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Research Output 2010 2019

  • 41 Article
  • 5 Review article
  • 3 Editorial
  • 1 Comment/Letter to the editor
2019

An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms

Iglesias, V. S., van Hoof, S. J., Vaniqui, A., Schyns, L. E., Lieuwes, N., Yaromina, A., Spiegelberg, L., Groot, A. J., Verhaegen, F., Theys, J., Dubois, L. & Vooijs, M., 2019, In : British Journal of Radiology. 92, 1095, 10 p., 20180476.

Research output: Contribution to journalArticleAcademicpeer-review

HIF-1 alpha and HIF-2 alpha Differently Regulate the Radiation Sensitivity of NSCLC Cells

Roig, E. M., Groot, A. J., Yaromina, A., Hendrickx, T. C., Barbeau, L. M. O., Giuranno, L., Dams, G., Ient, J., Pimentel, V. O., van Gisbergen, M. W., Dubois, L. J. & Vooijs, M. A., Jan 2019, In : Cells. 8, 1, 15 p., 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NOTCH signaling promotes the survival of irradiated basal airway stem cells

Giuranno, L., Wansleeben, C., Iannone, R., Arathoon, L., Hounjet, J., Groot, A. J. & Vooijs, M., Sep 2019, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 317, 3, p. L414-L423 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Radiation-Induced Lung Injury (RILI)

Giuranno, L., Ient, J., De Ruysscher, D. & Vooijs, M. A., 6 Sep 2019, In : Frontiers in Oncology. 9, 16 p., 877.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to gamma-secretase inhibition

Hounjet, J., Habets, R., Schaaf, M. B., Hendrickx, T. C., Barbeau, L. M. O., Yahyanejad, S., Rouschop, K. M., Groot, A. J. & Vooijs, M., 4 Jul 2019, In : Oncogene. 38, 27, p. 5457-5468 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Blocking 17 beta-hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach

Konings, G. F. J., Cornel, K. M. C., Xanthoulea, S., Delvoux, B., Skowron, M. A., Kooreman, L., Koskimies, P., Krakstad, C., Salvesen, H. B., van Kuijk, K., Schrooders, Y. J. M., Vooijs, M., Groot, A. J., Bongers, M. Y., Kruitwagen, R. F. P. M. & Romano, A., 1 Feb 2018, In : Journal of Pathology. 244, 2, p. 203-214 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Codon-specific translation reprogramming promotes resistance to targeted therapy

Rapino, F., Delaunay, S., Rambow, F., Zhou, Z., Tharun, L., De Tullio, P., Sin, O., Shostak, K., Schmitz, S., Piepers, J., Ghesquiere, B., Karim, L., Charloteaux, B., Jamart, D., Florin, A., Lambert, C., Rorive, A., Jerusalem, G., Leucci, E., Dewaele, M. & 9 others, Vooijs, M., Leidel, S. A., Georges, M., Voz, M., Peers, B., Buttner, R., Marine, J-C., Chariot, A. & Close, P., 28 Jun 2018, In : Nature. 558, 7711, p. 605-609 5 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Drug Resistance in Non-Small Cell Lung Cancer: A Potential for NOTCH Targeting?

Iglesias, V. S., Giuranno, L., Dubois, L. J., Theys, J. & Vooijs, M., 24 Jul 2018, In : Frontiers in Oncology. 8, 23 p., 267.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

Jutten, B., Keulers, T. G., Peeters, H. J. M., Schaaf, M. B. E., Savelkouls, K. G. M., Compter, I., Clarijs, R., Schijns, O. E. M. G., Ackermans, L., Teernstra, O. P. M., Zonneveld, M. I., Colaris, R. M. E., Dubois, L., Vooijs, M. A., Bussink, J., Sotelo, J., Theys, J., Lammering, G. & Rouschop, K. M. A., 1 Jan 2018, In : Autophagy. 14, 2, p. 283-295 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Moving Breast Cancer Therapy up a Notch

Mollen, E. W. J., Ient, J., Tjan-Heijnen, V. C. G., Boersma, L. J., Miele, L., Smidt, M. L. & Vooijs, M. A. G. G., 20 Nov 2018, In : Frontiers in Oncology. 8, 25 p., 518.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Noninvasive Glioblastoma Testing: Multimodal Approach to Monitoring and Predicting Treatment Response

Verduin, M., Compter, I., Steijvers, D., Postma, A. A., Eekers, D. B. P., Anten, M. M., Ackermans, L., ter Laan, M., Leijenaar, R. T. H., van de Weijer, T., Tjan-Heijnen, V. C. G., Hoeben, A. & Vooijs, M., 1 Jan 2018, In : Disease Markers. 2018, 11 p., 2908609.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

PD-(L)1 Inhibition and Cardiac Damage: A Relevant Toxicity?

De Ruysscher, D., Dingemans, A-M., Vooijs, M. & Heymans, S., 1 Apr 2018, In : Journal of Thoracic Oncology. 13, 4, p. 478-479 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis

Roig, E. M., Yaromina, A., Houben, R., Groot, A. J., Dubois, L. & Vooijs, M., 11 Jun 2018, In : Frontiers in Oncology. 8, 11 p., 224.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Synergistic Effects of NOTCH/gamma-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells

Iglesias, V. S., Theys, J., Groot, A. J., Barbeau, L. M. O., Lemmens, A., Yaromina, A., Losen, M., Houben, R., Dubois, L. & Vooijs, M., 7 Nov 2018, In : Frontiers in Oncology. 8, 13 p., 460.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Tenascin-C a novel regulator of brain tumor-initiating cells (BTIC) in glioma acts through NOTCH

Miyake, J. A. & Vooijs, M., Aug 2017, In : Translational Cancer Research. 6, p. S1054-S1056 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

2016

Benefits, limitations and opportunities of NOTCH inhibitors for treatment of glioma

Yahyanejad, S., Granton, P. V., Hoeben, A. & Vooijs, M. A., Aug 2016, In : Translational Cancer Research. 5, p. S290-S295

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

LC3/GABARAP family proteins: autophagy-(un) related functions

Schaaf, M. B. E., Keulers, T. G., Vooijs, M. A. & Rouschop, K. M. A., Dec 2016, In : Faseb Journal. 30, 12, p. 3961-3978

Research output: Contribution to journalArticleAcademicpeer-review

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice

Jeurissen, M. L. J., Walenbergh, S. M. A., Houben, T., Hendrikx, T., Li, J., Oligschläger, Y., van Gorp, P. J., Gijbels, M. J. J., Bitorina, A., Nessel, I., Radtke, F., Vooijs, M., Theys, J. & Shiri-Sverdlov, R., 29 Nov 2016, In : PLOS ONE. 11, 11, e0167199.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M. O., van Hoof, S. J., Groot, A. J., Habets, R., Prickaerts, J., Chalmers, A. J., Eekers, D. B. P., Theys, J., Short, S. C., Verhaegen, F. & Vooijs, M., 5 Jul 2016, In : Oncotarget. 7, 27, p. 41251-41264

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Restricted Location of PSEN2/gamma-Secretase Determines Substrate Specificity and Generates an Intracellular A beta Pool

Sannerud, R., Esselens, C., Ejsmont, P., Mattera, R., Rochin, L., Tharkeshwar, A. K., De Baets, G., De Wever, V., Habets, R., Baert, V., Vermeire, W., Michiels, C., Groot, A. J., Wouters, R., Dillen, K., Vints, K., Baatsen, P., Munck, S., Derua, R., Waelkens, E. & 10 others, Basi, G. S., Mercken, M., Vooijs, M., Bollen, M., Schymkowitz, J., Rousseau, F., Bonifacino, J. S., Van Niel, G., De Strooper, B. & Annaert, W., 30 Jun 2016, In : Cell. 166, 1, p. 193-208

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Targeting Notch to overcome radiation resistance

Yahyanejad, S., Theys, J. & Vooijs, M., 16 Feb 2016, In : Oncotarget. 7, 7, p. 7610-7628

Research output: Contribution to journalArticleAcademicpeer-review

2015
9 Citations (Scopus)

ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis

Caolo, V., Swennen, G., Chalaris, A., Wagenaar, A., Verbruggen, S., Rose-John, S., Molin, D. G. M., Vooijs, M. & Post, M. J., Jan 2015, In : Angiogenesis. 18, 1, p. 13-22

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

An image guided small animal radiation therapy platform (SmART) to monitor glioblastoma progression and therapy response

Yahyanejad, S., van Hoof, S. J., Theys, J., Barbeau, L. M. O., Granton, P. V., Paesmans, K., Verhaegen, F. & Vooijs, M., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 467-472

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Complementary Use of Bioluminescence Imaging and Contrast-Enhanced Micro-Computed Tomography in an Orthotopic Brain Tumor Model

Yahyanejad, S., Granton, P. V., Lieuwes, N. G., Gilmour, L., Dubois, L., Theys, J., Chalmers, A. J., Verhaegen, F. & Vooijs, M., Mar 2015, In : Molecular Imaging. 14

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia

Doi, K., Imai, T., Kressler, C., Yagita, H., Agata, Y., Vooijs, M., Hamazaki, Y., Inoue, J. & Minato, N., 23 Jan 2015, In : Scientific Reports. 5, 7978.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling

Li, H., Koo, Y., Mao, X., Sifuentes-Dominguez, L., Morris, L. L., Jia, D., Miyata, N., Faulkner, R. A., van Deursen, J. M., Vooijs, M., Billadeau, D. D., van de Sluis, B., Cleaver, O. & Burstein, E., 9 Nov 2015, In : Journal of Cell Biology. 211, 3, p. 605-617

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

GABARAPL1 is required for increased EGFR membrane expression during hypoxia

Keulers, T. G., Schaaf, M. B. E., Peeters, H. J. M., Savelkouls, K. G. M., Vooijs, M. A., Bussink, J., Jutten, B. & Rouschop, K. M. A., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 417-422

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

High dose rate and flattening filter free irradiation can be safely implemented in clinical practice

Dubois, L., Biemans, R., Reniers, B., Bosmans, G., Trani, D., Podesta, M., Kollaard, R., Rouschop, K. M. A., Theys, J., Vooijs, M., Pruschy, M., Verhaegen, F. & Lambin, P., 3 Oct 2015, In : International Journal of Radiation Biology. 91, 10, p. 778-785

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17

Habets, R. A. J., Groot, A. J., Yahyanejad, S., Tiyanont, K., Blacklow, S. C. & Vooijs, M., 5 Jun 2015, In : Journal of Biological Chemistry. 290, 23, p. 14705-14716

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region

Xu, X., Choi, S. H., Hu, T., Tiyanont, K., Habets, R., Groot, A. J., Vooijs, M., Aster, J. C., Chopra, R., Fryer, C. & Blacklow, S. C., 7 Jul 2015, In : Structure. 23, 7, p. 1227-1235

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

New ways to image and target tumour hypoxia and its molecular responses

Dubois, L. J., Niemans, R., van Kuijk, S. J. A., Panth, K. M., Parvathaneni, N-K., Peeters, S. G. J. A., Zegers, C. M. L., Rekers, N. H., van Gisbergen, M. W., Biemans, R., Lieuwes, N. G., Spiegelberg, L., Yaromina, A., Winum, J-Y., Vooijs, M. & Lambin, P., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 352-357

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

SmART-ER imaging and treatment of glioblastoma

Granton, P. V., Yahyanejad, S. & Vooijs, M. A., Jun 2015, In : Journal of Neuro-Oncology. 123, 2, p. 319-320

Research output: Contribution to journalArticleAcademicpeer-review

2014
13 Citations (Scopus)

Epigenetics in radiotherapy: Where are we heading?

Smits, K. M., Melotte, V., Niessen, H. E. C., Dubois, L., Oberije, C., Troost, E. G. C., Starmans, M. H. W., Boutros, P. C., Vooijs, M., van Engeland, M. & Lambin, P., May 2014, In : Radiotherapy and Oncology. 111, 2, p. 168-177

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

Groot, A. J., Habets, R., Yahyanejad, S., Hodin, C. M., Reiss, K., Saftig, P., Theys, J. & Vooijs, M., Aug 2014, In : Molecular and Cellular Biology. 34, 15, p. 2822-2832

Research output: Contribution to journalArticleAcademicpeer-review

2013
8 Citations (Scopus)

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

Jutten, B., Keulers, T. G., Schaaf, M. B. E., Savelkouls, K., Theys, J., Span, P. N., Vooijs, M. A., Bussink, J. & Rouschop, K. M. A., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 479-483

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

FER kinase promotes breast cancer metastasis by regulating alpha(6)- and beta(1)-integrin-dependent cell adhesion and anoikis resistance

Ivanova, I. A., Vermeulen, J. F., Ercan, C., Houthuijzen, J. M., Saig, F. A., Vlug, E. J., van der Wall, E., van Diest, P. J., Vooijs, M. & Derksen, P. W. B., 12 Dec 2013, In : Oncogene. 32, 50, p. 5582-5592

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

High NOTCH activity induces radiation resistance in non small cell lung cancer

Theys, J., Yahyanejad, S., Habets, R., Span, P., Dubois, L., Paesmans, K., Kattenbeld, B., Cleutjens, J., Groot, A. J., Schuurbiers, O. C. J., Lambin, P., Bussink, J. & Vooijs, M., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 440-445

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Hypoxia inducible NOD2 interacts with 3-O-sulfogalactoceramide and regulates vesicular homeostasis

Nabatov, A. A., Hatzis, P., Rouschop, K. M. A., van Diest, P. & Vooijs, M., Nov 2013, In : Biochimica et Biophysica Acta-general Subjects. 1830, 11, p. 5277-5286

Research output: Contribution to journalArticleAcademicpeer-review

State of the Art Radiation Therapy for Lung Cancer 2012: A Glimpse of the Future

De Ruysscher, D., Belderbos, J., Reymen, B., van Elmpt, W., van Baardwijk, A., Wanders, R., Hoebers, F., Vooijs, M., Oellers, M. & Lambin, P., Mar 2013, In : Clinical Lung Cancer. 14, 2, p. 89-95

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs

Dubois, L., Peeters, S. G. J. A., van Kuijk, S. J. A., Yaromina, A., Lieuwes, N. G., Saraya, R., Biemans, R., Rami, M., Parvathaneni, N. K., Vullo, D., Vooijs, M., Supuran, C. T., Winum, J-Y. & Lambin, P., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 523-528

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

Schaaf, M. B. E., Cojocari, D., Keulers, T. G., Jutten, B., Starmans, M. H., de Jong, M. C., Begg, A. C., Savelkouls, K. G. M., Bussink, J., Vooijs, M., Wouters, B. G. & Rouschop, K. M. A., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 529-534

Research output: Contribution to journalArticleAcademicpeer-review

2011

Cleavage of Notch1 by granzyme B disables its transcriptional activity

van Tetering, G., Bovenschen, N., Meeldijk, J., van Diest, P. J. & Vooijs, M., 15 Jul 2011, In : Biochemical Journal. 437, p. 313-322

Research output: Contribution to journalArticleAcademicpeer-review

E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells

Theys, J., Jutten, B., Habets, R., Paesmans, K., Groot, A. J., Lambin, P., Wouters, B. G., Lammering, G. & Vooijs, M., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 392-397

Research output: Contribution to journalArticleAcademicpeer-review

Mammary Development and Breast Cancer: The Role of Stem Cells

Ercan, C., van Diest, P. J. & Vooijs, M., Jun 2011, In : Current Molecular Medicine. 11, 4, p. 270-285

Research output: Contribution to journalArticleAcademicpeer-review

Notch: Architect, Landscaper, and Guardian of the Intestine

Vooijs, M., Liu, Z. & Kopan, R., Aug 2011, In : Gastroenterology. 141, 2, p. 448-459

Research output: Contribution to journalArticleAcademicpeer-review

Proteolytic Cleavage of Notch: "HIT and RUN"

van Tetering, G. & Vooijs, M., Jun 2011, In : Current Molecular Medicine. 11, 4, p. 255-269

Research output: Contribution to journalArticleAcademicpeer-review

The role of hypoxia inducible factor-1alpha in gynecological cancer

Seeber, L. M. S., Horree, N., Vooijs, M. A. G. G., Heintz, A. P. M., van der Wall, E., Verheijen, R. H. M. & van Diest, P. J., Jun 2011, In : Critical Reviews in Oncology/Hematology. 78, 3, p. 173-184

Research output: Contribution to journalArticleAcademicpeer-review

2010

Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis

Gomez-del Arco, P., Kashiwagi, M., Jackson, A. F., Naito, T., Zhang, J., Liu, F., Kee, B., Vooijs, M., Radtke, F., Miguel Redondo, J. & Georgopoulos, K., 24 Nov 2010, In : Immunity. 33, 5, p. 685-698

Research output: Contribution to journalArticleAcademicpeer-review

COMMD1 disrupts HIF-1 alpha/beta dimerization and inhibits human tumor cell invasion

van der Sluis, B., Mao, X., Zhai, Y., Groot, A. J., Vermeulen, J. F., van der Wall, E., van Diest, P. J., Hofker, M. H., Wijmenga, C., Klomp, L. W., Cho, K. R., Fearon, E. R., Vooijs, M. & Burstein, E., Jun 2010, In : Journal of Clinical Investigation. 120, 6, p. 2119-2130

Research output: Contribution to journalArticleAcademicpeer-review