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Research Output

2020

SOX17 expression and its down-regulation by promoter methylation in cervical adenocarcinoma in situ and adenocarcinoma

Hopman, A. N. H., Moshi, J. M., Hoogduin, K. J., Ummelen, M., Henfling, M. E. R., van Engeland, M., Wouters, K. A. D., Stoop, H., Looijenga, L. H. J. & Ramaekers, F. C. S., Feb 2020, In : Histopathology. 76, 3, p. 383-393 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Gene Promoter Methylation in Endometrial Carcinogenesis

Cornel, K. M. C., Wouters, K., Van de Vijver, K. K., van der Wurff, A. A. M., van Engeland, M., Kruitwagen, R. F. P. M. & Pijnenborg, J. M. A., Apr 2019, In : Pathology & oncology Research. 25, 2, p. 659-667 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MEXPRESS update 2019

Koch, A., Jeschke, J., Van Criekinge, W., van Engeland, M. & De Meyer, T., 2 Jul 2019, In : Nucleic Acids Research. 47, W1, p. W561-W565 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Molecular profiling of longitudinally observed small colorectal polyps: A cohort study

van Lanschot, M. C. J., Carvalho, B., Rausch, C., Snaebjornsson, P., van Engeland, M., Kuipers, E. J., Stoker, J., Nolthenius, C. J. T., Dekker, E. & Meijer, G. A., Jan 2019, In : EBioMedicine. 39, p. 292-300 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population

Bosch, L. J. W., Melotte, V., Mongera, S., Daenen, K. L. J., Coupe, V. M. H., van Turenhout, S. T., Stoop, E. M., de Wijkerslooth, T. R., Mulder, C. J. J., Rausch, C., Kuipers, E. J., Dekker, E., Domanico, M. J., Lidgard, G. P., Berger, B. M., van Engeland, M., Carvalho, B. & Meijer, G. A., Dec 2019, In : American Journal of Gastroenterology. 114, 12, p. 1909-1918 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The trans-DATA study: aims and design of a translational breast cancer prognostic marker identification study

de Ruijter, T. C., Smits, K. M., Aarts, M. J., van Hellemond, I. E. G., Van Neste, L., de Vries, B., Peer, P. G. M., Veeck, J., van Engeland, M. & Tjan-Heijnen, V. C. G., 2019, In : Diagnostic and prognostic research. 3, 8 p., 20.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

A combined literature and in silico analysis enlightens the role of the NDRG family in the gut

Vaes, N., Schonkeren, S. L., Brosens, E., Koch, A., McCann, C. J., Thapar, N., Hofstra, R. M. W., van Engeland, M. & Melotte, V., Oct 2018, In : Biochimica et Biophysica Acta-general Subjects. 1862, 10, p. 2140-2151 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Analysis of DNA methylation in cancer: location revisited

Koch, A., Joosten, S. C., Feng, Z., de Ruijter, T. C., Draht, M. X., Melotte, V., Smits, K. M., Veeck, J., Herman, J. G., Van Neste, L., Van Criekinge, W., De Meyer, T. & van Engeland, M., 1 Jul 2018, In : Nature Reviews Clinical Oncology. 15, 7, p. 459-466 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Author Correction: Analysis of DNA methylation in cancer: location revisited

Koch, A., Joosten, S., Feng, Z., de Ruijter, T., Draht, M., Melotte, V., Smits, K., Veeck, J., Herman, J. G., van Neste, L., Van Criekinge, W., De Meyer, T. & van Engeland, M., 2018, In : Nature Reviews Clinical Oncology. 15, p. 467

Research output: Contribution to journalErratum / corrigendumAcademic

Cost-effectiveness of High-performance Biomarker Tests vs Fecal Immunochemical Test for Noninvasive Colorectal Cancer Screening

Lansdorp-Vogelaar, I., Goede, S. L., Bosch, L. J. W., Melotte, V., Carvalho, B., van Engeland, M., Meijer, G. A., de Koning, H. J. & van Ballegooijen, M., 1 Apr 2018, In : Clinical gastroenterology and hepatology. 16, 4, p. 504-12 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Epigenetics in renal cell cancer: mechanisms and clinical applications

Joosten, S. C., Smits, K. M., Aarts, M. J., Melotte, V., Koch, A., Tjan-Heijnen, V. C. & van Engeland, M., 1 Jul 2018, In : Nature Reviews Urology. 15, 7, p. 430-451 22 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Prognostic DNA methylation markers for sporadic colorectal cancer: a systematic review

Draht, M. X. G., Goudkade, D., Koch, A., Grabsch, H. I., Weijenberg, M. P., van Engeland, M., Melotte, V. & Smits, K. M., 14 Mar 2018, In : Clinical epigenetics. 10, 16 p., 35.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2017

A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patients

van Vlodrop, I. J. H., Joosten, S. C., De Meyer, T., Smits, K. M., Van Neste, L., Melotte, V., Baldewijns, M. M. L. L., Schouten, L. J., van den Brandt, P. A., Jeschke, J., Yi, J. M., Schuebel, K. E., Ahuja, N., Herman, J. G., Aarts, M. J., Bosman, F. T., Van Criekinge, W. & van Engeland, M., 15 Apr 2017, In : Clinical Cancer Research. 23, 8, p. 2006-2018 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Assessing opportunities for coordinated R&D in early cancer detection and management in Europe

Ussi, A. E., Rebolj, M., Thorat, M. A., Bietrix, F., Fauvel, A-C., Hajduch, M., Hill, C., Walker, I., van Engeland, M., Cuzick, J. & Meijer, G., Apr 2017, In : International Journal of Cancer. 140, 7, p. 1700-1701 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Decoy receptor 1 (DCR1) promoter hypermethylation and response to irinotecan in metastatic colorectal cancer

Bosch, L. J. W., Trooskens, G., Snaebjornsson, P., Coupe, V. M. H., Mongera, S., Haan, J. C., Richman, S. D., Koopman, M., Tol, J., de Meyer, T., Louwagie, J., Dehaspe, L., van Grieken, N. C. T., Ylstra, B., Verheul, H. M. W., van Engeland, M., Nagtegaal, I. D., Herman, J. G., Quirke, P., Seymour, M. T. & 4 others, Punt, C. J. A., van Criekinge, W., Carvalho, B. & Meijer, G. A., 8 Sep 2017, In : Oncotarget. 8, 38, p. 63140-63154 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Details matter: the role of genomic location and assay standardization in DNA methylation analyses

Lind, G. E. & van Engeland, M., Jul 2017, In : Epigenomics. 9, 7, p. 933-935 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Molecular stool testing as an alternative for surveillance colonoscopy: a cross-sectional cohort study

van Lanschot, M. C. J., Carvalho, B., Coupe, V. M. H., van Engeland, M., Dekker, E. & Meijer, G. A., 7 Feb 2017, In : BMC Cancer. 17, 8 p., 116.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons

Vaes, N., Lentjes, M. H. F. M., Gijbels, M. J., Rademakers, G., Daenen, K. L., Boesmans, W., Wouters, K. A. D., Geuzens, A., Qu, X., Steinbusch, H. P. J., Rutten, B. P. F., Baldwin, S. H., Sharkey, K. A., Hofstra, R. M. W., van Engeland, M., Vanden Berghe, P. & Melotte, V., Sep 2017, In : Neurogastroenterology and Motility. 29, 9, 10 p., 13095.

Research output: Contribution to journalArticleAcademicpeer-review

Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation

De Smet, F., Rubio, M. S., Hompes, D., Naus, E., De Baets, G., Langenberg, T., Hipp, M. S., Houben, B., Claes, F., Charbonneau, S., Blanco, J. D., Plaisance, S., Ramkissoon, S., Ramkissoon, L., Simons, C., van den Brandt, P., Weijenberg, M., Van Engeland, M., Lambrechts, S., Amant, F. & 5 others, D'Hoore, A., Ligon, K. L., Sagaert, X., Schymkowitz, J. & Rousseau, F., May 2017, In : Journal of Pathology. 242, 1, p. 24-38 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prognostic DNA methylation markers for renal cell carcinoma: a systematic review

Joosten, S. C., Deckers, I. A. G., Aarts, M. J., Hoeben, A., van Roermund, J. G., Smits, K. M., Melotte, V., van Engeland, M. & Tjan-Heijnen, V. C., Sep 2017, In : Epigenomics. 9, 9, p. 1243-1257 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Promoter CpG island methylation in ion transport mechanisms and associated dietary intakes jointly influence the risk of clear-cell renal cell cancer

Deckers, I. A. G., van Engeland, M., van den Brandt, P. A., Van Neste, L., Soetekouw, P. M. M. B., Aarts, M. J. B., Baldewijns, M. M. L. L., Keszei, A. P. & Schouten, L. J., Apr 2017, In : International Journal of Epidemiology. 46, 2, p. 622-631 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Alcohol and Dietary Folate Intake and Promoter CpG Island Methylation in Clear-Cell Renal Cell Cancer

Schouten, L. J., Deckers, I. A. G., van den Brandt, P. A., Baldewijns, M. M. L. L. & van Engeland, M., 2016, In : Nutrition and Cancer-An International Journal. 68, 7, p. 1097-1107

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Analysis of RET promoter CpG island methylation using methylation-specific PCR (MSP), pyrosequencing, and methylation-sensitive high-resolution melting (MS-HRM): impact on stage II colon cancer patient outcome

Draht, M. X. G., Smits, K. M., Jooste, V., Tournier, B., Vervoort, M., Ramaekers, C., Chapusot, C., Weijenberg, M. P., van Engeland, M. & Melotte, V., 26 Apr 2016, In : Clinical epigenetics. 8, 44.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Potential role of gene-environment interactions in ion transport mechanisms in the etiology of renal cell cancer

Deckers, I. A. G., van den Brandt, P. A., van Engeland, M., van Schooten, F. J., Godschalk, R. W. L., Keszei, A. P., Hogervorst, J. G. F. & Schouten, L. J., 30 Sep 2016, In : Scientific Reports. 6, 34262.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The emerging role of GATA transcription factors in development and disease

Lentjes - Beer, M., Niessen, H. E. C., Akiyama, Y., De Bruine, A. P., Melotte, V. & Van Engeland, M., 8 Mar 2016, In : Expert Reviews in Molecular Medicine. 18, e3.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Formalin-fixed, paraffin-embedded (FFPE) tissue epigenomics using Infinium HumanMethylation450 BeadChip assays

de Ruijter, T. C., de Hoon, J. P. J., Slaats, J., de Vries, B., Janssen, M. J. F. W., van Wezel, T., Aarts, M. J. B., van Engeland, M., Tjan-Heijnen, V. C. G., Van Neste, L. & Veeck, J., Jul 2015, In : Laboratory Investigation. 95, 7, p. 833-842

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Methylation of RASSF10 Promotes Cell Proliferation and Serves as a Docetaxel Resistant Marker in Human Breast Cancer

Dong, T., Zhang, M., Dong, Y., Herman, J. G., van Engeland, M., Zhong, G. & Guo, M., Nov 2015, In : Discovery Medicine. 20, 111, p. 261-271

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Prognostic Significance of Promoter Hypermethylation and Diminished Gene Expression of SYNPO2 in Melanoma

Gao, L., van den Hurk, K., Nsengimana, J., Laye, J. P., van den Oord, J. J., Beck, S., Gruis, N. A., Zoutman, W. H., van Engeland, M., Newton-Bishop, J. A., Winnepenninckx, V. J. & van Doorn, R., Sep 2015, In : Journal of Investigative Dermatology. 135, 9, p. 2328-2331

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome

Deckers, I. A. G., Schouten, L. J., van Neste, L., van Vlodrop, I. J. H., Soetekouw, P. M. M. B., Baldewijns, M. M. L. L., Jeschke, J., Ahuja, N., Herman, J. G., van den Brandt, P. A. & van Engeland, M., 1 Jan 2015, In : Clinical Cancer Research. 21, 15, p. 3492-3500

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Resistance to sunitinib in renal cell carcinoma: From molecular mechanisms to predictive markers and future perspectives

Joosten, S. C., Hamming, L., Soetekouw, P. M., Aarts, M. J., Veeck, J., van Engeland, M. & Tjan-Heijnen, V. C., Jan 2015, In : Biochimica et Biophysica Acta-reviews on Cancer. 1855, 1, p. 1-16

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Spectrin Repeat Containing Nuclear Envelope 1 and Forkhead Box Protein E1 Are Promising Markers for the Detection of Colorectal Cancer in Blood

Melotte, V., Yi, J. M., Lentjes, M. H. F. M., Smits, K. M., Van Neste, L., Niessen, H. E. C., Wouters, K. A. D., Louwagie, J., Schuebel, K. E., Herman, J. G., Baylin, S. B., van Criekinge, W., Meijer, G. A., Ahuja, N. & van Engeland, M., Feb 2015, In : Cancer prevention research. 8, 2, p. 157-164

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

CHFR Promoter Methylation Indicates Poor Prognosis in Stage II Microsatellite Stable Colorectal Cancer

Cleven, A. H. G., Derks, S., Draht, M. X. G., Smits, K. M., Melotte, V., Van Neste, L., Tournier, B., Jooste, V., Chapusot, C., Weijenberg, M. P., Herman, J. G., de Bruine, A. P. & van Engeland, M., 15 Jun 2014, In : Clinical Cancer Research. 20, 12, p. 3261-3271

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Chordoma: the entity

Yakkioui, Y., van Overbeeke, J. J., Santegoeds, R., van Engeland, M. & Temel, Y., Dec 2014, In : Biochimica et Biophysica Acta. Mucoproteins and Mucopolysaccharides. 1846, 2, p. 655-69 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Dietary acrylamide intake and the risk of colorectal cancer with specific mutations in KRAS and APC

Hogervorst, J. G. F., de Bruijn-Geraets, D., Schouten, L. J., van Engeland, M., de Kok, T. M. C. M., Goldbohm, R. A., van den Brandt, P. A. & Weijenberg, M. P., May 2014, In : Carcinogenesis. 35, 5, p. 1032-1038 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine

Derks, S., Cleven, A. H. G., Melotte, V., Smits, K. M., Brandes, J. C., Azad, N., van Criekinge, W., de Bruine, A. P., Herman, J. G. & van Engeland, M., Mar 2014, In : Cancer and Metastasis Reviews. 33, 1, p. 161-171

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Epigenetics in radiotherapy: Where are we heading?

Smits, K. M., Melotte, V., Niessen, H. E. C., Dubois, L., Oberije, C., Troost, E. G. C., Starmans, M. H. W., Boutros, P. C., Vooijs, M., van Engeland, M. & Lambin, P., May 2014, In : Radiotherapy and Oncology. 111, 2, p. 168-177

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer

Deckers, I. A. G., van den Brandt, P. A., van Engeland, M., Soetekouw, P. M. M. B., Baldewijns, M. M. L. L., Goldbohm, R. A. & Schouten, L. J., 1 Jan 2014, In : British Journal of Cancer. 110, p. 797-801

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

MEN1 Gene Mutation and Reduced Expression Are Associated With Poor Prognosis in Pulmonary Carcinoids

Swarts, D. R. A., Scarpa, A., Corbo, V., van Criekinge, W., van Engeland, M., Gatti, G., Henfling, M. E. R., Papotti, M., Perren, A., Ramaekers, F. C. S., Speel, E-J. M. & Volante, M., Feb 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 2, p. E374-E378

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysis

Juo, Y. Y., Johnston, F. M., Zhang, D. Y., Juo, H. H., Wang, H., Pappou, E. P., Yu, T., Easwaran, H., Baylin, S., van Engeland, M. & Ahuja, N., Dec 2014, In : Annals of Oncology. 25, 12, p. 2314-2327

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Promoter CpG Island Hypermethylation in Dysplastic Nevus and Melanoma: CLDN11 as an Epigenetic Biomarker for Malignancy

Gao, L., van den Hurk, K., Moerkerk, P. T. M., Goeman, J. J., Beck, S., Gruis, N. A., van den Oord, J. J., Winnepenninckx, V. J., van Engeland, M. & van Doorn, R., Dec 2014, In : Journal of Investigative Dermatology. 134, 12, p. 2957-2966

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Promoter CpG island methylation of RET predicts poor prognosis in stage II colorectal cancer patients

Draht, M. X. G., Smits, K. M., Tournier, B., Jooste, V., Chapusot, C., Carvalho, B., Cleven, A. H. G., Derks, S., Wouters, K. A. D., Belt, E. J. T., Stockmann, H. B. A. C., Bril, H., Weijenberg, M. P., van den Brandt, P. A., de Bruïne, A. P., Herman, J. G., Meijer, G. A., Piard, F., Melotte, V. & van Engeland, M., 1 Jan 2014, In : Molecular oncology. 8, 3, p. 679-688

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
2013

An exploration of pathways involved in lung carcinoid progression using gene expression profiling

Swarts, D. R. A., Van Neste, L., Henfling, M. E. R., Eijkenboom, I., Eijk, P. P., van Velthuysen, M-L., Vink, A., Volante, M., Ylstra, B., Van Criekinge, W., van Engeland, M., Ramaekers, F. C. S. & Speel, E-J. M., Dec 2013, In : Carcinogenesis. 34, 12, p. 2726-2737

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis

Simons, C., Hughes, L. A. E., Smits, K. M., Khalid-de Bakker, C. A., de Bruine, A. P., Carvalho, B., Meijer, G. A., Schouten, L. J., van den Brandt, P. A., Weijenberg, M. P. & van Engeland, M., Aug 2013, In : Annals of Oncology. 24, 8, p. 2048-2056

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

CD44 and OTP Are Strong Prognostic Markers for Pulmonary Carcinoids

Swarts, D. R. A., Henfling, M. E. R., Van Neste, L., van Suylen, R-J., Dingemans, A-M. C., Dinjens, W. N. M., Haesevoets, A., Rudelius, M., Thunnissen, E., Volante, M., Van Criekinge, W., van Engeland, M., Ramaekers, F. C. S. & Speel, E-J. M., 15 Apr 2013, In : Clinical Cancer Research. 19, 8, p. 2197-2207

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Dietary heme iron and the risk of colorectal cancer with specific mutations in KRAS and APC

Gilsing, A. M. J., Fransen, F., de Kok, T. M., Goldbohm, A. R., Schouten, L. J., de Bruine, A. P., van Engeland, M., van den Brandt, P. A., de Goeij, A. F. P. M. & Weijenberg, M. P., Dec 2013, In : Carcinogenesis. 34, 12, p. 2757-2766

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)