No photo of Lowie Vanfleteren
  • Universiteitssingel50, UNS50

    6229 ER Maastricht

    Netherlands

20102019
If you made any changes in Pure these will be visible here soon.

Research Output 2010 2019

2019

Airflow Obstruction and Cardio-metabolic Comorbidities

Triest, F. J. J., Studnicka, M., Franssen, F. M. E., Vollmer, W. M., Lamprecht, B., Wouters, E. F. M., Burney, P. G. J. & Vanfleteren, L. E. G. W., 4 Mar 2019, In : Copd-Journal of Chronic Obstructive Pulmonary Disease. 16, 2, p. 109-117 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging

Triest, F. J. J., Franssen, F. M. E., Reynaert, N., Gaffron, S., Spruit, M. A., Janssen, D. J. A., Rutten, E. P. A., Wouters, E. F. M. & Vanfleteren, L. E. G. W., Apr 2019, In : Journal of Clinical Medicine. 8, 4, p. 1-18 18 p., 511.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Endobronchial valves for severe emphysema

Hartman, J. E., Vanfleteren, L. E. G. W., van Rikxoort, E. M., Klooster, K. & Slebost, D-J., 30 Jun 2019, In : European Respiratory Review. 28, 152, p. 1-7 7 p., 180121.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation

Goertz, Y. M. J., Spruit, M. A., Van't Hul, A. J., Peters, J. B., Van Herck, M., Nakken, N., Djamin, R. S., Burtin, C., Thong, M. S. Y., Coors, A., Meertens-Kerris, Y., Wouters, E. F. M., Prins, J. B., Franssen, F. M. E., Muris, J. W. M., Vanfleteren, L. E. G. W., Sprangers, M. A. G., Janssen, D. J. A. & Vercoulen, J. H., Sep 2019, In : Therapeutic Advances in Respiratory Disease. 13, 13 p., 1753466619878128.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impact of pulmonary rehabilitation on activities of daily living in patients with chronic obstructive pulmonary disease

Vaes, A. W., Delbressine, J. M. L., Mesquita, R., Goertz, Y. M. J., Janssen, D. J. A., Nakken, N., Franssen, F. M. E., Vanfleteren, L. E. G. W., Wouters, E. F. M. & Spruit, M. A., Mar 2019, In : Journal of Applied Physiology. 126, 3, p. 607-615 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Bronchoscopic Lung Volume Reduction Treatment Using Endobronchial Valves for Emphysema: Emerging Questions

Hartman, J. E., Van Fleteren, L. E. G. W., van Rikxoort, E. M. & Slebos, D-J., 1 Jan 2018, In : Respiration. 96, 6, p. 588-589 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease

Cleutjens, F. A. H. M., Spruit, M. A., Ponds, R. W. H. M., Vanfleteren, L. E. G. W., Franssen, F. M. E., Gijsen, C., Dijkstra, J. B., Wouters, E. F. M. & Janssen, D. J. A., May 2018, In : Chronic respiratory disease. 15, 2, p. 91-102 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Contribution of individual COPD assessment test (CAT) items to CAT total score and effects of pulmonary rehabilitation on CAT scores

Houben-Wilke, S., Janssen, D. J. A., Franssen, F. M. E., Vanfleteren, L. E. G. W., Wouters, E. F. M. & Spruit, M. A., 30 Oct 2018, In : Health and Quality of Life Outcomes. 16, 8 p., 205.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Determinants of functional, peak and endurance exercise capacity in people with chronic obstructive pulmonary disease

McNamara, R. J., Houben-Wilke, S., Franssen, F. M. E., Smid, D. E., Vanfleteren, L. E. G. W., Groenen, M. T. J., Uszko-Lencer, N. H. M. K., Wouters, E. F. M., Alison, J. A. & Spruit, M. A., May 2018, In : Respiratory Medicine. 138, p. 81-87 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effectiveness of Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease With Different Degrees of Static Lung Hyperinflation

Vanfleteren, M. J., Koopman, M., Spruit, M. A., Pennings, H-J., Smeenk, F., Pieters, W., van den Bergh, J. J., Michels, A-J., Wouters, E. F., Groenen, M. T., Franssen, F. M. & Vanfleteren, L. E., Nov 2018, In : Archives of Physical Medicine and Rehabilitation. 99, 11, p. 2279-2286 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients

Vaes, A. W., Spruit, M. A., Theunis, J., Goswami, N., Vanfleteren, L. E., Franssen, F. M. E., Wouters, E. F. M. & De Boever, P., Sep 2018, In : Acta Ophthalmologica. 96, 6, p. 539-549 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Personalised pulmonary rehabilitation in COPD

Wouters, E. F. M., Wouters, B. B. R. E. F., Augustin, I. M. L., Houben-Wilke, S., Vanfleteren, L. E. G. W. & Franssen, F. M. E., 31 Mar 2018, In : European Respiratory Review. 27, 147, 8 p., 170125.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Pulmonary rehabilitation for patients with COPD during and after an exacerbation-related hospitalisation: back to the future?

Spruit, M. A., Singh, S. J., Rochester, C. L., Greening, N. J., Franssen, F. M. E., Pitta, F., Troosters, T., Nolan, C., Vogiatzis, I., Clini, E. M., Man, W. D-C., Burtin, C., Goldstein, R. S., Vanfleteren, L. E. G. W., Kenn, K., Nici, L., Janssen, D. J. A., Casaburi, R., Shioya, T., Garvey, C. & 5 others, Carlin, B. W., ZuWallack, R. L., Steiner, M., Wouters, E. F. M. & Puhan, M. A., 1 Jan 2018, In : European Respiratory Journal. 51, 1, p. 1-4 4 p., 1701312.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Time for a longer and better life for patients with COPD

Vanfleteren, L. E. G. W., Ullman, A. & Fabbri, L. M., 1 Jan 2018, In : European Respiratory Journal. 51, 1, p. 1-5 5 p., 1702569.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Triple therapy (ICS/LABA/LAMA) in COPD: time for a reappraisal

Vanfleteren, L., Fabbri, L. M., Papi, A., Petruzzelli, S. & Celli, B., 1 Jan 2018, In : International journal of chronic obstructive pulmonary disease. 13, p. 3971-3981 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2017

Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study

Horner, A., Soriano, J. B., Puhan, M. A., Studnicka, M., Kaiser, B., Vanfleteren, L. E. G. W., Gnatiuc, L., Burney, P., Miravitlles, M., Garcia-Rio, F., Ancochea, J., Menezes, A. M., Perez-Padilla, R., de Oca, M. M., Torres-Duque, C. A., Caballero, A., Gonzalez-Garcia, M., Buist, S., Flamm, M. & Lamprecht, B., 23 Aug 2017, In : Respiratory Research. 18, 10 p., 162.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Domain-specific cognitive impairment in patients with COPD and control subjects

Cleutjens, F. A. H. M., Franssen, F. M. E., Spruit, M. A., Vanfleteren, O. E. G. W., Gijsen, C., Dijkstra, J. B., Ponds, R. W. H. M., Wouters, E. F. M. & Janssen, D. J. A., 2017, In : International journal of chronic obstructive pulmonary disease. 12, p. 1-11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Echocardiographic abnormalities and their impact on health status in patients with COPD referred for pulmonary rehabilitation

Houben-Wilke, S., Spruit, M. A., Uszko-Lencer, N. H. M. K., Otkinska, G., Vanfleteren, L. E. G. W., Jones, P. W., Wouters, E. F. M. & Franssen, F. M. E., Jul 2017, In : Respirology. 22, 5, p. 928-934 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Endothelial function in patients with chronic obstructive pulmonary disease: a systematic review of studies using flow mediated dilatation

Vaes, A. W., Spruit, M. A., Theunis, J., Goswami, N., Vanfleteren, L. E., Franssen, F. M. E., Wouters, E. F. M. & De Boever, P., 2017, In : Expert Review of Respiratory Medicine. 11, 12, p. 1021-1031 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Increased exercise tolerance using daytime mouthpiece ventilation for patients with diaphragm paralysis Case report

Koopman, M., Vanfleteren, L. E. G. W., Steijns, S., Wouters, E. F. M. & Sprooten, R., 1 Sep 2017, In : Breathe. 13, 3, p. 225-229 5 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Lower-limb muscle function is a determinant of exercise tolerance after lung resection surgery in patients with lung cancer

Burtin, C., Franssen, F. M. E., Vanfleteren, L. E. G. W., Groenen, M. T. J., Wouters, E. F. M. & Spruit, M. A., Aug 2017, In : Respirology. 22, 6, p. 1185-1189 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease

Smid, D. E., Franssen, F. M. E., Gonik, M., Miravitlles, M., Casanova, C., Cosio, B. G., de Lucas-Ramos, P., Marin, J. M., Martinez, C., Mir, I., Soriano, J. B., de Torres, J. P., Agusti, A., Atalay, N. B., Billington, J., Boutou, A. K., Brighenti-Zogg, S., Chaplin, E., Coster, S., Dodd, J. W. & 61 others, Durr, S., Fernandez-Villar, A., Groenen, M. T. J., Guimaraes, M., Hejduk, K., Higgins, V., Hopkinson, N. S., Horita, N., Houben-Wilke, S., Janssen, D. J. A., Jehn, M., Joerres, R., Karch, A., Kelly, J. L., Kim, Y-I., Kimura, H., Koblizek, V., Kocks, J. H., Kon, S. S. C., Kwon, N., Ladeira, I., Lee, S-D., Leuppi, J. D., Locantore, N., Lopez-Campos, J. L., Man, W. D-C., Maricic, L., Mendoza, L., Miedinger, D., Mihaltan, F., Minami, S., van der Molen, T., Murrells, T. J., Nakken, N., Nishijima, Y., Norman, I. J., Novotna, B., O'Donnell, D. E., Ogata, Y., Pereira, E. D., Piercy, J., Price, D., Pothirat, C., Raghavan, N., Ringbaek, T., Sajkov, D., Sigari, N., Singh, S., Small, M., da Silva, G. F., Tanner, R. J., Tsiligianni, I. G., Tulek, B., Tzanakis, N., Vanfleteren, L. E. G. W., Watz, H., Webb, K. A., Wouters, E. F. M., Xie, G. G., Yoshikawa, M. & Spruit, M. A., 1 Dec 2017, In : Journal of the American Medical Directors Association. 18, 12, 14 p., ARTN 1097.e11-1097.e24.

Research output: Contribution to journalArticleAcademicpeer-review

Responsiveness and MCID Estimates for CAT, CCQ, and HADS in Patients With COPD Undergoing Pulmonary Rehabilitation: A Prospective Analysis

Smid, D. E., Franssen, F. M. E., Houben-Wilke, S., Vanfleteren, L. E. G. W., Janssen, D. J. A., Wouters, E. F. M. & Spruit, M. A., Jan 2017, In : Journal of the American Medical Directors Association. 18, 1, p. 53-58 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tailoring the approach to multimorbidity in adults with respiratory disease: the NICE guideline

Vanfleteren, L. E. G. W., Spruit, M. A. & Franssen, F. M. E., Feb 2017, In : European Respiratory Journal. 49, 2, 5 p., 1601696.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

The Fat Lady Sings Again

Vanfleteren, L. E. G. W. & Slebos, D-J., 2017, In : Respiration. 94, 6, p. 488-490 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

The Impact of Cognitive Impairment on Efficacy of Pulmonary Rehabilitation in Patients With COPD

Cleutjens, F. A. H. M., Spruit, M. A., Ponds, R. W. H. M., Vanfleteren, L. E. G. W., Franssen, F. M. E., Dijkstra, J. B., Gijsen, C., Wouters, E. F. M. & Janssen, D. J. A., 1 May 2017, In : Journal of the American Medical Directors Association. 18, 5, p. 420-426 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The patient with a complex chronic respiratory disease: a specialist of his own life?

Houben-Wilke, S., Augustin, I. M. L., Wouters, B. B. R. E. F., Stevens, R. A. H., Janssen, D. J. A., Spruit, M. A., Vanfleteren, L. E. G. W., Franssen, F. M. E. & Wouters, E. F. M., 2017, In : Expert Review of Respiratory Medicine. 11, 12, p. 919-924 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study

Cleutjens, F. A. H. M., Ponds, R. W. H. M., Spruit, M. A., Burgmans, S., Jacobs, H. I. L., Gronenschild, E. H. B. M., Staals, J., Franssen, F. M. E., Dijkstra, J. B., Vanfleteren, L. E. G. W., Hofman, P. A., Wouters, E. F. M. & Janssen, D. J. A., 29 Mar 2017, In : Frontiers in Aging Neuroscience. 9, 9 p., 88.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
2 Citations (Scopus)

A new perspective on COPD exacerbations: monitoring impact by measuring physical, psychological and social resilience

Spruit, M. A., Franssen, F. M. E., Rutten, E. P. A., Wopereis, S., Wouters, E. F. M. & Vanfleteren, L. E. G. W., Apr 2016, In : European Respiratory Journal. 47, 4, p. 1024-1027

Research output: Contribution to journalEditorialAcademicpeer-review

2 Citations (Scopus)

Body mass index and chronic airflow limitation in a worldwide population-based study

Vanfleteren, L. E. G. W., Lamprecht, B., Studnicka, M., Kaiser, B., Gnatiuc, L., Burney, P., Wouters, E. F. M. & Franssen, F. M. E., May 2016, In : Chronic respiratory disease. 13, 2, p. 90-101

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study

Andrianopoulos, V., Celli, B. R., Franssen, F. M. E., Pinto-Plata, V. M., Calverley, P. M. A., Vanfleteren, L. E. G. W., Vogiatzis, I., Vestbo, J., Agusti, A., Bakke, P. S., Rennard, S. I., MacNee, W., Tal-Singer, R., Yates, J. C., Wouters, E. F. M. & Spruit, M. A., Oct 2016, In : Respiratory Medicine. 119, p. 87-95

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Effects of obesity on weight-bearing versus weight-supported exercise testing in patients with COPD

Maatman, R. C., Spruit, M. A., van Melick, P. P., Peeters, J. P., Rutten, E. P., Vanfleteren, L. E., Wouters, E. F. & Franssen, F., Apr 2016, In : Respirology. 21, 3, p. 483–488 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Health Status and Morbidities in Resident Relatives of Patients With COPD

Nakken, N., Spruit, M. A., van den Bogaart, E. H., van Vliet, M., de Vries, G. J., Custers, F. L., Vercoulen, J. H., Asijee, G. M., Muris, J. W., Vanfleteren, L. E., Franssen, F. M., Wouters, E. F. & Janssen, D. J. A., 1 Mar 2016, In : Journal of the American Medical Directors Association. 17, 3, p. 276.e1–276.e8 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Indacaterol-Glycopyrronium for COPD

Franssen, F. M. E., Wouters, E. F. M. & Vanfleteren, L. E. G. W., 1 Sep 2016, In : New England Journal of Medicine. 375, 9, p. 898-899

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Management of chronic obstructive pulmonary disease beyond the lungs

Vanfleteren, L. E. G. W., Spruit, M. A., Wouters, E. F. M. & Franssen, F. M. E., Nov 2016, In : The Lancet Respiratory medicine. 4, 11, p. 911-924

Research output: Contribution to journalArticleAcademicpeer-review

Transcutaneous carbon-dioxide partial pressure trends during six-minute walk test in patients with very severe COPD

Andrianopoulos, V., Vanfleteren, L. E. G. W., Jarosch, I., Gloeckl, R., Schneeberger, T., Wouters, E. F. M., Spruit, M. A. & Kenn, K., Nov 2016, In : Respiratory physiology & neurobiology. 233, p. 52-59

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

What is the impact of impaired left ventricular ejection fraction in COPD after adjusting for confounders?

Barreto de Mesquita, R., Franssen, F. M. E., Houben-Wilke, S., Lencer, N., Vanfleteren, L. E. G. W., Goertz, Y. M. J., Pitta, F., Wouters, E. F. M. & Spruit, M., 15 Dec 2016, In : International Journal of Cardiology. 225, p. 365-370

Research output: Contribution to journalArticleAcademicpeer-review

2015
1 Citation (Scopus)

Continuous fat-free mass decline in COPD: fact or fiction?

Rutten, E. P. A., Spruit, M. A., McDonald, M. L. N., Rennard, S., Agusti, A., Celli, B., Miller, B. E., Crim, C., Calverley, P. M. A., Hanson, C., MacNee, W., Franssen, F. M. E., Vanfleteren, L., ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points)Investigators, T. & Wouters, E. F. M., Nov 2015, In : European Respiratory Journal. 46, 5, p. 1496-1498 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

2 Citations (Scopus)
1081 Downloads (Pure)

COPD and comorbidity

Vanfleteren, L. E. G. W., 2015, Maastricht: Maastricht University. 224 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
File

COPD management: need for more consensus

Vanfleteren, L. E. G. W., Franssen, F. M. E., Wouters, E. F. M. & Spruit, M. A., 1 Jan 2015, In : The Lancet Respiratory medicine. 3, 7, p. e21-e22

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

38 Citations (Scopus)

Determinants of underdiagnosis of COPD in national and international surveys

Lamprecht, B., Soriano, J. B., Studnicka, M., Kaiser, B., Vanfleteren, L. E., Gnatiuc, L., Burney, P., Miravitlles, M., Garcia-Rio, F., Akbari, K., Ancochea, J., Menezes, A. M., Perez-Padilla, R., Montes de Oca, M., Torres-Duque, C. A., Caballero, A., Gonzalez-Garcia, M. & Buist, S., Oct 2015, In : Chest. 148, 4, p. 971-985 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Differential response to pulmonary rehabilitation in COPD: multidimensional profiling

Spruit, M. A., Augustin, I. M. L., Vanfleteren, L. E., Janssen, D. J. A., Gaffron, S., Pennings, H. J., Smeenk, F., Pieters, W., van den Bergh, J. J. A. M., Michels, A. J., Groenen, M. T. J., Rutten, E. P. A., Wouters, E. F. M. & Franssen, F. M. E., 9 Oct 2015, In : European Respiratory Journal. 46, 6, p. 1625-1635

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Does COPD stand for "COmorbidity with Pulmonary Disease"?

Vanfleteren, L. E., 1 Jan 2015, In : European Respiratory Journal. 45, 1, p. 14-17 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

New Insights in Chronic Obstructive Pulmonary Disease and Comorbidity

Cleutjens, F., Triest, F., Wilke, S., Vanfleteren, L. E. G. W., Franssen, F. M. E., Janssen, D. J. A., Rutten, E. P., Spruit, M. A. & Wouters, E. F. M., 1 May 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 9, p. 1081-1081 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

11 Citations (Scopus)

Objectively identified comorbidities in COPD: impact on pulmonary rehabilitation outcomes

Mesquita, R., Vanfleteren, L. E. G. W., Franssen, F. M. E., Sarv, J., Taib, Z., Groenen, M. T. J., Gaffron, S., Bruijnzeel, P. L. B., Pitta, F., Wouters, E. F. M. & Spruit, M. A., Aug 2015, In : European Respiratory Journal. 46, 2, p. 545-548 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

8 Citations (Scopus)

Poor agreement between chart-based and objectively identified comorbidities of COPD

Triest, F. J. J., Franssen, F. M. E., Spruit, M. A., Groenen, M. T. J., Wouters, E. F. M. & Vanfleteren, L. E. G. W., Nov 2015, In : European Respiratory Journal. 46, 5, p. 1492-1495 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

7 Citations (Scopus)

Prognostic value of variables derived from the six-minute walk test in patients with COPD: Results from the ECLIPSE study

Andrianopoulos, V., Wouters, E. F. M., Pinto-Plata, V. M., Vanfleteren, L. E. G. W., Bakke, P. S., Franssen, F. M. E., Agusti, A., MacNee, W., Rennard, S. I., Tal-Singer, R., Vogiatzis, I., Vestbo, J., Celli, B. R. & Spruit, M. A., Sep 2015, In : Respiratory Medicine. 109, 9, p. 1138-1146 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
5 Citations (Scopus)
16 Citations (Scopus)

Arterial stiffness in patients with COPD: the role of systemic inflammation and the effects of pulmonary rehabilitation

Vanfleteren, L. E. G. W., Spruit, M. A., Groenen, M. T. J., Bruijnzeel, P. L. B., Taib, Z., Rutten, E. P. A., op 't Roodt, J., Akkermans, M. A., Wouters, E. F. M. & Franssen, F. M. E., May 2014, In : European Respiratory Journal. 43, 5, p. 1306-1315 10 p.

Research output: Contribution to journalArticleAcademicpeer-review