1988 …2019
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Research Output 1988 2019

2019

AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism

Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M. & Schroen, B., 1 Mar 2019, In : Molecular Therapy - Nucleic Acids. 14, p. 424-437 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure

Verjans, R., Derks, W. J. A., Korn, K., Soennichsen, B., van Leeuwen, R. E. W., Schroen, B., van Bilsen, M. & Heymans, S., 15 Apr 2019, In : Scientific Reports. 9, 15 p., 6055.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Assessing fatty acid oxidation flux in rodent cardiomyocyte models

Rech, M., Luiken, J. J. F. P., Glatz, J. F. C., van Bilsen, M., Schroen, B. & Nabben, M., 24 Jan 2018, In : Scientific Reports. 8, 6 p., 1505.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Long non-coding RNAs in the failing heart and vasculature

Hermans-Beijnsberger, S., van Bilsen, M. & Schroen, B., Sep 2018, In : Non-coding RNA research. 3, 3, p. 118-130 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure

Verjans, R., Peters, T., Beaumont, F., van Leeuwen, R., van Herwaarden, T., Verhesen, W., Munts, C., Bijnen, M., Henkens, M., Diez, J., de Windt, L. J., van Nieuwenhoven, F. A., van Bilsen, M., Goumans, M. J., Heymans, S., Gonzalez, A. & Schroen, B., 1 Feb 2018, In : Hypertension. 71, 2, p. 280-288 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening

Sorop, O., Heinonen, I., van Kranenburg, M., van de Wouw, J., de Beer, V. J., Nguyen, I. T. N., Octavia, Y., van Duin, R. W. B., Stam, K., van Geuns, R-J., Wielopolski, P. A., Krestin, G. P., van den Meiracker, A. H., Verjans, R., van Bilsen, M., Danser, A. H. J., Paulus, W. J., Cheng, C., Linke, W. A., Joles, J. A. & 4 others, Verhaar, M. C., van der Velden, J., Merkus, D. & Duncker, D. J., 1 Jun 2018, In : Cardiovascular Research. 114, 7, p. 954-964 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NF-kappa B-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis

Remels, A. H. V., Derks, W. J. A., Cillero-Pastor, B., Verhees, K. J. P., Kelders, M. C., Heggermont, W., Carai, P., Summer, G., Ellis, S. R., de Theije, C. C., Heeren, R. M. A., Heymans, S., Papageorgiou, A. P. & van Bilsen, M., Aug 2018, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1864, 8, p. 2579-2589 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pathophysiological understanding of HFpEF: microRNAs as part of the puzzle

Rech, M., Aizpurua, A. B., van Empel, V., van Bilsen, M. & Schroen, B., 1 May 2018, In : Cardiovascular Research. 114, 6, p. 782-793 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Targeted HFpEF therapy based on matchmaking of human and animal models

Aizpurua, A. B., Schroen, B., van Bilsen, M. & van Empel, V., Dec 2018, In : American Journal of Physiology-heart and Circulatory Physiology. 315, 6, p. H1670-H1683 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2017

Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling

van Nieuwenhoven, F. A., Munts, C., op't Veld, R. C., Gonzalez, A., Diez, J., Heymans, S., Schroen, B. & van Bilsen, M., 22 Nov 2017, In : Scientific Reports. 7, 9 p., 16042.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction

Heggermont, W. A., Papageorgiou, A-P., Quaegebeur, A., Deckx, S., Carai, P., Verhesen, W., Eelen, G., Schoors, S., van Leeuwen, R., Alekseev, S., Elzenaar, I., Vinckier, S., Pokreisz, P., Walravens, A-S., Gijsbers, R., Van Den Haute, C., Nickel, A., Schroen, B., van Bilsen, M., Janssens, S. & 4 others, Maack, C., Pinto, Y., Carmeliet, P. & Heymans, S., 22 Aug 2017, In : Circulation. 136, 8, p. 747-761 33 p.

Research output: Contribution to journalArticleAcademicpeer-review

Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats

van Haare, J., Kooi, M. E., van Teeffelen, J. W. G. E., Vink, H., Slenter, J., Cobelens, H., Strijkers, G. J., Koehn, D., Post, M. J. & van Bilsen, M., 11 Apr 2017, In : Cardiovascular Diabetology. 16, 13 p., 47.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MiRNA Deregulation in Cardiac Aging and Associated Disorders

Verjans, R., van Bilsen, M. & Schroen, B., 2017, International Review of Cell and Molecular Biology: MiRNAs in Aging and Cancer. Galluzzi, L. & Vitale, I. (eds.). Elsevier Science, Vol. 334. p. 207-263 57 p. (International Review of Cell and Molecular Biology, Vol. 334).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

van Bilsen, M., Patel, H. C., Bauersachs, J., Boehm, M., Borggrefe, M., Brutsaert, D., Coats, A. J. S., de Boer, R. A., de Keulenaer, G., Filippatos, G. S., Floras, J., Grassi, G., Jankowska, E. A., Kornet, L., Lunde, I. G., Maack, C., Mahfoud, F., Pollesello, P., Ponikowski, P., Ruschitzka, F. & 10 others, Sabbah, H. N., Schultz, H. D., Seferovic, P., Slart, R. H. J. A., Taggart, P., Tocchetti, C. G., Van Laake, L., Zannad, F., Heymans, S. & Lyon, A. R., Nov 2017, In : European journal of heart failure. 19, 11, p. 1361-1378 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
1 Citation (Scopus)

Metabolic support for the heart: complementary therapy for heart failure?

Heggermont, W. A., Papageorgiou, A-P., Heymans, S. & van Bilsen, M., Dec 2016, In : European journal of heart failure. 18, 12, p. 1420-1429

Research output: Contribution to journalArticleAcademicpeer-review

Nutritional and Environmental Influences on Cardiac Metabolism and Performance

van Bilsen, M., 2016, The Scientist's Guide to Cardiac Metabolism. Schwarzer, M. & Doenst, T. (eds.). Academic Press, p. 139-153

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

The Network Library: a framework to rapidly integrate network biology resources

Summer, G., Kelder, T., Radonjic, M., van Bilsen, M., Wopereis, S. & Heymans, S., 1 Sep 2016, In : Bioinformatics. 32, 17, p. 473-478

Research output: Contribution to journalArticleAcademicpeer-review

2015
4 Citations (Scopus)

Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet

van Haare, J., Kooi, M. E., Vink, H., Post, M. J., van Teeffelen, J. W. G. E., Slenter, J., Munts, C., Cobelens, H., Strijkers, G. J., Koehn, D. & van Bilsen, M., 17 Nov 2015, In : Cardiovascular Diabetology. 14, 150.

Research output: Contribution to journalArticleAcademicpeer-review

2014
9 Citations (Scopus)

Fatty acids and cardiac disease: fuel carrying a message

van Bilsen, M. & Planavila, A., Jul 2014, In : Acta Physiologica. 211, 3, p. 476-490

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Hypertension Is a Conditional Factor for the Development of Cardiac Hypertrophy in Type 2 Diabetic Mice

van Bilsen, M., Daniels, A., Brouwers, O., Janssen, B. J. A., Derks, W. J. A., Brouns, A. E., Munts, C., Schalkwijk, C. G., van der Vusse, G. J. & van Nieuwenhoven, F. A., 9 Jan 2014, In : PLOS ONE. 9, 1, e85078.

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

Unsoeld, B., Kaul, A., Sbroggi, M., Schubert, C., Regitz-Zagrosek, V., Brancaccio, M., Damilano, F., Hirsch, E., Van Bilsen, M., Munts, C., Sipido, K., Bito, V., Detre, E., Wagner, N. M., Schaefer, K., Seidler, T., Vogt, J., Neef, S., Bleckmann, A., Maier, L. S. & 9 others, Balligand, J. L., Bouzin, C., Ventura-Clapier, R., Garnier, A., Eschenhagen, T., El-Armouche, A., Knoell, R., Tarone, G. & Hasenfuss, G., 1 Jan 2014, In : Cardiovascular Research. 101, 1, p. 97-107

Research output: Contribution to journalArticleAcademicpeer-review

2013
79 Citations (Scopus)

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice

Planavila, A., Redondo, I., Hondares, E., Vinciguerra, M., Munts, C., Iglesias, R., Gabrielli, L. A., Sitges, M., Giralt, M., van Bilsen, M. & Villarroya, F., Jun 2013, In : Nature Communications. 4, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome

Hermida, N., Markl, A., Hamelet, J., Van Assche, T., Vanderper, A., Herijgers, P., van Bilsen, M., Hilfiker-Kleiner, D., Noppe, G., Beauloye, C., Horman, S. & Balligand, J-L., 1 Jul 2013, In : Cardiovascular Research. 99, 1, p. 44-54

Research output: Contribution to journalArticleAcademicpeer-review

71 Citations (Scopus)

Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure

Heymans, S., Corsten, M. F., Verhesen, W., Carai, P., van Leeuwen, R. E., Custers, K., Peters, T., Hazebroek, M., Stoger, L., Wijnands, E., Janssen, B. J., Creemers, E. E., Pinto, Y. M., Grimm, D., Schurmann, N., Vigorito, E., Thum, T., Stassen, F. R., Yin, X., Mayr, M. & 9 others, De Windt, L. J., Lutgens, E., Wouters, K., de Winther, M. P., Zacchigna, S., Giacca, M., van Bilsen, M., Papageorgiou, A. P. & Schroen, B. L., 24 Sep 2013, In : Circulation. 128, 13, p. 1420-1432

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Stretch-Induced Upregulation of Connective Tissue Growth Factor in Rabbit Cardiomyocytes

Blaauw, E., Lorenzen-Schmidt, I., Babiker, F. A., Munts, C., Prinzen, F. W., Snoeckx, L. H., van Bilsen, M., van der Vusse, G. J. & van Nieuwenhoven, F. A., Oct 2013, In : Journal of Cardiovascular Translational Research. 6, 5, p. 861-869

Research output: Contribution to journalArticleAcademicpeer-review

2012

A Diet Rich in Unsaturated Fatty Acids Prevents Progression Toward Heart Failure in a Rabbit Model of Pressure and Volume Overload

den Ruijter, H. M., Verkerk, A. O., Schumacher, C. A., Houten, S. M., Belterman, C. N. W., Baartscheer, A., Brouwer, I. A., van Bilsen, M., de Roos, B. & Coronel, R., May 2012, In : Circulation-Heart Failure. 5, 3, p. 376-384

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease

Bieghs, V., van Gorp, P. J., Wouters, K., Hendrikx, T., Gijbels, M. J., van Bilsen, M., de Bakker, J., Binder, C. J., Lutjohann, D., Staels, B., Hofker, M. H. & Sverdlov, R., 25 Jan 2012, In : PLOS ONE. 7, 1, e30668.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
30 Citations (Scopus)

Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats

Daniels, A., Linz, D., van Bilsen, M., Ruetten, H., Sadowski, T., Ruf, S., Juretschke, H-P., Neumann-Haefelin, C., Munts, C., van der Vusse, G. J. & van Nieuwenhoven, F. A., Feb 2012, In : European journal of heart failure. 14, 2, p. 193-201

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

MEK1 Inhibits Cardiac PPAR alpha Activity by Direct Interaction and Prevents Its Nuclear Localization

el Azzouzi, H., Leptidis, S., Bourajjaj, M., van Bilsen, M., Martins, P. A. D. C. & De Windt, L. J., 19 Jun 2012, In : PLOS ONE. 7, 6, e36799.

Research output: Contribution to journalArticleAcademicpeer-review

2011
4 Citations (Scopus)

Early-pregnancy changes in maternal lipid profile in women with recurrent preeclampsia and previously preeclamptic women with normal next pregnancy

Sep, S., Rijvers, C., Smits, L., van Bilsen, M., Bekers, O. & Peeters, L., 1 Jan 2011, In : Reproductive Sciences. 18, 10, p. 998-1004 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Peroxisome Proliferator-activated Receptor (PPAR) Gene Profiling Uncovers Insulin-like Growth Factor-1 as a PPAR alpha Target Gene in Cardioprotection

el Azzouzi, H., Leptidis, S., Bourajjaj, M., Armand, A-S., van der Nagel, R., van Bilsen, M., Martins, P. A. D. C. & De Windt, L. J., 22 Apr 2011, In : Journal of Biological Chemistry. 286, 16, p. 14598-14607

Research output: Contribution to journalArticleAcademicpeer-review

2010
32 Citations (Scopus)

Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling

Daniels, A., van Bilsen, M., Janssen, B. J. A., Brouns, A. E., Cleutjens, J. P. M., Roemen, T. H., Schaart, G., van der Velden, J., van der Vusse, G. J. & van Nieuwenhoven, F. A., Sep 2010, In : Acta Physiologica. 200, 1, p. 11-22 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by Peroxisome Proliferator-Activated Receptor beta/delta and Protects Against Fatty Acid-Induced Oxidative Stress

Georgiadi, A., Lichtenstein, L., Degenhardt, T., Boekschoten, M. V., van Bilsen, M., Desvergne, B., Muller, M. & Kersten, S., 11 Jun 2010, In : Circulation Research. 106, 11, p. 1712-1721

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice.

Wouters, K., van Bilsen, M., van Gorp, P. J., Bieghs, V., Lutjohann, D., Kerksiek, A., Staels, B., Hofker, M. H. & Sverdlov, R., 29 Jan 2010, In : Febs Letters. 584, 5, p. 1001-1005

Research output: Contribution to journalArticleAcademicpeer-review

PPARs as therapeutic targets in cardiovascular disease

van Bilsen, M. & van Nieuwenhoven, F. A., Oct 2010, In : Expert Opinion on Therapeutic Targets. 14, 10, p. 1029-1045

Research output: Contribution to journalArticleAcademicpeer-review

69 Citations (Scopus)

Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice

Bieghs, V., Wouters, K., van Gorp, P. J., Gijbels, M. J. J., de Winther, M. P. J., Binder, C. J., Lutjohann, D., Febbraio, M., Moore, K. J., van Bilsen, M., Hofker, M. H. & Shiri-Sverdlov, R., Jun 2010, In : Gastroenterology. 138, 7, p. 2477-2486 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes

Blaauw, E., van Nieuwenhoven, F. A., Willemsen, P., Delhaas, T., Prinzen, F. W., Snoeckx, L. H., van Bilsen, M. & van der Vusse, G. J., Sep 2010, In : American Journal of Physiology-heart and Circulatory Physiology. 299, 3, p. H780-H787

Research output: Contribution to journalArticleAcademicpeer-review

2009
57 Citations (Scopus)

Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences

Tintu, A., Rouwet, E., Verlohren, S., Brinkmann, J., Ahmad, S., Crispi, F., van Bilsen, M., Carmeliet, P., Staff, A. C., Tjwa, M., Cetin, I., Gratacos, E., Hernandez Andrade, E., Hofstra, L., Jacobs, M. J., Lamers, W. H., Morano, I., Safak, E., Ahmed, A. & le Noble, F., 1 Jan 2009, In : PLOS ONE. 4, 4, e5155.

Research output: Contribution to journalArticleAcademicpeer-review

2008
246 Citations (Scopus)

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

Wouters, K., van Gorp, P. J. J., Bieghs, V., Gijbels, M. J., Duimel, H., Lutjohann, D., Kerksiek, A., van Kruchten, R., Maeda, N., Staels, B., van Bilsen, M., Sverdlov, R. & Hofker, M. H., Aug 2008, In : Hepatology. 48, 2, p. 474-486

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Transcriptomic analysis of PPARalpha-dependent alterations during cardiac hypertrophy.

Smeets, P. J., de Vogel van de Bosch, H. M., Willemsen, P. H., Stassen, A. P., Ayoubi, T., van der Vusse, G. J. & van Bilsen, M., 1 Jan 2008, In : Physiological genomics. 36, 1, p. 15-23

Research output: Contribution to journalArticleAcademicpeer-review

2006
96 Citations (Scopus)

Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates

Shiri-Sverdlov, R., Wouters, K., van Gorp, P. J. J., Gijbels, M. J. J., Noel, B., Buffat, L., Staels, B., Maeda, N., van Bilsen, M. & Hofker, M. H., Apr 2006, In : Journal of Hepatology. 44, 4, p. 732-741

Research output: Contribution to journalArticleAcademicpeer-review

2005
69 Citations (Scopus)
2003
32 Citations (Scopus)
109 Downloads (Pure)

Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation

Hoeks, J., Hesselink, M. K. C., van Bilsen, M., Schaart, G., van der Vusse, G. J., Saris, W. H. M. & Schrauwen, P., 1 Jan 2003, In : Febs Letters. 555, 3, p. 631-637 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
88 Citations (Scopus)
166 Downloads (Pure)

Uncoupling protein 3 as a mitochondrial fatty acid anion exporter

Schrauwen, P., Hoeks, J., Schaart, G., Kornips, C. F. P., Binas, B., van der Vusse, G. J., van Bilsen, M., Luiken, J. J. F. P., Coort, S. L. M., Glatz, J. F., Saris, W. H. M. & Hesselink, M. K. C., 1 Jan 2003, In : Faseb Journal. 17, 15, p. 2272-2274 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2002
11 Citations (Scopus)

Increased muscle fatigability in GLUT-4-deficient mice

Gorselink, M., Bemelman, W. A., de Brouwer, K. F. J., Schaart, G., van Kranenburg, G. P. J., Roemen, T. H. M., van Bilsen, M., Charron, M. J. & van der Vusse, G. J., 1 Jan 2002, In : American Journal of Physiology : Endocrinology and Metabolism. 282, 2, p. E348-E354 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

1999
32 Citations (Scopus)

Cytochrome P450, peroxisome proliferation, and cytoplasmic fatty acid-binding protein content in liver, heart and kidney of the diabetic rat

Engels, W., van Bilsen, M., Wolffenbuttel, B. H. R., van der Vusse, G. J. & Glatz, J. F., 1 Jan 1999, In : Molecular and Cellular Biochemistry. 192, 1-2, p. 53–61

Research output: Contribution to journalArticleAcademicpeer-review

1988
259 Downloads (Pure)
Open Access
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