Kasper Rouschop

Research output

Research output per year 2007 2013 2015 2018 2021 2024

• 39 Article
• 6 (Systematic) Review article
• 1 Erratum / corrigendum / retractions

Research output per year

Research output per year

Search results

• 2024

  GABARAPL1 is essential in extracellular vesicle cargo loading and metastasis development

  Beaumont, J. E. J., Ju, J., Barbeau, L. M. O., Demers, I., Savelkouls, K. G., Derks, K., Bouwman, F. G., Wauben, M. H. M., Zonneveld, M. I., Keulers, T. G. H. & Rouschop, K. M. A., 1 Jan 2024, In: Radiotherapy and Oncology. 190, 11 p., 109968.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer

  Sanchez-Castillo, A., Heylen, E., Hounjet, J., Savelkouls, K. G., Lieuwes, N. G., Biemans, R., Dubois, L. J., Reynders, K., Rouschop, K. M., Vaes, R. D. W., De Keersmaecker, K., Lambrecht, M., Hendriks, L. E. L., De Ruysscher, D. K. M., Vooijs, M. & Kampen, K. R., 9 Mar 2024, In: British Journal of Cancer. 130, 4, p. 568-584 17 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2022

  ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer

  Keulers, T. G., Koch, A., van Gisbergen, M. W., Barbeau, L. M. O., Zonneveld, M. I., de Jong, M. C., Savelkouls, K. G. M., Wanders, R. G., Bussink, J., Melotte, V. & Rouschop, K. M. A., 3 Aug 2022, In: Autophagy. 18, 8, p. 1898-1914 17 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Physiological Oxygen Levels Differentially Regulate Adipokine Production in Abdominal and Femoral Adipocytes from Individuals with Obesity Versus Normal Weight

  Lempesis, I. G., Hoebers, N., Essers, Y., Jocken, J. W. E., Rouschop, K. M. A., Blaak, E. E., Manolopoulos, K. N. & Goossens, G. H., 8 Nov 2022, In: Cells. 11, 22, 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2021

  Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial

  Compter, I., Eekers, D. B. P., Hoeben, A., Rouschop, K. M. A., Reymen, B., Ackermans, L., Beckervordersantforth, J., Bauer, N. J. C., Anten, M. M., Wesseling, P., Postma, A. A., De Ruysscher, D. & Lambin, P., 2 Sept 2021, In: Autophagy. 17, 9, p. 2604-2612 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  78 Downloads (Pure)

• Identification of Potential Prognostic and Predictive Immunological Biomarkers in Patients with Stage I and Stage III Non-Small Cell Lung Cancer (NSCLC): A Prospective Exploratory Study

  Vaes, R. D. W., Reynders, K., Sprooten, J., Nevola, K. T., Rouschop, K. M. A., Vooijs, M., Garg, A. D., Lambrecht, M., Hendriks, L. E. L., Rucevic, M. & De Ruysscher, D., 1 Dec 2021, In: Cancers. 13, 24, 18 p., 6259.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2

  Vaes, N., Schonkeren, S. L., Rademakers, G., Holland, A. M., Koch, A., Gijbels, M. J., Keulers, T. G., de Wit, M., Moonen, L., Van der Meer, J. R. M., van den Boezem, E., Wolfs, T. G. A. M., Threadgill, D. W., Demmers, J., Fijneman, R. J. A., Jimenez, C. R., Vanden Berghe, P., Smits, K. M., Rouschop, K. M. A., Boesmans, W., & 2 othersHofstra, R. M. W. & Melotte, V., 4 Jun 2021, In: Embo Reports. 22, 6, 17 p., e51913.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity

  van Meijel, R. L. J., Vogel, M. A. A., Jocken, J. W. E., Vliex, L. M. M., Smeets, J. S. J., Hoebers, N., Hoeks, J., Essers, Y., Schoffelen, P. F. M., Sell, H., Kersten, S., Rouschop, K. M. A., Blaak, E. E. & Goossens, G. H., 1 Nov 2021, In: Molecular Metabolism. 53, 13 p., 101287.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Secretion of pro-angiogenic extracellular vesicles during hypoxia is dependent on the autophagy-related protein GABARAPL1

  Keulers, T. G., Libregts, S. F., Beaumont, J. E. J., Savelkouls, K. G., Bussink, J., Duimel, H., Dubois, L., Zonneveld, M. I., Lopez-Iglesias, C., Bezstarosti, K., Demmers, J. A., Vooijs, M., Wauben, M. & Rouschop, K. M. A., 1 Dec 2021, In: Journal of Extracellular Vesicles. 10, 14, 21 p., e12166.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2020

  Iron deficiency-induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria-containing vesicles

  Leermakers, P. A., Remels, A. H. V., Zonneveld, M. I., Rouschop, K. M. A., Schols, A. M. W. J. & Gosker, H. R., May 2020, In: Faseb Journal. 34, 5, p. 6703-6717 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2019

  The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition

  Hounjet, J., Habets, R., Schaaf, M. B., Hendrickx, T. C., Barbeau, L. M. O., Yahyanejad, S., Rouschop, K. M., Groot, A. J. & Vooijs, M., 4 Jul 2019, In: Oncogene. 38, 27, p. 5457-5468 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
• 2018

  Differences in Upper and Lower Body Adipose Tissue Oxygen Tension Contribute to the Adipose Tissue Phenotype in Humans

  Vogel, M. A. A., Jocken, J. W. E., Sell, H., Hoebers, N., Essers, Y., Rouschop, K. M. A., Cajlakovic, M., Blaak, E. E. & Goossens, G. H., Oct 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 10, p. 3688-3697 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

  Jutten, B., Keulers, T. G., Peeters, H. J. M., Schaaf, M. B. E., Savelkouls, K. G. M., Compter, I., Clarijs, R., Schijns, O. E. M. G., Ackermans, L., Teernstra, O. P. M., Zonneveld, M. I., Colaris, R. M. E., Dubois, L., Vooijs, M. A., Bussink, J., Sotelo, J., Theys, J., Lammering, G. & Rouschop, K. M. A., 1 Jan 2018, In: Autophagy. 14, 2, p. 283-295 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

  Bowler, E., Porazinski, S., Uzor, S., Thibault, P., Durand, M., Lapointe, E., Rouschop, K. M. A., Hancock, J., Wilson, I. & Ladomery, M., 2 Apr 2018, In: BMC Cancer. 18, 11 p., 355.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Learning radiation oncology in Europe: Results of the ESTRO multidisciplinary survey

  Bibault, J., Franco, P., Borst, G. R., van Elmpt, W., Thorwhart, D., Schmid, M. P., Rouschop, K., Spalek, M., Mullaney, L., Redalen, K. R., Dubois, L., Verfaillie, C. & Eriksen, J. G., Feb 2018, In: Clinical and Translational Radiation Oncology. 9, p. 61-67 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

  Author collaboration, 23 Nov 2018, In: Journal of Extracellular Vesicles. 7, 1, 43 p., 1535750.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2017

  Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress

  van Gisbergen, M. W., Voets, A. M., Biemans, R., Hoffmann, R. F., Drittij-Reijnders, M-J., Haenen, G. R. M. M., Heijink, I. H., Rouschop, K. M. A., Dubois, L. J. & Lambin, P., 3 Aug 2017, In: PLOS ONE. 12, 8, 13 p., 0182508.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2016

  Autophagy-Dependent Secretion: Contribution to Tumor Progression

  Keulers, T. G., Schaaf, M. B. E. & Rouschop, K. M. A., 25 Nov 2016, In: Frontiers in Oncology. 6, 251.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• LC3/GABARAP family proteins: autophagy-(un) related functions

  Schaaf, M. B. E., Keulers, T. G., Vooijs, M. A. & Rouschop, K. M. A., Dec 2016, In: Faseb Journal. 30, 12, p. 3961-3978

  Research output: Contribution to journal › Article › Academic › peer-review
• 2015

  GABARAPL1 is required for increased EGFR membrane expression during hypoxia

  Keulers, T. G., Schaaf, M. B. E., Peeters, H. J. M., Savelkouls, K. G. M., Vooijs, M. A., Bussink, J., Jutten, B. & Rouschop, K. M. A., Sept 2015, In: Radiotherapy and Oncology. 116, 3, p. 417-422

  Research output: Contribution to journal › Article › Academic › peer-review

• High dose rate and flattening filter free irradiation can be safely implemented in clinical practice

  Dubois, L., Biemans, R., Reniers, B., Bosmans, G., Trani, D., Podesta, M., Kollaard, R., Rouschop, K. M. A., Theys, J., Vooijs, M., Pruschy, M., Verhaegen, F. & Lambin, P., 3 Oct 2015, In: International Journal of Radiation Biology. 91, 10, p. 778-785

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  66 Downloads (Pure)

• Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A

  Sarkar, S., van Gelder, M., Noort, W., Xu, Y., Rouschop, K. M. A., Groen, R., Schouten, H. C., Tilanus, M. G. J., Germeraad, W. T. V., Martens, A. C. M., Bos, G. M. J. & Wieten, L., Aug 2015, In: Cancer Immunology Immunotherapy. 64, 8, p. 951-963

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

  Pettersen, E. O., Ebbesen, P., Gieling, R. G., Williams, K. J., Dubois, L., Lambin, P., Ward, C., Meehan, J., Kunkler, I. H., Langdon, S. P., Ree, A. H., Flatmark, K., Lyng, H., Calzada, M. J., del Peso, L., Landazuri, M. O., Goerlach, A., Flamm, H., Kieninger, J., Urban, G., & 27 othersWeltin, A., Singleton, D. C., Haider, S., Buffa, F. M., Harris, A. L., Scozzafava, A., Supuran, C. T., Moser, I., Jobst, G., Busk, M., Toustrup, K., Overgaard, J., Alsner, J., Pouyssegur, J., Chiche, J., Mazure, N., Marchiq, I., Parks, S., Ahmed, A., Ashcroft, M., Pastorekova, S., Cao, Y., Rouschop, K. M., Wouters, B. G., Koritzinsky, M., Mujcic, H. & Cojocari, D., 2015, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 30, 5, p. 689-721

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2014

  EGFR signaling and autophagy dependence for growth, survival, and therapy resistance

  Jutten, B. & Rouschop, K. M. A., 1 Jan 2014, In: Cell Cycle. 13, 1, p. 42-51

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Opposite role of CD44-standard and CD44-variant-3 in tubular injury and development of renal fibrosis during chronic obstructive nephropathy

  Rampanelli, E., Rouschop, K. M. A., Claessen, N., Teske, G. J. D., Pals, S. T., Leemans, J. C. & Florquin, S., Sept 2014, In: Kidney International. 86, 3, p. 558-569

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2013

  CD44v3-v10 reduces the profibrotic effects of TGF-beta 1 and attenuates tubular injury in the early stage of chronic obstructive nephropathy

  Rampanelli, E., Rouschop, K., Teske, G. J. D., Claessen, N., Leemans, J. C. & Florquin, S., Nov 2013, In: American Journal of Physiology-Renal Physiology. 305, 10, p. F1445-F1454

  Research output: Contribution to journal › Article › Academic › peer-review

• EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

  Jutten, B., Keulers, T. G., Schaaf, M. B. E., Savelkouls, K., Theys, J., Span, P. N., Vooijs, M. A., Bussink, J. & Rouschop, K. M. A., Sept 2013, In: Radiotherapy and Oncology. 108, 3, p. 479-483

  Research output: Contribution to journal › Article › Academic › peer-review

• Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells

  Sarkar, S., Germeraad, W. T. V., Rouschop, K. M. A., Steeghs, E. M. P., van Gelder, M., Bos, G. M. J. & Wieten, L., 28 May 2013, In: PLOS ONE. 8, 5, e64835.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Hypoxia inducible NOD2 interacts with 3-O-sulfogalactoceramide and regulates vesicular homeostasis

  Nabatov, A. A., Hatzis, P., Rouschop, K. M. A., van Diest, P. & Vooijs, M., Nov 2013, In: Biochimica et Biophysica Acta-general Subjects. 1830, 11, p. 5277-5286

  Research output: Contribution to journal › Article › Academic › peer-review

• Hypoxic Activation of the PERK/eIF2 alpha Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

  Mujcic, H., Nagelkerke, A., Rouschop, K. M. A., Chung, S., Chaudary, N., Span, P. N., Clarke, B., Milosevic, M., Sykes, J., Hill, R. P., Koritzinsky, M. & Wouters, B. G., 15 Nov 2013, In: Clinical Cancer Research. 19, 22, p. 6126-6137

  Research output: Contribution to journal › Article › Academic › peer-review

• PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

  Rouschop, K. M., Dubois, L. J., Keulers, T. G., van den Beucken, T., Lambin, P., Bussink, J., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., 19 Mar 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 12, p. 4622-4627

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  37 Downloads (Pure)

• The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

  Schaaf, M. B. E., Cojocari, D., Keulers, T. G., Jutten, B., Starmans, M. H., de Jong, M. C., Begg, A. C., Savelkouls, K. G. M., Bussink, J., Vooijs, M., Wouters, B. G. & Rouschop, K. M. A., Sept 2013, In: Radiotherapy and Oncology. 108, 3, p. 529-534

  Research output: Contribution to journal › Article › Academic › peer-review
• 2011

  Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

  Rouschop, K. M. A., Dubois, L., Schaaf, M. B. E., van den Beucken, T., Lieuwes, N., Keulers, T. G. H., Savelkouls, K. G. M., Bussink, J., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jun 2011, In: Radiotherapy and Oncology. 99, 3, p. 385-391

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  42 Downloads (Pure)

• Level of activation of the unfolded protein response correlates with paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion.

  Grootjans, J., Hodin, C. M. I., de Haan, J., Derikx, J. P. M., Rouschop, K. M. A., Verheyen, F. K., van Dam, R. M., Dejong, C. H. C., Buurman, W. A. & Lenaerts, K., Feb 2011, In: Gastroenterology. 140, 2, p. 529-539 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response

  Wennemers, M., Bussink, J., Scheijen, B., Nagtegaal, I. D., van Laarhoven, H. W. M., Raleigh, J. A., Varia, M. A., Heuvel, J. J. T. M., Rouschop, K. M., Sweep, F. C. G. J. & Span, P. N., 2011, In: Breast Cancer Research. 13, 4, p. 14

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2010

  Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase

  Mellor, H. R., Rouschop, K. M., Wigfield, S. M., Wouters, B. G. & Harris, A. L., 1 Jun 2010, In: Biochemical Pharmacology. 79, 11, p. 1562-1572

  Research output: Contribution to journal › Article › Academic › peer-review

• The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

  Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., Lambin, P., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jan 2010, In: Journal of Clinical Investigation. 120, 1, p. 127-141

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  35 Downloads (Pure)
• 2009

  The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment

  Theys, J., Jutten, B., Dubois, L. J., Rouschop, K. M. A., Chiu, R. K., Li, Y., Paesmans, K., Lambin, P., Lammering, G. & Wouters, B. G., Sept 2009, In: Radiotherapy and Oncology. 92, 3, p. 399-404 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  42 Downloads (Pure)
• 2007

  Impact of supervised gene signatures of early hypoxia on patient survival.

  Seigneuric, R., Starmans, M. H. W., Fung, G., Krishnapuram, B., Nuyten, D. S. A., van Erk, A. A., Magagnin, M. G., Rouschop, K. M. A., Krishnan, S., Rao, R. B., Evelo, C. T. A., Beqq, A. C., Wouters, B. G. & Lambin, P., 1 Jan 2007, In: Radiotherapy and Oncology. 83, 3, p. 374-382

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  117 Downloads (Pure)