Kasper Rouschop

2025

MAP1LC3C repression reduces CIITA- and HLA class II expression in non-small cell lung cancer

Barbeau, L. M. O., Beelen, N. A., Savelkouls, K. G., Keulers, T. G. H., Wieten, L. & Rouschop, K. M. A., 10 Feb 2025, In: PLOS ONE. 20, 2, 19 p., e0316716.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2024

Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKa activation

Beaumont, J. E. J., Barbeau, L. M. O., Ju, J., Savelkouls, K. G., Bouwman, F. G., Zonneveld, M. I., Bronckaers, A., Kampen, K. R., Keulers, T. G. H. & Rouschop, K. M. A., 1 Jul 2024, In: Journal of Extracellular Vesicles. 13, 7, 19 p., e12449.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

GABARAPL1 is essential in extracellular vesicle cargo loading and metastasis development

Beaumont, J. E. J., Ju, J., Barbeau, L. M. O., Demers, I., Savelkouls, K. G., Derks, K., Bouwman, F. G., Wauben, M. H. M., Zonneveld, M. I., Keulers, T. G. H. & Rouschop, K. M. A., 1 Jan 2024, In: Radiotherapy and Oncology. 190, 11 p., 109968.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. ?. G., Mohanty, S., Möller, A., Nieuwland, R. & Ochiya, T. & 38 others, Sahoo, S., Torrecilhas, A. C., Zheng, L., Zijlstra, A., Abuelreich, S., Bagabas, R., Bergese, P., Bridges, E. M., Brucale, M., Burger, D., Carney, R. P., Cocucci, E., Crescitelli, R., Hanser, E., Harris, A. L., Haughey, N. J., Hendrix, A., Ivanov, A. R., Jovanovic-Talisman, T., Kruh-Garcia, N. A., Faustino, V. K. L., Kyburz, D., Lässer, C., Lennon, K. M., Lötvall, J., Maddox, A. L., Martens-Uzunova, E. S., Mizenko, R. R., Newman, L. A., Ridolfi, A., MISEV Consortium, Rouschop, K., Stassen, F., Thery, C., Witwer, K. W., Beaumont, J., Benedikter, B. & Keulers, T., Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, e12404.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas

Sanchez-Castillo, A., Savelkouls, K. G., Baldini, A., Hounjet, J., Sonveaux, P., Verstraete, P., De Keersmaecker, K., Dewaele, B., Bjorkblom, B., Melin, B., Wu, W. Y., Sjoberg, R. L., Rouschop, K. M. A., Broen, M. P. G., Vooijs, M. & Kampen, K. R., 13 Nov 2024, In: Oncogenesis. 13, 1, 18 p., 39.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer

Sanchez-Castillo, A., Heylen, E., Hounjet, J., Savelkouls, K. G., Lieuwes, N. G., Biemans, R., Dubois, L. J., Reynders, K., Rouschop, K. M., Vaes, R. D. W., De Keersmaecker, K., Lambrecht, M., Hendriks, L. E. L., De Ruysscher, D. K. M., Vooijs, M. & Kampen, K. R., 9 Mar 2024, In: British Journal of Cancer. 130, 4, p. 568-584 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2022

ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer

Keulers, T. G., Koch, A., van Gisbergen, M. W., Barbeau, L. M. O., Zonneveld, M. I., de Jong, M. C., Savelkouls, K. G. M., Wanders, R. G., Bussink, J., Melotte, V. & Rouschop, K. M. A., 3 Aug 2022, In: Autophagy. 18, 8, p. 1898-1914 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Physiological Oxygen Levels Differentially Regulate Adipokine Production in Abdominal and Femoral Adipocytes from Individuals with Obesity Versus Normal Weight

Lempesis, I. G., Hoebers, N., Essers, Y., Jocken, J. W. E., Rouschop, K. M. A., Blaak, E. E., Manolopoulos, K. N. & Goossens, G. H., 8 Nov 2022, In: Cells. 11, 22, 8 p., 3532.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2021

Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial

Compter, I., Eekers, D. B. P., Hoeben, A., Rouschop, K. M. A., Reymen, B., Ackermans, L., Beckervordersantforth, J., Bauer, N. J. C., Anten, M. M., Wesseling, P., Postma, A. A., De Ruysscher, D. & Lambin, P., 2 Sept 2021, In: Autophagy. 17, 9, p. 2604-2612 9 p.

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Open Access

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Identification of Potential Prognostic and Predictive Immunological Biomarkers in Patients with Stage I and Stage III Non-Small Cell Lung Cancer (NSCLC): A Prospective Exploratory Study

Vaes, R. D. W., Reynders, K., Sprooten, J., Nevola, K. T., Rouschop, K. M. A., Vooijs, M., Garg, A. D., Lambrecht, M., Hendriks, L. E. L., Rucevic, M. & De Ruysscher, D., 1 Dec 2021, In: Cancers. 13, 24, 18 p., 6259.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2

Vaes, N., Schonkeren, S. L., Rademakers, G., Holland, A. M., Koch, A., Gijbels, M. J., Keulers, T. G., de Wit, M., Moonen, L., Van der Meer, J. R. M., van den Boezem, E., Wolfs, T. G. A. M., Threadgill, D. W., Demmers, J., Fijneman, R. J. A., Jimenez, C. R., Vanden Berghe, P., Smits, K. M., Rouschop, K. M. A. & Boesmans, W. & 2 others, Hofstra, R. M. W. & Melotte, V., 4 Jun 2021, In: Embo Reports. 22, 6, 17 p., e51913.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity

van Meijel, R. L. J., Vogel, M. A. A., Jocken, J. W. E., Vliex, L. M. M., Smeets, J. S. J., Hoebers, N., Hoeks, J., Essers, Y., Schoffelen, P. F. M., Sell, H., Kersten, S., Rouschop, K. M. A., Blaak, E. E. & Goossens, G. H., 1 Nov 2021, In: Molecular Metabolism. 53, 13 p., 101287.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Secretion of pro-angiogenic extracellular vesicles during hypoxia is dependent on the autophagy-related protein GABARAPL1

Keulers, T. G., Libregts, S. F., Beaumont, J. E. J., Savelkouls, K. G., Bussink, J., Duimel, H., Dubois, L., Zonneveld, M. I., Lopez-Iglesias, C., Bezstarosti, K., Demmers, J. A., Vooijs, M., Wauben, M. & Rouschop, K. M. A., 1 Dec 2021, In: Journal of Extracellular Vesicles. 10, 14, 21 p., e12166.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2020

Iron deficiency-induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria-containing vesicles

Leermakers, P. A., Remels, A. H. V., Zonneveld, M. I., Rouschop, K. M. A., Schols, A. M. W. J. & Gosker, H. R., May 2020, In: Faseb Journal. 34, 5, p. 6703-6717 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2019

The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition

Hounjet, J., Habets, R., Schaaf, M. B., Hendrickx, T. C., Barbeau, L. M. O., Yahyanejad, S., Rouschop, K. M., Groot, A. J. & Vooijs, M., 4 Jul 2019, In: Oncogene. 38, 27, p. 5457-5468 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

2018

Differences in Upper and Lower Body Adipose Tissue Oxygen Tension Contribute to the Adipose Tissue Phenotype in Humans

Vogel, M. A. A., Jocken, J. W. E., Sell, H., Hoebers, N., Essers, Y., Rouschop, K. M. A., Cajlakovic, M., Blaak, E. E. & Goossens, G. H., Oct 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 10, p. 3688-3697 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

Jutten, B., Keulers, T. G., Peeters, H. J. M., Schaaf, M. B. E., Savelkouls, K. G. M., Compter, I., Clarijs, R., Schijns, O. E. M. G., Ackermans, L., Teernstra, O. P. M., Zonneveld, M. I., Colaris, R. M. E., Dubois, L., Vooijs, M. A., Bussink, J., Sotelo, J., Theys, J., Lammering, G. & Rouschop, K. M. A., 1 Jan 2018, In: Autophagy. 14, 2, p. 283-295 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

Bowler, E., Porazinski, S., Uzor, S., Thibault, P., Durand, M., Lapointe, E., Rouschop, K. M. A., Hancock, J., Wilson, I. & Ladomery, M., 2 Apr 2018, In: BMC Cancer. 18, 1, 11 p., 355.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Learning radiation oncology in Europe: Results of the ESTRO multidisciplinary survey

Bibault, J., Franco, P., Borst, G. R., van Elmpt, W., Thorwhart, D., Schmid, M. P., Rouschop, K., Spalek, M., Mullaney, L., Redalen, K. R., Dubois, L., Verfaillie, C. & Eriksen, J. G., Feb 2018, In: Clinical and Translational Radiation Oncology. 9, p. 61-67 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Author collaboration, 23 Nov 2018, In: Journal of Extracellular Vesicles. 7, 1, 43 p., 1535750.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2017

Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress

van Gisbergen, M. W., Voets, A. M., Biemans, R., Hoffmann, R. F., Drittij-Reijnders, M.-J., Haenen, G. R. M. M., Heijink, I. H., Rouschop, K. M. A., Dubois, L. J. & Lambin, P., 3 Aug 2017, In: PLOS ONE. 12, 8, 13 p., 0182508.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2016

Autophagy-Dependent Secretion: Contribution to Tumor Progression

Keulers, T. G., Schaaf, M. B. E. & Rouschop, K. M. A., 25 Nov 2016, In: Frontiers in Oncology. 6, NOV, 251.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

LC3/GABARAP family proteins: autophagy-(un) related functions

Schaaf, M. B. E., Keulers, T. G., Vooijs, M. A. & Rouschop, K. M. A., Dec 2016, In: Faseb Journal. 30, 12, p. 3961-3978

Research output: Contribution to journal › Article › Academic › peer-review

2015

GABARAPL1 is required for increased EGFR membrane expression during hypoxia

Keulers, T. G., Schaaf, M. B. E., Peeters, H. J. M., Savelkouls, K. G. M., Vooijs, M. A., Bussink, J., Jutten, B. & Rouschop, K. M. A., Sept 2015, In: Radiotherapy and Oncology. 116, 3, p. 417-422

Research output: Contribution to journal › Article › Academic › peer-review

High dose rate and flattening filter free irradiation can be safely implemented in clinical practice

Dubois, L., Biemans, R., Reniers, B., Bosmans, G., Trani, D., Podesta, M., Kollaard, R., Rouschop, K. M. A., Theys, J., Vooijs, M., Pruschy, M., Verhaegen, F. & Lambin, P., 3 Oct 2015, In: International Journal of Radiation Biology. 91, 10, p. 778-785

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A

Sarkar, S., van Gelder, M., Noort, W., Xu, Y., Rouschop, K. M. A., Groen, R., Schouten, H. C., Tilanus, M. G. J., Germeraad, W. T. V., Martens, A. C. M., Bos, G. M. J. & Wieten, L., Aug 2015, In: Cancer Immunology Immunotherapy. 64, 8, p. 951-963

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

Pettersen, E. O., Ebbesen, P., Gieling, R. G., Williams, K. J., Dubois, L., Lambin, P., Ward, C., Meehan, J., Kunkler, I. H., Langdon, S. P., Ree, A. H., Flatmark, K., Lyng, H., Calzada, M. J., del Peso, L., Landazuri, M. O., Goerlach, A., Flamm, H., Kieninger, J. & Urban, G. & 27 others, Weltin, A., Singleton, D. C., Haider, S., Buffa, F. M., Harris, A. L., Scozzafava, A., Supuran, C. T., Moser, I., Jobst, G., Busk, M., Toustrup, K., Overgaard, J., Alsner, J., Pouyssegur, J., Chiche, J., Mazure, N., Marchiq, I., Parks, S., Ahmed, A., Ashcroft, M., Pastorekova, S., Cao, Y., Rouschop, K. M., Wouters, B. G., Koritzinsky, M., Mujcic, H. & Cojocari, D., 2015, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 30, 5, p. 689-721

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2014

EGFR signaling and autophagy dependence for growth, survival, and therapy resistance

Jutten, B. & Rouschop, K. M. A., 1 Jan 2014, In: Cell Cycle. 13, 1, p. 42-51

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Opposite role of CD44-standard and CD44-variant-3 in tubular injury and development of renal fibrosis during chronic obstructive nephropathy

Rampanelli, E., Rouschop, K. M. A., Claessen, N., Teske, G. J. D., Pals, S. T., Leemans, J. C. & Florquin, S., Sept 2014, In: Kidney International. 86, 3, p. 558-569

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2013

CD44v3-v10 reduces the profibrotic effects of TGF-beta 1 and attenuates tubular injury in the early stage of chronic obstructive nephropathy

Rampanelli, E., Rouschop, K., Teske, G. J. D., Claessen, N., Leemans, J. C. & Florquin, S., Nov 2013, In: American Journal of Physiology-Renal Physiology. 305, 10, p. F1445-F1454

Research output: Contribution to journal › Article › Academic › peer-review

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

Jutten, B., Keulers, T. G., Schaaf, M. B. E., Savelkouls, K., Theys, J., Span, P. N., Vooijs, M. A., Bussink, J. & Rouschop, K. M. A., Sept 2013, In: Radiotherapy and Oncology. 108, 3, p. 479-483

Research output: Contribution to journal › Article › Academic › peer-review

Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells

Sarkar, S., Germeraad, W. T. V., Rouschop, K. M. A., Steeghs, E. M. P., van Gelder, M., Bos, G. M. J. & Wieten, L., 28 May 2013, In: PLOS ONE. 8, 5, e64835.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Hypoxia inducible NOD2 interacts with 3-O-sulfogalactoceramide and regulates vesicular homeostasis

Nabatov, A. A., Hatzis, P., Rouschop, K. M. A., van Diest, P. & Vooijs, M., Nov 2013, In: Biochimica et Biophysica Acta-general Subjects. 1830, 11, p. 5277-5286

Research output: Contribution to journal › Article › Academic › peer-review

Hypoxic Activation of the PERK/eIF2 alpha Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

Mujcic, H., Nagelkerke, A., Rouschop, K. M. A., Chung, S., Chaudary, N., Span, P. N., Clarke, B., Milosevic, M., Sykes, J., Hill, R. P., Koritzinsky, M. & Wouters, B. G., 15 Nov 2013, In: Clinical Cancer Research. 19, 22, p. 6126-6137

Research output: Contribution to journal › Article › Academic › peer-review

PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

Rouschop, K. M., Dubois, L. J., Keulers, T. G., van den Beucken, T., Lambin, P., Bussink, J., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., 19 Mar 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 12, p. 4622-4627

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Open Access

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The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

Schaaf, M. B. E., Cojocari, D., Keulers, T. G., Jutten, B., Starmans, M. H., de Jong, M. C., Begg, A. C., Savelkouls, K. G. M., Bussink, J., Vooijs, M., Wouters, B. G. & Rouschop, K. M. A., Sept 2013, In: Radiotherapy and Oncology. 108, 3, p. 529-534

Research output: Contribution to journal › Article › Academic › peer-review

2011

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

Rouschop, K. M. A., Dubois, L., Schaaf, M. B. E., van den Beucken, T., Lieuwes, N., Keulers, T. G. H., Savelkouls, K. G. M., Bussink, J., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jun 2011, In: Radiotherapy and Oncology. 99, 3, p. 385-391

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Open Access

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Level of activation of the unfolded protein response correlates with paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion.

Grootjans, J., Hodin, C. M. I., de Haan, J., Derikx, J. P. M., Rouschop, K. M. A., Verheyen, F. K., van Dam, R. M., Dejong, C. H. C., Buurman, W. A. & Lenaerts, K., Feb 2011, In: Gastroenterology. 140, 2, p. 529-539 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response

Wennemers, M., Bussink, J., Scheijen, B., Nagtegaal, I. D., van Laarhoven, H. W. M., Raleigh, J. A., Varia, M. A., Heuvel, J. J. T. M., Rouschop, K. M., Sweep, F. C. G. J. & Span, P. N., 2011, In: Breast Cancer Research. 13, 4, p. 14

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2010

Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase

Mellor, H. R., Rouschop, K. M., Wigfield, S. M., Wouters, B. G. & Harris, A. L., 1 Jun 2010, In: Biochemical Pharmacology. 79, 11, p. 1562-1572

Research output: Contribution to journal › Article › Academic › peer-review

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., Lambin, P., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jan 2010, In: Journal of Clinical Investigation. 120, 1, p. 127-141

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2009

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment

Theys, J., Jutten, B., Dubois, L. J., Rouschop, K. M. A., Chiu, R. K., Li, Y., Paesmans, K., Lambin, P., Lammering, G. & Wouters, B. G., Sept 2009, In: Radiotherapy and Oncology. 92, 3, p. 399-404 6 p.

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Open Access

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2007

Impact of supervised gene signatures of early hypoxia on patient survival.

Seigneuric, R., Starmans, M. H. W., Fung, G., Krishnapuram, B., Nuyten, D. S. A., van Erk, A. A., Magagnin, M. G., Rouschop, K. M. A., Krishnan, S., Rao, R. B., Evelo, C. T. A., Beqq, A. C., Wouters, B. G. & Lambin, P., 1 Jan 2007, In: Radiotherapy and Oncology. 83, 3, p. 374-382

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Kasper Rouschop

Research output

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