No photo of Marcel Herwijnen
  • Universiteitssingel50, UNS50

    6229 ER Maastricht

    Netherlands

19982019

Research output per year

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Research Output

2019

Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

Jiang, J., Messner, S., Kelm, J. M., van Herwijnen, M., Jennen, D. G. J., Kleinjans, J. C. & de Kok, T. M., 15 Sep 2019, In : Toxicology Letters. 312, p. 34-44 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Short-term transcriptome and microRNAs responses to exposure to different air pollutants in two population studies

Espin-Perez, A., Krauskopf, J., Chadeau-Hyam, M., van Veldhoven, K., Chung, F., Cullinan, P., Piepers, J., van Herwijnen, M., Kubesch, N., Carrasco-Turigas, G., Nieuwenhuijsen, M., Vineis, P., Kleinjans, J. C. S. & de Kok, T. M. C. M., Nov 2018, In : Environmental Pollution. 242, p. 182-190 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis

Van den Hof, W. F. P. M., Coonen, M. L. J., van Herwijnen, M., Brauers, K., Jennen, D., Damink, S. W. M. O., Schaap, F. G. & Kleinjans, J. C. S., Oct 2017, In : Toxicology in Vitro. 44, p. 322-329 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes

Jetten, M. J. A., Ruiz-Aracama, A., Coonen, M. L. J., Claessen, S. M., van Herwijnen, M. H. M., Lommen, A., van Delft, J., Peijnenburg, A. A. C. M. & Kleinjans, J. C. S., May 2016, In : Archives of Toxicology. 90, 5, p. 1103-1115

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis

Souza, T., Jennen, D., van Delft, J., van Herwijnen, M., Kyrtoupolos, S. & Kleinjans, J., Jun 2016, In : Archives of Toxicology. 90, 6, p. 1449-1458

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
2015

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

van Breda, S. G. J., Claessen, S. M. H., Lo, K., van Herwijnen, M., Brauers, K. J. J., Lisanti, S., Theunissen, D. H. J., Jennen, D. G. J., Gaj, S., de Kok, T. & Kleinjans, J. C. S., Nov 2015, In : Archives of Toxicology. 89, 11, p. 1959-1969

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
7 Citations (Scopus)
2014

Classification of Hepatotoxicants Using HepG2 Cells: A Proof of Principle Study

Van den Hof, W. F. P. M., Coonen, M. L. J., van Herwijnen, M., Brauers, K., Wodzig, W. K. W. H., van Delft, J. H. M. & Keinjans, J. C. S., Mar 2014, In : Chemical Research in Toxicology. 27, 3, p. 433-442

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Elimination of Heparin Interference During Microarray Processing of Fresh and Biobank-Archived Blood Samples

Hebels, D. G. A. J., van Herwijnen, M. H. M., Brauers, K. J. J., de Kok, T. M. C. M., Chalkiadaki, G., Kyrtopoulos, S. A. & Kleinjans, J. C. S., Jul 2014, In : Environmental and Molecular Mutagenesis. 55, 6, p. 482-491

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity

Van den Hof, W. F. P. M., Van Summeren, A., Lommen, A., Coonen, M. L. J., Brauers, K., van Herwijnen, M., Wodzig, W. K. W. H. & Kleinjans, J. C. S., 3 Oct 2014, In : Toxicology. 324, p. 18-26

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
2013

Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: Toxicokinetics is essential for in vivo'in vitro comparisons.

van Kesteren, P. C., Zwart, P. E., Schaap, M. M., Pronk, T. E., van Herwijnen, M. H., Kleinjans, J. C., Bokkers, B. G., Godschalk, R. W. L., Zeilmaker, M. J., van Steeg, H. & Luijten, M., Mar 2013, In : Archives of Toxicology. 87, 3, p. 505-515 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
2012

Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn)

Theunissen, P. T., Robinson, J. F., Pennings, J. L. A., van Herwijnen, M. H., Kleinjans, J. C. S. & Piersma, A. H., 1 Aug 2012, In : Toxicology and Applied Pharmacology. 262, 3, p. 330-340

Research output: Contribution to journalArticleAcademicpeer-review

Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon.

Hebels, D., Sveje, K. M., de Kok, M. C., van Herwijnen, M. H., Kuhnle, G. G., Engels, L. G. B., Vleugels Simon, C. B., Mares, W. G., Pierik, M. J., Masclee, A. A. M., Kleinjans, J. & de Kok, T. M., 1 Jan 2012, In : Food and Chemical Toxicology. 50, 2, p. 95-103

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)
2011

N-nitroso compound exposure-associated transcriptomic profiles are indicative of an increased risk for colorectal cancer

Hebels, D. G., Sveje, K. M., de Kok, M. C., van Herwijnen, M. H., Kuhnle, G. G., Engels, L. G. B., Vleugels Simon, C. B., Mares, W. G., Pierik, M. J., Masclee, A. A. M., Kleinjans, J. C. & de Kok, T. M., 1 Oct 2011, In : Cancer Letters. 309, 1, p. 1-10 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells

Hebels, D. G. A. J., Brauers, K. J. J., van Herwijnen, M. H. M., Georgiadis, P. A., Kyrtopoulos, S. A., Kleinjans, J. C. S. & de Kok, T. M. C. M., 15 Dec 2011, In : Toxicology Letters. 207, 3, p. 232-241

Research output: Contribution to journalArticleAcademicpeer-review

Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells

Hebels, D. G. A. J., Jennen, D. G. J., van Herwijnen, M. H. M., Moonen, E. J. C., Pedersen, M., Knudsen, L. E., Kleinjans, J. C. S. & de Kok, T. M. C. M., Nov 2011, In : Mutagenesis. 26, 6, p. 753-761

Research output: Contribution to journalArticleAcademicpeer-review

2010

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.

Jennen, D. G., Christina Magkoufopoulou, C., Ketelslegers, H. B., van Herwijnen, M. H., Kleinjans, J. C. & van Delft, J. H., May 2010, In : Toxicological Sciences. 115, 1, p. 66-79 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

97 Citations (Scopus)

Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells.

Briede, J. J., van Delft, J. H. M., de Kok, T. M., van Herwijnen, M. H., Maas, L. M., Gottschalk, R. W. & Kleinjans, J. C., Apr 2010, In : Toxicological Sciences. 114, 2, p. 193-203 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes.

van Dartel, D. A., Pennings, J. L., de la Fonteyne, L. J., van Herwijnen, M. H. M., van Delft, J. H. M., van Schooten, F. J. & Piersma, A. H., Jul 2010, In : Toxicological Sciences. 116, 1, p. 130-139 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)

Time series analysis of benzo[A]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets.

van Delft, J. H. M., Mathijs, K., Staal, Y. C., van Herwijnen, M. H. M., Brauers, K. J., Boorsma, A. & Kleinjans, J. C. S., Oct 2010, In : Toxicological Sciences. 117, 2, p. 381-392 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)
2009

A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.

Kienhuis, A. S., van de Poll, M. C., Dejong, C. H., Gottschalk, R., van Herwijnen, M., Boorsma, A., Kleinjans, J. C., Stierum, R. H. & van Delft, J. H., 1 Jan 2009, In : Toxicology in Vitro. 23, 6, p. 1163-1169

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Discrimination for genotoxic and non-genotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time

Mathijs, K., Brauers, K. J., Jennen, D. G., Boorsma, A., van Herwijnen, M. H., Gottschalk, R. W., Kleinjans, J. C. & van Delft, J. H., 1 Jan 2009, In : Toxicological Sciences. 112, 2, p. 374-384

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.

Kienhuis, A. S., van de Poll, M. C., Wortelboer, H., van Herwijnen, M., Gottschalk, R., Dejong, C. H., Boorsma, A., Paules, R. S., Kleinjans, J. C., Stierum, R. H. & van Delft, J. H., 1 Jan 2009, In : Toxicological Sciences. 107, 2, p. 544-552

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)
2008

Genomic analysis suggests higher susceptibility of children to air pollution.

van Leeuwen, D. M., Pedersen, M., Hendriksen, P. J., Boorsma, A., van Herwijnen, M. H., Gottschalk, R. W., Kirsch Volders, M., Knudsen, L. E., Sram, R. J., Bajak, E., van Delft, J. H. & Kleinjans, J. C., 1 Jan 2008, In : Carcinogenesis. 29, 5, p. 977-983

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Interactions between polycyclic aromatic hydrocarbons in binary mixtures: effects on gene expression and DNA adduct formation in precision-cut rat liver slices.

Staal, Y. C., Pushparajah, D. S., van Herwijnen, M. H., Gottschalk, R. W., Maas, L. M., Ioannides, C., van Schooten, F. J. & van Delft, J. H., 1 Jan 2008, In : Mutagenesis. 23, 6, p. 491-499

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
2007

A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling

Kienhuis, A. S., Wortelboer, H. M., Maas, W. J., van Herwijnen, M. H. M., Kleinjans, J. C., van Delft, J. H. M. & Stierum, R. H., 1 Jan 2007, In : Toxicology in Vitro. 21, 5, p. 892-901

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Cigarette smoke-induced differential gene expression in blood cells from monozygotic twin pairs

van Leeuwen, D. M., van Agen, E., Gottschalk, R. W., Vlietinck, R., Gielen, M. J. F., van Herwijnen, M. H. M., Maas, L. M., Kleinjans, J. C. & van Delft, J. H. M., 1 Jan 2007, In : Carcinogenesis. 28, 3, p. 691-697

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)
2006

Genome-wide differential gene expression in children exposed to air pollution in the Czech Republic

van Leeuwen, D. M., van Herwijnen, M. H. M., Pedersen, M., Knudsen, L. E., Kirsch Volders, M., Sram, R. J., Staal, Y. C., Bajak, E., van Delft, J. H. M. & Kleinjans, J. C., 1 Jan 2006, In : Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 600, 1-2, p. 12-22

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

Modulation of gene expression and DNA adduct formation in HepG2 cells by polycyclic aromatic hydrocarbons with different carcinogenic potencies

Staal, Y. C., van Herwijnen, M. H., van Schooten, F. J. & van Delft, J. H. M., 1 Jan 2006, In : Carcinogenesis. 27, 3, p. 646-655

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

Potential protein markers for nutritional health effects on colorectal cancer in the mouse as revealed by proteomics analysis

Breikers, G., van Breda, S. G., Bouwman, F. G., van Herwijnen, M. H. M., Renes, J., Mariman, E. C., Kleinjans, J. C. & van Delft, J. H., 1 Jan 2006, In : Proteomics. 6, 9, p. 2844-2852

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)
2005

Application of four dyes in gene expression analyses by microarrays

Staal, Y., van Herwijnen, M. H. M., van Schooten, F. J. & van Delft, J. H. M., 1 Jan 2005, In : BMC Genomics. 6, p. 101

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)

Differential gene expression in human peripheral blood mononuclear cells induced by cigarette smoke and its constituents

van Leeuwen, D. M., Gottschalk, R. W., van Herwijnen, M. H. M., Moonen, E. J. C., Kleinjans, J. C. & van Delft, J. H., 1 Jan 2005, In : Toxicological Sciences. 86, 1, p. 200-210

Research output: Contribution to journalArticleAcademicpeer-review

57 Citations (Scopus)

Genotoxicity and physicochemical characteristics of traffic-related ambient particulate matter

de Kok, T. M., Hogervorst, J. G. F., Briede, J. J., van Herwijnen, M. H. M., Maas, L. M., Moonen, E. J. C., Driece, H. A. & Kleinjans, J. C., 1 Jan 2005, In : Environmental and Molecular Mutagenesis. 46, 2, p. 71-80

Research output: Contribution to journalArticleAcademicpeer-review

65 Citations (Scopus)
2004

Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling

van Delft, J. H., van Agen, E., van Breda, S. G. J., van Herwijnen, M. H. M., Staal, Y. & Kleinjans, J. C., 1 Jan 2004, In : Carcinogenesis. 25, 7, p. 1265-1276

Research output: Contribution to journalArticleAcademicpeer-review

107 Citations (Scopus)
14 Citations (Scopus)

In vitro investigations into the interaction of beta-carotene with DNA: evidence for the role of carbon-centered free radicals

Kleinjans, J. C., van Herwijnen, M. H. M., van Maanen, J. M. S., Maas, L. M., de Kok, T. M., Moonen, H. J. & Briede, J. J., 1 Jan 2004, In : Carcinogenesis. 25, 7, p. 1249-1256

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
2001

A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms.

Nia, A. B., van Schooten, F. J., Schilderman-Houba, P. A. E. L., de Kok, T. M. C. M., Haenen, G. R. M. M., van Herwijnen, M. H. M., van Agen, E., Pachen, D. M. F. A. & Kleinjans, J. C. S., 1 Jan 2001, In : Carcinogenesis. 22, p. 395-401 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

73 Citations (Scopus)

Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1.

van Delft, J. H. M., Steenwinkel, M., van Asten, J., de Vogel, N., Bruijntjes-Rozier, T., Schouten, T., Cramers, T., Maas, L., van Herwijnen, M. H. M., van Schooten, F. J. & Hopmans, P., 1 Jan 2001, In : Annals of Occupational Hygiene. 45, 5, p. 395-408 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

79 Citations (Scopus)

Biomonitoring the intake of garlic via urinary excretion of allyl mercapturic acid.

Verhagen, H., Hageman, G. J., Rauma, A. L., Versluis-de Haan, G., van Herwijnen, M. H. M., de Groot, J., Torronen, R. & Mykkanen, H., 1 Jan 2001, In : Journal of Nutrition. 86 suppl 1, p. S111-S114 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
1999

In vitro effects of coal fly ashes: hydroxyl radical generation, iron release, and DNA damage and toxicity in rat lung epithelial cells.

van Maanen, J. M. S., Borm, P. J. A., Knaapen, A. M., van Herwijnen, M. H. M., Schilderman-Houba, P. A. E. L., Smith, K. R., Aust, A. E., Tomatis, M. & Fubini, B., 1 Jan 1999, In : Inhalation Toxicology. 11, 12, p. 1123-1141 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

102 Citations (Scopus)
1998

Nicotinic acid supplementation: effects on niacin status, cytogenetic damage, and poly(ADP-ribosylation) in lymphocytes of smokers.

Hageman, G. J., Stierum, R. H., van Herwijnen, M. H. M., van der Veer, M. S. & Kleinjans, J. C. S., 1 Jan 1998, In : Nutrition and Cancer-An International Journal. 32, 2, p. 113-120 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Oxidative DNA damage and cytogenetic effects in flight engineers exposed to cosmic radiation.

Zwingmann, I. H., Welle, I. J., van Herwijnen, M. H. M., Engelen, J. J. M., Schilderman-Houba, P. A. E. L., Smid, T. & Kleinjans, J. C. S., 1 Jan 1998, In : Environmental and Molecular Mutagenesis. 32, 2, p. 121-129 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)