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Research Output 1994 2017

  • 24 Article
  • 1 Comment/Letter to the editor
2017

Early prediction of thiopurine-induced hepatotoxicity in inflammatory bowel disease

Wong, D. R., Coenen, M. J. H., Derijks, L. J. J., Vermeulen, S. H., van Marrewijk, C. J., Klungel, O. H., Scheffer, H., Franke, B., Guchelaar, H. -J., de Jong, D. J., Engels, L. G. J. B., Verbeek, A. L. M., Masclee, A. & Hooymans, P. M., Feb 2017, In : Alimentary Pharmacology & Therapeutics. 45, 3, p. 391-402 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
4 Citations (Scopus)

The pharmacokinetic effect of adalimumab on thiopurine metabolism in Crohn's disease patients

Wong, D. R., Pierik, M., Seinen, M. L., van Bodegraven, A. A., Gilissen, L. P. L., Bus, P., Bakker, J. A., Masclee, A. A. M., Neef, C., Engels, L. G. J. B. & Hooymans, P. M., 1 Feb 2014, In : Journal of Crohn's & Colitis. 8, 2, p. 120-128 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012
19 Citations (Scopus)

Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon.

Hebels, D., Sveje, K. M., de Kok, M. C., van Herwijnen, M. H., Kuhnle, G. G., Engels, L. G. B., Vleugels Simon, C. B., Mares, W. G., Pierik, M. J., Masclee, A. A. M., Kleinjans, J. & de Kok, T. M., 1 Jan 2012, In : Food and Chemical Toxicology. 50, 2, p. 95-103

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Therapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy.

Gilissen, L. P., Wong, D. R., Engels, L. G. B., Bierau, J., Bakker, J. A., Paulussen, A. D. C., Romberg-Camps, M., Stronkhorst, A., Bus, P., Bos, L. P., Hooymans, P. M., Stockbrügger, R. W., Neef, C. K. & Masclee, A. A. M., 1 Jan 2012, In : Journal of Crohn's & Colitis. 6, 6, p. 698-707

Research output: Contribution to journalArticleAcademicpeer-review

2011
12 Citations (Scopus)

N-nitroso compound exposure-associated transcriptomic profiles are indicative of an increased risk for colorectal cancer

Hebels, D. G., Sveje, K. M., de Kok, M. C., van Herwijnen, M. H., Kuhnle, G. G., Engels, L. G. B., Vleugels Simon, C. B., Mares, W. G., Pierik, M. J., Masclee, A. A. M., Kleinjans, J. C. & de Kok, T. M., 1 Oct 2011, In : Cancer Letters. 309, 1, p. 1-10 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

The long-term effect of ursodeoxycholic acid on laboratory liver parameters in biochemically non-advanced primary biliary cirrhosis.

Kuiper, E. M., Hansen, B. E., Lesterhuis, W., Robijn, R. J., Thijs, J. C., Engels, L. G. B., Koek, G. H., Aparicio, M. N., Kerbert Dreteler, M. J. & van Buuren, H. R., 1 Jan 2011, In : Clinics and research in hepatology and gastroenterology. 35, 1, p. 29-33 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2010
59 Citations (Scopus)

Fatigue and health-related quality of life in inflammatory bowel disease: Results from a population-based study in the Netherlands: The IBD-South Limburg cohort.

Romberg-Camps, M., Bol, Y., Dagnelie, P. C., van der Hesselink-Kruijs, M. A. M., Kester, A. D., Engels, L. G. B., van Deursen, C., Hameeteman, W. H., Pierik, M. J., Wolters, F., Russel, M. G. & Stockbrügger, R. W., 1 Jan 2010, In : Inflammatory Bowel Diseases. 16, 12, p. 2137-2147

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Scopus)

Proton pump inhibitor use is associated with an increased risk for microscopic colitis: a case-control study

Keszthelyi, D., Jansen, S. V., Schouten, G. A., de Kort, S., Scholtes, B., Engels, L. G. B. & Masclee, A. A. M., 1 Nov 2010, In : Alimentary Pharmacology & Therapeutics. 32, 9, p. 1124-1128 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2009
133 Citations (Scopus)

Influence of phenotype at diagnosis and of other potential prognostic factors on the course of inflammatory bowel disease

Romberg-Camps, M., Dagnelie, P. C., Kester, A. D., van der Hesselink-Kruijs, M. A. M., Cilissen, M., Engels, L. G., van Deursen, C., Hameeteman, W., Wolters, F. L., Russel, M. G. & Stockbrugger, R. W., 1 Jan 2009, In : American Journal of Gastroenterology. 104, 2, p. 371-83

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
2008
37 Citations (Scopus)

Absence of nodular regenerative hyperplasia after low-dose 6-thioguanine maintenance therapy in inflammatory bowel disease patients

de Boer, N. K., Zondervan, P. E., Gilissen, L. P., den Hartog, G., Westerveld, B. D., Derijks, L. J., Bloemena, E., Engels, L. G., van Bodegraven, A. A. & Mulder, C. J., 1 Jan 2008, In : Digestive and Liver Disease. 40, 2, p. 108-13

Research output: Contribution to journalArticleAcademicpeer-review

2007
30 Citations (Scopus)

Toxicity of 6-thioguanine: no hepatotoxicity in a series of IBD patients treated with long-term, low dose 6-thioguanine Some evidence for dose or metabolite level dependent effects?

Gilissen, L. P., Derijks, L. J., Driessen, A., Bos, L. P., Hooymans, P. M., Stockbrugger, R. W. & Engels, L. G. B., 1 Jan 2007, In : Digestive and Liver Disease. 39, 2, p. 156-159

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Treatment of irritable bowel syndrome with osteopathy: results of a randomized controlled pilot study

Hundscheid, H. W., Pepels, M. J. A. E., Engels, L. G. B. & Loffeld, R. J., 1 Jan 2007, In : Journal of Gastroenterology and Hepatology. 22, 9, p. 1394-1398

Research output: Contribution to journalArticleAcademicpeer-review

2005
16 Citations (Scopus)

Inflammatory bowel disease stimulates formation of carcinogenic N-nitroso compounds

de Kok, T. M., Engels, L. G. B., Moonen, E. J. & Kleinjans, J. C., 1 Jan 2005, In : Gut. 54, 5, p. 731

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

32 Citations (Scopus)

On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprine or 6-mercaptopurine intolerant IBD patients

de Boer, N. K., Derijks, L. J., Gilissen, L. P., Hommes, D. W., Engels, L. G. B., de Boer, S. Y., den Hartog, G., Hooymans, P. M., Makelburg, A. B., Westerveld, B. D., Naber, A. H., Mulder, C. J. & de Jong, D. J., 1 Jan 2005, In : World Journal of Gastroenterology. 11, 35, p. 5540-5544

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients

Gilissen, L. P., Bierau, J., Derijks, L. J., Bos, L. P., Hooymans, P. M., van Gennip, A., Stockbrugger, R. W. & Engels, L. G. B., 1 Jan 2005, In : Alimentary Pharmacology & Therapeutics. 22, 7, p. 605-611

Research output: Contribution to journalArticleAcademicpeer-review

2004
14 Citations (Scopus)

Altered vegetable intake affects pivotal carcinogenesis pathways in colon mucosa from adenoma patients and controls

van Breda, S. G. J., van Agen, E., Engels, L. G. B., Moonen, E. J. C., Kleinjans, J. C. & van Delft, J. H., 1 Jan 2004, In : Carcinogenesis. 25, 11, p. 2207-2216

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Neutrophil-mediated formation of carcinogenic N-nitroso compounds in an in vitro model for intestinal inflammation

Vermeer, I. T. M., Henderson, L. Y., Moonen, E. J. C., Engels, L. G. B., Dallinga, J. W., van Maanen, J. M. S. & Kleinjans, J. C., 1 Jan 2004, In : Toxicology Letters. 154, 3, p. 175-182

Research output: Contribution to journalArticleAcademicpeer-review

2002
9 Citations (Scopus)

Helicobacter pylori does not mediate the formation of carcinogenic N-nitrosamines

Vermeer, I. T. M., Gerrits, M. M., Moonen, E. J. C., Engels, L. G. B., Dallinga, J. W., Kleinjans, J. C. S., van Maanen, J. M. S., Kuipers, E. J. & Kusters, J. G., 1 Jan 2002, In : Helicobacter. 7, 3, p. 163-169 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2001
23 Citations (Scopus)

Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole.

Vermeer, I. T. M., Engels, L. G. B., Pachen, D. M. F. A., Dallinga, J. W., Kleinjans, J. C. S. & van Maanen, J. M. S., 1 Jan 2001, In : Gastroenterology. 121, p. 517-525 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2000
1 Citation (Scopus)

Does biliary reflux of polycyclic aromatic hydrocarbons increase pancreatic cancer risk in smokers?

de Kok, T. M. C. M., Moonen, E. J. C., van der Ent, F. W. C., Engels, L. G. B. & Kleinjans, J. C. S., 1 Jan 2000, In : Cancer Causes & Control. 11, p. 975-976 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

1999
48 Citations (Scopus)

Bile acid concentrations, cytotoxicity, and pH of fecal water from patients with colorectal adenomas.

de Kok, T. M. C. M., van Faassen, A., Glinghammar, B., Pachen, D. M. F. A., Eng, M., Rafter, J. J., Baeten, C. G. M. I., Engels, L. G. B. & Kleinjans, J. C. S., 1 Jan 1999, In : Digestive Diseases and Sciences. 44, 11, p. 2218-2225 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

1998
94 Citations (Scopus)

Modern life' in the epidemiology of inflammatory bowel disease: a case-control study with special emphasis on nutritional factors.

Russel, M. G. V. M., Engels, L. G. B., Muris, J. W. M., Limonard, C. B., Volovics, A., Brummer, R. J. M. & Stockbrügger, R. W., 1 Jan 1998, In : European Journal of Gastroenterology & Hepatology. 10, 3, p. 243-249 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

1996

Whipple's disease: a difficult diagnosis?

Peters, F. P. J., Elbrecht, E. A., Wouters, R. S. M. E., Engels, L. G. B. & Stockbrugger, R. W., 1 Jan 1996, In : Netherlands Journal of Medicine. 49, p. 106-111

Research output: Contribution to journalArticleAcademicpeer-review

1994
91 Citations (Scopus)

Proliferating cell nuclear antigen (PCNA): a new marker to study human colonic cell proliferation

Kubben, F., Haesevoets, A. M., Engels, L. G. B., Baeten, C. G. M. I., Schutte, B., Arends, J. W., Stockbrügger, R. W. & Blijham, G. H., 1 Jan 1994, In : Gut. 35, 4, p. 530-535

Research output: Contribution to journalArticleAcademicpeer-review