If you made any changes in Pure these will be visible here soon.

Research Output 2005 2019

  • 32 Article
  • 2 Review article
  • 1 Erratum / corrigendum
  • 1 Doctoral Thesis
2019

Adipose tissue macrophages do not affect atherosclerosis development in mice

Bijnen, M., van de Gaar, J., Vroomen, M., Gijbels, M. J., de Winther, M., Schalkwijk, C. G. & Wouters, K., Feb 2019, In : Atherosclerosis. 281, p. 31-37 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hepatic PPAR alpha is critical in the metabolic adaptation to sepsis

Paumelle, R., Haas, J. T., Hennuyer, N., Bauge, E., Deleye, Y., Mesotten, D., Langouche, L., Vanhoutte, J., Cudejko, C., Wouters, K., Hannou, S. A., Legry, V., Lancel, S., Lalloyer, F., Polizzi, A., Smati, S., Gourdy, P., Vallez, E., Bouchaert, E., Derudas, B. & 10 others, Dehondt, H., Gheeraert, C., Fleury, S., Tailleux, A., Montagner, A., Wahli, W., Van den Berghe, G., Guillou, H., Dombrowicz, D. & Staels, B., May 2019, In : Journal of Hepatology. 70, 5, p. 963-973 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions

Wetzels, S., Vanmierlo, T., Scheijen, J. L. J. M., van Horssen, J., Amor, S., Somers, V., Schalkwijk, C. G., Hendriks, J. J. A. & Wouters, K., 24 Apr 2019, In : Frontiers in Immunology. 10, 9 p., 855.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?"

Plat, J., Baumgartner, S., Vanmierlo, T., Luetjohann, D., Calkins, K. L., Burrin, D. G., Guthrie, G., Thijs, C., Te Velde, A. A., Vreugdenhil, A. C. E., Sverdlov, R., Garssen, J., Wouters, K., Trautwein, E. A., Wolfs, T. G., van Gorp, C., Mulder, M. T., Riksen, N. P., Groen, A. K. & Mensink, R. P., Apr 2019, In : Progress in Lipid Research. 74, p. 87-102 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Verboven, K., Wouters, K., Gaens, K., Hansen, D., Bijnen, M., Wetzels, S., Stehouwer, C. D., Goossens, G. H., Schalkwijk, C. G., Blaak, E. E. & Jocken, J. W., 16 Mar 2018, In : Scientific Reports. 8, 8 p., 4677.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice

Bijnen, M., Josefs, T., Cuijpers, I., Maalsen, C. J., van de Gaar, J., Vroomen, M., Wijnands, E., Rensen, S. S., Greve, J. W. M., Hofker, M. H., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G. & Wouters, K., Jul 2018, In : Gut. 67, 7, p. 1317-1327 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Wetzels, S., Bijnen, M., Wijnands, E., Biessen, E. A. L., Schalkwijk, C. G. & Wouters, K., 1 Mar 2018, In : Journal of visualized experiment. 133, 9 p., e57319 .

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access
2017

A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis

Rienks, M., Papageorgiou, A., Wouters, K., Verhesen, W., van Leeuwen, R., Carai, P., Summer, G., Westermann, D. & Heymans, S., Apr 2017, In : Cellular and Molecular Life Sciences. 74, 8, p. 1511-1525 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating classical monocytes are associated with CD11c(+) macrophages in human visceral adipose tissue

Wouters, K., Gaens, K., Bijnen, M., Verboven, K., Jocken, J., Wetzels, S., Wijnands, E., Hansen, D., van Greevenbroek, M., Duijvestijn, A. M., Biessen, E. A. L., Blaak, E. E., Stehouwer, C. D. A. & Schalkwijk, C. G., 15 Feb 2017, In : Scientific Reports. 7, 8 p., 42665.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Corrigendum: Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes

Bogie, J. F. J., Mailleux, J., Wouters, E., Jorissen, W., Grajchen, E., Vanmol, J., Wouters, K., Hellings, N., van Horssen, J., Vanmierlo, T. & Hendriks, J. J. A., 22 Dec 2017, In : Scientific Reports. 7, 1 p., 46925.

Research output: Contribution to journalErratum / corrigendumAcademic

Open Access

Macrophage complexity in human atherosclerosis: opportunities for treatment?

Biessen, E. A. L. & Wouters, K., Oct 2017, In : Current Opinion in Lipidology. 28, 5, p. 419-426 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Methylglyoxal-Derived Advanced Glycation Endproducts in Multiple Sclerosis

Wetzels, S., Wouters, K., Schalkwijk, C. G., Vanmierlo, T. & Hendriks, J. J. A., 15 Feb 2017, In : International journal of molecular sciences. 18, 2, 15 p., 421.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes

Bogie, J. F. J., Mailleux, J., Wouters, E., Jorissen, W., Grajchen, E., Vanmol, J., Wouters, K., Hellings, N., Van Horsen, J., Vanmierlo, T. & Hendriks, J. J. A., 20 Mar 2017, In : Scientific Reports. 7, 9 p., 44794.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The tumour suppressor CDKN2A/p16(INK4a) regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue

Wouters, K., Deleye, Y., Hannou, S. A., Vanhoutte, J., Marechal, X., Coisne, A., Tagzirt, M., Derudas, B., Bouchaert, E., Duhem, C., Vallez, E., Schalkwijk, C. G., Pattou, F., Montaigne, D., Staels, B. & Paumelle, R., Nov 2017, In : Diabetes & Vascular Disease Research. 14, 6, p. 516-524 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Cardiac Troponin T and I Release After a 30-km Run

Klinkenberg, L. J. J., Luyten, P., van der Linden, N., Urgel, K., Snijders, D. P. C., Knackstedt, C., Dennert, R., Kietselaer, B. L. J. H., Mingels, A., Cardinaels, E. P. M., Peeters, F. E. C. M., van Suijlen, J. D. E., ten Kate, J., Marsch, E., Theelen, T. L., Sluimer, J. C., Wouters, K., Bekers, O., Bekkers, B., van Loon, L. & 2 others, Visser - van Dieijen, M. & Meex, S. J. R., 15 Jul 2016, In : American Journal of Cardiology. 118, 2, p. 281-287

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia

Marsch, E., Demandt, J. A. F., Theelen, T. L., Tullemans, B. M. E., Wouters, K., Boon, M. R., van Dijk, T. H., Gijbels, M. J., Dubois, L. J., Meex, S. J. R., Mazzone, M., Hung, G., Fisher, E. A., Biessen, E. A. L., Daemen, M. J. A. P., Rensen, P. C. N., Carmeliet, P., Groen, A. K. & Sluimer, J. C., 14 Oct 2016, In : European Heart Journal. 37, 39, p. 2993-2997

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
2015
3 Citations (Scopus)

Ablation of CD8 alpha(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice

Legein, B., Janssen, E. M., Theelen, T. L., Gijbels, M. J., Walraven, J., Klarquist, J. S., Hennies, C. M., Wouters, K., Seijkens, T. T. P., Wijnands, E., Sluimer, J. C., Lutgens, E., Zenke, M., Hildner, K., Biessen, E. A. L. & Temmerman, L., 21 Oct 2015, In : Scientific Reports. 5, 15414.

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?

Hannou, S. A., Wouters, K., Paumelle, R. & Staels, B., Apr 2015, In : Trends in Endocrinology and Metabolism. 26, 4, p. 176-184

Research output: Contribution to journalArticleAcademicpeer-review

2014
7 Citations (Scopus)

Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE(-/-) mice with or without diabetes

Hanssen, N. M. J., Brouwers, O., Gijbels, M. J., Wouters, K., Wijnands, E., Cleutjens, J. P. M., De Mey, J. G., Miyata, T., Biessen, E. A., Stehouwer, C. D. A. & Schalkwijk, C. G., 1 Oct 2014, In : Cardiovascular Research. 104, 1, p. 160-170

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype

Hanssen, N. M. J., Wouters, K., Huijberts, M. S., Gijbels, M. J., Sluimer, J. C., Scheijen, J. L. J. M., Heeneman, S., Biessen, E. A. L., Daemen, M. J. A. P., Brownlee, M., de Kleijn, D. P., Stehouwer, C. D. A., Pasterkamp, G. & Schalkwijk, C. G., May 2014, In : European Heart Journal. 35, 17, p. 1137-1146

Research output: Contribution to journalArticleAcademicpeer-review

2013
71 Citations (Scopus)

Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure

Heymans, S., Corsten, M. F., Verhesen, W., Carai, P., van Leeuwen, R. E., Custers, K., Peters, T., Hazebroek, M., Stoger, L., Wijnands, E., Janssen, B. J., Creemers, E. E., Pinto, Y. M., Grimm, D., Schurmann, N., Vigorito, E., Thum, T., Stassen, F. R., Yin, X., Mayr, M. & 9 others, De Windt, L. J., Lutgens, E., Wouters, K., de Winther, M. P., Zacchigna, S., Giacca, M., van Bilsen, M., Papageorgiou, A. P. & Schroen, B. L., 24 Sep 2013, In : Circulation. 128, 13, p. 1420-1432

Research output: Contribution to journalArticleAcademicpeer-review

2012

Bone Marrow p16(INK4a)-Deficiency Does Not Modulate Obesity, Glucose Homeostasis or Atherosclerosis Development

Wouters, K., Cudejko, C., Gijbels, M. J. J., Fuentes, L., Bantubungi, K., Vanhoutte, J., Dievart, R., Paquet, C., Bouchaert, E., Hannou, S. A., Gizard, F., Tailleux, A., de Winther, M. P. J., Staels, B. & Paumelle, R., 5 Mar 2012, In : PLOS ONE. 7, 3, p. e32440

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Internalization of modified lipids by cd36 and sr-a leads to hepatic inflammation and lysosomal cholesterol storage in kupffer cells

Bieghs, V., Verheyen, F., van Gorp, P. J., Hendrikx, T., Wouters, K., Lutjohann, D., Gijbels, M. J., Febbraio, M., Binder, C. J., Hofker, M. H. & Sverdlov, R., 28 Mar 2012, In : PLOS ONE. 7, 3, 7 p., e34378.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
49 Citations (Scopus)

LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease

Bieghs, V., van Gorp, P. J., Wouters, K., Hendrikx, T., Gijbels, M. J., van Bilsen, M., de Bakker, J., Binder, C. J., Lutjohann, D., Staels, B., Hofker, M. H. & Sverdlov, R., 25 Jan 2012, In : PLOS ONE. 7, 1, e30668.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2011
40 Citations (Scopus)

Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice

Lalloyer, F., Wouters, K., Baron, M., Caron, S., Vallez, E., Vanhoutte, J., Bauge, E., Sverdlov, R., Hofker, M., Staels, B. & Tailleux, A., Jul 2011, In : Arteriosclerosis Thrombosis and Vascular Biology. 31, 7, p. 1573-1579

Research output: Contribution to journalArticleAcademicpeer-review

2010
41 Citations (Scopus)

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice.

Wouters, K., van Bilsen, M., van Gorp, P. J., Bieghs, V., Lutjohann, D., Kerksiek, A., Staels, B., Hofker, M. H. & Sverdlov, R., 29 Jan 2010, In : Febs Letters. 584, 5, p. 1001-1005

Research output: Contribution to journalArticleAcademicpeer-review

69 Citations (Scopus)

Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice

Bieghs, V., Wouters, K., van Gorp, P. J., Gijbels, M. J. J., de Winther, M. P. J., Binder, C. J., Lutjohann, D., Febbraio, M., Moore, K. J., van Bilsen, M., Hofker, M. H. & Shiri-Sverdlov, R., Jun 2010, In : Gastroenterology. 138, 7, p. 2477-2486 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2008
19 Citations (Scopus)

Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice.

Vanschoonbeek, K., Wouters, K., van der Meijden, P. E., van Gorp, P. J. J., Feijge, M. A., Herfs, M., Schurgers, L. J., Hofker, M. H., de Maat, M. P. & Heemskerk, J. W., 1 Jan 2008, In : Arteriosclerosis Thrombosis and Vascular Biology. 28, 11, p. 2023-2029

Research output: Contribution to journalArticleAcademicpeer-review

246 Citations (Scopus)

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

Wouters, K., van Gorp, P. J. J., Bieghs, V., Gijbels, M. J., Duimel, H., Lutjohann, D., Kerksiek, A., van Kruchten, R., Maeda, N., Staels, B., van Bilsen, M., Sverdlov, R. & Hofker, M. H., Aug 2008, In : Hepatology. 48, 2, p. 474-486

Research output: Contribution to journalArticleAcademicpeer-review

239 Downloads (Pure)

Non-alcoholic steatohepatitis : second hit or strike out?

Wouters, K. A. M., 1 Jan 2008, Maastricht: Maastricht University. 192 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
File
2006
96 Citations (Scopus)

Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates

Shiri-Sverdlov, R., Wouters, K., van Gorp, P. J. J., Gijbels, M. J. J., Noel, B., Buffat, L., Staels, B., Maeda, N., van Bilsen, M. & Hofker, M. H., Apr 2006, In : Journal of Hepatology. 44, 4, p. 732-741

Research output: Contribution to journalArticleAcademicpeer-review

2005
69 Citations (Scopus)