20012020

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2020

Intimal and medial calcification in relation to cardiovascular risk factors

Zwakenberg, S. R., de Jong, P. A., Hendriks, E. J., Westerink, J., Spiering, W., de Borst, G. J., Cramer, M. J., Bartstra, J. W., Doesburg, T., Rutters, F., van der Heijden, A. A., Schalkwijk, C., Schurgers, L. J., van der Schouw, Y. T., Beulens, J. W. J. & SMART Study Grp, 13 Jul 2020, In : PLOS ONE. 15, 7, 14 p., 0235228.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia

Kaesler, N., Goettsch, C., Weis, D., Schurgers, L., Hellmann, B., Floege, J. & Kramann, R., Jan 2020, In : Nephrology Dialysis Transplantation. 35, 1, p. 65-73 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease

Jaminon, A. M. G., Dai, L., Qureshi, A. R., Evenepoel, P., Ripsweden, J., Soderberg, M., Witasp, A., Olauson, H., Schurgers, L. J. & Stenvinkel, P., 20 Apr 2020, In : Scientific Reports. 10, 1, 9 p., 6586.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pharmacological and Nutritional Modulation of Vascular Calcification

Vossen, L. M., Kroon, A. A., Schurgers, L. J. & de Leeuw, P. W., Jan 2020, In : Nutrients. 12, 1, 15 p., 100.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity

Rao, P. S., Ramanjaneyulu, Y. S., Prisk, V. R. & Schurgers, L. J., 2019, In : International Journal of Medical Sciences. 16, 6, p. 845-853 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population

Dekker, L. H., Vinke, P. C., Riphagen, I. J., Minovic, I., Eggersdorfer, M. L., van den Heuvel, E. G. H. M., Schurgers, L. J., Kema, I. P., Bakker, S. J. L. & Navis, G., 17 Dec 2019, In : Frontiers in nutrition. 6, 9 p., 185.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults

van Ballegooijen, A. J., Beulens, J. J., Schurgers, L. J., de Koning, E. J., Lips, P., van Schoor, N. M. & Vervloet, M. G., Feb 2019, In : Nutrients. 11, 2, 10 p., 231.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study

Schumacher, S. P., Schurgers, L. J., Vervloet, M. G. & Neradova, A., Feb 2019, In : Nephrology. 24, 2, p. 221-226 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice

Posthuma, J. J., Posma, J. J. N., van Oerle, R., Leenders, P., van Gorp, R. H., Jaminon, A. M. G., Mackman, N., Heitmeier, S., Schurgers, L. J., ten Cate, H. & Spronk, H. M. H., 7 Mar 2019, In : Scientific Reports. 9, 9 p., 3909.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial

Zwakenberg, S. R., de Jong, P. A., Bartstra, J. W., van Asperen, R., Westerink, J., de Valk, H., Slart, R. H. J. A., Luurtsema, G., Wolterink, J. M., de Borst, G. J., van Herwaarden, J. A., van de Ree, M. A., Schurgers, L. J., van der Schouw, Y. T. & Beulens, J. W. J., Oct 2019, In : American Journal of Clinical Nutrition. 110, 4, p. 883-890 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Vitamin K deficiency in critical ill patients; a prospective observational study

Dahlberg, S., Schurgers, L., Schott, U. & Kander, T., Feb 2019, In : Journal of Critical Care. 49, p. 105-109 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

AnnexinA5-pHrodo: a new molecular probe for measuring efferocytosis

Stoehr, R., Deckers, N., Schurgers, L., Marx, N. & Reutelingsperger, C. P., 7 Dec 2018, In : Scientific Reports. 8, 9 p., 17731.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers

Eersels, K., Diliën, H., Lowdon, J., Steen Redeker, E., Rogosic, R., Heidt, B., Peeters, M., Cornelis, P., Lux, P., Reutelingsperger, C., Schurgers, L., Cleij, T. & van Grinsven, B., 11 Jun 2018, In : Nutrients. 10, 6, p. 751 12 p., 751.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein)

Viegas, C. S. B., Santos, L., Macedo, A. L., Matos, A. A., Silva, A. P., Neves, P. L., Staes, A., Gevaert, K., Morais, R., Vermeer, C., Schurgers, L. & Simes, D. C., 1 Mar 2018, In : Arteriosclerosis Thrombosis and Vascular Biology. 38, 3, p. 575-587 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study

Popko, J., Karpinski, M., Chojnowska, S., Maresz, K., Milewski, R., Badmaev, V. & Schurgers, L. J., 1 Jun 2018, In : Nutrients. 10, 6, 7 p., 734.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Desphospho-Uncarboxylated Matrix-Gla Protein Is Increased Postoperatively in Cardiovascular Risk Patients

Dahlberg, S., Ede, J., Schurgers, L., Vermeer, C., Kander, T., Klarin, B. & Schott, U., 1 Jan 2018, In : Nutrients. 10, 1, 11 p., 46.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Missense mutation of VKORC1 leads to medial arterial calcification in rats

Michaux, A., Matagrin, B., Debaux, J-V., Schurgers, L. J., Benoit, E. & Lattard, V., 13 Sep 2018, In : Scientific Reports. 8, 11 p., 13733.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome

Miyata, K. N., Nast, C. C., Dai, T., Dukkipati, R., LaPage, J. A., Troost, J. P., Schurgers, L. J., Kretzler, M. & Adler, S. G., 1 Aug 2018, In : Experimental and Molecular Pathology. 105, 1, p. 120-129 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The role of kidney transplantation and phosphate binder use in vitamin K status

Jansz, T. T., Neradova, A., van Ballegooijen, A. J., Verhaar, M. C., Vervloet, M. G., Schurgers, L. J. & van Jaarsveld, B. C., 30 Aug 2018, In : PLOS ONE. 13, 8, 13 p., e0203157.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling

Willems, B. A., Furmanik, M., Caron, M. M. J., Chatrou, M. L. L., Kusters, D. H. M., Welting, T. J. M., Stock, M., Rafael, M. S., Viegas, C. S. B., Simes, D. C., Vermeer, C., Reutelingsperger, C. P. M. & Schurgers, L. J., 21 Mar 2018, In : Scientific Reports. 8, 11 p., 4961.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Annexin A5 reduces early plaque formation in ApoE -/- mice

Stoehr, R., Schurgers, L., van Gorp, R., Jaminon, A., Marx, N. & Reutelingsperger, C., 21 Dec 2017, In : PLOS ONE. 12, 12, 8 p., 0190229.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating annexin A5 levels are associated with carotid intima-media thickness but not coronary plaque composition

Burgmaier, M., Reith, S., Schurgers, L., Kahles, F., Marx, N. & Reutelingsperger, C., Sep 2017, In : Diabetes & Vascular Disease Research. 14, 5, p. 415-422 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Does statins promote vascular calcification in chronic kidney disease?

Chen, Z., Qureshi, A. R., Parini, P., Hurt-Camejo, E., Ripsweden, J., Brismar, T. B., Barany, P., Jaminon, A. M., Schurgers, L. J., Heimburger, O., Lindholm, B. & Stenvinkel, P., Feb 2017, In : European Journal of Clinical Investigation. 47, 2, p. 137-148 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study

Neradova, A., Schumacher, S. P., Hubeek, I., Lux, P., Schurgers, L. J. & Vervloet, M. G., 2 May 2017, In : Bmc Nephrology. 18, 5 p., 149.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype

Vajen, T., Benedikter, B. J., Heinzmann, A. C. A., Vasina, E. M., Henskens, Y., Parsons, M., Maguire, P. B., Stassen, F. R., Heemskerk, J. W. M., Schurgers, L. J. & Koenen, R. R., 16 May 2017, In : Journal of Extracellular Vesicles . 6, 1, 14 p., 1322454.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification

Kapustin, A. N., Schoppet, M., Schurgers, L. J., Reynolds, J. L., McNair, R., Heiss, A., Jahnen-Dechent, W., Hackeng, T. M., Schlieper, G., Harrison, P. & Shanahan, C. M., Mar 2017, In : Arteriosclerosis Thrombosis and Vascular Biology. 37, 3, p. E22-E32 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation Results From a Prospective Interventional Proof-of-Concept Study

Brandenburg, V. M., Reinartz, S., Kaesler, N., Krueger, T., Dirrichs, T., Kramann, R., Peeters, F., Floege, J., Keszei, A., Marx, N., Schurgers, L. J. & Koos, R., 23 May 2017, In : Circulation. 135, 21, p. 2081-2083 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging

Hendrikx, G., Hackeng, T. M., van Gorp, R., Bauwens, M., Schurgers, L. J., Mottaghy, F. M., Post, M. J. & Dijkgraaf, I., 2017, In : Contrast Media & Molecular Imaging. 2017, 9 p., 8638549.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies

Doring, Y., Noels, H., van der Vorst, E. P. C., Neideck, C., Egea, V., Drechsler, M., Mandl, M., Pawig, L., Jansen, Y., Schroeder, K., Bidzhekov, K., Megens, R. T. A., Theelen, W., Klinkhammer, B. M., Boor, P., Schurgers, L., van Gorp, R., Ries, C., Kusters, P. J. H., van der Wal, A. & 11 others, Hackeng, T. M., Gaebel, G., Brandes, R. P., Soehnlein, O., Lutgens, E., Vestweber, D., Teupser, D., Holdt, L. M., Rader, D. J., Saleheen, D. & Weber, C., 25 Jul 2017, In : Circulation. 136, 4, p. 388-403 39 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE(-/-) Mice

Donners, M. M. P. C., Bai, L., Lutgens, S., Wijnands, E., Johnson, J., Schurgers, L. J., Liu, C-L., Daemen, M., Cleutjens, K. B. J. M., Shi, G-P., Biessen, E. A. L. & Heeneman, S., 16 Sep 2016, In : PLOS ONE. 11, 9, e0162595.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating annexin A5 predicts mortality in patients with heart failure

Schurgers, L. J., Burgmaier, M., Ueland, T., Schutters, K., Aakhus, S., Hofstra, L., Gullestad, L., Aukrust, P., Hellmich, M., Narula, J. & Reutelingsperger, C. P., Jan 2016, In : Journal of Internal Medicine. 279, 1, p. 89-97

Research output: Contribution to journalArticleAcademicpeer-review

Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis?

Brandenburg, V. M., Evenepoel, P., Floege, J., Goldsmith, D., Kramann, R., Massy, Z., Mazzaferro, S., Schurgers, L. J., Sinha, S., Torregrosa, V., Urena-Torres, P., Vervloet, M. & Cozzolino, M., Aug 2016, In : Nephrology Dialysis Transplantation. 31, 8, p. 1211-1219

Research output: Contribution to journalArticleAcademicpeer-review

Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis

Horn, P., Erkilet, G., Veulemans, V., Kroepil, P., Schurgers, L., Zeus, T., Heiss, C., Kelm, M. & Westenfeld, R., 24 Mar 2016, In : PLOS ONE. 11, 3, e0151499.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Vascular calcification in chronic kidney disease: an update

Schlieper, G., Schurgers, L., Brandenburg, V., Reutelingsperger, C. & Floege, J., Jan 2016, In : Nephrology Dialysis Transplantation. 31, 1, p. 31-39

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: role of vitamin K treatment?

Zaragatski, E., Grommes, J., Schurgers, L. J., Langer, S., Kennes, L., Tamm, M., Koeppel, T. A., Kranz, J., Hackhofer, T., Arakelyan, K., Jacobs, M. J. & Kokozidou, M., Mar 2016, In : Kidney International. 89, 3, p. 601-611

Research output: Contribution to journalArticleAcademicpeer-review

2015

Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells

van Niel, G., Bergam, P., Di Cicco, A., Hurbain, I., Lo Cicero, A., Dingli, F., Palmulli, R., Fort, C., Potier, M. C., Schurgers, L. J., Loew, D., Levy, D. & Raposo, G., 6 Oct 2015, In : Cell Reports. 13, 1, p. 43-51

Research output: Contribution to journalArticleAcademicpeer-review

High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification

Scheiber, D., Veulemans, V., Horn, P., Chatrou, M. L., Potthoff, S. A., Kelm, M., Schurgers, L. J. & Westenfeld, R., Aug 2015, In : Nutrients. 7, 8, p. 6991-7011

Research output: Contribution to journalArticleAcademicpeer-review

Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis

Chatrou, M. L. L., Cleutjens, J. P., van der Vusse, G. J., Roijers, R. B., Mutsaers, P. H. A. & Schurgers, L. J., 10 Nov 2015, In : PLOS ONE. 10, 11, e0142335.

Research output: Contribution to journalArticleAcademicpeer-review

Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial)

Vossen, L. M., Schurgers, L. J., van Varik, B. J., Kietselaer, B. L. J. H., Vermeer, C., Meeder, J. G., Rahel, B. M., van Cauteren, Y. J. M., Hoffland, G. A., Rennenberg, R. J. M. W., Reesink, K. D., de Leeuw, P. W. & Kroon, A. A., Nov 2015, In : Nutrients. 7, 11, p. 8905-8915

Research output: Contribution to journalArticleAcademicpeer-review

Myeloid A Disintegrin and Metalloproteinase Domain 10 Deficiency Modulates Atherosclerotic Plaque Composition by Shifting the Balance from Inflammation toward Fibrosis

van der Vorst, E. P. C., Jeurissen, M., Wolfs, I. M. J., Keijbeck, A., Theodorou, K., Wijnands, E., Schurgers, L., Weber, S., Gijbels, M. J., Hamers, A. A. J., Dreymueller, D., Rose-John, S., de Winther, M. P. J., Ludwig, A., Saftig, P., Biessen, E. A. L. & Donners, M. M. P. C., Apr 2015, In : American Journal of Pathology. 185, 4, p. 1145-1155

Research output: Contribution to journalArticleAcademicpeer-review

New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs)

van Gorp, R. H. & Schurgers, L. J., Nov 2015, In : Nutrients. 7, 11, p. 9538-9557

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet

Kusters, D. H., Chatrou, M. L., Willems, B. A., De Saint-Hubert, M., Bauwens, M., van der Vorst, E., Bena, S., Biessen, E. A., Perretti, M., Schurgers, L. J. & Reutelingsperger, C. P., 19 Jun 2015, In : PLOS ONE. 10, 6, 15 p., e0130484.

Research output: Contribution to journalArticleAcademicpeer-review

Prevention of vasculopathy by vitamin K supplementation: Can we turn fiction into fact?

Brandenburg, V. M., Schurgers, L. J., Kaesler, N., Puesche, K., van Gorp, R. H., Leftheriotis, G., Reinartz, S., Koos, R. & Krueger, T., May 2015, In : Atherosclerosis. 240, 1, p. 10-16

Research output: Contribution to journalArticleAcademicpeer-review

Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., Furmanik, M., Sanchis, P., De Rosales, R. T. M., Alvarez-Hernandez, D., Shroff, R., Yin, X., Muller, K., Skepper, J. N., Mayr, M., Reutelingsperger, C. P., Chester, A., Bertazzo, S., Schurgers, L. J. & Shanahan, C. M., 10 Apr 2015, In : Circulation Research. 116, 8, p. 1312-1323

Research output: Contribution to journalArticleAcademicpeer-review