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Research Output 1998 2019

  • 106 Article
  • 1 Conference Abstract/Poster in journal
  • 1 Comment/Letter to the editor

Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults

15 Oct 2019, In : Biological Psychiatry. 86, 8, p. 599-607 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Incidence of cardiovascular disease in familial combined hyperlipidemia: A 15-year follow-up study

Luijten, J., van Greevenbroek, M. M. J., Schaper, N. C., Meex, S. J. R., van der Steen, C., Meijer, L. J., de Boer, D., de Graaf, J., Stehouwer, C. D. A. & Brouwers, M. C. G. J., Jan 2019, In : Atherosclerosis. 280, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

Onderwater, G. L. J., Ligthart, L., Bot, M., Demirkan, A., Fu, J., van der Kallen, C. J. H., Vijfhuizen, L. S., Pool, R., Liu, J., Vanmolkot, F. H. M., Beekman, M., Wen, K., Amin, N., Thesing, C. S., Pijpers, J. A., Kies, D. A., Zielman, R., de Boer, I., van Greevenbroek, M. M. J., Arts, I. C. W. & 16 others, Milaneschi, Y., Schram, M. T., Dagnelie, P. C., Franke, L., Ikram, M. A., Ferrari, M. D., Goeman, J. J., Slagboom, P. E., Wijmenga, C., Stehouwer, C. D. A., Boomsma, D. I., van Duijn, C. M., Penninx, B. W., 't Hoen, P. A. C., Terwindt, G. M. & van den Maagdenberg, A. M. J. M., 16 Apr 2019, In : Neurology. 92, 16, p. E1899-E1911 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M-J., Franke, L., Frayling, T. & 30 others, Gharib, S. A., Gibson, G., Heijmans, B. T., Hemani, G., Jansen, R., Kahonen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg-Guzman, J., Kukushkina, V., Lee, B., Lehtimaki, T., Loeffler, M., Marigorta, U. M., Mei, H., Milani, L., Montgomery, G. W., Mueler-Nurasyid, M., Nauck, M., Stehouwer, C. D. A., Isaacs, A., Schalkwijk, C. G., Stehouwer, C. D. A., van der Kallen, C. J. H. & van Greevenbroek, M. M. J., 24 Jul 2019, In : Nature Communications. 10, 12 p., 3300.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Plasma lipid profiling of tissue-specific insulin resistance in human obesity

May 2019, In : International Journal of Obesity. 43, 5, p. 989-998 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Skewed X-inactivation is common in the general female population

Shvetsova, E., Sofronova, A., Monajemi, R., Gagalova, K., Draisma, H. H. M., White, S. J., Santen, G. W. E., Lopes, S. M. C. D. S., Heijmans, B. T., van Meurs, J., Jansen, R., Franke, L., Kielbasa, S. M., den Dunnen, J. T., 't Hoen, P. A. C., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Van Greevenbroek, M. M. J. & 30 others, Da Stehouwer, C., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., Isaacs, A., van Dijk, F., Li, M., Isaacs, A., Cox, D. R., Li, Y., Chen, R., Li, N., Wang, J. & van Ommen, G. J., Mar 2019, In : European Journal of Human Genetics. 27, 3, p. 455-465 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans

van der Kolk, B. W., Kalafati, M., Adriaens, M., van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., Astrup, A., Valsesia, A., Langin, D., van der Kallen, C. J. H., Eussen, S. J. P. M., Schalkwijk, C. G., Stehouwer, C. D. A., Goossens, G. H., Arts, I. C. W., Jocken, J. W. E., Evelo, C. T. & Blaak, E. E., Dec 2019, In : Diabetes. 68, 12, p. 2247-2258 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Abdominal subcutaneous adipose tissue gene expression in relation to tissue-specific insulin resistance in human obesity

Oct 2018, In : Diabetologia. 61, p. S110-S110 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

A SNP panel for identification of DNA and RNA specimens

Yousefi, S., Abbassi-Daloii, T., Kraaijenbrink, T., Vermaat, M., Mei, H., van't Hof, P., van Iterson, M., Zhernakova, D. V., Claringbould, A., Franke, L., 't Hart, L. M., Slieker, R. C., van der Heijden, A., de Knijff, P., 't Hoen, P. A. C., Jansen, R., van Meurs, J., Heijmans, B. T., Boomsma, D. I., van Dongen, J. & 44 others, Hottenga, J-J., Slagboom, P. E., Suchiman, H. E. D., van Iterson, M., van Zwet, E. W., 't Hoen, P., Pool, R., van Greevenbroek, M., Stehouwer, C., van der Kallen, C., Schalkwijk, C., Wijmenga, C., Zhernakova, A., Tigchelaar, E. F., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., Bot, J., Zhernakova, D. V., Van't Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Bonder, M. J., van Dijk, F., van Galen, M., Arindrarto, W., Kielbasa, S. M., Swertz, M. A., Isaacs, A. & Franke, L., 25 Jan 2018, In : BMC Genomics. 19, 90, 12 p., 90.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults

Parmar, P., Lowry, E., Cugliari, G., Suderman, M., Wilson, R., Karhunen, V., Andrew, T., Wiklund, P., Wielscher, M., Guarrera, S., Teumer, A., Lehne, B., Milani, L., de Klein, N., Mishra, P. P., Melton, P. E., Mandaviya, P. R., Kasela, S., Nano, J., Zhang, W. & 30 others, Zhang, Y., Uitterlinden, A. G., Peters, A., Schoettker, B., Gieger, C., Anderson, D., Boomsma, D., Grabe, H. J., Panico, S., Veldink, J. H., van Meurs, J. B. J., van den Berg, L., Beilin, L. J., Franke, L., Loh, M., van Greevenbroek, M. M. J., Nauck, M., Kahonen, M., Hurme, M. A., Raitakari, O. T., Franco, O. H., Slagboom, P. E., van der Harst, P., Kunze, S., Felix, S. B., Zhang, T., Chen, W., Mori, T. A., Bonnefond, A. & Heijmans, B. T., Dec 2018, In : EBioMedicine. 38, p. 206-216 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

Luijk, R., Wu, H., Ward-Caviness, C. K., Hannon, E., Carnero-Montoro, E., Min, J. L., Mandaviya, P., Muller-Nurasyid, M., Mei, H., van der Maarel, S. M., Relton, C., Mill, J., Waldenberger, M., Bell, J. T., Jansen, R., Zhernakova, A., Franke, L., 't Hoen, P. A. C., Boomsma, D. I., van Duijn, C. M. & 8 others, van Greevenbroek, M. M. J., Veldink, J. H., Wijmenga, C., van Meurs, J., Daxinger, L., Slagboom, P. E., van Zwet, E. W. & Heijmans, B. T., 14 Sep 2018, In : Nature Communications. 9, 9 p., 3738.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Blood Metabolomic Measures Associate With Present and Future Glycemic Control in Type 2 Diabetes

't Hart, L. M., Vogelzangs, N., Mook-Kanamori, D. O., Brahimaj, A., Nano, J., van der Heijden, A. A. W. A., van Dijk, K. W., Slieker, R. C., Steyerberg, E. W., Ikram, M. A., Beekman, M., Boomsma, D. I., van Duijn, C. M., Slagboom, P. E., Stehouwer, C. D. A., Schalkwijk, C. G., Arts, I. C. W., Dekker, J. M., Dehghan, A., Muka, T. & 3 others, van der Kallen, C. J. H., Nijpels, G. & van Greevenbroek, M. M. J., Dec 2018, In : Journal of Clinical Endocrinology & Metabolism. 103, 12, p. 4569-4579 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies

Wanders, A. J., Alssema, M., De Hoon, S. E. M., Feskens, E. J. M., van Woudenbergh, G. J., van der Kallen, C. J., Zock, P. L., Refsum, H., Drevon, C. A., Elshorbagy, A., Schalkwijk, C. G., Stehouwer, C. D. A., Dekker, J. M. & van Greevenbroek, M. M. J., 1 Jan 2018, In : Annals of Nutrition and Metabolism. 72, 2, p. 117-125 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genome-wide identification of directed gene networks using large-scale population genomics data

Luijk, R., Dekkers, K. F., van Iterson, M., Arindrarto, W., Claringbould, A., Hop, P., Boomsma, D., van Duijn, C. M., van Greevenbroek, M. M. J., Veldink, J. H., Wijmenga, C., Franke, L., 't Hoend, P. A. C., Jansen, R., van Meurs, J., Mei, H., Slagboomi, P. E., Heijmans, B. T. & van Zwet, E. W., 6 Aug 2018, In : Nature Communications. 9, 10 p., 3097.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating classical monocytes are associated with CD11c(+) macrophages in human visceral adipose tissue

Wouters, K., Gaens, K., Bijnen, M., Verboven, K., Jocken, J., Wetzels, S., Wijnands, E., Hansen, D., van Greevenbroek, M., Duijvestijn, A. M., Biessen, E. A. L., Blaak, E. E., Stehouwer, C. D. A. & Schalkwijk, C. G., 15 Feb 2017, In : Scientific Reports. 7, 8 p., 42665.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Disease variants alter transcription factor levels and methylation of their binding sites

Bonder, M. J., Luijk, R., Zhernakova, D. V., Moed, M., Deelen, P., Vermaat, M., van Iterson, M., van Dijk, F., van Galen, M., Bot, J., Slieker, R. C., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Arindrarto, W., Kielbasa, S. M. & 30 others, Jonkers, I., van 't Hof, P., Nooren, I., Beekman, M., Deelen, J., van Heemst, D., Zhernakova, A., Tigchelaar, E. F., Swertz, M. A., Hofman, A., Uitterlinden, A. G., Pool, R., van Dongen, J., Hottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., van den Berg, L. H., van Zwet, E. W., Mei, H., Li, Y., Lemire, M., Hudson, T. J., Slagboom, P. E., Wijmenga, C., Veldink, J. H., van Greevenbroek, M. M. J., van Duijn, C. M., Boomsma, D. I. & Isaacs, A., Jan 2017, In : Nature Genetics. 49, 1, p. 131-138 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

Richard, M. A., Huan, T., Ligthart, S., Gondalia, R., Jhun, M. A., Brody, J. A., Irvin, M. R., Marioni, R., Shen, J., Tsai, P-C., Montasser, M. E., Jia, Y., Syme, C., Salfati, E. L., Boerwinkle, E., Guan, W., Mosley, T. H., Bressler, J., Morrison, A. C., Liu, C. & 30 others, Mendelson, M. M., Uitterlinden, A. G., van Meurs, J. B., Franco, O. H., Zhang, G., Li, Y., Stewart, J. D., Bis, J. C., Psaty, B. M., Chen, Y-D. I., Kardia, S. L. R., Zhao, W., Turner, S. T., Absher, D., Aslibekyan, S., Starr, J. M., Mcrae, A. F., Hou, L., Just, A. C., Schwartz, J. D., Vokonas, P. S., Menni, C., Spector, T. D., Shuldiner, A., Damcott, C. M., Rotter, J. I., van Greevenbroek, M., Stehouwer, C., van der Kallen, C. & Schalkwijk, C., 7 Dec 2017, In : American Journal of Human Genetics. 101, 6, p. 888-902 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

Mandaviya, P. R., Joehanes, R., Aissi, D., Kuehnel, B., Marioni, R. E., Truong, V., Stolk, L., Beekman, M., Bonder, M. J., Franke, L., Gieger, C., Huan, T., Ikram, M. A., Kunze, S., Liang, L., Lindemann, J., Liu, C., McRae, A. F., Mendelson, M. M., Muller-Nurasyid, M. & 18 others, Peters, A., Slagboom, P. E., Starr, J. M., Tregouet, D. -A., Uitterlinden, A. G., van Greevenbroek, M. M. J., van Heemst, D., van Iterson, M., Wells, P. S., Yao, C., Deary, I. J., Gagnon, F., Heijmans, B. T., Levy, D., Morange, P-E., Waldenberger, M., Heil, S. G. & van Meurs, J. B. J., 30 Oct 2017, In : PLOS ONE. 12, 10, 19 p., 0182472.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

Mandaviya, P. R., Aissi, D., Dekkers, K. F., Joehanes, R., Kasela, S., Vinh Truong, Stolk, L., van Heemst, D., Ikram, M. A., Lindemans, J., Slagboom, P. E., Tregouet, D-A., Uitterlinden, A. G., Wei, C., Wells, P., Gagnon, F., van Greevenbroek, M. M. J., Heijmans, B. T., Milani, L., Morange, P-E. & 2 others, van Meurs, J. B. J. & Heil, S. G., Nov 2017, In : Epigenomics. 9, 11, p. 1403-1422 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Identification of context-dependent expression quantitative trait loci in whole blood

Zhernakova, D. V., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F., Westra, H-J., Bonder, M. J., van Rooij, J., Verkerk, M., Jhamai, P. M., Moed, M., Kielbasa, S. M., Bot, J., Nooren, I., Pool, R., van Dongen, J. & 27 others, Hottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Zhernakova, A., Li, Y., Tigchelaar, E. F., de Klein, N., Beekman, M., Deelen, J., van Heemst, D., van den Berg, L. H., Hofman, A., Uitterlinden, A. G., van Greevenbroek, M. M. J., Veldink, J. H., Boomsma, D. I., van Duijn, C. M., Wijmenga, C., Slagboom, P. E., Swertz, M. A., Isaacs, A., van Meurs, J. B. J., Jansen, R., Heijmans, B. T., 't Hoen, P. A. C. & Franke, L., Jan 2017, In : Nature Genetics. 49, 1, p. 139-145 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

Slieker, R. C., van Iterson, M., Luijk, R., Beekman, M., Zhernakova, D. V., Moed, M. H., Mei, H., van Galen, M., Deelen, P., Bonder, M. J., Zhernakova, A., Uitterlinden, A. G., Tigchelaar, E. F., Stehouwer, C. D. A., Schalkwijk, C. G., van der Kallen, C. J. H., Hofman, A., van Heemst, D., de Geus, E. J., van Dongen, J. & 14 others, Deelen, J., van den Berg, L. H., van Meurs, J., Jansen, R., 't Hoen, P. A. C., Franke, L., Wijmenga, C., Veldink, J. H., Swertz, M. A., van Greevenbroek, M. M. J., van Duijn, C. M., Boomsma, D. I., Slagboom, P. E. & Heijmans, B. T., 22 Sep 2016, In : Genome Biology (Online). 17, 191.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Blood lipids influence DNA methylation in circulating cells

Dekkers, K. F., van Iterson, M., Slieker, R. C., Moed, M. H., Bonder, M. J., van Galen, M., Mei, H., Zhernakova, D. V., van den Berg, L. H., Deelen, J., van Dongen, J., van Heemst, D., Hofman, A., Hottenga, J. J., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., Tigchelaar, E. F., Uitterlinden, A. G., Willemsen, G. & 14 others, Zhernakova, A., Franke, L., 't Hoen, P. A. C., Jansen, R., van Meurs, J., Boomsma, D. I., van Duijn, C. M., van Greevenbroek, M. M. J., Veldink, J. H., Wijmenga, C., van Zwet, E. W., Slagboom, P. E., Jukema, J. W. & Heijmans, B. T., 27 Jun 2016, In : Genome Biology (Online). 17, 135.

Research output: Contribution to journalArticleAcademicpeer-review

Comment on Sergeant et al.: Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans

Wanders, A. J., Alssema, M., van Greevenbroek, M. J., Elshorbagy, A., Zock, P. L., Dekker, J. M. & Brouwer, I. A., 14 Jun 2016, In : British Journal of Nutrition. 115, 11, p. 2077-2078

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

1 Citation (Scopus)

Impaired HDL cholesterol efflux in metabolic syndrome is unrelated to glucose tolerance status: the CODAM study

Annema, W., Dikkers, A., de Boer, J. F., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., Dullaart, R. P. F. & Tietge, U. J. F., 8 Jun 2016, In : Scientific Reports. 6, 27367.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

The alternative complement pathway is longitudinally associated with adverse cardiovascular outcomes The CODAM study

Hertle, E., Arts, I. C. W., van der Kallen, C. J. H., Feskens, E. J. M., Schalkwijk, C. G., Stehouwer, C. D. A. & van Greevenbroek, M. M. J., Feb 2016, In : Thrombosis and Haemostasis. 115, 2, p. 446-457 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015
16 Citations (Scopus)
2 Citations (Scopus)

BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies

van Moorsel, D., van Greevenbroek, M. M. J., Schaper, N. C., Henry, R. M. A., Geelen, C. C., van Rossum, E. F. C., Nijpels, G., 't Hart, L. M., Schalkwijk, C. G., van der Kallen, C. J. H., Sauerwein, H. P., Dekker, J. M., Stehouwer, C. D. A. & Havekes, B., 1 Jan 2015, In : European Journal of Endocrinology. 173, 4, p. 455-464

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Iron metabolism is prospectively associated with insulin resistance and glucose intolerance over a 7-year follow-up period: the CODAM study

Wlazlo, N., van Greevenbroek, M. M. J., Ferreira, I., Jansen, E. H. J. M., Feskens, E. J. M., van der Kallen, C. J. H., Schalkwijk, C. G., Bravenboer, B. & Stehouwer, C. D. A., Apr 2015, In : Acta Diabetologica. 52, 2, p. 337-348

Research output: Contribution to journalArticleAcademicpeer-review

2014
7 Citations (Scopus)

A metabolomic profile is associated with the risk of incident coronary heart disease

Vaarhorst, A. A. M., Verhoeven, A., Weller, C. M., Böhringer, S., Göraler, S., Meissner, A., Deelder, A. M., Henneman, P., Gorgels, A. P. M., van den Brandt, P. A., Schouten, L. J., van Greevenbroek, M. M., Merry, A. H. H., Verschuren, W. M. M., van den Maagdenberg, A. M. J. M., van Dijk, K. W., Isaacs, A., Boomsma, D., Oostra, B. A., van Duijn, C. M. & 5 others, Jukema, J. W., Boer, J. M. A., Feskens, E., Heijmans, B. T. & Slagboom, P. E., 1 Jan 2014, In : American Heart Journal. 168, 1, p. 45-52.e7

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)