20012019

Research output per year

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Research Output

2015

New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs)

van Gorp, R. H. & Schurgers, L. J., Nov 2015, In : Nutrients. 7, 11, p. 9538-9557

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet

Kusters, D. H., Chatrou, M. L., Willems, B. A., De Saint-Hubert, M., Bauwens, M., van der Vorst, E., Bena, S., Biessen, E. A., Perretti, M., Schurgers, L. J. & Reutelingsperger, C. P., 19 Jun 2015, In : PLOS ONE. 10, 6, 15 p., e0130484.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Prevention of vasculopathy by vitamin K supplementation: Can we turn fiction into fact?

Brandenburg, V. M., Schurgers, L. J., Kaesler, N., Puesche, K., van Gorp, R. H., Leftheriotis, G., Reinartz, S., Koos, R. & Krueger, T., May 2015, In : Atherosclerosis. 240, 1, p. 10-16

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., Furmanik, M., Sanchis, P., De Rosales, R. T. M., Alvarez-Hernandez, D., Shroff, R., Yin, X., Muller, K., Skepper, J. N., Mayr, M., Reutelingsperger, C. P., Chester, A., Bertazzo, S., Schurgers, L. J. & Shanahan, C. M., 10 Apr 2015, In : Circulation Research. 116, 8, p. 1312-1323

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)
2014

AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice

Burgmaier, M., Schutters, K., Willems, B., Van der Vorst, E. P. C., Kusters, D., Chatrou, M., Norling, L., Biessen, E. A. L., Cleutjens, J., Perretti, M., Schurgers, L. J. & Reutelingsperger, C., Oct 2014, In : Journal of Cellular and Molecular Medicine. 18, 10, p. 2117-2124

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
7 Citations (Scopus)

Mutations in the ABCC6 Gene as a Cause of Generalized Arterial Calcification of Infancy: Genotypic Overlap with Pseudoxanthoma Elasticum

Li, Q., Brodsky, J. L., Conlin, L. K., Pawel, B., Glatz, A. C., Gafni, R. I., Schurgers, L., Uitto, J., Hakonarson, H., Deardorff, M. A. & Levine, M. A., Mar 2014, In : Journal of Investigative Dermatology. 134, 3, p. 658-665

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification

Willems, B. A. G., Vermeer, C., Reutelingsperger, C. P. M. & Schurgers, L. J., Aug 2014, In : Molecular Nutrition & Food Research. 58, 8, p. 1620-1635

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Vitamin K1 to slow vascular calcification in haemodialysis patients (VitaVasK trial): a rationale and study protocol

Krueger, T., Schlieper, G., Schurgers, L., Cornelis, T., Cozzolino, M., Jacobi, J., Jadoul, M., Ketteler, M., Rump, L. C., Stenvinkel, P., Westenfeld, R., Wiecek, A., Reinartz, S., Hilgers, R-D. & Floege, J., Sep 2014, In : Nephrology Dialysis Transplantation. 29, 9, p. 1633-1638

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
2013

Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells

Schutters, K., Kusters, D. H. M., Chatrou, M. L. L., Montero-Melendez, T., Donners, M., Deckers, N. M., Krysko, D. V., Vandenabeele, P., Perretti, M., Schurgers, L. J. & Reutelingsperger, C. P. M., Jan 2013, In : Cell Death and Differentiation. 20, 1, p. 49-56

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Circulating matrix Gla protein is associated with coronary artery calcification and vitamin K status in healthy women

Dalmeijer, G. W., van der Schouw, Y. T., Vermeer, C., Magdeleyns, E. J., Schurgers, L. J. & Beulens, J. W. J., Apr 2013, In : Journal of Nutritional Biochemistry. 24, 4, p. 624-628

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Ectopic calcification in beta-thalassemia patients is associated with increased oxidative stress and lower MGP carboxylation

Boraldi, F., Garcia-Fernandez, M., Paolinelli-deVincenzi, C., Annovi, G., Schurgers, L., Vermeer, C., Cianciulli, P., Ronchetti, I. & Quaglino, D., Dec 2013, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1832, 12, p. 2077-2084

Research output: Contribution to journalArticleAcademicpeer-review

Effect of low-dose supplements of menaquinone-7 (vitamin K-2) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers

Theuwissen, E., Teunissen, K. J., Spronk, H. M. H., Hamulyak, K., Ten Cate, H., Shearer, M. J., Vermeer, C. & Schurgers, L. J., Jun 2013, In : Journal of Thrombosis and Haemostasis. 11, 6, p. 1085-1092

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Matrix Gla Protein and Alkaline Phosphatase Are Differently Modulated in Human Dermal Fibroblasts from PXE Patients and Controls

Boraldi, F., Annovi, G., Vermeer, C., Schurgers, L. J., Trenti, T., Tiozzo, R., Guerra, D. & Quaglino, D., Apr 2013, In : Journal of Investigative Dermatology. 133, 4, p. 946-954

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy

Kramann, R., Brandenburg, V. M., Schurgers, L. J., Ketteler, M., Westphal, S., Leisten, I., Bovi, M., Jahnen-Dechent, W., Knuechel, R., Floege, J. & Schneider, R. K., Apr 2013, In : Nephrology Dialysis Transplantation. 28, 4, p. 856-868

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: a cross-sectional study

Brandenburg, V. M., Kramann, R., Koos, R., Krueger, T., Schurgers, L., Muehlenbruch, G., Huebner, S., Gladziwa, U., Drechsler, C. & Ketteler, M., 10 Oct 2013, In : Bmc Nephrology. 14, 219.

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Scopus)

Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization

Schurgers, L. J., Uitto, J. & Reutelingsperger, C. P., Apr 2013, In : Trends in Molecular Medicine. 19, 4, p. 217-226

Research output: Contribution to journalArticleAcademicpeer-review

Warfarin Accelerates Ectopic Mineralization in Abcc6(-/-) Mice Clinical Relevance to Pseudoxanthoma Elasticum

Li, Q., Guo, H., Chou, D. W., Harrington, D. J., Schurgers, L. J., Terry, S. F. & Uitto, J., Apr 2013, In : American Journal of Pathology. 182, 4, p. 1139-1150

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Warfarin Induces Cardiovascular Damage in Mice

Krueger, T., Oelenberg, S., Kaesler, N., Schurgers, L. J., van de Sandt, A. M., Boor, P., Schlieper, G., Brandenburg, V. M., Fekete, B. C., Veulemans, V., Ketteler, M., Vermeer, C., Jahnen-Dechent, W., Floege, J. & Westenfeld, R., Nov 2013, In : Arteriosclerosis Thrombosis and Vascular Biology. 33, 11, p. 2618-2624

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)
2012

Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight

Knapen, M. H. J., Schurgers, L. J., Shearer, M. J., Newman, P., Theuwissen, E. & Vermeer, C., 28 Sep 2012, In : British Journal of Nutrition. 108, 6, p. 1017-1024

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Effect of Vitamin K-2 Supplementation on Functional Vitamin K Deficiency in Hemodialysis Patients: A Randomized Trial

Westenfeld, R., Krueger, T., Schlieper, G., Cranenburg, E. C. M., Magdeleyns, E. J. P., Heidenreich, S., Holzmann, S., Vermeer, C., Jahnen-Dechent, W., Ketteler, M., Floege, J. & Schurgers, L. J., Feb 2012, In : American Journal of Kidney Diseases. 59, 2, p. 186-195

Research output: Contribution to journalArticleAcademicpeer-review

Incorporation of Disulfide Containing Protein Modules into Multivalent Antigenic Conjugates: Generation of Antibodies against the Thrombin-Sensitive Region of Murine Protein S

Van de Vijver, P., Schmitt, M., Suylen, D., Scheer, L., Thomassen, M. C. L. G. D., Schurgers, L. J., Griffin, J. H., Koenen, R. R. & Hackeng, T. M., 28 Nov 2012, In : Journal of the American Chemical Society. 134, 47, p. 19318-19321

Research output: Contribution to journalArticleAcademicpeer-review

Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects

Theuwissen, E., Cranenburg, E. C., Knapen, M. H., Magdeleyns, E. J., Teunissen, K. J., Schurgers, L. J., Smit, E. & Vermeer, C., 14 Nov 2012, In : British Journal of Nutrition. 108, 9, p. 1652-1657

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Imaging to Identify the Vulnerable Plaque-From Basic Research to Clinical Practice

Kusters, D. H. M., Tegtmeier, J., Schurgers, L. J. & Reutelingsperger, C. P. M., Oct 2012, In : Molecular Imaging and Biology. 14, 5, p. 523-533

Research output: Contribution to journalArticleAcademicpeer-review

Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists

Chatrou, M. L. L., Winckers, K., Hackeng, T. M., Reutelingsperger, C. P. M. & Schurgers, L. J., Jul 2012, In : Blood Reviews. 26, 4, p. 155-166

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype

Schurgers, L. J., Joosen, I. A., Laufer, E. M., Chatrou, M. L. L., Herfs, M., Winkens, M. H. M., Westenfeld, R., Veulemans, V., Krueger, T., Shanahan, C. M., Jahnen-Dechent, W., Biessen, E., Narula, J., Vermeer, C., Hofstra, L. & Reutelingsperger, C. P., 29 Aug 2012, In : PLOS ONE. 7, 8, e43229.

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin K Intake and Plasma Desphospho-Uncarboxylated Matrix Gla-Protein Levels in Kidney Transplant Recipients

Boxma, P. Y., van den Berg, E., Geleijnse, J. M., Laverman, G. D., Schurgers, L. J., Vermeer, C., Kema, I. P., Muskiet, F. A., Navis, G., Bakker, S. J. L. & de Borst, M. H., 31 Oct 2012, In : PLOS ONE. 7, 10, e47991.

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin K intake and status are low in hemodialysis patients

Cranenburg, E. C. M., Schurgers, L. J., Uiterwijk, H. H., Beulens, J. W. J., Dalmeijer, G. W., Westerhuis, R., Magdeleyns, E. J., Herfs, M., Vermeer, C. & Laverman, G. D., Sep 2012, In : Kidney International. 82, 5, p. 605-610

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)
2011

Administration of vitamin K does not counteract the ectopic mineralization of connective tissues in Abcc6(-/-) mice, a model for pseudoxanthoma elasticum

Jiang, Q., Li, Q., Grand-Pierre, A. E., Schurgers, L. J. & Uitto, J., 15 Feb 2011, In : Cell Cycle. 10, 4, p. 701-707

Research output: Contribution to journalArticleAcademicpeer-review

Atypical Presentation of Pseudoxanthoma Elasticum With Abdominal Cutis Laxa: Evidence for a Spectrum of Ectopic Calcification Disorders?

Vanakker, O. M., Leroy, B. P., Schurgers, L. J., Vermeer, C., Coucke, P. J. & De Paepe, A., Nov 2011, In : American Journal of Medical Genetics Part A. 155A, 11, p. 2855-2859

Research output: Contribution to journalArticleAcademicpeer-review

Calcium Regulates Key Components of Vascular Smooth Muscle Cell-Derived Matrix Vesicles to Enhance Mineralization

Kapustin, A. N., Davies, J. D., Reynolds, J. L., McNair, R., Jones, G. T., Sidibe, A., Schurgers, L. J., Skepper, J. N., Proudfoot, D., Mayr, M. & Shanahan, C. M., 24 Jun 2011, In : Circulation Research. 109, 1, p. E1-U41

Research output: Contribution to journalArticleAcademicpeer-review

Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure

Ueland, T., Dahl, C. P., Gullestad, L., Aakhus, S., Broch, K., Skardal, R., Vermeer, C., Aukrust, P. & Schurgers, L. J., Aug 2011, In : Clinical Science. 121, 3-4, p. 119-127

Research output: Contribution to journalArticleAcademicpeer-review

Circulating matrix gamma-carboxyglutamate protein (MGP) species are refractory to vitamin K treatment in a new case of Keutel syndrome

Cranenburg, E. C. M., van Spaendonck-Zwarts, K. Y., Bonafe, L., Crettol, L. M., Rodiger, L. A., Dikkers, F. G., van Essen, A. J., Superti-Furga, A., Alexandrakis, E., Vermeer, C., Schurgers, L. J. & Laverman, G. D., Jun 2011, In : Journal of Thrombosis and Haemostasis. 9, 6, p. 1225-1235

Research output: Contribution to journalArticleAcademicpeer-review

Circulating Nonphosphorylated Carboxylated Matrix Gla Protein Predicts Survival in ESRD

Schlieper, G., Westenfeld, R., Krueger, T., Cranenburg, E. C., Magdeleyns, E. J. P., Brandenburg, V. M., Djuric, Z., Damjanovic, T., Ketteler, M., Vermeer, C., Dimkovic, N., Floege, J. & Schurgers, L. J., Feb 2011, In : Journal of the American Society of Nephrology. 22, 2, p. 387-395

Research output: Contribution to journalArticleAcademicpeer-review

Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries

Roijers, R. B., Debernardi, N., Cleutjens, J. P. M., Schurgers, L. J., Mutsaers, P. H. A. & van der Vusse, G. J., Jun 2011, In : American Journal of Pathology. 178, 6, p. 2879-2887

Research output: Contribution to journalArticleAcademicpeer-review

Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients

Noordzij, M., Cranenburg, E. M., Engelsman, L. F., Hermans, M. M. H., Boeschoten, E. W., Brandenburg, V. M., Bos, W. J., Kooman, J. P., Dekker, F. W., Ketteler, M., Schurgers, L. J., Krediet, R. T. & Korevaar, J. C., May 2011, In : Nephrology Dialysis Transplantation. 26, 5, p. 1662-1669 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

76 Citations (Scopus)

Role of vitamin K-dependent proteins in the arterial vessel wall

Chatrou, M. L. L., Reutelingsperger, C. P. & Schurgers, L. J., Nov 2011, In : Hämostaseologie. 31, 4, p. 251-257

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum

Gorgels, T. G. M. F., Waarsing, J. H., Herfs, M., Versteeg, D., Schoensiegel, F., Sato, T., Schlingemann, R. O., Ivandic, B., Vermeer, C., Schurgers, L. J. & Bergen, A. A. B., Nov 2011, In : Journal of Molecular Medicine. 89, 11, p. 1125-1135

Research output: Contribution to journalArticleAcademicpeer-review

2010

Analysis of Calcifications in Patients with Coral Reef Aorta

Schlieper, G., Grotemeyer, D., Aretz, A., Schurgers, L. J., Krueger, T., Rehbein, H., Weirich, T. E., Westenfeld, R., Brandenburg, V. M., Eitner, F., Mayer, J., Floege, J., Sandmann, W. & Ketteler, M., Apr 2010, In : Annals of Vascular Surgery. 24, 3, p. 408-414

Research output: Contribution to journalArticleAcademicpeer-review

An Unusual Severe Vascular Case of Pseudoxanthoma Elasticum Presenting as Generalized Arterial Calcification of Infancy

Le Boulanger, G., Labreze, C., Croue, A., Schurgers, L. J., Chassaing, N., Wittkampf, T., Rutsch, F. & Martin, C. L., Jan 2010, In : American Journal of Medical Genetics Part A. 152A, 1, p. 118-123

Research output: Contribution to journalArticleAcademicpeer-review

Arterial calcifications

Rennenberg, R. J. W. M., Schurgers, L. J., Kroon, A. A. & Stehouwer, C. D. A., 1 Jan 2010, In : Journal of Cellular and Molecular Medicine. 14, 9, p. 2203-2210

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Associations between Body Composition, Circulating Interleukin-1 Receptor Antagonist, Osteocalcin, and Insulin Metabolism in Active Acromegaly

Ueland, T., Fougner, S. L., Godang, K., Lekva, T., Schurgers, L. J., Scholz, H., Halvorsen, B., Schreiner, T., Aukrust, P. & Bollerslev, J., Jan 2010, In : Journal of Clinical Endocrinology & Metabolism. 95, 1, p. 361-368

Research output: Contribution to journalArticleAcademicpeer-review

Calcium scores and matrix Gla protein levels: association with vitamin K status

Rennenberg, R. J. M. W., de Leeuw, P. W., Kessels, A. G. H., Schurgers, L. J., Vermeer, C., van Engelshoven, J. M. A., Kemerink, G. J. & Kroon, A. A., Apr 2010, In : European Journal of Clinical Investigation. 40, 4, p. 344-349

Research output: Contribution to journalArticleAcademicpeer-review

Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species

Cranenburg, E. C. M., Koos, R., Schurgers, L. J., Magdeleyns, E. J. P., Schoonbrood, T. H. M., Landewe, R. B., Brandenburg, V. M., Bekers, O. & Vermeer, C., Oct 2010, In : Thrombosis and Haemostasis. 104, 4, p. 811-822

Research output: Contribution to journalArticleAcademicpeer-review

Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans

Rennenberg, R. J. M. W., van Varik, B. J., Schurgers, L. J., Hamulyak, K., ten Cate, H., Leiner, T., Vermeer, C., de Leeuw, P. W. & Kroon, A. A., 17 Jun 2010, In : Blood. 115, 24, p. 5121-5123

Research output: Contribution to journalArticleAcademicpeer-review

Chronic Mineral Dysregulation Promotes Vascular Smooth Muscle Cell Adaptation and Extracellular Matrix Calcification

Shroff, R. C., McNair, R., Skepper, J. N., Figg, N., Schurgers, L. J., Deanfield, J., Rees, L. & Shanahan, C. M., Jan 2010, In : Journal of the American Society of Nephrology. 21, 1, p. 103-112

Research output: Contribution to journalArticleAcademicpeer-review

Hydrolysed Formula Is a Risk Factor for Vitamin K Deficiency in Infants With Unrecognised Cholestasis

van Hasselt, P. M., de Vries, W., de Vries, E., Kok, K., Cranenburg, E. C. M., de Koning, T. J., Schurgers, L. J., Verkade, H. J. & Houwen, R. H. J., Dec 2010, In : Journal of Pediatric Gastroenterology and Nutrition. 51, 6, p. 773-776

Research output: Contribution to journalArticleAcademicpeer-review

Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome

Vanakker, O. M., Martin, L., Schurgers, L. J., Quaglino, D., Costrop, L., Vermeer, C., Pasquali-Ronchetti, I., Coucke, P. J. & De Paepe, A., Jun 2010, In : Laboratory Investigation. 90, 6, p. 895-905

Research output: Contribution to journalArticleAcademicpeer-review