Natasha Mason

2025

Ayahuasca enhances the formation of hippocampal-dependent episodic memory without impacting false memory susceptibility in experienced ayahuasca users: An observational study

Doss, M. K., Kloft, L., Mason, N. L., Mallaroni, P., Reckweg, J. T., van Oorsouw, K., Tupper, N., Otgaar, H. & Ramaekers, J. G., Apr 2025, In: Journal of Psychopharmacology. 39, 4, p. 339-349 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Benefits and Challenges of Ultra-Fast, Short-Acting Psychedelics in the Treatment of Depression

Ramaekers, J. G., Reckweg, J. T. & Mason, N. L., 1 Jan 2025, In: The American journal of psychiatry. 182, 1, p. 33-46 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness

Timmermann, C., Sanders, J. W., Reydellet, D., Barba, T., Luan, L. X., Angona, Ó. S., Ona, G., Allocca, G., Smith, C. H., Daily, Z. G., Mason, N. L., Kloft-Heller, L., Kuchar, M., Janeckova, L., Palenicek, T., Erritzoe, D., Ramaekers, J. G., Carhart-Harris, R. L. & Uthaug, M. V., 19 Apr 2025, In: Neuroscience of Consciousness. 2025, 1, 8 p., niaf007.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Metabolomic profiling of cannabis use and cannabis intoxication in humans

Madrid-Gambin, F., Haro, N., Mason, N. L., Mallaroni, P., Theunissen, E. L., Toennes, S. W., Pozo, O. J. & Ramaekers, J. G., 12 Mar 2025, (E-pub ahead of print) In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 6, 8 p., 104433.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2024

Dynamic Functional Hyperconnectivity after Psilocybin Intake is Primarily Associated with Oceanic Boundlessness

Mortaheb, S., Fort, L. D., Mason, N. L., Mallaroni, P., Ramaekers, J. G. & Demertzi, A., Jul 2024, In: Biological psychiatry. Cognitive neuroscience and neuroimaging. 9, 7, p. 681-692 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Inter-individual variability in neural response to low doses of LSD

Hutten, N. R. P. W., Quaedflieg, C. W. E. M., Mason, N. L., Theunissen, E. L., Liechti, M. E., Duthaler, U., Kuypers, K. P. C., Bonnelle, V., Feilding, A. & Ramaekers, J. G., 15 Jul 2024, In: Translational Psychiatry. 14, 1, 10 p., 288.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Potential analgesic effects of psychedelics on select chronic pain conditions: A survey study

Cavarra, M., Mason, N. L., Kuypers, K. P. C., Bonnelle, V., Smith, W. J., Feilding, A., Kryskow, P. & Ramaekers, J. G., Jan 2024, In: European Journal of Pain. 28, 1, p. 153-165 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Psilocybin and 2C-B at Encoding Distort Episodic Familiarity

Doss, M. K., Mallaroni, P., Mason, N. L. & Ramaekers, J. G., Oct 2024, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 9, 10, p. 1048-1057 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Psychedelic intimacy: Altered states of consciousness in romantic relationships

Neubert, J. J., Anderson, K. & Mason, N. L., 4 Sept 2024, In: Journal of Psychedelic Studies. 8, 2, p. 219-232 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Psychedelic Research as a Career Path: A Roundtable Discussion with Early Career Researchers in the Field

Aday, J. S., Mason, N. L., Wood, B. J., Kramer, H. M., Ortiz, C. E., Vest, M. F., Sagrera, C. & Healy, C. J., 12 Mar 2024, In: Psychedelic medicine (New Rochelle, N.Y.). 2, 1, p. 44-59 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study

Ramaekers, J. G., Reckweg, J. T., Mason, N. L., Kuypers, K. P. C., Toennes, S. W. & Theunissen, E. L., 24 Dec 2024, (E-pub ahead of print) In: Neuropsychopharmacology. 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Shared functional connectome fingerprints following ritualistic ayahuasca intake

Mallaroni, P., Mason, N. L., Kloft, L., Reckweg, J. T., van Oorsouw, K., Toennes, S. W., Tolle, H. M., Amico, E. & Ramaekers, J. G., Jan 2024, In: Neuroimage. 285, 16 p., 120480.

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Open Access

The unique neural signature of your trip: Functional connectome fingerprints of subjective psilocybin experience

Tolle, H. M., Farah, J. C., Mallaroni, P., Mason, N. L., Ramaekers, J. G. & Amico, E., 1 Apr 2024, In: Network neuroscience. 8, 1, p. 203-225 23 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Use patterns of classic, novel, and herbal opioids

Prevete, E., Mason, N. L., Kuypers, K. P. C., Theunissen, E. L., Mallaroni, P., Pasquini, M. & Ramaekers, J. G., 1 Dec 2025, In: Emerging Trends in Drugs, Addictions, and Health. 5, 100166.

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Open Access

2023

Altered State of Consciousness and Mental Imagery as a Function of N, N-dimethyltryptamine Concentration in Ritualistic Ayahuasca Users

Ramaekers, J., Mallaroni, P., Kloft, L., Reckweg, J., Toennes, S., van Oorsouw, K. & Mason, N., 1 Sept 2023, In: Journal of Cognitive Neuroscience. 35, 9, p. 1382-1393 12 p.

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Open Access

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A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression

Reckweg, J. T., van Leeuwen, C. J., Henquet, C., van Amelsvoort, T., Theunissen, E. L., Mason, N. L., Paci, R., Terwey, T. H. & Ramaekers, J. G., 20 Jun 2023, In: Frontiers in Psychiatry. 14, 8 p., 1133414.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Assessment of the Acute Effects of 2C-B vs. Psilocybin on Subjective Experience, Mood, and Cognition

Mallaroni, P., Mason, N. L., Reckweg, J. T., Paci, R., Ritscher, S., Toennes, S. W., Theunissen, E. L., Kuypers, K. P. C. & Ramaekers, J. G., Aug 2023, In: Clinical Pharmacology & Therapeutics. 114, 2, p. 423-433 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Cortical structural differences following repeated ayahuasca use hold molecular signatures

Mallaroni, P., Mason, N. L., Kloft, L., Reckweg, J. T., van Oorsouw, K. & Ramaekers, J. G., 5 Oct 2023, In: Frontiers in Neuroscience. 17, 14 p., 1217079.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Examining the Psychoactive Differences between Kratom Strains

Huisman, G., Menke, M., Grundmann, O., Schreiber, R. & Mason, N., 1 Jul 2023, In: International Journal of Environmental Research and Public Health. 20, 14, 6425.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Methylphenidate as a treatment option for substance use disorder: a transdiagnostic perspective

van Ruitenbeek, P., Franzen, L., Mason, N. L., Stiers, P. & Ramaekers, J. G., 3 Aug 2023, In: Frontiers in Psychiatry. 14, 17 p., 1208120.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study

Mason, N. L., Szabo, A., Kuypers, K. P. C., Mallaroni, P. A., de la Torre Fornell, R., Reckweg, J. T., Tse, D. H. Y., Hutten, N. R. P. W., Feilding, A. & Ramaekers, J. G., Nov 2023, In: Brain Behavior and Immunity. 114, p. 299-310 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2022

A Comparison of Acute Neurocognitive and Psychotomimetic Effects of a Synthetic Cannabinoid and Natural Cannabis at Psychotropic Dose Equivalence

Theunissen, E. L., Kuypers, K. P. C., Mason, N. L. & Ramaekers, J. G., 19 May 2022, In: Frontiers in Psychiatry. 13, 14 p., 891811.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Analgesic potential of macrodoses and microdoses of classical psychedelics in chronic pain sufferers: a population survey

Bonnelle, V., Smith, W. J., Mason, N. L., Cavarra, M., Kryskow, P., Kuypers, K. P. C., Ramaekers, J. G. & Feilding, A., Dec 2022, In: British Journal of Pain. 16, 6, p. 619-631 13 p., 20494637221114962.

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Open Access

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Cannabis Use and Neuroadaptation: A Call for Δ 9 -Tetrahydrocannabinol Challenge Studies

Ramaekers, J. G., Theunissen, E. L., van Ruitenbeek, P. & Mason, N. L., 14 Apr 2022, In: Frontiers in Psychiatry. 13, p. 1-7 7 p., 870750.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Decreases in State and Trait Anxiety Post-psilocybin: A Naturalistic, Observational Study Among Retreat Attendees

Kiraga, M. K., Kuypers, K. P. C., Uthaug, M. V., Ramaekers, J. G. & Mason, N. L., 7 Jul 2022, In: Frontiers in Psychiatry. 13, 15 p., 883869.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Functional brain connectomes reflect acute and chronic cannabis use

Ramaekers, J. G., Mason, N. L., Toennes, S. W., Theunissen, E. L. & Amico, E., 14 Feb 2022, In: Scientific Reports. 12, 1, 12 p., 2449.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

LSD and creativity: Increased novelty and symbolic thinking, decreased utility and convergent thinking

Wiessner, I., Falchi, M., Maia, L. O., Daldegan-Bueno, D., Palhano-Fontes, F., Mason, N. L., Ramaekers, J. G., Gross, M. E., Schooler, J. W., Feilding, A., Ribeiro, S., Araujo, D. B. & Tofoli, L. F., Mar 2022, In: Journal of Psychopharmacology. 36, 3, p. 348-359 12 p., 02698811211069113.

Research output: Contribution to journal › Article › Academic › peer-review

Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

Madrid-Gambin, F., Gomez-Gomez, A., Busquets-Garcia, A., Haro, N., Marco, S., Mason, N. L., Reckweg, J. T., Mallaroni, P., Kloft, L., van Oorsouw, K., Toennes, S. W., de la Torre, R., Ramaekers, J. G. & Pozo, O. J., May 2022, In: Biomedicine & Pharmacotherapy. 149, 10 p., 112845.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

The use patterns of novel psychedelics: experiential fingerprints of substituted phenethylamines, tryptamines and lysergamides

Mallaroni, P., Mason, N. L., Vinckenbosch, F. R. J. & Ramaekers, J. G., Jun 2022, In: Psychopharmacology. 239, 6, p. 1783-1796 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2021

A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers

Ramaekers, J. G., Hutten, N., Mason, N. L., Dolder, P., Theunissen, E. L., Holze, F., Liechti, M. E., Feilding, A. & Kuypers, K. P., Apr 2021, In: Journal of Psychopharmacology. 35, 4, p. 398-405 8 p., 0269881120940937.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

An experience with Holotropic Breathwork is associated with improvement in non-judgement and satisfaction with life while reducing symptoms of stress in a Czech-speaking population

Uthaug, M. V., Mason, N. L., Havenith, M. N., Vancura, M. & Ramaekers, J. G., 1 Dec 2021, In: Journal of Psychedelic Studies. 5, 3, p. 176-189 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers

Reckweg, J., Mason, N. L., van Leeuwen, C., Toennes, S. W., Terwey, T. H. & Ramaekers, J. G., 25 Nov 2021, In: Frontiers in Pharmacology. 12, 12 p., 760671.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

A placebo-controlled study of the effects of ayahuasca, set and setting on mental health of participants in ayahuasca group retreats

Uthaug, M. V., Mason, N. L., Toennes, S. W., Reckweg, J. T., de Sousa Fernandes Perna, E. B., Kuypers, K. P. C., van Oorsouw, K., Riba, J. & Ramaekers, J. G., Jul 2021, In: Psychopharmacology. 238, 7, p. 1899-1910 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

Hutten, N. R. P. W., Mason, N. L., Dolder, P. C., Theunissen, E. L., Holze, F., Liechti, M. E., Varghese, N., Eckert, A., Feilding, A., Ramaekers, J. G. & Kuypers, K. P. C., 9 Apr 2021, In: ACS Pharmacology & Translational Science. 4, 2, p. 461-466 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Persisting Effects of Ayahuasca on Empathy, Creative Thinking, Decentering, Personality, and Well-Being

Kiraga, M. K., Mason, N. L., Uthaug, M. V., van Oorsouw, K. I. M., Toennes, S. W., Ramaekers, J. G. & Kuypers, K. P. C., 1 Oct 2021, In: Frontiers in Pharmacology. 12, 14 p., 721537.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Pharmacokinetics and pharmacodynamics of lysergic acid diethylamide microdoses in healthy participants

Holze, F., Liechti, M. E., Hutten, N. R. P. W., Mason, N. L., Dolder, P. C., Theunissen, E. L., Duthaler, U., Feilding, A., Ramaekers, J. G. & Kuypers, K. P. C., Mar 2021, In: Clinical Pharmacology & Therapeutics. 109, 3, p. 658-666 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users

Mason, N. L., Theunissen, E. L., Hutten, N. R. P. W., Tse, D. H. Y., Toennes, S. W., Jansen, J. F. A., Stiers, P. & Ramaekers, J. G., Jan 2021, In: Addiction Biology. 26, 1, 9 p., e12870.

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Open Access

Spontaneous and deliberate creative cognition during and after psilocybin exposure

Mason, N. L., Kuypers, K. P. C., Reckweg, J. T., Muller, F., Tse, D. H. Y., Da Rios, B., Toennes, S. W., Stiers, P., Feilding, A. & Ramaekers, J. G., 8 Apr 2021, In: Translational Psychiatry. 11, 1, 13 p., 209.

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Open Access

Sub-acute and long-term effects of ayahuasca on mental health and well-being in healthy ceremony attendants: A replication study

Van Oorsouw, K. I., Uthaug, M. V., Mason, N. L., Broers, N. J. & Ramaekers, J. G., 15 Oct 2021, In: Journal of Psychedelic Studies. 5, 2, p. 103-113 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2020

Blunted highs: Pharmacodynamic and behavioral models of cannabis tolerance

Ramaekers, J. G., Mason, N. L. & Theunissen, E. L., Jul 2020, In: European Neuropsychopharmacology. 36, p. 191-205 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

Mason, N. L., Kuypers, K. P. C., Müller, F., Reckweg, J., Tse, D. H. Y., Toennes, S. W., Hutten, N. R. P. W., Jansen, J. F. A., Stiers, P., Feilding, A. & Ramaekers, J. G., Nov 2020, In: Neuropsychopharmacology. 45, 12, p. 2003-2011 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study

Hutten, N. R. P. W., Mason, N. L., Dolder, P. C., Theunissen, E. L., Holze, F., Liechti, M. E., Feilding, A., Ramaekers, J. G. & Kuypers, K. P. C., Dec 2020, In: European Neuropsychopharmacology. 41, p. 81-91 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Reported effects of psychedelic use on those with low well-being given various emotional states and social contexts

Mason, N. L., Dolder, P. C. & Kuypers, K. P. C., 2020, In: Drug Science, Policy and Law. 6, p. 1-11

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2019

A First-in-Man Study with 4-Fluoroamphetamine Demonstrates it Produces a Mild Psychedelic State

Kuypers, K. P. C., De Sousa Fernandes Perna, E. B., Theunissen, E. L., Toennes, S. W., Mason, N. L., Hutten, N. R. P. W. & Ramaekers, J. G., 27 May 2019, In: Journal of Psychoactive Drugs. 51, 3, p. 225-235 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms

Uthaug, M. V., Lancelotta, R., van Oorsouw, K., Kuypers, K. P. C., Mason, N., Rak, J., Šuláková, A., Jurok, R., Maryška, M., Kuchař, M., Páleníček, T., Riba, J. & Ramaekers, J. G., Sept 2019, In: Psychopharmacology. 236, 9, p. 2653–2666 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access