0161040.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
11 Citations (Scopus)

[F-18]VM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models

Peeters, S. G. J. A., Dubois, L., Lieuwes, N. G., Laan, D., Mooijer, M., Schuit, R. C., Vullo, D., Supuran, C. T., Eriksson, J., Windhorst, A. D. & Lambin, P., Oct 2015, In : Molecular Imaging and Biology. 17, 5, p. 615-619

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

A Comparative Study of the Hypoxia PET Tracers [F-18] HX4, [F-18] FAZA, and [F-18] FMISO in a Preclinical Tumor Model

Peeters, S. G. J. A., Zegers, C. M. L., Lieuwes, N. G., van Elmpt, W., Eriksson, J., van Dongen, G. A. M. S., Dubois, L. & Lambin, P., 1 Feb 2015, In : International Journal of Radiation Oncology Biology Physics. 91, 2, p. 351-359

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model

Rekers, N. H., Zegers, C. M. L., Yaromina, A., Lieuwes, N. G., Biemans, R., Senden-Gijsbers, B. L. M. G., Losen, M., Van Limbergen, E. J., Germeraad, W. T. V., Neri, D., Dubois, L. & Lambin, P., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 438-442

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Complementary Use of Bioluminescence Imaging and Contrast-Enhanced Micro-Computed Tomography in an Orthotopic Brain Tumor Model

Yahyanejad, S., Granton, P. V., Lieuwes, N. G., Gilmour, L., Dubois, L., Theys, J., Chalmers, A. J., Verhaegen, F. & Vooijs, M., Mar 2015, In : Molecular Imaging. 14

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Is there a causal relationship between genetic changes and radiomics-based image features? An in vivo preclinical experiment with doxycycline inducible GADD34 tumor cells

Panth, K. M., Leijenaar, R. T. H., Carvalho, S., Lieuwes, N. G., Yaromina, A., Dubois, L. & Lambin, P., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 462-466

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

New ways to image and target tumour hypoxia and its molecular responses

Dubois, L. J., Niemans, R., van Kuijk, S. J. A., Panth, K. M., Parvathaneni, N-K., Peeters, S. G. J. A., Zegers, C. M. L., Rekers, N. H., van Gisbergen, M. W., Biemans, R., Lieuwes, N. G., Spiegelberg, L., Yaromina, A., Winum, J-Y., Vooijs, M. & Lambin, P., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 352-357

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Preclinical Assessment of Efficacy of Radiation Dose Painting Based on Intratumoral FDG-PET Uptake

Trani, D., Yaromina, A., Dubois, L., Granzier, M., Peeters, S. G. J. A., Biemans, R., Nalbantov, G., Lieuwes, N., Reniers, B., Troost, E. E. G. C., Verhaegen, F. & Lambin, P., 15 Dec 2015, In : Clinical Cancer Research. 21, 24, p. 5511-5518

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Radiotherapy Combined with the Immunocytokine L19-IL2 Provides Long-lasting Antitumor Effects

Zegers, C. M. L., Rekers, N. H., Quaden, D. H. F., Lieuwes, N. G., Yaromina, A., Germeraad, W. T. V., Wieten, L., Biessen, E. A. L., Boon, L., Neri, D., Troost, E. G. C., Dubois, L. J. & Lambin, P., Mar 2015, In : Clinical Cancer Research. 21, 5, p. 1151-1160

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [F-18]HX4 Hypoxia PET Imaging

Peeters, S. G. J. A., Zegers, C. M. L., Biemans, R., Lieuwes, N. G., van Stiphout, R. G. P. M., Yaromina, A., Sun, J. D., Hart, C. P., Windhorst, A. D., van Elmpt, W., Dubois, L. J. & Lambin, P., 1 Jul 2015, In : Clinical Cancer Research. 21, 13, p. 2984-2992

Research output: Contribution to journalArticleAcademicpeer-review

2014

A Longitudinal Evaluation of Partial Lung Irradiation in Mice by Using a Dedicated Image-Guided Small Animal Irradiator

Granton, P. V., Dubois, L., van Elmpt, W., van Hoof, S. J., Lieuwes, N. G., De Ruysscher, D. & Verhaegen, F., 1 Nov 2014, In : International Journal of Radiation Oncology Biology Physics. 90, 3, p. 696-704

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Development and biological evaluation of Tc-99m-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers

Akurathi, V., Dubois, L., Celen, S., Lieuwes, N. G., Chitneni, S. K., Cleynhens, B. J., Innocenti, A., Supuran, C. T., Verbruggen, A. M., Lambin, P. & Bormans, G. M., Jan 2014, In : European Journal of Medicinal Chemistry. 71, p. 374-384

Research output: Contribution to journalArticleAcademicpeer-review

2013
37 Citations (Scopus)

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs

Dubois, L., Peeters, S. G. J. A., van Kuijk, S. J. A., Yaromina, A., Lieuwes, N. G., Saraya, R., Biemans, R., Rami, M., Parvathaneni, N. K., Vullo, D., Vooijs, M., Supuran, C. T., Winum, J-Y. & Lambin, P., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 523-528

Research output: Contribution to journalArticleAcademicpeer-review

2012

Independent and functional validation of a multi-tumour-type proliferation signature

Starmans, M. H. W., Lieuwes, N. G., Span, P. N., Haider, S., Dubois, L., Nguyen, F., van Laarhoven, H. W., Sweep, F. C. G. J., Wouters, B. G., Boutros, P. C. & Lambin, P., 24 Jul 2012, In : British Journal of Cancer. 107, 3, p. 508-515

Research output: Contribution to journalArticleAcademicpeer-review

2011

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

Rouschop, K. M. A., Dubois, L., Schaaf, M. B. E., van den Beucken, T., Lieuwes, N., Keulers, T. G. H., Savelkouls, K. G. M., Bussink, J., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 385-391

Research output: Contribution to journalArticleAcademicpeer-review

miR-210 as a marker of chronic hypoxia, but not a therapeutic target in prostate cancer

Quero, L., Dubois, L., Lieuwes, N. G., Hennequin, C. & Lambin, P., Oct 2011, In : Radiotherapy and Oncology. 101, 1, p. 203-208

Research output: Contribution to journalArticleAcademicpeer-review

Preclinical evaluation and validation of [F-18]HX4, a promising hypoxia marker for PET imaging

Dubois, L. J., Lieuwes, N. G., Janssen, M. H. M., Peeters, W. J. M., Windhorst, A. D., Walsh, J. C., Kolb, H. C., Ollers, M. C., Bussink, J., van Dongen, G. A. M. S., van der Kogel, A. J. & Lambin, P., 30 Aug 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. 14620-14625

Research output: Contribution to journalArticleAcademicpeer-review

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation

Dubois, L., Peeters, S., Lieuwes, N. G., Geusens, N., Thiry, A., Wigfield, S., Carta, F., Mcintyre, A., Scozzafava, A., Dogne, J-M., Supuran, C. T., Harris, A. L., Masereel, B. & Lambin, P., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 424-431

Research output: Contribution to journalArticleAcademicpeer-review

2010

Synthesis and biological evaluation of a Tc-99m-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia

Akurathi, V., Dubois, L., Lieuwes, N. G., Chitneni, S. K., Cleynhens, B. J., Vullo, D., Supuran, C. T., Verbruggen, A. M., Lambin, P. & Bormans, G. M., Jul 2010, In : Nuclear Medicine and Biology. 37, 5, p. 557-564

Research output: Contribution to journalArticleAcademicpeer-review