19992019
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Research Output 1999 2019

2019

A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt signalling and miRNA dysregulation

Calore, M., Lorenzon, A., Vitiello, L., Poloni, G., Khan, M. A. F., Beffagna, G., Dazzo, E., Sacchetto, C., Polishchuk, R., Sabatelli, P., Doliana, R., Carnevale, D., Lembo, G., Bonaldo, P., De Windt, L., Braghetta, P. & Rampazzo, A., 15 Mar 2019, In : Cardiovascular Research. 115, 4, p. 739-751 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of different chemically modified inhibitors of miR-199b in vivo

Duygu, B., Juni, R., Ottaviani, L., Bitsch, N., Wit, J. B. M., de Windt, L. J. & Martins, P. A. D. C., Jan 2019, In : Biochemical Pharmacology. 159, p. 106-115 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The continuous heart failure spectrum: moving beyond an ejection fraction classification

Triposkiadis, F., Butler, J., Abboud, F. M., Armstrong, P. W., Adamopoulos, S., Atherton, J. J., Backs, J., Bauersachs, J., Burkhoff, D., Bonow, R. O., Chopra, V. K., de Boer, R. A., de Windt, L., Hamdani, N., Hasenfuss, G., Heymans, S., Hulot, J-S., Konstam, M., Lee, R. T., Linke, W. A. & 22 others, Lunde, I. G., Lyon, A. R., Maack, C., Mann, D. L., Mebazaa, A., Mentz, R. J., Nihoyannopoulos, P., Papp, Z., Parissis, J., Pedrazzini, T., Rosano, G., Rouleau, J., Seferovic, P. M., Shah, A. M., Starling, R. C., Tocchetti, C. G., Trochu, J-N., Thum, T., Zannad, F., Brutsaert, D. L., Segers, V. F. & De Keulenaer, G., 7 Jul 2019, In : European Heart Journal. 40, 26, p. 2155-2163 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure

Raso, A., Dirkx, E., Philippen, L. E., Fernandez-Celis, A., De Majo, F., Sampaio-Pinto, V., Sansonetti, M., Juni, R., el Azzouzi, H., Calore, M., Bitsch, N., Olieslagers, S., Oerlemans, M. I. F. J., Huibers, M. M., de Weger, R. A., Reckman, Y. J., Pinto, Y. M., Zentilin, L., Zacchigna, S., Giacca, M. & 3 others, da Costa Martins, P. A., Lopez-Andres, N. & De Windt, L. J., 6 Mar 2019, In : Molecular Therapy. 27, 3, p. 584-599 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

Lourenco, A. P., Leite-Moreira, A. F., Balligand, J-L., Bauersachs, J., Dawson, D., de Boer, R. A., de Windt, L. J., Falcao-Pires, I., Fontes-Carvalho, R., Franz, S., Giacca, M., Hilfiker-Kleiner, D., Hirsch, E., Maack, C., Mayr, M., Pieske, B., Thum, T., Tocchetti, C. G., Brutsaert, D. L. & Heymans, S., 1 Feb 2018, In : European journal of heart failure. 20, 2, p. 216-227 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiac remodeling and pre-eclampsia: an overview of microRNA expression patterns

Mohseni, Z., Spaanderman, M. E. A., Oben, J., Calore, M., Derksen, E., Al-Nasiry, S., De Windt, L. J. & Ghossein-Doha, C., 1 Sep 2018, In : Ultrasound in Obstetrics & Gynecology. 52, 3, p. 310-317 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

If you like it, put a ring on it!

el Azzouzi, H. & De Windt, L. J., 1 Oct 2018, In : Cardiovascular Research. 114, 12, p. 1575-1577 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure

Verjans, R., Peters, T., Beaumont, F., van Leeuwen, R., van Herwaarden, T., Verhesen, W., Munts, C., Bijnen, M., Henkens, M., Diez, J., de Windt, L. J., van Nieuwenhoven, F. A., van Bilsen, M., Goumans, M. J., Heymans, S., Gonzalez, A. & Schroen, B., 1 Feb 2018, In : Hypertension. 71, 2, p. 280-288 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

RNA therapeutics for heart disease

De Majo, F. & De Windt, L. J., 1 Sep 2018, In : Biochemical Pharmacology. 155, p. 468-478 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC

Frantz, S., Falcao-Pires, I., Balligand, J-L., Bauersachs, J., Brutsaert, D., Ciccarelli, M., Dawson, D., de Windt, L. J., Giacca, M., Hamdani, N., Hilfiker-Kleiner, D., Hirsch, E., Leite-Moreira, A., Mayr, M., Thum, T., Tocchetti, C. G., van der Velden, J., Varricchi, G. & Heymans, S., 1 Mar 2018, In : European journal of heart failure. 20, 3, p. 445-459 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy

Damanafshan, A., Elzenaar, I., Samson-Couterie, B., van der Made, I., Bourajjaj, M., van den Hoogenhof, M. M., van Veen, H. A., Picavet, D. I., Beqqali, A., Ehler, E., DeWindt, L. J., Pinto, Y. M. & van Oort, R. J., 1 Sep 2018, In : Cardiovascular Research. 114, 11, p. 1474-1486 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism

Dahlmans, D., Houzelle, A., Andreux, P., Jorgensen, J. A., Wang, X., de Windt, L. J., Schrauwen, P., Auwerx, J. & Hoeks, J., Nov 2017, In : Molecular Metabolism. 6, 11, p. 1429-1442 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heartd

Perrino, C., Barabasi, A-L., Condorelli, G., Davidson, S. M., De Windt, L., Dimmeler, S., Engel, F. B., Hausenloy, D. J., Hill, J. A., Van Laake, L. W., Lecour, S., Leor, J., Madonna, R., Mayr, M., Prunier, F., Sluijter, J. P. G., Schulz, R., Thum, T., Ytrehus, K. & Ferdinandy, P., 1 Jun 2017, In : Cardiovascular Research. 113, 7, p. 725-736 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Pre-eclampsia: an important risk factor for asymptomatic heart failure

Ghossein-Doha, C., Van Neer, J., Wissink, B., Breetveld, N. M., De Windt, L. J., Van Dijk, A. P. J., Van Der Vlugt, M. J., Janssen, M. C. H., Heidema, W. M., Scholten, R. R. & Spaanderman, M. E. A., Jan 2017, In : Ultrasound in Obstetrics & Gynecology. 49, 1, p. 143-149 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Translational Perspective on Epigenetics in Cardiovascular Disease

van der Harst, P., de Windt, L. J. & Chambers, J. C., 1 Aug 2017, In : Journal of the American College of Cardiology. 70, 5, p. 590-606 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?

Zucker, I. H., Lindsey, M. L., Delmar, M., De Windt, L. J., Rosiers, C. D., Diz, D. I., Hester, R. L., Jones, S. P., Kanagy, N. L., Kitakaze, M., Liao, R., Lopaschuk, G. D., Patel, K. P., Recchia, F. A., Sadoshima, J., Shah, A. M., Ungvari, Z., Benjamin, I. J., Blaustein, M. P., Charkoudian, N. & 7 others, Efimov, I. R., Gutterman, D., Kass, D. A., Liao, Y., O'Leary, D. S., Ripplinger, C. M. & Wolin, M. S., Aug 2017, In : American Journal of Physiology-heart and Circulatory Physiology. 313, 2, p. H221-H223 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Wnt/beta-catenin pathway in arrhythmogenic cardiomyopathy

Lorenzon, A., Calore, M., Poloni, G., De Windt, L. J., Braghetta, P. & Rampazzo, A., 1 Sep 2017, In : Oncotarget. 8, 36, p. 60640-60655 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

Exosomes: scytales in the damaged heart

Ottaviani, L., De Windt, L. J. & da Costa Martins, P. A., Jun 2016, In : Annals of translational medicine. 4, 11, 222.

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Long noncoding RNA Chast promotes cardiac remodeling

Viereck, J., Kumarswamy, R., Foinquinos, A., Xiao, K., Avramopoulos, P., Kunz, M., Dittrich, M., Maetzig, T., Zimmer, K., Remke, J., Just, A., Fendrich, J., Scherf, K., Bolesani, E., Schambach, A., Weidemann, F., Zweigerdt, R., de Windt, L. J., Engelhardt, S., Dandekar, T. & 2 others, Batkai, S. & Thum, T., 17 Feb 2016, In : Science Translational Medicine. 8, 326, 326ra22.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice

Peters, T., Beijnsberger, S., Beqqali, A., Bitsch, N., Nakagawa, S., Prasanth, K. V., de Windt, L. J., van Oort, R. J., Heymans, S. & Schroen, B., 26 Feb 2016, In : PLOS ONE. 11, 2, e0150236.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
24 Citations (Scopus)

MicroRNAs in heart failure: from biomarker to target for therapy

Vegter, E. L., van der Meer, P., de Windt, L. J., Pinto, Y. M. & Voors, A. A., May 2016, In : European journal of heart failure. 18, 5, p. 457-468

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction

Gupta, S. K., Foinquinos, A., Thum, S., Remke, J., Zimmer, K., Bauters, C., de Groote, P., Boon, R. A., de Windt, L. J., Preissl, S., Hein, L., Batkai, S., Pinet, F. & Thum, T., 4 Oct 2016, In : Journal of the American College of Cardiology. 68, 14, p. 1557-1571

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Targeting microRNAs in heart failure

Duygu, B., de Windt, L. J. & Da Costa Martins, P., Feb 2016, In : Trends in Cardiovascular Medicine. 26, 2, p. 99-110

Research output: Contribution to journalArticleAcademicpeer-review

2015
3 Citations (Scopus)

A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy

d'Avenia, M., Citro, R., De Marco, M., Veronese, A., Rosati, A., Visone, R., Leptidis, S., Philippen, L., Vitale, G., Cavallo, A., Silverio, A., Prota, C., Gravina, P., De Cola, A., Carletti, E., Coppola, G., Gallo, S., Provenza, G., Bossone, E., Piscione, F. & 4 others, Hahne, M., De Windt, L. J., Turco, M. C. & De laurenzi, V., Oct 2015, In : Cell Death & Disease. 6, e1948.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Antisense MicroRNA Therapeutics in Cardiovascular Disease: Quo Vadis?

Philippen, L. E., Dirkx, E., Wit, J. B. M., Burggraaf, K., de Windt, L. J. & Martins, P. A. D. C., Dec 2015, In : Molecular Therapy. 23, 12, p. 1810-1818

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Cardiac LXR protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization

Cannon, M. V., Sillje, H. H. W., Sijbesma, J. W. A., Vreeswijk-Baudoin, I., Ciapaite, J., van der Sluis, B., van Deursen, J., Silva, G. J. J., de Windt, L. J., Gustafsson, J-A., van der Harst, P., van Gilst, W. H. & de Boer, R. A., Sep 2015, In : EMBO Molecular Medicine. 7, 9, p. 1229-1243

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases

Calore, M., De Windt, L. J. & Rampazzo, A., Dec 2015, In : Journal of Molecular and Cellular Cardiology. 89, p. 27-34

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

HypoxamiRs: regulators of cardiac hypoxia and energy metabolism

el Azzouzi, H., Leptidis, S., Doevendans, P. A. & De Windt, L. J., Sep 2015, In : Trends in Endocrinology and Metabolism. 26, 9, p. 502-508

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Longing for Naiades in Heart Failure

Calore, M. & De Windt, L. J., 3 Nov 2015, In : Journal of the American College of Cardiology. 66, 18, p. 2016-2018

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Non-coding RNA in control of gene regulatory programs in cardiac development and disease

Philippen, L. E., Dirkx, E., da Costa-Martins, P. A. & De Windt, L. J., Dec 2015, In : Journal of Molecular and Cellular Cardiology. 89, Pt A, p. 51-8 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
78 Citations (Scopus)

Circulating miR-29a, Among Other Up-Regulated MicroRNAs, Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy

Roncarati, R., Anselmi, C. V., Losi, M. A., Papa, L., Cavarretta, E., Martins, P. D. C., Contaldi, C., Jotti, G. S., Franzone, A., Galastri, L., Latronico, M. V. G., Imbriaco, M., Esposito, G., De Windt, L., Betocchi, S. & Condorelli, G., 11 Mar 2014, In : Journal of the American College of Cardiology. 63, 9, p. 920-927

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models

Leite-Moreira, A. F., Lourenco, A. P., Balligand, J-L., Bauersachs, J., Clerk, A., De Windt, L. J., Heymans, S., Hilfiker-Kleiner, D., Hirsch, E., Iaccarino, G., Kaminski, K. A., Knoell, R., Mayr, M., Tarone, G., Thum, T. & Tocchetti, C. G., May 2014, In : European journal of heart failure. 16, 5, p. 509-518

Research output: Contribution to journalArticleAcademicpeer-review

Nuclear Calcium Transients Hermes Propylaios in the Heart

Martins, P. A. D. C., Leptidis, S. & De Windt, L. J., 15 Jul 2014, In : Circulation. 130, 3, p. 221-223

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Supplementing exposure to hypoxia with a copper depleted diet does not exacerbate right ventricular remodeling in mice

Poels, E. M., Bitsch, N., Slenter, J. M., Kooi, M. E., de Theije, C. C., De Windt, L. J., van Empel, V. P. & da Costa Martins, P. A., 15 Apr 2014, In : PLOS ONE. 9, 4, 7 p., 92983.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
36 Citations (Scopus)

Targeting myocardial remodelling to develop novel therapies for heart failure A position paper from the Working Group on Myocardial Function of the European Society of Cardiology

Tarone, G., Balligand, J-L., Bauersachs, J., Clerk, A., De Windt, L., Heymans, S., Hilfiker-Kleiner, D., Hirsch, E., Iaccarino, G., Knoell, R., Leite-Moreira, A. F., Lourenco, A. P., Mayr, M., Thum, T. & Tocchetti, C. G., May 2014, In : European journal of heart failure. 16, 5, p. 494-508

Research output: Contribution to journalArticleAcademicpeer-review

2013
37 Citations (Scopus)

A Deep Sequencing Approach to Uncover the miRNOME in the Human Heart

Leptidis, S., el Azzouzi, H., Lok, S. I., de Weger, R., Olieslagers, S., Kisters, N., Silva, G. J., Heymans, S., Cuppen, E., Berezikov, E., De Windt, L. J. & Martins, P. D. C., 27 Feb 2013, In : PLOS ONE. 8, 2, e57800.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
29 Citations (Scopus)

An SRF/miR-1 axis regulates NCX1 and Annexin A5 protein levels in the normal and failing heart

Tritsch, E., Mallat, Y., Lefebvre, F., Diguet, N., Escoubet, B., Blanc, J., De Windt, L. J., Catalucci, D., Vandecasteele, G., Li, Z. & Mericskay, M., 1 Jun 2013, In : Cardiovascular Research. 98, 3, p. 372-380

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure

Dirkx, E., Gladka, M. M., Philippen, L. E., Armand, A-S., Kinet, V., Leptidis, S., el Azzouzi, H., Salic, K., Bourajjaj, M., da Silva, G. J. J., Olieslagers, S., van der Nagel, R., de Weger, R., Bitsch, N., Kisters, N., Seyen, S., Morikawa, Y., Chanoine, C., Heymans, S., Volders, P. G. A. & 6 others, Thum, T., Dimmeler, S., Cserjesi, P., Eschenhagen, T., Martins, P. A. D. C. & De Windt, L. J., Nov 2013, In : Nature Cell Biology. 15, 11, p. 1282-1293

Research output: Contribution to journalArticleAcademicpeer-review

Regulation of fetal gene expression in heart failure

Dirkx, E., da Costa Martins, P. A. & De Windt, L. J., Dec 2013, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1832, 12, p. 2414-2424

Research output: Contribution to journalArticleAcademicpeer-review

2012

Circulating miRNAs: Reflecting or Affecting Cardiovascular Disease?

van Empel, V. P. M., De Windt, L. J. & Martins, P. A. D. C., Dec 2012, In : Current Hypertension Reports. 14, 6, p. 498-509

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Dominant-Negative Control of cAMP-Dependent I-Ks Upregulation in Human Long-QT Syndrome Type 1

Heijman, J., Spätjens, R., Seyen, S. R. M., Lentink, V., Kuijpers, H. J. H., Boulet, I. R., de Windt, L. J., David, M. & Volders, P. G. A., 20 Jan 2012, In : Circulation Research. 110, 2, p. 211-+

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

MEK1 Inhibits Cardiac PPAR alpha Activity by Direct Interaction and Prevents Its Nuclear Localization

el Azzouzi, H., Leptidis, S., Bourajjaj, M., van Bilsen, M., Martins, P. A. D. C. & De Windt, L. J., 19 Jun 2012, In : PLOS ONE. 7, 6, e36799.

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNAs as Biomarkers for Myocardial Infarction

Salic, K. & De Windt, L. J., Jun 2012, In : Current Atherosclerosis Reports. 14, 3, p. 193-200

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNAs in control of cardiac hypertrophy

Martins, P. A. D. C. & De Windt, L. J., 15 Mar 2012, In : Cardiovascular Research. 93, 4, p. 563-572

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog

Bourgonje, V. J. A., Schoenmakers, M., Beekman, J. D. M., van der Nagel, R., Houtman, M. J. C., Miedema, L. F., Antoons, G., Sipido, K., de Windt, L. J., van Veen, T. A. B. & Vos, M. A., Nov 2012, In : Heart Rhythm. 9, 11, p. 1875-+

Research output: Contribution to journalArticleAcademicpeer-review

Small changes can make a big difference - MicroRNA regulation of cardiac hypertrophy

Gladka, M. M., Martins, P. A. D. C. & de Windt, L. J., Jan 2012, In : Journal of Molecular and Cellular Cardiology. 52, 1, p. 74-82

Research output: Contribution to journalArticleAcademicpeer-review

2011

Apoptosis-Inducing Factor Regulates Skeletal Muscle Progenitor Cell Number and Muscle Phenotype

Armand, A-S., Laziz, I., Djeghloul, D., Lecolle, S., Bertrand, A. T., Biondi, O., De Windt, L. J. & Chanoine, C., 4 Nov 2011, In : PLOS ONE. 6, 11, p. 15

Research output: Contribution to journalArticleAcademicpeer-review

Differential responses of the right ventricle to abnormal loading conditions in mice: pressure vs. volume load

Bartelds, B., Borgdorff, M. A., Smit-van Oosten, A., Takens, J., Boersma, B., Nederhoff, M. G., Elzenga, N. J., van Gilst, W. H., De Windt, L. J. & Berger, R. M. F., Dec 2011, In : European journal of heart failure. 13, 12, p. 1275-1282

Research output: Contribution to journalArticleAcademicpeer-review

144 Downloads (Pure)

Het onzichtbare zichtbaar maken

de Windt, L. J., 1 Jan 2011, Maastricht: Maastricht University.nl.

Research output: Book/ReportInaugural speechPopular

Open Access
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