No photo of Marijke Kuijpers
  • Universiteitssingel50, UNS50

    6229 ER Maastricht

    Netherlands

20062019

Research output per year

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Research Output

2019

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

Nagy, M., van Geffen, J. P., Stegner, D., Adams, D. J., Braun, A., de Witt, S. M., Elvers, M., Geer, M. J., Kuijpers, M. J. E., Kunzelmann, K., Mori, J., Oury, C., Pircher, J., Pleines, I., Poole, A. W., Senis, Y. A., Verdoold, R., Weber, C., Nieswandt, B., Heemskerk, J. W. M. & 1 others, Baaten, C. C. F. M. J., 30 Jul 2019, In : Frontiers in cardiovascular medicine. 6, 15 p., 99.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

van Geffen, A., Brouns, S., Batista, J., McKinney, H., Kempster, C., Nagy, M., Sivapalaratnam, S., Baaten, C., Bourry, N., Frontini, M., Jurk, K., Krause, M., Pilliteri, D., Swieringa, F., Verdoold, R., Cavill, R., Kuijpers, M., Ouwehand, W. H., Downes, K. & Heemskerk, J., 31 May 2019, In : Haematologica-the Hematology Journal. 104, 6, p. 1256-1267 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Platelets: the holy grail in cancer blood biomarker research?

Sabrkhany, S., Kuijpers, M. J. E., Griffioen, A. W. & Egbrink, M. G. A. O., Feb 2019, In : Angiogenesis. 22, 1, p. 1-2 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice

Kiouptsi, K., Jaeckel, S., Pontarollo, G., Grill, A., Kuijpers, M. J. E., Wilms, E., Weber, C., Sommer, F., Nagy, M., Neideck, C., Jansen, Y., Ascher, S., Formes, H., Karwot, C., Bayer, F., Kollar, B., Subramaniam, S., Molitor, M., Wenzel, P., Rosenstiel, P. & 8 others, Todorov, H., Gerber, S., Walter, U., Jurk, K., Heemskerk, J. W. M., van der Vorst, E. P. C., Doering, Y. & Reinhardt, C., 2019, In : Mbio. 10, 5, 16 p., e02298-19.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice

Hofmann, I., Geer, M. J., Vogtle, T., Crispin, A., Campagna, D. R., Barr, A., Calicchio, M. L., Heising, S., van Geffen, J. P., Kuijpers, M. J. E., Heemskerk, J. W. M., Eble, J. A., Schmitz-Abe, K., Obeng, E. A., Douglas, M., Freson, K., Pondarre, C., Favier, R., Jarvis, G. E., Markianos, K. & 5 others, Turro, E., Ouwehand, W. H., Mazharian, A., Fleming, M. D. & Senis, Y. A., 27 Sep 2018, In : Blood. 132, 13, p. 1399-1412 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Exploration of the platelet proteome in patients with early-stage cancer

Sabrkhany, S., Kuijpers, M. J. E., Knol, J. C., Damink, S. W. M. O., Dingemans, A-M. C., Verheul, H. M., Piersma, S. R., Pham, T. V., Griffioen, A. W., Egbrink, M. G. A. O. & Jimenez, C. R., 15 Apr 2018, In : Journal of Proteomics. 177, p. 65-74 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148

Mori, J., Nagy, Z., Di Nunzio, G., Smith, C. W., Geer, M. J., Al Ghaithi, R., van Geffen, J. P., Heising, S., Boothman, L., Tullemans, B. M. E., Correia, J. N., Tee, L., Kuijpers, M. J. E., Harrison, P., Heemskerk, J. W. M., Jarvis, G. E., Tarakhovsky, A., Weiss, A., Mazharian, A. & Senis, Y. A., 8 Mar 2018, In : Blood. 131, 10, p. 1122-1144 23 p.

Research output: Contribution to journalArticleAcademicpeer-review

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

Geer, M. J., van Geffen, J. P., Gopalasingam, P., Vogtle, T., Smith, C. W., Heising, S., Kuijpers, M. J. E., Tullemans, B. M. E., Jarvis, G. E., Eble, J. A., Jeeves, M., Overduin, M., Heemskerk, J. W. M., Mazharian, A. & Senis, Y. A., 27 Sep 2018, In : Blood. 132, 13, p. 1413-1425 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

A combination of platelet features allows detection of early-stage cancer

Sabrkhany, S., Kuijpers, M. J. E., van Kuijk, S. M. J., Sanders, L., Pineda, S., Damink, S. W. M. O., Dingemans, A-M. C., Griffioen, A. W. & Egbrink, M. G. A. O., Jul 2017, In : European Journal of Cancer. 80, p. 5-13 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-kappa B/STAT1-IRF1 Signaling

van der Vorst, E. P. C., Theodorou, K., Wu, Y., Hoeksema, M. A., Goossens, P., Bursill, C. A., Aliyev, T., Huitema, L. F. A., Tas, S. W., Wolfs, I. M. J., Kuijpers, M. J. E., Gijbels, M. J., Schalkwijk, C. G., Koonen, D. P. Y., Abdollahi-Roodsaz, S., McDaniels, K., Wang, C-C., Leitges, M., Lawrence, T., Plat, J. & 6 others, Van Eck, M., Rye, K-A., Touqui, L., de Winther, M. P. J., Biessen, E. A. L. & Donners, M. M. P. C., 10 Jan 2017, In : Cell Metabolism. 25, 1, p. 197-207 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes

Gerdes, N., Seijkens, T., Lievens, D., Kuijpers, M. J. E., Winkels, H., Projahn, D., Hartwig, H., Beckers, L., Megens, R. T. A., Boon, L., Noelle, R. J., Soehnlein, O., Heemskerk, J. W. M., Weber, C. & Lutgens, E., Mar 2016, In : Arteriosclerosis Thrombosis and Vascular Biology. 36, 3, p. 482-490

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Sunitinib uptake inhibits platelet function in cancer patients

Sabrkhany, S., Griffioen, A. W., Pineda, S., Sanders, L., Mattheij, N., van Geffen, A., Aarts, M. J., Heemskerk, J. W. M., Oude Egbrink, M. & Kuijpers, M. J. E., Oct 2016, In : European Journal of Cancer. 66, p. 47-54 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage

Mattheij, N. J. A., Braun, A., van Kruchten, R., Castoldi, E., Pircher, J., Baaten, C. C. F. M. J., Wuelling, M., Kuijpers, M. J. E., Koehler, R., Poole, A. W., Schreiber, R., Vortkamp, A., Collins, P. W., Nieswandt, B., Kunzelmann, K., Cosemans, J. M. E. M. & Heemskerk, J. W. M., Feb 2016, In : Faseb Journal. 30, 2, p. 727-737

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling and swelling

Mattheij, N., Braun, A., van Kruchten, R., Castoldi, E., PIRCHER, J., Baaten, C., WÜLLING, M., Kuijpers, M., KÖHLER, R., POOLE, A. W., Schreiber, R., VORTKAMP, A., COLLINS, P. W., Nieswandt, B., KUNZELMANN, K., Cosemans, J. & Heemskerk, J., 2016, In : Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde. 41, p. 207-208

Research output: Contribution to journalArticleAcademicpeer-review

2015

Dual-Specificity Phosphatase 3 Deficiency or Inhibition Limits Platelet Activation and Arterial Thrombosis

Musumeci, L., Kuijpers, M. J., Gilio, K., Hego, A., Theatre, E., Maurissen, L., Vandereyken, M., Diogo, C. V., Lecut, C., Guilmain, W., Bobkova, E. V., Eble, J. A., Dahl, R., Drion, P., Rascon, J., Mostofi, Y., Yuan, H., Sergienko, E., Chung, T. D. Y., Thiry, M. & 8 others, Senis, Y., Moutschen, M., Mustelin, T., Lancellotti, P., Heemskerk, J. W. M., Tautz, L., Oury, C. & Rahmouni, S., 17 Feb 2015, In : Circulation. 131, 7, p. 656-U194

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase beta, and Not Via CD40 and I kappa B Kinase alpha

Kuijpers, M. J. E., Mattheij, N. J. A., Cipolla, L., van Geffen, J. P., Lawrence, T., Donners, M. M. P. C., Boon, L., Lievens, D., Torti, M., Noels, H., Gerdes, N., Cosemans, J. M. E. M., Lutgens, E. & Heemskerk, J. W. M., Jun 2015, In : Arteriosclerosis Thrombosis and Vascular Biology. 35, 6, p. 1374-1381

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Platelets: an unexploited data source in biomarker research

Sabrkhany, S., Kuijpers, M. J. E., Verheul, H. M. W., Griffioen, A. W. & Egbrink, M. G. A. O., Dec 2015, In : The Lancet Haematology . 2, 12, p. E512-E513

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2014

Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake

Angin, Y., Schwenk, R. W., Nergiz-Unal, R., Hoebers, N., Heemskerk, J. W. M., Kuijpers, M. J., Coumans, W. A., van Zandvoort, M. A. M. J., Bonen, A., Neumann, D., Glatz, J. F. C. & Luiken, J., 15 Jul 2014, In : American Journal of Physiology : Endocrinology and Metabolism. 307, 2, p. E225-E236

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Factor XII Regulates the Pathological Process of Thrombus Formation on Ruptured Plaques

Kuijpers, M. J. E., van der Meijden, P. E. J., Feijge, M. A. H., Mattheij, N. J. A., May, F., Govers-Riemslag, J., Meijers, J. C. M., Heemskerk, J. W. M., Renne, T. & Cosemans, J. M. E. M., Aug 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 8, p. 1674-+

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Factor XI Regulates Pathological Thrombus Formation on Acutely Ruptured Atherosclerotic Plaques

van Montfoort, M. L., Kuijpers, M. J. E., Knaup, V. L., Bhanot, S., Monia, B. P., Roelofs, J. J. T. H., Heemskerk, J. W. M. & Meijers, J. C. M., Aug 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 8, p. 1668-+

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Supporting Roles of Platelet Thrombospondin-1 and CD36 in Thrombus Formation on Collagen

Kuijpers, M. J. E., de Witt, S., Nergiz-Unal, R., van Kruchten, R., Korporaal, S. J. A., Verhamme, P., Febbraio, M., Tjwa, M., Voshol, P. J., Hoylaerts, M. F., Cosemans, J. M. E. M. & Heemskerk, J. W. M., Jun 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 6, p. 1187-1192

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Targeting platelet receptor function in thrombus formation: The risk of bleeding

Swieringa, F., Kuijpers, M. J. E., Heemskerk, J. W. M. & van der Meijden, P. E. J., Jan 2014, In : Blood Reviews. 28, 1, p. 9-21

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Whole blood thrombin generation in Bmal1-deficient mice

Ninivaggi, M., Kelchtermans, H., Kuijpers, M. J., Hemmeryckx, B., Heemskerk, J. W. M., Lindhout, T., Hoylaerts, M. F. & de Laat, B., Aug 2014, In : Thrombosis and Haemostasis. 112, 2, p. 271-275

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
2013

Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors.

Nergiz-Unal, R., Kuijpers, M. J. E., de Witt, S. M., Heeneman, S., Feijge, M. A. H., Garcia Caraballo, S., Biessen, E. A., Haenen, G. R. M. M., Cosemans, J. M. & Heemskerk, J. W., 1 Jan 2013, In : Thrombosis Research. 131, 5, p. 411-417

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

Westein, E., van der Meer, A. D., Kuijpers, M. J. E., Frimat, J-P., van den Berg, A. & Heemskerk, J. W. M., 22 Jan 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1357-1362

Research output: Contribution to journalArticleAcademicpeer-review

2012

Antithrombotic Potential of Blockers of Store-Operated Calcium Channels in Platelets

van Kruchten, R., Braun, A., Feijge, M. A. H., Kuijpers, M. J. E., Rivera-Galdos, R., Kraft, P., Stoll, G., Kleinschnitz, C., Bevers, E. M., Nieswandt, B. & Heemskerk, J. W. M., Jul 2012, In : Arteriosclerosis Thrombosis and Vascular Biology. 32, 7, p. 1717-1723

Research output: Contribution to journalArticleAcademicpeer-review

2011

Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y(12) antagonist ticagrelor

Kuijpers, M. J. E., Megens, R. T. A., Nikookhesal, E., Feijge, M. A. H., De Mey, J. G. R., Egbrink, M. G. A. O., van Giezen, J. J. J. & Heemskerk, J. W. M., Dec 2011, In : Thrombosis and Haemostasis. 106, 6, p. 1179-1188

Research output: Contribution to journalArticleAcademicpeer-review

Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoprotein

Nergiz-Unal, R., Lamers, M. M. E., Van Kruchten, R., Luiken, J. J., Cosemans, J. M. E. M., Glatz, J. F. C., Kuijpers, M. J. E. & Heemskerk, J. W. M., Sep 2011, In : Journal of Thrombosis and Haemostasis. 9, 9, p. 1835-1846

Research output: Contribution to journalArticleAcademicpeer-review

2010

Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase C gamma 2

Elvers, M., Pozgaj, R., Pleines, I., May, F., Kuijpers, M. J. E., Heemskerk, J. M. W., Yu-Wai-Man, P. & Nieswandt, B., Jun 2010, In : Journal of Thrombosis and Haemostasis. 8, 6, p. 1353-1363

Research output: Contribution to journalArticleAcademicpeer-review

Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation

Gilio, K., van Kruchten, R., Braun, A., Berna-Erro, A., Feijge, M. A. H., Stegner, D., van der Meijden, P. E. J., Kuijpers, M. J. E., Varga-Szabo, D., Heemskerk, J. W. M. & Nieswandt, B., 30 Jul 2010, In : Journal of Biological Chemistry. 285, 31, p. 23629-23638

Research output: Contribution to journalArticleAcademicpeer-review

Stabilizing Role of Platelet P2Y(12) Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques

Nergiz-Unal, R., Cosemans, J. M. E. M., Feijge, M. A. H., van der Meijden, P. E. J., Storey, R. F., van Giezen, J. J. J., Egbrink, M. G. A. O., Heemskerk, J. W. M. & Kuijpers, M. J. E., 12 Apr 2010, In : PLOS ONE. 5, 4, p. 13

Research output: Contribution to journalArticleAcademicpeer-review

2006

Platelet receptors and procoagulant activity in thrombus formation

Kuijpers, M. J. E., 1 Jan 2006, Maastricht: Datawyse / Universitaire Pers Maastricht. 189 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
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