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Research Output 2005 2019

2019

ADAM8 in the cardiovascular system: An innocent bystander with clinical use?

van der Vorst, E. P. C. & Donners, M. M. P. C., Jul 2019, In : Atherosclerosis. 286, p. 147-149 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis

Mentrup, T., Theodorou, K., Cabrera-Cabrera, F., Hethig, A. O., Happ, K., Gijbels, M., Gradtke, A-C., Rabe, B., Fukumori, A., Steiner, H., Tholey, A., Fluhrer, R., Donners, M. & Schroeder, B., Apr 2019, In : Journal of Experimental Medicine. 216, 4, p. 807-830 24 p.

Research output: Contribution to journalArticleAcademicpeer-review

Message in a Microbottle: Modulation of Vascular Inflammation and Atherosclerosis by Extracellular Vesicles

van der Vorst, E. P. C., de Jong, R. J. & Donners, M. M. P. C., 22 Jan 2018, In : Frontiers in cardiovascular medicine. 5, 8 p., 2.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects

Baaten, C. C. F. M. J., Swieringa, F., Misztal, T., Mastenbroek, T. G., Feijge, M. A. H., Bock, P. E., Donners, M. M. P. C., Collins, P. W., Li, R., van der Meijden, P. E. J. & Heemskerk, J. W. M., 25 Sep 2018, In : Blood advances. 2, 18, p. 2320-2331 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Disease- or Storage-Associated Structural Modifications Are Unlikely to Explain HDL Pro-inflammatory Effects on Macrophages

van der Vorst, E. P. C., Theodorou, K., Biessen, E. A. L. & Donners, M. M. P. C., 5 Jul 2017, In : Cell Metabolism. 26, 1, p. 4-5 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases

Dreymueller, D., Theodorou, K., Donners, M. & Ludwig, A., 2017, In : Mediators of Inflammation. 2017, 22 p., 9621724.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-kappa B/STAT1-IRF1 Signaling

van der Vorst, E. P. C., Theodorou, K., Wu, Y., Hoeksema, M. A., Goossens, P., Bursill, C. A., Aliyev, T., Huitema, L. F. A., Tas, S. W., Wolfs, I. M. J., Kuijpers, M. J. E., Gijbels, M. J., Schalkwijk, C. G., Koonen, D. P. Y., Abdollahi-Roodsaz, S., McDaniels, K., Wang, C-C., Leitges, M., Lawrence, T., Plat, J. & 6 others, Van Eck, M., Rye, K-A., Touqui, L., de Winther, M. P. J., Biessen, E. A. L. & Donners, M. M. P. C., 10 Jan 2017, In : Cell Metabolism. 25, 1, p. 197-207 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression

Theodorou, K., van der Vorst, E. P. C., Gijbels, M. J., Wolfs, I. M. J., Jeurissen, M., Theelen, T. L., Sluimer, J. C., Wijnands, E., Cleutjens, J. P., Li, Y., Jansen, Y., Weber, C., Ludwig, A., Bentzon, J. F., Bartsch, J. W., Biessen, E. A. L. & Donners, M. M. P. C., 15 Sep 2017, In : Scientific Reports. 7, 11 p., 11670.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
6 Citations (Scopus)

ADAM17 controls IL-6 signaling by cleavage of the murine IL-6R alpha from the cell surface of leukocytes during inflammatory responses

Yan, I., Schwarz, J., Luecke, K., Schumacher, N., Schumacher, V., Schmidt, S., Rabe, B., Saftig, P., Donners, M., Rose-John, S., Mittruecker, H-W. & Chalaris, A., May 2016, In : Journal of Leukocyte Biology. 99, 5, p. 749-760

Research output: Contribution to journalArticleAcademicpeer-review

Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE(-/-) Mice

Donners, M. M. P. C., Bai, L., Lutgens, S., Wijnands, E., Johnson, J., Schurgers, L. J., Liu, C-L., Daemen, M., Cleutjens, K. B. J. M., Shi, G-P., Biessen, E. A. L. & Heeneman, S., 16 Sep 2016, In : PLOS ONE. 11, 9, e0162595.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

High density lipoproteins exert pro-inflammatory effects on macrophages via passive cholesterol depletion and PKC-NF-kB/STAT1-IRF1 signaling

Van der Vorst, E. P. C., Theodorou, K., Hoeksema, M. A., Wu, Y., Goossens, P., Van Eck, M., Rye, K-A., De Winther, M. P. J., Biessen, E. A. L. & Donners, M. M. P., 1 Jul 2016, In : Cardiovascular Research. 111, p. S10-S10

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr(-/-) mice

Jeurissen, M. L. J., Walenbergh, S. M. A., Houben, T., Gijbels, M. J. J., Li, J., Hendrikx, T., Oligschläger, Y., van Gorp, P. J., Binder, C. J., Donners, M. M. P. C. & Shiri-Sverdlov, R., Dec 2016, In : Atherosclerosis. 255, p. 59-65

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
5 Citations (Scopus)

Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development in Ldlr(-/-) mice

Hendrikx, T., Jeurissen, M. L. J., van Gorp, P. J., Gijbels, M. J., Walenbergh, S. M. A., Houben, T., van Gorp, R., Pottgens, C. C., Stienstra, R., Netea, M. G., Hofker, M., Donners, M. M. & Shiri-Sverdlov, R., 1 Jan 2015, In : FEBS Journal. 282, 12, p. 2327-2338

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Myeloid A Disintegrin and Metalloproteinase Domain 10 Deficiency Modulates Atherosclerotic Plaque Composition by Shifting the Balance from Inflammation toward Fibrosis

van der Vorst, E. P. C., Jeurissen, M., Wolfs, I. M. J., Keijbeck, A., Theodorou, K., Wijnands, E., Schurgers, L., Weber, S., Gijbels, M. J., Hamers, A. A. J., Dreymueller, D., Rose-John, S., de Winther, M. P. J., Ludwig, A., Saftig, P., Biessen, E. A. L. & Donners, M. M. P. C., Apr 2015, In : American Journal of Pathology. 185, 4, p. 1145-1155

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase beta, and Not Via CD40 and I kappa B Kinase alpha

Kuijpers, M. J. E., Mattheij, N. J. A., Cipolla, L., van Geffen, J. P., Lawrence, T., Donners, M. M. P. C., Boon, L., Lievens, D., Torti, M., Noels, H., Gerdes, N., Cosemans, J. M. E. M., Lutgens, E. & Heemskerk, J. W. M., Jun 2015, In : Arteriosclerosis Thrombosis and Vascular Biology. 35, 6, p. 1374-1381

Research output: Contribution to journalArticleAcademicpeer-review

2014
86 Citations (Scopus)

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo

Jetten, N., Verbruggen, S., Gijbels, M. J., Post, M. J., De Winther, M. P. J. & Donners, M. M. P. C., Jan 2014, In : Angiogenesis. 17, 1, p. 109-118

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space

Pruessmeyer, J., Hess, F. M., Alert, H., Groth, E., Pasqualon, T., Schwarz, N., Nyamoya, S., Kollert, J., van der Vorst, E., Donners, M., Martin, C., Uhlig, S., Saftig, P., Dreymueller, D. & Ludwig, A., 26 Jun 2014, In : Blood. 123, 26, p. 4077-4088

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

Reprogramming macrophages to an anti-inflammatory phenotype by helminth antigens reduces murine atherosclerosis

Wolfs, I. M. J., Stoger, J. L., Goossens, P., Pottgens, C., Gijbels, M. J. J., Wijnands, E., van der Vorst, E. P. C., van Gorp, P., Beckers, L., Engel, D., Biessen, E. A. L., Kraal, G., van Die, I., Donners, M. M. P. C. & de Winther, M. P. J., Jan 2014, In : Faseb Journal. 28, 1, p. 288-299

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis

Marsch, E., Theelen, T. L., Demandt, J. A., Jeurissen, M., van Gink, M., Verjans, R., Janssen, A., Cleutjens, J. P., Meex, S. J., Donners, M. M., Haenen, G., Schalkwijk, C. G., Dubois, L. J., Lambin, P., Mallat, Z., Gijbels, M. J., Heemskerk, J. W., Fisher, E. A., Biessen, E. A., Janssen, B. J. & 2 others, Daemen, M. J. & Sluimer, J. C., 1 Jan 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 12, p. 2545-2553

Research output: Contribution to journalArticleAcademicpeer-review

2013
14 Citations (Scopus)

Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells

Schutters, K., Kusters, D. H. M., Chatrou, M. L. L., Montero-Melendez, T., Donners, M., Deckers, N. M., Krysko, D. V., Vandenabeele, P., Perretti, M., Schurgers, L. J. & Reutelingsperger, C. P. M., Jan 2013, In : Cell Death and Differentiation. 20, 1, p. 49-56

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Local Delivery of Polarized Macrophages Improves Reperfusion Recovery in a Mouse Hind Limb Ischemia Model

Jetten, N., Donners, M. M. P. C., Wagenaar, A., Cleutjens, J. P. M., van Rooijen, N., de Winther, M. P. J. & Post, M. J., 24 Jul 2013, In : PLOS ONE. 8, 7, e68811.

Research output: Contribution to journalArticleAcademicpeer-review

2012

A disintegrin and metalloproteases: Molecular scissors in angiogenesis, inflammation and atherosclerosis

van der Vorst, E. P. C., Keijbeck, A. A., de Winther, M. P. J. & Donners, M. M. P. C., Oct 2012, In : Atherosclerosis. 224, 2, p. 302-308

Research output: Contribution to journalArticleAcademicpeer-review

73 Citations (Scopus)

Hematopoietic miR155 Deficiency Enhances Atherosclerosis and Decreases Plaque Stability in Hyperlipidemic Mice

Donners, M. M. P. C., Wolfs, I. M. J., Stoger, L. J., van der Vorst, E. P. C., Pottgens, C. C. H., Heymans, S., Schroen, B., Gijbels, M. J. J. & de Winther, M. P. J., 25 Apr 2012, In : PLOS ONE. 7, 4, e35877.

Research output: Contribution to journalArticleAcademicpeer-review

2011

Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation

Wolfs, I. M. J., Donners, M. M. P. C. & de Winther, M. P. J., Nov 2011, In : Thrombosis and Haemostasis. 106, 5, p. 763-771

Research output: Contribution to journalArticleAcademicpeer-review

2010

A Disintegrin and Metalloprotease 10 Is a Novel Mediator of Vascular Endothelial Growth Factor: Induced Endothelial Cell Function in Angiogenesis and Is Associated With Atherosclerosis

Donners, M. P. C., Wolfs, I. M. J., Olieslagers, S., Mohammadi-Motahhari, Z., Tchaikovski, V., Heeneman, S., van Buul, J. D., Caolo, V., Molin, D. G. M., Post, M. J. & Waltenberger, J., Nov 2010, In : Arteriosclerosis Thrombosis and Vascular Biology. 30, 11, p. 2188-U382

Research output: Contribution to journalArticleAcademicpeer-review

Feed-forward Signaling by Membrane-bound Ligand Receptor Circuit THE CASE OF NOTCH DELTA-LIKE 4 LIGAND IN ENDOTHELIAL CELLS

Caolo, V., van den Akker, N. M. S., Verbruggen, S., Donners, M. M. P. C., Swennen, G., Schulten, H., Waltenberger, J., Post, M. J. & Molin, D. G. M., 24 Dec 2010, In : Journal of Biological Chemistry. 285, 52, p. 40681-40689

Research output: Contribution to journalArticleAcademicpeer-review

2005
197 Downloads (Pure)
Open Access
File
45 Citations (Scopus)

Proteomic analysis of differential protein expression in human atherosclerotic plaque progression

Donners, M. M. P. C., Verluyten, M. J., Bouwman, F. G., Mariman, E. C., Devreese, B., Vanrobaeys, F., van Beeumen, J., van den Akker, L. H., Daemen, M. J. & Heeneman, S., 1 Jan 2005, In : Journal of Pathology. 206, 1, p. 39-45

Research output: Contribution to journalArticleAcademicpeer-review