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Research Output 2003 2018

2018

Analysis of DNA methylation in cancer: location revisited

Koch, A., Joosten, S. C., Feng, Z., de Ruijter, T. C., Draht, M. X., Melotte, V., Smits, K. M., Veeck, J., Herman, J. G., Van Neste, L., Van Criekinge, W., De Meyer, T. & van Engeland, M., 1 Jul 2018, In : Nature Reviews Clinical Oncology. 15, 7, p. 459-466 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Author Correction: Analysis of DNA methylation in cancer: location revisited

Koch, A., Joosten, S., Feng, Z., de Ruijter, T., Draht, M., Melotte, V., Smits, K., Veeck, J., Herman, J. G., van Neste, L., Van Criekinge, W., De Meyer, T. & van Engeland, M., 2018, In : Nature Reviews Clinical Oncology. 15, p. 467

Research output: Contribution to journalErratum / corrigendumAcademic

Epigenetics in renal cell cancer: mechanisms and clinical applications

Joosten, S. C., Smits, K. M., Aarts, M. J., Melotte, V., Koch, A., Tjan-Heijnen, V. C. & van Engeland, M., 1 Jul 2018, In : Nature Reviews Urology. 15, 7, p. 430-451 22 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Prognostic DNA methylation markers for sporadic colorectal cancer: a systematic review

Draht, M. X. G., Goudkade, D., Koch, A., Grabsch, H. I., Weijenberg, M. P., van Engeland, M., Melotte, V. & Smits, K. M., 14 Mar 2018, In : Clinical epigenetics. 10, 16 p., 35.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2017

A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patients

van Vlodrop, I. J. H., Joosten, S. C., De Meyer, T., Smits, K. M., Van Neste, L., Melotte, V., Baldewijns, M. M. L. L., Schouten, L. J., van den Brandt, P. A., Jeschke, J., Yi, J. M., Schuebel, K. E., Ahuja, N., Herman, J. G., Aarts, M. J., Bosman, F. T., Van Criekinge, W. & van Engeland, M., 15 Apr 2017, In : Clinical Cancer Research. 23, 8, p. 2006-2018 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

51 Downloads (Pure)

Decision support systems for personalized and participative radiation oncology

Lambin, P., Zindler, J., Vanneste, B. G. L., Van De Voorde, L., Eekers, D., Compter, I., Panth, K. M., Peerlings, J., Larue, R. T. H. M., Deist, T. M., Jochems, A., Lustberg, T., van Soest, J., de Jong, E. E. C., Even, A. J. G., Reymen, B., Rekers, N., van Gisbergen, M., Roelofs, E., Carvalho, S. & 19 others, Leijenaar, R. T. H., Zegers, C. M. L., Jacobs, M., van Timmeren, J., Brouwers, P., Lal, J. A., Dubois, L., Yaromina, A., Van Limbergen, E. J., Berbee, M., van Elmpt, W., Oberije, C., Ramaekers, B., Dekker, A., Boersma, L. J., Hoebers, F., Smits, K. M., Berlanga, A. J. & Walsh, S., 15 Jan 2017, In : Advanced Drug Delivery Reviews. 109, p. 131-153 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File

PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer

van Loon, J., Even, A. J. G., Aerts, H. J. W. L., Ollers, M., Hoebers, F., van Elmpt, W., Dubois, L., Dingemans, A-M. C., Lalisang, R. I., Kempers, P., Brans, B., Winnepenninckx, V., Speel, E-J., Thunnissen, E., Smits, K. M., Boellaard, R., Vugts, D. J., De Ruysscher, D. & Lambin, P., Feb 2017, In : Radiotherapy and Oncology. 122, 2, p. 267-273 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prognostic DNA methylation markers for renal cell carcinoma: a systematic review

Joosten, S. C., Deckers, I. A. G., Aarts, M. J., Hoeben, A., van Roermund, J. G., Smits, K. M., Melotte, V., van Engeland, M. & Tjan-Heijnen, V. C., Sep 2017, In : Epigenomics. 9, 9, p. 1243-1257 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016
2 Citations (Scopus)

Analysis of RET promoter CpG island methylation using methylation-specific PCR (MSP), pyrosequencing, and methylation-sensitive high-resolution melting (MS-HRM): impact on stage II colon cancer patient outcome

Draht, M. X. G., Smits, K. M., Jooste, V., Tournier, B., Vervoort, M., Ramaekers, C., Chapusot, C., Weijenberg, M. P., van Engeland, M. & Melotte, V., 26 Apr 2016, In : Clinical epigenetics. 8, 44.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
14 Citations (Scopus)

Modern clinical research: How rapid learning health care and cohort multiple randomised clinical trials complement traditional evidence based medicine

Lambin, P., Zindler, J., Vanneste, B., Van De Voorde, L., Jacobs, M., Eekers, D., Peerlings, J., Reymen, B., Larue, R. T. H. M., Deist, T. M., De Jong, E. E. C., Even, A. J. G., Berlanga, A. J., Roelofs, E., Cheng, Q., Carvalho, S., Leijenaar, R. T. H., Zegers, C. M. L., Van Limbergen, E., Berbee, M. & 10 others, Van Elmpt, W., Oberije, C., Houben, R., Dekker, A., Boersma, L., Verhaegen, F., Bosmans, G., Hoebers, F., Smits, K. & Walsh, S., 21 Oct 2015, In : Acta Oncologica. 54, 9, p. 1289-1300

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Spectrin Repeat Containing Nuclear Envelope 1 and Forkhead Box Protein E1 Are Promising Markers for the Detection of Colorectal Cancer in Blood

Melotte, V., Yi, J. M., Lentjes, M. H. F. M., Smits, K. M., Van Neste, L., Niessen, H. E. C., Wouters, K. A. D., Louwagie, J., Schuebel, K. E., Herman, J. G., Baylin, S. B., van Criekinge, W., Meijer, G. A., Ahuja, N. & van Engeland, M., Feb 2015, In : Cancer prevention research. 8, 2, p. 157-164

Research output: Contribution to journalArticleAcademicpeer-review

2014
7 Citations (Scopus)

CHFR Promoter Methylation Indicates Poor Prognosis in Stage II Microsatellite Stable Colorectal Cancer

Cleven, A. H. G., Derks, S., Draht, M. X. G., Smits, K. M., Melotte, V., Van Neste, L., Tournier, B., Jooste, V., Chapusot, C., Weijenberg, M. P., Herman, J. G., de Bruine, A. P. & van Engeland, M., 15 Jun 2014, In : Clinical Cancer Research. 20, 12, p. 3261-3271

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine

Derks, S., Cleven, A. H. G., Melotte, V., Smits, K. M., Brandes, J. C., Azad, N., van Criekinge, W., de Bruine, A. P., Herman, J. G. & van Engeland, M., Mar 2014, In : Cancer and Metastasis Reviews. 33, 1, p. 161-171

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Epigenetics in radiotherapy: Where are we heading?

Smits, K. M., Melotte, V., Niessen, H. E. C., Dubois, L., Oberije, C., Troost, E. G. C., Starmans, M. H. W., Boutros, P. C., Vooijs, M., van Engeland, M. & Lambin, P., May 2014, In : Radiotherapy and Oncology. 111, 2, p. 168-177

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Promoter CpG island methylation of RET predicts poor prognosis in stage II colorectal cancer patients

Draht, M. X. G., Smits, K. M., Tournier, B., Jooste, V., Chapusot, C., Carvalho, B., Cleven, A. H. G., Derks, S., Wouters, K. A. D., Belt, E. J. T., Stockmann, H. B. A. C., Bril, H., Weijenberg, M. P., van den Brandt, P. A., de Bruïne, A. P., Herman, J. G., Meijer, G. A., Piard, F., Melotte, V. & van Engeland, M., 1 Jan 2014, In : Molecular oncology. 8, 3, p. 679-688

Research output: Contribution to journalArticleAcademicpeer-review

2013
33 Citations (Scopus)

A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis

Simons, C., Hughes, L. A. E., Smits, K. M., Khalid-de Bakker, C. A., de Bruine, A. P., Carvalho, B., Meijer, G. A., Schouten, L. J., van den Brandt, P. A., Weijenberg, M. P. & van Engeland, M., Aug 2013, In : Annals of Oncology. 24, 8, p. 2048-2056

Research output: Contribution to journalArticleAcademicpeer-review

2012

Promoter CpG island methylation markers in colorectal cancer: the road ahead

Draht, M. X. G., Riedl, R. G., Niessen, H., Carvalho, B., Meijer, G. A., Herman, J. G., van Engeland, M., Melotte, V. & Smits, K. M., Apr 2012, In : Epigenomics. 4, 2, p. 179-194

Research output: Contribution to journalArticleAcademicpeer-review

67 Citations (Scopus)

The cpg island methylator phenotype in colorectal cancer: Progress and problems

Hughes, L. A. E., Khalid - de Bakker, C. A., Smits, K. M., van den Brandt, P. A., Jonkers, D., Ahuja, N., Herman, J. G., Weijenberg, M. P. & van Engeland, M., 1 Jan 2012, In : Biochimica et Biophysica Acta-reviews on Cancer. 1825, 1, p. 77-85

Research output: Contribution to journalArticleAcademicpeer-review

2011

A Let-7 MicroRNA SNP in the KRAS 3 ' UTR Is Prognostic in Early-Stage Colorectal Cancer

Smits, K. M., Paranjape, T., Nallur, S., Wouters, K. A. D., Weijenberg, M. P., Schouten, L. J., van den Brandt, P. A., Bosman, F. T., Weidhaas, J. B. & van Engeland, M., 15 Dec 2011, In : Clinical Cancer Research. 17, 24, p. 7723-7731

Research output: Contribution to journalArticleAcademicpeer-review

Colorectal Cancer Epigenetics: Complex Simplicity

van Engeland, M., Derks, S., Smits, K. M., Meijer, G. A. & Herman, J. G., 1 Apr 2011, In : Journal of Clinical Oncology. 29, 10, p. 1382-1391

Research output: Contribution to journalArticleAcademicpeer-review

Genomic and Epigenomic Integration Identifies a Prognostic Signature in Colon Cancer

Yi, J. M., Dhir, M., Van Neste, L., Downing, S. R., Jeschke, J., Gloeckner, S. C., Calmon, M. D. F., Hooker, C. M., Funes, J. M., Boshoff, C., Smits, K. M., van Engeland, M., Weijenberg, M. P., Iacobuzio-Donahue, C. A., Herman, J. G., Schuebel, K. E., Baylin, S. B. & Ahuja, N., 15 Mar 2011, In : Clinical Cancer Research. 17, 6, p. 1535-1545

Research output: Contribution to journalArticleAcademicpeer-review

Loss of SerpinA5 protein expression is associated with advanced-stage serous ovarian tumors

Bijsmans, I. T. G. W., Smits, K. M., de Graeff, P., Wisman, G. B. A., van der Zee, A. G. J., Slangen, B. F., de Bruine, A. P., van Engeland, M., Sieben, N. L. & Van de Vijver, K. K., Mar 2011, In : Modern Pathology. 24, 3, p. 463-470

Research output: Contribution to journalArticleAcademicpeer-review

Modified UroVysion scoring criteria increase the urothelial carcinoma detection rate in cases of equivocal urinary cytology

Huysentruyt, C. J. R., Baldewijns, M. M., Ruland, A. M., Tonk, R. J. W., Vervoort, P. S. A. M., Smits, K. M., van de Beek, C. & Speel, E-J. M., Jun 2011, In : Histopathology. 58, 7, p. 1048-1053

Research output: Contribution to journalArticleAcademicpeer-review

2010

Body Mass Index and von Hippel-Lindau Gene Mutations in Clear-cell Renal Cancer: Results of the Netherlands Cohort Study on Diet and Cancer

Smits, K. M., Schouten, L. J., Hudak, E., Verhage, B., Van Dijk, B. A. C., Hulsbergen-van de Kaa, C. A., Goldbohm, R. A. S., Oosterwijk, E. & Van Den Brandt, P. A., May 2010, In : Annals of Epidemiology. 20, 5, p. 401-404

Research output: Contribution to journalArticleAcademicpeer-review

Prognostic Significance of Gremlin1 (GREM1) Promoter CpG Island Hypermethylation in Clear Cell Renal Cell Carcinoma

van Vlodrop, I. J. H., Baldewijns, M. M. L., Smits, K. M., Schouten, L. J., van Neste, L., Van Criekinge, W., van Poppel, H., Lerut, E., Schuebel, K. E., Ahuja, N., Herman, J. G., de Bruine, A. P. & van Engeland, M., Feb 2010, In : American Journal of Pathology. 176, 2, p. 575-584

Research output: Contribution to journalArticleAcademicpeer-review

2009
103 Citations (Scopus)

GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer

Hellebrekers, D. M., Lentjes, M. H., van den Bosch, S. M., Melotte, V., Wouters, K. A., Daenen, K. L., Smits, K. M., Akiyama, Y., Yuasa, Y., Sanduleanu, S., Khalid - de Bakker, C. A., Jonkers, D., Weijenberg, M. P., Louwagie, J., van Criekinge, W., Carvalho, B., Meijer, G. A., Baylin, S. B., Herman, J. G., de Bruine, A. P. & 1 others, van Engeland, M., 1 Jan 2009, In : Clinical Cancer Research. 15, 12, p. 3990-7

Research output: Contribution to journalArticleAcademicpeer-review

138 Citations (Scopus)

Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer

Glockner, S. C., Dhir, M., Yi, J. M., McGarvey, K. E., van Neste, L., Louwagie, J., Chan, T. A., Kleeberger, W., de Bruine, A. P., Smits, K. M., Khalid - de Bakker, C. A., Jonkers, D. M., Stockbrugger, R. W., Meijer, G. A., Oort, F. A., Iacobuzio Donahue, C., Bierau, K., Herman, J. G., Baylin, S. B., van Engeland, M. & 2 others, Schuebel, K. E. & Ahuja, N., 1 Jan 2009, In : Cancer Research. 69, 11, p. 4691-9

Research output: Contribution to journalArticleAcademicpeer-review

105 Citations (Scopus)

N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer

Melotte, V., Lentjes, M. H., van den Bosch, S. M., Hellebrekers, D. M., de Hoon, J. P. J., Wouters, K. A., Daenen, K. L., Partouns Hendriks, I. E., Stessels, F., Louwagie, J., Smits, K. M., Weijenberg, M. P., Sanduleanu, S., Khalid - de Bakker, C. A., Oort, F. A., Meijer, G. A., Jonkers, D. M., Herman, J. G., de Bruine, A. P. & van Engeland, M., 1 Jan 2009, In : Journal of the National Cancer Institute. 101, 13, p. 916-27

Research output: Contribution to journalArticleAcademicpeer-review

2008
94 Citations (Scopus)
95 Downloads (Pure)

Lamin A/C is a risk biomarker in colorectal cancer

Willis, N. D., Cox, T. R., Rahman-Casans, S. F., Smits, K. M., Przyborski, S. A., van den Brandt, P. A., van Engeland, M., Weijenberg, M. P., Wilson, R. G., de Bru¿, A. P. & Hutchison, C. J., 1 Jan 2008, In : PLOS ONE. 3, 8, e2988.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
8 Citations (Scopus)
99 Downloads (Pure)

Polymorphisms in genes related to activation or detoxification of carcinogens might interact with smoking to increase renal cancer risk: results from The Netherlands Cohort Study on diet and cancer.er risk: results from The Netherlands Cohort Study on diet and cancer.

Smits, K. M., Schouten, L. J., van Dijk, B. A., van Houwelingen, K., Hulsbergen van de Kaa, C. A., Kiemeney, L. A., Goldbohm, R. A., Oosterwijk, E. & van den Brandt, P. A., 1 Jan 2008, In : World Journal of Urology. 26, 1, p. 103-110

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2007
27 Citations (Scopus)
115 Downloads (Pure)

Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study

van den Brandt, P. A., Smits, K. M., Goldbohm, R. A. & Weijenberg, M. P., 1 Jan 2007, In : British Journal of Cancer. 96, 3, p. 510-513

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Polymorphisms in genes related to activation or detoxification of carcinogens might increase renal cancer risk: results from the Netherlands Cohort Study Maastricht

Smits, K. M., Schouten, L. J., Houwelingen, K. P., van Dijk, B. A. C., Hulsbergen-van de Kaa, C. A., Kiemeney, L. A. L. M., Goldbohm, R. A., Oosterwijk, E. & van den Brandt, P. A., 1 Jan 2007, WEON 2007.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

2006
198 Downloads (Pure)

Pharmacogenetic studies in depression: a focus on the serotonin transporter gene

Smits, K. M., 1 Jan 2006, Maastricht: Datawyse / Universitaire Pers Maastricht. 125 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
File
2004
24 Citations (Scopus)

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

Smits, K. M., Benhamou, S., Garte, S., Weijenberg, M. P., Alamanos, Y. & Manni, J. J., 1 Jan 2004, In : International Journal of Cancer. 110, 2, p. 266-270 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

2003
25 Citations (Scopus)

Interaction between smoking, GSTM1 deletion and colorectal cancer: results from the GSEC study

Smits, K. M., Gaspari, L., Weijenberg, M. P., Dolzan, V., Golka, K., Roemer, H. C., Kristensen, V. N., Lechner, M. C., Mehling, G. I., Seidegard, J., Strange, R. C. & Taioli, E., 1 Jan 2003, In : Biomarkers. 8, 3-4, p. 299-310 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

217 Citations (Scopus)
191 Downloads (Pure)

K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study

Brink, M., de Goeij, A. F. P. M., Weijenberg, M. P., Roemen, G. M. J. M., Lentjens, M. H., Pachen, M. M. M., Smits, K. M., de Bruine, A. P., Goldbohm, R. A. & van den Brandt, P. A., 1 Jan 2003, In : Carcinogenesis. 24, 4, p. 703-710 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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