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Research Output

2020

Diurnal Regulation of Peripheral Glucose Metabolism: Potential Effects of Exercise Timing

Mancilla, R., Krook, A., Schrauwen, P. & Hesselink, M. K. C., Jul 2020, In : Obesity. 28, S1, p. S38-S45 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Exercising your fat (metabolism) into shape: a muscle-centred view

Gemmink, A., Schrauwen, P. & Hesselink, M. K. C., Aug 2020, In : Diabetologia. 63, 8, p. 1453-1463 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Skeletal muscle in healthy humans exhibits a day -night rhythm in lipid metabolism

Held, N. M., Wefers, J., van Weeghel, M., Daemen, S., Hansen, J., Vas, F. M., van Moorsel, D., Hesselink, M. K. C., Houtkooper, R. H. & Schrauwen, P., Jul 2020, In : Molecular Metabolism. 37, 11 p., 100989.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion

Phielix, E., Begovatz, P., Gancheva, S., Bierwagen, A., Kornips, E., Schaart, G., Hesselink, M. K. C., Schrauwen, P. & Roden, M., 1 Nov 2019, In : JCI INSIGHT. 4, 21, 12 p., 127928.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Analysing a cycling grand tour: Can we monitor fatigue with intensity or load ratios?

Sanders, D., Heijboer, M., Hesselink, M. K. C., Myers, T. & Akubat, I., 1 Jan 2018, In : Journal of Sports Sciences. 36, 12, p. 1385-1391 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Wefers, J., van Moorsel, D., Hansen, J., Connell, N. J., Havekes, B., Hoeks, J., Lichtenbelt, W. D. V. M., Duez, H., Phielix, E., Kalsbeek, A., Boekschoten, M. V., Hooiveld, G. J., Hesselink, M. K. C., Kersten, S., Staels, B., Scheer, F. A. J. L. & Schrauwen, P., 24 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. 7789-7794 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

Gemmink, A., Daemen, S., Brouwers, B., Huntjens, P. R., Schaart, G., Moonen-Kornips, E., Jorgensen, J., Hoeks, J., Schrauwen, P. & Hesselink, M. K. C., 1 Mar 2018, In : Journal of Physiology. 596, 5, p. 857-868 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox

Daemen, S., Gemmink, A., Brouwers, B., Meex, R. C. R., Huntjens, P. R., Schaart, G., Moonen-Komips, E., Jorgensen, J., Hoeks, J., Schrauwen, P. & Hesselink, M. K. C., Nov 2018, In : Molecular Metabolism. 17, p. 71-81 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity

Lancel, S., Hesselink, M. K. C., Woldt, E., Rouille, Y., Dorchies, E., Delhaye, S., Duhem, C., Thorel, Q., Mayeuf-Louchart, A., Pourcet, B., Montel, V., Schaart, G., Beton, N., Picquet, F., Briand, O., Salles, J. P., Duez, H., Schrauwen, P., Bastide, B., Bailleul, B. & 2 others, Staels, B. & Sebti, Y., 3 May 2018, In : JCI INSIGHT. 3, 9, p. 1-13 13 p., e98081.

Research output: Contribution to journalArticleAcademicpeer-review

Exercise counteracts lipotoxicity by improving lipid turnover and lipid droplet quality

Zacharewicz, E., Hesselink, M. K. C. & Schrauwen, P., Nov 2018, In : Journal of Internal Medicine. 284, 5, p. 505-518 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity

Stinkens, R., Brouwers, B., Jocken, J. W., Blaak, E. E., Teunissen-Beekman, M. F., Hesselink, M. K., van Baak, M. A., Schrauwen, P. & Goossens, G. H., Nov 2018, In : Journal of Applied Physiology. 125, 5, p. 1585-1593 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver

Brouwers, B., Schrauwen-Hinderling, V. B., Jelenik, T., Gemmink, A., Sparks, L. M., Havekes, B., Bruls, Y., Dahlmans, D., Roden, M., Hesselink, M. K. C. & Schrauwen, P., Feb 2018, In : American Journal of Physiology : Endocrinology and Metabolism. 314, 2, p. E165-E173 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The effect of diet and exercise on lipid droplet dynamics in human muscle tissue

Daemen, S., van Polanen, N. & Hesselink, M. K. C., Mar 2018, In : Journal of Experimental Biology. 221, 12 p., 167015.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2017

Benefits of Substitution Sitting with Standing and Walking in Free-living Conditions for Cardiometabolic Risk Markers, cognition and Mood in Overweight Adults

Duvivier, B. M. F. M., Schaper, N. C., Koster, A., van Kan, L., Peters, H. P. F., Adam, J. J., Giesbrecht, T., Kornips, E., Hulsbosch, M., Willems, P., Hesselink, M. K. C., Schrauwen, P. & Savelberg, H. H. C. M., 8 Jun 2017, In : Frontiers in physiology. 8, 9 p., 353.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes

Duvivier, B. M. F. M., Schaper, N. C., Hesselink, M. K. C., van Kan, L., Stienen, N., Winkens, B., Koster, A. & Savelberg, H. H. C. M., Mar 2017, In : Diabetologia. 60, 3, p. 490-498 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups

Dahlmans, D., Houzelle, A., Jorgensen, J. A., Phielix, E., Lindeboom, L., Hesselink, M. K. C., Schrauwen, P. & Hoeks, J., 21 Sep 2017, In : Frontiers in physiology. 8, 10 p., 711.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intramyocellular lipid droplets and insulin sensitivity, the human perspective

Gemmink, A., Goodpaster, B. H., Schrauwen, P. & Hesselink, M. K. C., Oct 2017, In : Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1862, 10, p. 1242-1249 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians

Gemmink, A., Bakker, L. E. H., Guigas, B., Kornips, E., Schaart, G., Meinders, A. E., Jazet, I. M. & Hesselink, M. K. C., 14 Feb 2017, In : Scientific Reports. 7, 9 p., 42393.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Longitudinal relaxation time editing for acetylcarnitine detection with H-MRS

Lindeboom, L., Bruls, Y. M. H., van Ewijk, P. A., Hesselink, M. K. C., Wildberger, J. E., Schrauwen, P. & Schrauwen-Hinderling, V. B., Feb 2017, In : Magnetic Resonance in Medicine. 77, 2, p. 505–510 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Mechanical Efficiency in Chronic Obstructive Pulmonary Disease

Gosens, W., van't Hul, A. J., Oomen, J. M., Hesselink, M. K. C. & Borghouts, L. B., Mar 2017, In : Journal of Cardiopulmonary Rehabilitation and Prevention. 37, 2, p. 146-153 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes

Brouwers, B., Schrauwen-Hinderling, V. B., Jelenik, T., Gemmink, A., Havekes, B., Bruls, Y., Dahlmans, D., Roden, M., Hesselink, M. K. C. & Schrauwen, P., 1 Aug 2017, In : Clinical Science. 131, 15, p. 1905-1917 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Methods of Monitoring Training Load and Their Relationships to Changes in Fitness and Performance in Competitive Road Cyclists

Sanders, D., Abt, G., Hesselink, M. K. C., Myers, T. & Akubat, I., May 2017, In : International Journal of Sports Physiology and Performance. 12, 5, p. 668-675 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Predicting High-Power Performance in Professional Cyclists

Sanders, D., Heijboer, M., Akubat, I., Meijer, K. & Hesselink, M. K., Mar 2017, In : International Journal of Sports Physiology and Performance. 12, 3, p. 410-413 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Recent advances in lipid droplet biology

Coleman, R. A. & Hesselink, M. K., Oct 2017, In : Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1862, 10, p. 1129-1130 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

What are the benefits of being big?

Hesselink, M. K. C., Daemen, S., van Polanen, N. & Gemmink, A., 15 Aug 2017, In : Journal of Physiology. 595, 16, p. 5409-5410 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

2016

A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats

van Bree, B. W. J., Lenaers, E., Nabben, M., Briede, J. J., Jorgensen, J. A., Schaart, G., Schrauwen, P., Hoeks, J. & Hesselink, M. K. C., 14 Mar 2016, In : Scientific Reports. 6, 22854.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity

van Moorsel, D., Hansen, J., Havekes, B., Scheer, F. A. J. L., Jorgensen, J. A., Hoeks, J., Schrauwen-Hinderling, V. B., Duez, H., Lefebvre, P., Schaper, N. C., Hesselink, M. K. C., Staels, B. & Schrauwen, P., Aug 2016, In : Molecular Metabolism. 5, 8, p. 635-645

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Effects of exercise training on intrahepatic lipid content in humans

Brouwers, B., Hesselink, M. K. C., Schrauwen, P. & Schrauwen-Hinderling, V. B., Oct 2016, In : Diabetologia. 59, 10, p. 2068-2079

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Microscopy tools for the investigation of intracellular lipid storage and dynamics

Daemen, S., van Zandvoort, M. A. M. J., Parekh, S. H. & Hesselink, M. K. C., Mar 2016, In : Molecular Metabolism. 5, 3, p. 153-163

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Quantum coherence spectroscopy to measure dietary fat retention in the liver

Lindeboom, L., de Graaf, R. A., Nabuurs, C. I., van Ewijk, E., Hesselink, M. K. C., Wildberger, J. E., Schrauwen, P. & Schrauwen-Hinderling, V. B., 18 Aug 2016, In : JCI INSIGHT. 1, 13, e84671.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial

Timmers, S., de Ligt, M., Phielix, E., van de Weijer, T., Hansen, J., Moonen-Kornips, E., Schaart, G., Kunz, I., Hesselink, M. K. C., Schrauwen-Hinderling, V. B. & Schrauwen, P., Dec 2016, In : Diabetes Care. 39, 12, p. 2211-2217

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

Hesselink, M. K. C., Schrauwen-Hinderling, V. & Schrauwen, P., Nov 2016, In : Nature Reviews Endocrinology. 12, 11, p. 633-645

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes

Hansen, J., Timmers, S., Moonen-Kornips, E., Duez, H., Staels, B., Hesselink, M. K. C. & Schrauwen, P., 19 Oct 2016, In : Scientific Reports. 6, 35047.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Acute exercise does not decrease liver fat in men with overweight or NAFLD

Bilet, L., Brouwers, B., van Ewijk, P. A., Hesselink, M. K., Kooi, M. E., Schrauwen, P. & Schrauwen-Hinderling, V. B., 13 Apr 2015, In : Scientific Reports. 5, 7 p., 9709.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

Dijk, W., Heine, M., Vergnes, L., Boon, M. R., Schaart, G., Hesselink, M., Reue, K., van Marken Lichtenbelt, W., Olivecrona, G., Rensen, P. C., Heeren, J. & Kersten, S., 17 Oct 2015, In : Elife. 4, 23 p., e08428.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring

van Ewijk, P. A., Paglialunga, S. A., Kooi, M. E., Nunes, P. M., Gemmink, A., Slenter, J., Moonen Kornips, E., Jorgensen, J. A., Hoeks, J., Wildberger, J. E., Hesselink, M. K., Glatz, J. F., Heerschap, A., Kersten, S., Schrauwen, P. & Schrauwen-Hinderling, V. B., 1 Jan 2015, In : Obesity. 23, 11, p. 2242-2250

Research output: Contribution to journalArticleAcademicpeer-review

Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans

van de Weijer, T., Phielix, E., Bilet, L., Williams, E. G., Ropelle, E. R., Bierwagen, A., Livingstone, R., Nowotny, P., Sparks, L. M., Paglialunga, S. A., Szendroedi, J., Havekes, B., Moullan, N., Pirinen, E., Hwang, J. H., Schrauwen-Hinderling, V. B., Hesselink, M. K., Auwerx, J., Roden, M. & Schrauwen, P., Apr 2015, In : Diabetes. 64, 4, p. 1193-1201 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Genomic and transcriptomic predictors of triglyceride response to regular exercise

Sarzynski, M. A., Davidsen, P. K., Sung, Y. J., Hesselink, M., Schrauwen, P., Rice, T. K., Rao, D. C., Falciani, F. & Bouchard, C., Dec 2015, In : British Journal of Sports Medicine. 49, 23, p. 1524-1531 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter

Gnaiger, E., Boushel, R., Sondergaard, H., Munch-Andersen, T., Damsgaard, R., Hagen, C., Diez-Sanchez, C., Ara, I., Wright-Paradis, C., Schrauwen, P., Hesselink, M., Calbet, J. A., Christiansen, M., Helge, J. W. & Saltin, B., Dec 2015, In : Scandinavian Journal of Medicine & Science in Sports. 25, Suppl 4, p. 126-134 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging

Billecke, N., Bosma, M., Rock, W., Fleissner, F., Best, G., Schrauwen, P., Kersten, S., Bonn, M., Hesselink, M. & Parekh, S. H., Apr 2015, In : Integrative Biology. 7, 4, p. 467-476 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., Jorgensen, J. A., Boekschoten, M. V., Hesselink, M. K., Havekes, B., Kersten, S., Mottaghy, F. M., van Marken Lichtenbelt, W. D. & Schrauwen, P., Aug 2015, In : Nature Medicine. 21, 8, p. 863-865 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)
2014

Chemical imaging of lipid droplets in muscle tissues using hyperspectral coherent Raman microscopy

Billecke, N., Rago, G., Bosma, M., Eijkel, G., Gemmink, A., Leproux, P., Huss, G., Schrauwen, P., Hesselink, M. K., Bonn, M. & Parekh, S. H., 1 Jan 2014, In : Histochemistry and Cell Biology. 141, 3, p. 263-273

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers - van Gogh, I., Schaart, G., Jeppesen, J., Kneppers, A., Mensink, M., Voshol, P. J., Olivecrona, G., Tan, N. S., Hesselink, M. K., Berbee, J. F., Rensen, P. C., Kalkhoven, E., Schrauwen, P. & Kersten, S., 18 Mar 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. E1043-E1052 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.

Nabben, M., van Bree, B. W., Lenaers, E., Hoeks, J., Hesselink, M. K., Schaart, G., Gijbels, M. J., Glatz, J. F., da Silva, G. J., De Windt, L. J., Tian, R., Mike, E., Skapura, D. G., Wehrens, X. H. & Schrauwen, P., Nov 2014, In : Basic Research in Cardiology. 109, 6, 12 p., 447.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection

Lindeboom, L., Nabuurs, C. I., Hoeks, J., Brouwers, B., Phielix, E., Kooi, M. E., Hesselink, M. K., Wildberger, J. E., Stevens, R. D., Koves, T., Muoio, D. M., Schrauwen, P. & Schrauwen-Hinderling, V. B., Nov 2014, In : Journal of Clinical Investigation. 124, 11, p. 4915-4925 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Reduced incorporation of Fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes.

Sparks, L. M., Bosma, M., Brouwers, B., van de Weijer, T., Bilet, L., Schaart, G., Kornips, E., Eichmann, T. O., Lass, A., Hesselink, M. K. & Schrauwen, P., May 2014, In : Diabetes. 63, 5, p. 1583-1593 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
2013

Blocking the entrance to open the gate

Schrauwen, P., Timmers, S. & Hesselink, M. K. C., Mar 2013, In : Diabetes. 62, 3, p. 703-705 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

1 Citation (Scopus)