19972018

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Article
2018

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding

Baaten, C. C. F. M. J., Meacham, S., de Witt, S. M., Feijge, M. A. H., Adams, D. J., Akkerman, J-W. N., Cosemans, J. M. E. M., Grassi, L., Jupe, S., Kostadima, M., Mattheij, N. J. A., Prins, M. H., Ramirez-Solis, R., Soehnlein, O., Swieringa, F., Weber, C., White, J. K., Ouwehand, W. H. & Heemskerk, J. W. M., 13 Dec 2018, In : Blood. 132, 24, p. E35-E46 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects

Baaten, C. C. F. M. J., Swieringa, F., Misztal, T., Mastenbroek, T. G., Feijge, M. A. H., Bock, P. E., Donners, M. M. P. C., Collins, P. W., Li, R., van der Meijden, P. E. J. & Heemskerk, J. W. M., 25 Sep 2018, In : Blood advances. 2, 18, p. 2320-2331 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Suppressive Role of Tissue Factor Pathway Inhibitor-alpha in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength

Thomassen, S., Mastenbroek, T. G., Swieringa, F., Winckers, K., Feijge, M. A. H., Schrijver, R., Cosemans, J. M. E. M., Maroney, S. A., Mast, A. E., Hackeng, T. M. & Heemskerk, J. W. M., 1 Mar 2018, In : Thrombosis and Haemostasis. 118, 3, p. 502-513 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Happy Despite Pain A Randomized Controlled Trial of an 8-Week Internet-delivered Positive Psychology Intervention for Enhancing Well-being in Patients With Chronic Pain

Peters, M. L., Smeets, E., Feijge, M., van Breukelen, G., Andersson, G., Buhrman, M. & Linton, S. J., Nov 2017, In : Clinical Journal of Pain. 33, 11, p. 962-975

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015

Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding

Swieringa, F., Lance, M. D., Fuchs, B., Feijge, M. A. H., Solecka, B. A., Verheijen, L. P. J., Hughes, K. R., Van Oerle, R., Deckmyn, H., Kannicht, C., Heemskerk, J. W. M. & Van der Meijden, P. E. J., Aug 2015, In : Journal of Thrombosis and Haemostasis. 13, 8, p. 1503-1513

Research output: Contribution to journalArticleAcademicpeer-review

Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity

Mastenbroek, T. G., Feijge, M. A. H., Kremers, R. M. W., van den Bosch, M. T. J., Swieringa, F., De Groef, L., Moons, L., Bennett, C., Ghevaert, C., Johnson, J. L., van der Meijden, P. E. J. & Cosemans, J. M. E. M., Dec 2015, In : Arteriosclerosis Thrombosis and Vascular Biology. 35, 12, p. 2554-2561

Research output: Contribution to journalArticleAcademicpeer-review

2014

Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation

Muenzer, P., Borst, O., Walker, B., Schmid, E., Feijge, M. A. H., Cosemans, J. M. E. M., Chatterjee, M., Schmidt, E-M., Schmidt, S., Towhid, S. T., Leibrock, C., Elvers, M., Schaller, M., Seizer, P., Ferlinz, K., May, A. E., Gulbins, E., Heemskerk, J. W. M., Gawaz, M. & Lang, F., Jan 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 1, p. 61-+

Research output: Contribution to journalArticleAcademicpeer-review

Additive roles of platelets and fibrinogen in whole-blood fibrin clot formation upon dilution as assessed by thromboelastometry

Ninivaggi, M., Feijge, M. A. H., Baaten, C. C. F. M. J., Kuiper, G. J. A. J. M., Marcus, M. A. E., ten Cate, H., Lance, M. D., Heemskerk, J. W. M. & van der Meijden, P. E. J., Mar 2014, In : Thrombosis and Haemostasis. 111, 3, p. 447-457

Research output: Contribution to journalArticleAcademicpeer-review

Factor XII Regulates the Pathological Process of Thrombus Formation on Ruptured Plaques

Kuijpers, M. J. E., van der Meijden, P. E. J., Feijge, M. A. H., Mattheij, N. J. A., May, F., Govers-Riemslag, J., Meijers, J. C. M., Heemskerk, J. W. M., Renne, T. & Cosemans, J. M. E. M., Aug 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 8, p. 1674-+

Research output: Contribution to journalArticleAcademicpeer-review

2013

Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors.

Nergiz-Unal, R., Kuijpers, M. J. E., de Witt, S. M., Heeneman, S., Feijge, M. A. H., Garcia Caraballo, S., Biessen, E. A., Haenen, G. R. M. M., Cosemans, J. M. & Heemskerk, J. W., 1 Jan 2013, In : Thrombosis Research. 131, 5, p. 411-417

Research output: Contribution to journalArticleAcademicpeer-review

Both TMEM16F-dependent and TMEM16F-independent pathways contribute to phosphatidylserine exposure in platelet apoptosis and platelet activation

van Kruchten, R., Mattheij, N. J. A., Saunders, C., Feijge, M. A. H., Swieringa, F., Wolfs, J. L. N., Collins, P. W., Heemskerk, J. W. M. & Bevers, E. M., 7 Mar 2013, In : Blood. 121, 10, p. 1850-1857

Research output: Contribution to journalArticleAcademicpeer-review

Platelet Dysfunction in Thrombosis Patients Treated with Vitamin K Antagonists and Recurrent Bleeding

van der Meijden, P. E. J., Bouman, A. C., Feijge, M. A. H., van Oerle, R., Spronk, H. M. H., Hamulyak, K., ten Cate-Hoek, A. J., ten Cate, H. & Heemskerk, J. W. M., 28 May 2013, In : PLOS ONE. 8, 5

Research output: Contribution to journalArticleAcademicpeer-review

2012

Antithrombotic Potential of Blockers of Store-Operated Calcium Channels in Platelets

van Kruchten, R., Braun, A., Feijge, M. A. H., Kuijpers, M. J. E., Rivera-Galdos, R., Kraft, P., Stoll, G., Kleinschnitz, C., Bevers, E. M., Nieswandt, B. & Heemskerk, J. W. M., Jul 2012, In : Arteriosclerosis Thrombosis and Vascular Biology. 32, 7, p. 1717-1723

Research output: Contribution to journalArticleAcademicpeer-review

Key role of integrin alpha(IIb)beta(3) signaling to Syk kinase in tissue factor-induced thrombin generation

van der Meijden, P. E. J., Feijge, M. A. H., Swieringa, F., Gilio, K., Nergiz-Unal, R., Hamulyak, K. & Heemskerk, J. W. M., Oct 2012, In : Cellular and Molecular Life Sciences. 69, 20, p. 3481-3492

Research output: Contribution to journalArticleAcademicpeer-review

Perioperative dilutional coagulopathy treated with fresh frozen plasma and fibrinogen concentrate: a prospective randomized intervention trial

Lance, M. D., Ninivaggi, M., Schols, S. E. M., Feijge, M. A. H., Oehrl, S. K., Kuiper, G. J. A. J. M., Nikiforou, M., Marcus, M. A. E., Hamulyak, K., van Pampus, E. C. M., ten Cate, H. & Heemskerk, J. W. M., Jul 2012, In : Vox Sanguinis. 103, 1, p. 25-34

Research output: Contribution to journalArticleAcademicpeer-review

2011

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow

Cosemans, J. M. E. M., Schols, S. E. M., Stefanini, L., de Witt, S., Feijge, M. A. H., Hamulyak, K., Deckmyn, H., Bergmeier, W. & Heemskerk, J. W. M., 13 Jan 2011, In : Blood. 117, 2, p. 651-660

Research output: Contribution to journalArticleAcademicpeer-review

Microparticles from apoptotic platelets promote resident macrophage differentiation

Vasina, E. M., Cauwenberghs, S., Feijge, M. A. H., Heemskerk, J. W. M., Weber, C. & Koenen, R. R., Sep 2011, In : Cell Death & Disease. 2, p. 10

Research output: Contribution to journalArticleAcademicpeer-review

Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y(12) antagonist ticagrelor

Kuijpers, M. J. E., Megens, R. T. A., Nikookhesal, E., Feijge, M. A. H., De Mey, J. G. R., Egbrink, M. G. A. O., van Giezen, J. J. J. & Heemskerk, J. W. M., Dec 2011, In : Thrombosis and Haemostasis. 106, 6, p. 1179-1188

Research output: Contribution to journalArticleAcademicpeer-review

2010

Impaired thrombin generation and fibrin clot formation in patients with dilutional coagulopathy during major surgery

Schols, S. E. M., Lance, M. D., Feijge, M. A. H., Damoiseaux, J., Marcus, M. A., Hamulyak, K., ten Cate, H., Heemskerk, J. W. M. & van Pampus, E. C. M., Feb 2010, In : Thrombosis and Haemostasis. 103, 2, p. 318-328

Research output: Contribution to journalArticleAcademicpeer-review

Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation

Gilio, K., van Kruchten, R., Braun, A., Berna-Erro, A., Feijge, M. A. H., Stegner, D., van der Meijden, P. E. J., Kuijpers, M. J. E., Varga-Szabo, D., Heemskerk, J. W. M. & Nieswandt, B., 30 Jul 2010, In : Journal of Biological Chemistry. 285, 31, p. 23629-23638

Research output: Contribution to journalArticleAcademicpeer-review

Stabilizing Role of Platelet P2Y(12) Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques

Nergiz-Unal, R., Cosemans, J. M. E. M., Feijge, M. A. H., van der Meijden, P. E. J., Storey, R. F., van Giezen, J. J. J., Egbrink, M. G. A. O., Heemskerk, J. W. M. & Kuijpers, M. J. E., 12 Apr 2010, In : PLOS ONE. 5, 4, p. 13

Research output: Contribution to journalArticleAcademicpeer-review

2008

Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice.

Vanschoonbeek, K., Wouters, K., van der Meijden, P. E., van Gorp, P. J. J., Feijge, M. A., Herfs, M., Schurgers, L. J., Hofker, M. H., de Maat, M. P. & Heemskerk, J. W., 1 Jan 2008, In : Arteriosclerosis Thrombosis and Vascular Biology. 28, 11, p. 2023-2029

Research output: Contribution to journalArticleAcademicpeer-review

2007

Plasma Triacylglycerol and Coagulation Factor Concentrations Predict the Anticoagulant Effect of Dietary Fish Oil in Overweight Subjects

Vanschoonbeek, K., Feijge, M. A., Saris, W. H., de Maat, M. P. M. & Heemskerk, J. W., 1 Jan 2007, In : Journal of Nutrition. 137, 1, p. 7-13

Research output: Contribution to journalArticleAcademicpeer-review

2006

Plasma ectonucleotidases prevent desensitization of purinergic receptors in stored platelets: importance for platelet activity during thrombus formation

Cauwenberghs, S., Feijge, M. A., Hageman, G., Hoylaerts, M., Akkerman, J. W., Curvers, J. & Heemskerk, J. W., 1 Jan 2006, In : Transfusion. 46, 6, p. 1018-1028

Research output: Contribution to journalArticleAcademicpeer-review

2005

Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk

van der Meijden, P. E. J., Feijge, M. A. H., Giesen, P. L. A., Huijberts, M. S. P., van Raak, L. P. & Heemskerk, J. W., 1 Jan 2005, In : Thrombosis and Haemostasis. 93, 6, p. 1128-1136

Research output: Contribution to journalArticleAcademicpeer-review

2004

Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: Subject-dependent variation in thrombogram characteristics

Vanschoonbeek, K., Feijge, M. A. H., van Kampen, R. J. . W., Kenis, H., Hemker, H. C., Giesen, P. L. A. & Heemskerk, J. W. M., 2004, In : Journal of Thrombosis and Haemostasis. 2, 3, p. 476-484 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generation

Vanschoonbeek, K., Feijge, M. A. H., Paquay, M., Rosing, J., Saris, W., Kluft, C., Giesen, P. L. A., de Maat, M. P. M. & Heemskerk, J. W., 1 Jan 2004, In : Arteriosclerosis Thrombosis and Vascular Biology. 24, 9, p. 1734-1740

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2002

Irregular spiking in free calcium concentration in single, human platelets. Regulation by modulation of the inositol trisphosphate receptors

van Gorp Beisser, R. M. A., Feijge, M. A. H., Vuist, M. W. J., Rook, M. B. & Heemskerk, J. W. M., 1 Jan 2002, In : European Journal of Biochemistry. 269, 5, p. 1543-1552 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin-induced Hyperactivity of Platelets of Young Stroke Patients

Vanschoonbeek, K., Feijge, M. A. H., Keuren, J. F. W., Hemker, H. C., Lodder, J., Hamulyak, K., van Pampus, E. C. M. & Heemskerk, J. W. M., 1 Jan 2002, In : Thrombosis and Haemostasis. 88, 6, p. 931-937 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2001

Modulation of rat platelet activation by vessel wall-derived prostaglandin and platelet-derived thromboxane: effects of dietary fish oil on thromboxane-prostaglandin balance

Nieuwenhuys, C. M. A., Feijge, M. A. H., Offermans, R., Kester, A. D. M., Hornstra, G. & Heemskerk, J. W. M., 1 Jan 2001, In : Atherosclerosis. 154, p. 355-366 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Platelet adhesion enhances the glycoprotein VI-dependent procoagulant response: Involvement of p38 MAP kinase and calpain.

Siljander, P. R. M., Farndale, R. W., Feijge, M. A. H., Comfurius, P., Kos, S., Bevers, E. M. & Heemskerk, J. W. M., 1 Jan 2001, In : Arteriosclerosis Thrombosis and Vascular Biology. 21, p. 618-627 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin K-dependent and vitamin K-independent hypocoagulant effects of dietary fish oil in rats

Nieuwenhuys, C. M. A., Feijge, M. A. H., Vermeer, C., Hennissen, A. A. H. M., Béguin, S. & Heemskerk, J. W. M., 1 Jan 2001, In : Thrombosis Research. 104, p. 137-147 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2000

alpha2A-Adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels

Keularts, I. M. L. W., van Gorp Beisser, R. M. A., Feijge, M. A. H., Vuist, M. W. J. & Heemskerk, J. W. M., 1 Jan 2000, In : Journal of Biological Chemistry. 275, 3, p. 1763-1772 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Monitoring hypocoagulant conditions in rat plasma: factors determining the endogenous thrombin potential of tissue factor-activated plasma

Nieuwenhuys, C. M. A., Feijge, M. A. H., Béguin, S. & Heemskerk, J. W. M., 1 Jan 2000, In : Thrombosis and Haemostasis. 84, 6, p. 1045-1051 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

1999

The procoagulant effect of thrombin on fibrin(ogen)-bound platelets.

Sanders, M. W., Nieuwenhuys, C. M. A., Feijge, M. A. H., Rook, M. B., Béguin, S. & Heemskerk, J. W. M., 1 Jan 1999, In : Haemostasis. 28, 6, p. 289-300 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

1998

Contribution of thromboxane and endomembrane Ca2+-ATPases to variability in Ca2+ signalling of platelets from healthy volunteers.

Feijge, M. A. H., Lacabaratz-Porret, C., van Pampus, E. C. M., Hamulyak, K., Lévy-Toledano, S., Enouf, J. & Heemskerk, J. W. M., 1 Jan 1998, In : Platelets. 9, 3-4, p. 179-184 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inter-individual variability in Ca2+ signalling in platelets from healthy volunteers: effects of aspirin and relationship with expression of endomembrane Ca2+-ATPases.

Feijge, M. A. H., van Pampus, E. C. M., Lacabaratz-Porret, C., Hamulyak, K., Lévy-Toledano, S., Enouf, J. & Heemskerk, J. W. M., 1 Jan 1998, In : British Journal of Haematology. 102, 3, p. 850-859 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Human platelet activation is inhibited upstream of the activation of phospholipase A2 by U73343.

Heemskerk, J. W. M., Feijge, M. A. H., Sage, S. O. & Farndale, R. W., 1 Jan 1997, In : Biochemical Pharmacology. 53, 9, p. 1257-1262 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Kinetics of store-operated Ca2+ influx evoked by endomembrane Ca2+-ATPase inhibitors in human platelets.

Vuist, M. W. J., Feijge, M. A. H. & Heemskerk, J. W. M., 1 Jan 1997, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 57, 4-5, p. 447-450 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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