20012019

Research output per year

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Research Output

2019

A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity

Rao, P. S., Ramanjaneyulu, Y. S., Prisk, V. R. & Schurgers, L. J., 2019, In : International Journal of Medical Sciences. 16, 6, p. 845-853 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population

Dekker, L. H., Vinke, P. C., Riphagen, I. J., Minovic, I., Eggersdorfer, M. L., van den Heuvel, E. G. H. M., Schurgers, L. J., Kema, I. P., Bakker, S. J. L. & Navis, G., 17 Dec 2019, In : Frontiers in nutrition. 6, 9 p., 185.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults

van Ballegooijen, A. J., Beulens, J. J., Schurgers, L. J., de Koning, E. J., Lips, P., van Schoor, N. M. & Vervloet, M. G., Feb 2019, In : Nutrients. 11, 2, 10 p., 231.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study

Schumacher, S. P., Schurgers, L. J., Vervloet, M. G. & Neradova, A., Feb 2019, In : Nephrology. 24, 2, p. 221-226 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice

Posthuma, J. J., Posma, J. J. N., van Oerle, R., Leenders, P., van Gorp, R. H., Jaminon, A. M. G., Mackman, N., Heitmeier, S., Schurgers, L. J., ten Cate, H. & Spronk, H. M. H., 7 Mar 2019, In : Scientific Reports. 9, 9 p., 3909.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Bone-Vasculature Axis: Calcium Supplementation and the Role of Vitamin K

Wasilewski, G. B., Vervloet, M. G. & Schurgers, L. J., 5 Feb 2019, In : Frontiers in cardiovascular medicine. 6, p. 1-16 16 p., 6.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial

Zwakenberg, S. R., de Jong, P. A., Bartstra, J. W., van Asperen, R., Westerink, J., de Valk, H., Slart, R. H. J. A., Luurtsema, G., Wolterink, J. M., de Borst, G. J., van Herwaarden, J. A., van de Ree, M. A., Schurgers, L. J., van der Schouw, Y. T. & Beulens, J. W. J., Oct 2019, In : American Journal of Clinical Nutrition. 110, 4, p. 883-890 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes

Jaminon, A., Reesink, K., Kroon, A. & Schurgers, L., Nov 2019, In : International journal of molecular sciences. 20, 22, 29 p., 5694.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access

Vitamin K deficiency in critical ill patients; a prospective observational study

Dahlberg, S., Schurgers, L., Schott, U. & Kander, T., Feb 2019, In : Journal of Critical Care. 49, p. 105-109 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

AnnexinA5-pHrodo: a new molecular probe for measuring efferocytosis

Stoehr, R., Deckers, N., Schurgers, L., Marx, N. & Reutelingsperger, C. P., 7 Dec 2018, In : Scientific Reports. 8, 9 p., 17731.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers

Eersels, K., Diliën, H., Lowdon, J., Steen Redeker, E., Rogosic, R., Heidt, B., Peeters, M., Cornelis, P., Lux, P., Reutelingsperger, C., Schurgers, L., Cleij, T. & van Grinsven, B., 11 Jun 2018, In : Nutrients. 10, 6, p. 751 12 p., 751.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Calcific aortic valve stenosis: hard disease in the heart

Peeters, F. E. C. M., Meex, S. J. R., Dweck, M. R., Aikawa, E., Crijns, H. J. G. M., Schurgers, L. J. & Kietselaer, B. L. J. H., 21 Jul 2018, In : European Heart Journal. 39, 28, p. 2618–2624 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein)

Viegas, C. S. B., Santos, L., Macedo, A. L., Matos, A. A., Silva, A. P., Neves, P. L., Staes, A., Gevaert, K., Morais, R., Vermeer, C., Schurgers, L. & Simes, D. C., 1 Mar 2018, In : Arteriosclerosis Thrombosis and Vascular Biology. 38, 3, p. 575-587 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Coronary Artery Calcification A Janus-Faced Biomarker?

Reutelingsperger, C. & Schurgers, L., 1 Sep 2018, In : JACC-Cardiovascular Imaging. 11, 9, p. 1324-1326 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study

Popko, J., Karpinski, M., Chojnowska, S., Maresz, K., Milewski, R., Badmaev, V. & Schurgers, L. J., 1 Jun 2018, In : Nutrients. 10, 6, 7 p., 734.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Desphospho-Uncarboxylated Matrix-Gla Protein Is Increased Postoperatively in Cardiovascular Risk Patients

Dahlberg, S., Ede, J., Schurgers, L., Vermeer, C., Kander, T., Klarin, B. & Schott, U., 1 Jan 2018, In : Nutrients. 10, 1, 11 p., 46.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Missense mutation of VKORC1 leads to medial arterial calcification in rats

Michaux, A., Matagrin, B., Debaux, J-V., Schurgers, L. J., Benoit, E. & Lattard, V., 13 Sep 2018, In : Scientific Reports. 8, 11 p., 13733.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome

Miyata, K. N., Nast, C. C., Dai, T., Dukkipati, R., LaPage, J. A., Troost, J. P., Schurgers, L. J., Kretzler, M. & Adler, S. G., 1 Aug 2018, In : Experimental and Molecular Pathology. 105, 1, p. 120-129 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The role of kidney transplantation and phosphate binder use in vitamin K status

Jansz, T. T., Neradova, A., van Ballegooijen, A. J., Verhaar, M. C., Vervloet, M. G., Schurgers, L. J. & van Jaarsveld, B. C., 30 Aug 2018, In : PLOS ONE. 13, 8, 13 p., e0203157.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling

Willems, B. A., Furmanik, M., Caron, M. M. J., Chatrou, M. L. L., Kusters, D. H. M., Welting, T. J. M., Stock, M., Rafael, M. S., Viegas, C. S. B., Simes, D. C., Vermeer, C., Reutelingsperger, C. P. M. & Schurgers, L. J., 21 Mar 2018, In : Scientific Reports. 8, 11 p., 4961.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Vasculaire verkalking: een hard-nekkig probleem

Schurgers, L. J., 12 Oct 2018, Maastricht University.

Research output: Book/ReportInaugural speechPopular

Open Access
File
735 Downloads (Pure)
2017

Annexin A5 reduces early plaque formation in ApoE -/- mice

Stoehr, R., Schurgers, L., van Gorp, R., Jaminon, A., Marx, N. & Reutelingsperger, C., 21 Dec 2017, In : PLOS ONE. 12, 12, 8 p., 0190229.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating annexin A5 levels are associated with carotid intima-media thickness but not coronary plaque composition

Burgmaier, M., Reith, S., Schurgers, L., Kahles, F., Marx, N. & Reutelingsperger, C., Sep 2017, In : Diabetes & Vascular Disease Research. 14, 5, p. 415-422 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Does statins promote vascular calcification in chronic kidney disease?

Chen, Z., Qureshi, A. R., Parini, P., Hurt-Camejo, E., Ripsweden, J., Brismar, T. B., Barany, P., Jaminon, A. M., Schurgers, L. J., Heimburger, O., Lindholm, B. & Stenvinkel, P., Feb 2017, In : European Journal of Clinical Investigation. 47, 2, p. 137-148 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study

Neradova, A., Schumacher, S. P., Hubeek, I., Lux, P., Schurgers, L. J. & Vervloet, M. G., 2 May 2017, In : Bmc Nephrology. 18, 5 p., 149.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype

Vajen, T., Benedikter, B. J., Heinzmann, A. C. A., Vasina, E. M., Henskens, Y., Parsons, M., Maguire, P. B., Stassen, F. R., Heemskerk, J. W. M., Schurgers, L. J. & Koenen, R. R., 16 May 2017, In : Journal of Extracellular Vesicles . 6, 1, 14 p., 1322454.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification

Kapustin, A. N., Schoppet, M., Schurgers, L. J., Reynolds, J. L., McNair, R., Heiss, A., Jahnen-Dechent, W., Hackeng, T. M., Schlieper, G., Harrison, P. & Shanahan, C. M., Mar 2017, In : Arteriosclerosis Thrombosis and Vascular Biology. 37, 3, p. E22-E32 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation Results From a Prospective Interventional Proof-of-Concept Study

Brandenburg, V. M., Reinartz, S., Kaesler, N., Krueger, T., Dirrichs, T., Kramann, R., Peeters, F., Floege, J., Keszei, A., Marx, N., Schurgers, L. J. & Koos, R., 23 May 2017, In : Circulation. 135, 21, p. 2081-2083 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging

Hendrikx, G., Hackeng, T. M., van Gorp, R., Bauwens, M., Schurgers, L. J., Mottaghy, F. M., Post, M. J. & Dijkgraaf, I., 2017, In : Contrast Media & Molecular Imaging. 2017, 9 p., 8638549.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies

Doring, Y., Noels, H., van der Vorst, E. P. C., Neideck, C., Egea, V., Drechsler, M., Mandl, M., Pawig, L., Jansen, Y., Schroeder, K., Bidzhekov, K., Megens, R. T. A., Theelen, W., Klinkhammer, B. M., Boor, P., Schurgers, L., van Gorp, R., Ries, C., Kusters, P. J. H., van der Wal, A. & 11 others, Hackeng, T. M., Gaebel, G., Brandes, R. P., Soehnlein, O., Lutgens, E., Vestweber, D., Teupser, D., Holdt, L. M., Rader, D. J., Saleheen, D. & Weber, C., 25 Jul 2017, In : Circulation. 136, 4, p. 388-403 39 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE(-/-) Mice

Donners, M. M. P. C., Bai, L., Lutgens, S., Wijnands, E., Johnson, J., Schurgers, L. J., Liu, C-L., Daemen, M., Cleutjens, K. B. J. M., Shi, G-P., Biessen, E. A. L. & Heeneman, S., 16 Sep 2016, In : PLOS ONE. 11, 9, e0162595.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating annexin A5 predicts mortality in patients with heart failure

Schurgers, L. J., Burgmaier, M., Ueland, T., Schutters, K., Aakhus, S., Hofstra, L., Gullestad, L., Aukrust, P., Hellmich, M., Narula, J. & Reutelingsperger, C. P., Jan 2016, In : Journal of Internal Medicine. 279, 1, p. 89-97

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis?

Brandenburg, V. M., Evenepoel, P., Floege, J., Goldsmith, D., Kramann, R., Massy, Z., Mazzaferro, S., Schurgers, L. J., Sinha, S., Torregrosa, V., Urena-Torres, P., Vervloet, M. & Cozzolino, M., Aug 2016, In : Nephrology Dialysis Transplantation. 31, 8, p. 1211-1219

Research output: Contribution to journalArticleAcademicpeer-review

Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis

Horn, P., Erkilet, G., Veulemans, V., Kroepil, P., Schurgers, L., Zeus, T., Heiss, C., Kelm, M. & Westenfeld, R., 24 Mar 2016, In : PLOS ONE. 11, 3, e0151499.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Response to letter to the editor: annexin A5 levels or circulating microparticles: what we see depends mainly on what we look for

Burgmaier, M., Schurgers, L. & Reutelingsperger, C., Jun 2016, In : Journal of Internal Medicine. 279, 6, p. 606-607

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Vascular calcification in chronic kidney disease: an update

Schlieper, G., Schurgers, L., Brandenburg, V., Reutelingsperger, C. & Floege, J., Jan 2016, In : Nephrology Dialysis Transplantation. 31, 1, p. 31-39

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: role of vitamin K treatment?

Zaragatski, E., Grommes, J., Schurgers, L. J., Langer, S., Kennes, L., Tamm, M., Koeppel, T. A., Kranz, J., Hackhofer, T., Arakelyan, K., Jacobs, M. J. & Kokozidou, M., Mar 2016, In : Kidney International. 89, 3, p. 601-611

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

What's in a name? The pharmacy of vitamin K

Card, D. J., Shearer, M. J., Schurgers, L. J., Gomez, K. & Harrington, D. J., Sep 2016, In : British Journal of Haematology. 174, 6, p. 989-990

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

2015

Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells

van Niel, G., Bergam, P., Di Cicco, A., Hurbain, I., Lo Cicero, A., Dingli, F., Palmulli, R., Fort, C., Potier, M. C., Schurgers, L. J., Loew, D., Levy, D. & Raposo, G., 6 Oct 2015, In : Cell Reports. 13, 1, p. 43-51

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification

Scheiber, D., Veulemans, V., Horn, P., Chatrou, M. L., Potthoff, S. A., Kelm, M., Schurgers, L. J. & Westenfeld, R., Aug 2015, In : Nutrients. 7, 8, p. 6991-7011

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis

Chatrou, M. L. L., Cleutjens, J. P., van der Vusse, G. J., Roijers, R. B., Mutsaers, P. H. A. & Schurgers, L. J., 10 Nov 2015, In : PLOS ONE. 10, 11, e0142335.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial)

Vossen, L. M., Schurgers, L. J., van Varik, B. J., Kietselaer, B. L. J. H., Vermeer, C., Meeder, J. G., Rahel, B. M., van Cauteren, Y. J. M., Hoffland, G. A., Rennenberg, R. J. M. W., Reesink, K. D., de Leeuw, P. W. & Kroon, A. A., Nov 2015, In : Nutrients. 7, 11, p. 8905-8915

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)