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Research Output 2008 2019

2019
Open Access

Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans

van der Kolk, B. W., Kalafati, M., Adriaens, M., van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., Astrup, A., Valsesia, A., Langin, D., van der Kallen, C. J. H., Eussen, S. J. P. M., Schalkwijk, C. G., Stehouwer, C. D. A., Goossens, G. H., Arts, I. C. W., Jocken, J. W. E., Evelo, C. T. & Blaak, E. E., Dec 2019, In : Diabetes. 68, 12, p. 2247-2258 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Exploring the cellular network of metabolic flexibility in the adipose tissue

Tareen, S. H. K., Kutmon, M., Adriaens, M., Mariman, E., de Kok, T., Arts, I. & Evelo, C., 5 Jul 2018, In : Genes and nutrition. 13, 8 p., 17.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

From SNPs to pathways: Biological interpretation of type 2 diabetes (T2DM) genome wide association study (GWAS) results

Cirillo, E., Kutmon, M., Gonzalez Hernandez, M., Hooimeijer, T., Adriaens, M. E., Eijssen, L. M. T., Parnell, L. D., Coort, S. L. & Evelo, C. T., 4 Apr 2018, In : PLOS ONE. 13, 4, p. e0193515 19 p., 0193515.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Genomic approaches for the elucidation of genes and gene networks underlying cardiovascular traits

Adriaens, M. E. & Bezzina, C. R., Aug 2018, In : Biophysical Reviews. 10, 4, p. 1053-1060 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Profiling cellular processes in adipose tissue during weight loss using time series gene expression

Tareen, S. H. K., Adriaens, M. E., Arts, I. C. W., de Kok, T. M., Vink, R. G., Roumans, N. J. T., van Baak, M. A., Mariman, E. C. M., Evelo, C. T. & Kutmon, M., Nov 2018, In : Genes. 9, 11, 16 p., 525.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction

Adriaens, M. E., Lodder, E. M., Moreno-Moral, A., Silhavy, J., Heinig, M., Glinge, C., Belterman, C., Wolswinkel, R., Petretto, E., Pravenec, M., Remme, C. A. & Bezzina, C. R., 6 Nov 2018, In : Journal of the American Heart Association. 7, 21, 17 p., e009243.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Maternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring

McKay, J. A., Xie, L., Adriaens, M., Evelo, C. T., Ford, D. & Mathers, J. C., Apr 2017, In : Molecular Nutrition & Food Research. 61, 4, 16 p., 1600713.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

Heinig, M., Adriaens, M. E., Schafer, S., van Deutekom, H. W. M., Lodder, E. M., Ware, J. S., Schneider, V., Felkin, L. E., Creemers, E. E., Meder, B., Katus, H. A., Rühle, F., Stoll, M., Cambien, F., Villard, E., Charron, P., Varro, A., Bishopric, N. H., George, A. L., Dos Remedios, C. & 11 others, Moreno-Moral, A., Pesce, F., Bauerfeind, A., Rüschendorf, F., Rintisch, C., Petretto, E., Barton, P. J., Cook, S. A., Pinto, Y. M., Bezzina, C. R. & Hubner, N., 14 Sep 2017, In : Genome Biology. 18, 1, p. 170 21 p., 170.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

PRC1 Prevents Replication Stress during Chondrogenic Transit Amplification

Spaapen, F., Eijssen, L., Adriaens, M., Welting, T., Prickaerts, P., Salvaing, J., Dahlmans, V. E. H., Surtel, D., Kruitz, F., Kuijer, R., Takihara, Y., Marks, H., Stunnenberg, H., Wouters, B., Vidal, M. & Voncken, J., Dec 2017, In : Epigenomes. 1, 3, 31 p., 22.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
5 Citations (Scopus)

52 Genetic Loci Influencing Myocardial Mass

van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., Wang, X., Mateo Leach, I., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikäinen, L-P., Polašek, O., Tanaka, T., Arking, D. E., Ulivi, S., Trompet, S., Müller-Nurasyid, M. & 140 others, Smith, A. V., Dörr, M., Kerr, K. F., Magnani, J. W., Del Greco M, F., Zhang, W., Nolte, I. M., Silva, C. T., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, G. R., Adriaens, M. E., Andersen, K., Barnett, P., Bis, J. C., Bodmer, R., Buckley, B. M., Campbell, H., Cannon, M. V., Chakravarti, A., Chen, L. Y., Delitala, A., Devereux, R. B., Doevendans, P. A., Dominiczak, A. F., Ferrucci, L., Ford, I., Gieger, C., Harris, T. B., Haugen, E., Heinig, M., Hernandez, D. G., Hillege, H. L., Hirschhorn, J. N., Hofman, A., Hubner, N., Hwang, S-J., Iorio, A., Kähönen, M., Kellis, M., Kolcic, I., Kooner, I. K., Kooner, J. S., Kors, J. A., Lakatta, E. G., Lage, K., Launer, L. J., Levy, D., Lundby, A., Macfarlane, P. W., May, D., Meitinger, T., Metspalu, A., Nappo, S., Naitza, S., Neph, S., Nord, A. S., Nutile, T., Okin, P. M., Olsen, J. V., Oostra, B. A., Penninger, J. M., Pennacchio, L. A., Pers, T. H., Perz, S., Peters, A., Pinto, Y. M., Pfeufer, A., Pilia, M. G., Pramstaller, P. P., Prins, B. P., Raitakari, O. T., Raychaudhuri, S., Rice, K. M., Rossin, E. J., Rotter, J. I., Schafer, S., Schlessinger, D., Schmidt, C. O., Sehmi, J., Silljé, H. H. W., Sinagra, G., Sinner, M. F., Slowikowski, K., Soliman, E. Z., Spector, T. D., Spiering, W., Stamatoyannopoulos, J. A., Stolk, R. P., Strauch, K., Tan, S-T., Tarasov, K. V., Trinh, B., Uitterlinden, A. G., van den Boogaard, M., van Duijn, C. M., van Gilst, W. H., Viikari, J. S., Visscher, P. M., Vitart, V., Völker, U., Waldenberger, M., Weichenberger, C. X., Westra, H-J., Wijmenga, C., Wolffenbuttel, B. H., Yang, J., Bezzina, C. R., Munroe, P. B., Snieder, H., Wright, A. F., Rudan, I., Boyer, L. A., Asselbergs, F. W., van Veldhuisen, D. J., Stricker, B. H., Psaty, B. M., Ciullo, M., Sanna, S., Lehtimäki, T., Wilson, J. F., Bandinelli, S., Alonso, A., Gasparini, P., Jukema, J. W., Kääb, S., Gudnason, V., Felix, S. B., Heckbert, S. R., de Boer, R. A., Newton-Cheh, C., Hicks, A. A., Chambers, J. C., Jamshidi, Y., Visel, A., Christoffels, V. M., Isaacs, A., Samani, N. J. & de Bakker, P. I. W., 27 Sep 2016, In : Journal of the American College of Cardiology. 68, 13, p. 1435-1448 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Gene promoter DNA methylation patterns have a limited role in orchestrating transcriptional changes in the fetal liver in response to maternal folate depletion during pregnancy.

McKay, J. A., Adriaens, M., Evelo, C. T., Ford, D. & Mathers, J. C., Sep 2016, In : Molecular Nutrition & Food Research. 60, 9, p. 2031-2042 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart

Creemers, E. E., Bawazeer, A., Ugalde, A. P., van Deutekom, H. W. M., van der Made, I., de Groot, N. E., Adriaens, M. E., Cook, S. A., Bezzina, C. R., Hubner, N., van der Velden, J., Elkon, R., Agami, R. & Pinto, Y. M., 5 Feb 2016, In : Circulation Research. 118, 3, p. 433-438 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

Adriaens, M. E., Prickaerts, P., Beucken, T. V. D., Koch, E., Dubois, L., Dahlmans, V. E. H., Gits, C., Evelo, C. T. A., Chan-Seng-Yue, M., Wouters, B. G. & Voncken, W., 26 Oct 2016, In : Epigenetics & Chromatin. 9, p. 46 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Organ-Specific Gene Expression Changes in the Fetal Liver and Placenta in Response to Maternal Folate Depletion

McKay, J. A., Xie, L., Adriaens, M., Evelo, C. T., Ford, D. & Mathers, J. C., 22 Oct 2016, In : Nutrients. 8, 10, 20 p., 661.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia

Adriaens, M. E., Prickaerts, P., Chan-Seng-Yue, M., van den Beucken, T., Dahlmans, V. E. H., Eijssen, L. M., Beck, T., Wouters, B. G., Voncken, W. & Evelo, C. T. A., 1 Nov 2016, In : Epigenetics & Chromatin. 9, 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number

Otten, A. B. C., Stassen, A. P. M., Adriaens, M., Gerards, M., Dohmen, R. G. J., Timmer, A. J., Vanherle, S. J. V., Kamps, R., Boesten, I. B. W., Vanoevelen, J. M., Muller, M. & Smeets, B., Dec 2016, In : Genetics. 204, 4, p. 1423-1431 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

A user-friendly workflow for analysis of Illumina gene expression bead array data available at the arrayanalysis.org portal

Eijssen, L. M. T., Goelela, V. S., Kelder, T., Adriaens, M. E., Evelo, C. T. & Radonjic, M., 1 Jan 2015, In : BMC Genomics. 16, 482.

Research output: Contribution to journalArticleAcademicpeer-review

2014
45 Citations (Scopus)

A common genetic variant within SCN10A modulates cardiac SCN5A expression. A common genetic variant within SCN10A modulates cardiac SCN5A expression.

van den Boogaard, M., Smemo, S., Burnicka-Turek, O., Arnolds, D. E., van de Werken, H. J., Klous, P., McKean, D., Muehlschlegel, J. D., Moosmann, J., Toka, O., Yang, X. H., Koopmann, T. T., Adriaens, M. E., Bezzina, C. R., de Laat, W., Seidman, C., Seidman, JG., Christoffels, V. M., Nobrega, M. A., Barnett, P. & 1 others, Moskowitz, I. P., 2014, In : Journal of Clinical Investigation. 124, 4, p. 1844-1852 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia. Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.

Marsman, R. F., Bezzina, C. R., Freiberg, F., Verkerk, A. O., Adriaens, M. E., Podliesna, S., Chen, C., Purfürst, B., Spallek, B., Koopmann, T. T., Baczko, I., Dos Remedios, C. G., George, A. L., Bishopric, N. H., Lodder, E. M., de Bakker, J. M., Fischer, R., Coronel, R., Wilde, A. A., Gotthardt, M. & 1 others, Remme, C. A., 2014, In : Journal of the American College of Cardiology. 63, 6, p. 549-559 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart. Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart.

Koopmann, T. T., Adriaens, M. E., Moerland, P. D., Marsman, R. F., Westerveld, M. L., Lal, S., Zhang, T., Simmons, C. Q., Baczko, I., dos Remedios, C., Bishopric, N. H., Varro, A., George, A. L., Lodder, E. M. & Bezzina, C. R., 2014, In : PLOS ONE. 9, 5

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

van den Beucken, T., Koch, E., Chu, K., Rupaimoole, R., Prickaerts, P., Adriaens, M., Voncken, J. W., Harris, A. L., Buffa, F. M., Haider, S., Starmans, M. H., Yao, C. Q., Ivan, M., Ivan, C., Pecot, C. V., Boutros, P. C., Sood, A. K., Koritzinsky, M. & Wouters, B. G., 2014, In : Nature Communications. 5, p. 5203 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.

Lodder, E. M., Scicluna, B. P., Beekman, L., Arends, D., Moerland, P. D., Tanck, M. W., Adriaens, M. E. & Bezzina, C. R., 2014, In : Circulation : Cardiovascular Genetics. 7, 6, p. 790-798 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Procyanidin induces apoptosis of esophageal adenocarcinoma cells via JNK activation of c-Jun. Procyanidin induces apoptosis of esophageal adenocarcinoma cells via JNK activation of c-Jun.

Connor, C. A., Adriaens, M., Pierini, R., Johnson, I. T. & Belshaw, N. J., 2014, In : Nutrition and Cancer-An International Journal. 66, 2, p. 335-341 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013
44 Citations (Scopus)

Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16.

Cordell, H. J., Bentham, J., Topf, A., Zelenika, D., Heath, S., Mamasoula, C., Cosgrove, C., Blue, G., Granados-Riveron, J., Setchfield, K., Thornborough, C., Breckpot, J., Soemedi, R., Martin, R., Rahman, T. J., Hall, D., van Engelen, K., Moorman, A. F., Zwinderman, A. H., Barnett, P. & 21 others, Koopmann, T. T., Adriaens, M. E., Varro, A., George, A. L., dos Remedios, C., Bishopric, N. H., Bezzina, C. R., O'Sullivan, J., Gewillig, M., Bu'Lock, F. A., Winlaw, D., Bhattacharya, S., Devriendt, K., Brook, JD., Mulder, B. J., Mital, S., Postma, A. V., Lathrop, GM., Farrall, M., Goodship, J. A. & Keavney, B. D., 2013, In : Nature Genetics. 45, 7, p. 822-824 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

User-friendly solutions for microarray quality control and pre-processing on ArrayAnalysis.org.

Eijssen, L. M. T., Jaillard, M. N. L., Michiel Adriaens, M. E., Gaj, S., de Groot, P. J., Muller, M. & Evelo, C. T. A., 1 Jan 2013, In : Nucleic Acids Research. 41W1, p. W71-76

Research output: Contribution to journalArticleAcademicpeer-review

2012
12 Citations (Scopus)

An evaluation of two-channel ChIP-on-chip and DNA methylation microarray normalization strategies

Michiel Adriaens, M. E., Jaillard, M. N. L., Eijssen, L. M. T., Mayer, C. D. & Evelo, C. T. A., 25 Jan 2012, In : BMC Genomics. 13, 1, p. 42 14 p., 42.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice

Mykkanen, O. T., Kalesnykas, G., Adriaens, M., Evelo, C. T., Torronen, R. & Kaarniranta, K., 7 Sep 2012, In : Molecular Vision. 18, 247, p. 2338-2351 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome.

Kolehmainen, M., Mykkänen, O., Kirjavainen, P. V., Leppänen, T., Moilanen, E., Adriaens, M., Laaksonen, D. E., Hallikainen, M., Puupponen-Pimiä, R., Pulkkinen, L., Mykkänen, H., Gylling, H., Poutanen, K. & Törrönen, R., 2012, In : Molecular Nutrition & Food Research. 56, 10, p. 1501-1510 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Mapping of lamin A- and progerin-interacting genome regions.

Kubben, N., Adriaens, M., Meuleman, W., Voncken, J. W., van Steensel, B. & Misteli, T., 2012, In : Chromosoma. 121, 5, p. 447-464 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

MK3 controls Polycomb target gene expression via negative feedback on ERK.

Prickaerts, P., Niessen, H. E., Mouchel-Vielh, E., Dahlmans, V. E., van den Akker, G. G., Geijselaers, C., Adriaens, M. E., Spaapen, F., Takihara, Y., Rapp, U. R., Peronnet, F. & Voncken, J. W., 2012, In : Epigenetics & Chromatin. 5, 1, p. 12 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Molecular pathways involved in prostate carcinogenesis: insights from public microarray datasets

Baetke, S. C., Michiel Adriaens, M. E., Seigneuric, R., Evelo, C. T. A. & Eijssen, L. M. T., 20 Nov 2012, In : PLOS ONE. 7, 11, 11 p., e49831.

Research output: Contribution to journalArticleAcademicpeer-review

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2010
22 Citations (Scopus)
2009
30 Citations (Scopus)

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway

Orton, R. J., Michiel Adriaens, M. E., Gormand, A., Sturm, O. E., Kolch, W. & Gilbert, D. R., 1 Jan 2009, In : BMC Systems Biology. 3, p. 100

Research output: Contribution to journalArticleAcademicpeer-review

2008
4 Citations (Scopus)

Bioinformatic interrogation of expression array data to identify nutritionally regulated genes potentially modulated by DNA methylation

McKay, J. A., Michiel Adriaens, M. E., Ford, D., Relton, C. L., Evelo, C. T. & Mathers, J. C., 1 Jan 2008, In : Genes and nutrition. 3, 3-4, p. 167-71

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

The public road to high-quality curated biological pathways

Michiel Adriaens, M. E., Jaillard, M., Waagmeester, A. S., Coort, S. L., Pico, A. R. & Evelo, C. T., 1 Jan 2008, In : Drug Discovery Today. 13, 19-20, p. 856-862

Research output: Contribution to journalArticleAcademicpeer-review