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Research Output 2005 2019

2019

Acute haemodynamic changes during haemodialysis do not exacerbate gut hyperpermeability

Wong, J., Lenaerts, K., Meesters, D. M., Damink, S. W. M. O., van Eijk, H. M. H., Vilar, E. & Farrington, K., 30 Apr 2019, In : Bioscience Reports. 39, 4, p. 1-14 14 p., 20181704.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Beneficial Effects of Vitamin D Treatment in an Obese Mouse Model of Non-Alcoholic Steatohepatitis

Jahn, D., Dorbath, D., Kircher, S., Nier, A., Bergheim, I., Lenaerts, K., Hermanns, H. M. & Geier, A., Jan 2019, In : Nutrients. 11, 1, p. 1-14 14 p., 77.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinical management of chronic mesenteric ischemia

van Dijk, L. J. D., van Noord, D., de Vries, A. C., Kolkman, J. J., Geelkerken, R. H., Verhagen, H. J. M., Moelker, A., Bruno, M. J., Balm, R., de Borst, G. J., Blauw, J. T., Bakker, O. J., Buscher, H. C. J. L., Fioole, B., Hamming, J. F., Harki, J., van den Heuvel, D. A. F., van Hattum, E. S., Hinnen, J. W., van der Laan, M. J. & 8 others, Lenaerts, K., Peppelenbosch, M. P., van Petersen, A. S., Rijnja, P., van der Schaar, P. J., Terlouw, L. G., de Vries, J. P. P. M. & Vroegindeweij, D., Mar 2019, In : United European Gastroenterology Journal. 7, 2, p. 179-188 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Comparing Five New Polymer Barriers for the Prevention of Intra-abdominal Adhesions in a Rat Model

van Steensel, S., Liu, H., Mommers, E. H. H., Lenaerts, K. & Bouvy, N. D., Nov 2019, In : Journal of Surgical Research. 243, p. 453-459 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Covered stents versus Bare-metal stents in c hronic atherosclerotic Gastrointestinal Ischemia (CoBaGI): study protocol for a randomized controlled trial

van Dijk, L. J. D., Harki, J., van Noord, D., Verhagen, H. J. M., Kolkman, J. J., Geelkerken, R. H., Bruno, M. J., Moelker, A., Balm, R., de Borst, G. J., Blauw, J. T., Bruno, M. J., Bakker, O. J., van Dijk, L. J. D., Buscher, H. C. J. L., Fioole, B., Geelkerken, R. H., Hamming, J. F., Harki, J., van den Heuvel, D. A. F. & 15 others, van Hattum, E. S., Hinnen, J. W., Kolkman, J. J., van der Laan, M. J., Lenaerts, K., Moelker, A., van Noord, D., Peppelenbosch, M. P., van Petersen, A. S., Rijnja, P., van der Schaar, P. J., Terlouw, L. G., Verhagen, H. J. M., de Vries, J. P. P. M. & Vroegindeweij, D., 20 Aug 2019, In : Trials. 20, 1, 9 p., 519.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Distal versus proximal intestinal short-chain fatty acid release in man

Neis, E. P. J. G., van Eijk, H. M. H., Lenaerts, K., Damink, S. W. M. O., Blaak, E. E., Dejong, C. H. C. & Rensen, S. S., Apr 2019, In : Gut. 68, 4, p. 764-765 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Histopathology of human small intestinal and colonic ischemia-reperfusion: Experiences from human IR-models

Leenarts, C. A. J., Grootjans, J., Hundscheid, I. H., Schellekens, D. H. S. M., Lenaerts, K., Buurman, W. A., Dejong, C. H. C. & Derikx, J. P. M., Jul 2019, In : Histology and Histopathology. 34, 7, p. 711-722 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Sucrose but Not Nitrate Ingestion Reduces Strenuous Cycling-induced Intestinal Injury

Jonvik, K. L., Lenaerts, K., Smeets, J. S. J., Kolkman, J. J., Van Loon, L. J. C. & Verdijk, L. B., Mar 2019, In : Medicine and Science in Sports and Exercise. 51, 3, p. 436-444 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Increased Small Intestinal Permeability during Severe Acute Exacerbations of COPD

Sprooten, R. T. M., Lenaerts, K., Braeken, D. C. W., Grimbergen, I., Rutten, E. P., Wouters, E. F. M. & Rohde, G. G. U., 1 Jan 2018, In : Respiration. 95, 5, p. 334-342 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

SM22 a Plasma Biomarker for Human Transmural Intestinal Ischemia

Schellekens, D. H. S. M., Reisinger, K. W., Lenaerts, K., Hadfoune, M., Damink, S. W. O., Buurman, W. A., Dejong, C. H. C. & Derikx, J. P. M., Jul 2018, In : Annals of Surgery. 268, 1, p. 120-126 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Adaptation of exercise-induced stress in well-trained healthy young men

JanssenDuijghuijsen, L. M., Keijer, J., Mensink, M., Lenaerts, K., Ridder, L., Nierkens, S., Kartaram, S. W., Verschuren, M. C. M., Pieters, R. H. H., Bas, R., Witkamp, R. F., Wichers, H. J. & van Norren, K., 1 Jan 2017, In : Experimental Physiology. 102, 1, p. 86-99 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans

Duijghuijsen, L. M. J., van Norren, K., Grefte, S., Koppelman, S. J., Lenaerts, K., Keijer, J., Witkamp, R. F. & Wichers, H. J., Jan 2017, In : Nutrients. 9, 1, 11 p., 84.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

Lebrun, L. J., Lenaerts, K., Kiers, D., de Barros, J-P. P., Le Guern, N., Plesnik, J., Thomas, C., Bourgeois, T., Dejong, C. H. C., Kox, M., Hundscheid, I. H. R., Khan, N. A., Mandard, S., Deckert, V., Pickkers, P., Drucker, D. J., Lagrost, L. & Grober, J., 31 Oct 2017, In : Cell Reports. 21, 5, p. 1160-1168 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Erratum to: Human splanchnic amino-acid metabolism (vol 49, pg 161, 2017)

Neis, E. P. J. G., Sabrkhany, S., Hundscheid, I., Schellekens, D., Lenaerts, K., Damink, S. W. O., Blaak, E. E., Dejong, C. H. C. & Rensen, S. S., Jun 2017, In : Amino Acids. 49, 6, 1 p.

Research output: Contribution to journalErratum / corrigendumAcademic

Open Access

Farnesoid X Receptor Activation Attenuates Intestinal Ischemia Reperfusion Injury in Rats

Ceulemans, L. J., Verbeke, L., Decuypere, J-P., Farre, R., De Hertogh, G., Lenaerts, K., Jochmans, I., Monbaliu, D., Nevens, F., Tack, J., Laleman, W. & Pirenne, J., 6 Jan 2017, In : PLOS ONE. 12, 1, 17 p., e0169331.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fructose and Sucrose Intake Increase Exogenous Carbohydrate Oxidation during Exercise

Trommelen, J., Fuchs, C. J., Beelen, M., Lenaerts, K., Jeukendrup, A. E., Cermak, N. M. & van Loon, L. J. C., Feb 2017, In : Nutrients. 9, 2, 12 p., 167.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Human small intestine is capable of restoring barrier function after short ischemic periods

Schellekens, D. H. S. M., Hundscheid, I. H. R., Leenarts, C. A. J. I., Grootjans, J., Lenaerts, K., Buurman, W. A., Dejong, C. H. C. & Derikx, J. P. M., 28 Dec 2017, In : World Journal of Gastroenterology. 23, 48, p. 8452-8464 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Human splanchnic amino-acid metabolism

Neis, E. P. J. G., Sabrkhany, S., Hundscheid, I., Schellekens, D., Lenaerts, K., Damink, S. W. O., Blaak, E. E., Dejong, C. H. C. & Rensen, S. S., Jan 2017, In : Amino Acids. 49, 1, p. 161-172 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Parenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver disease

Koelfat, K. V. K., Schaap, F. G., Hodin, C. M. J. M., Visschers, R. G. J., Svavarsson, B. I., Lenicek, M., Shiri-Sverdlov, R., Lenaerts, K. & Damink, S. W. M. O., Oct 2017, In : Clinical Nutrition. 36, 5, p. 1403-1410 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing

van der Beek, C. M., Dejong, C. H. C., Troost, F. J., Masclee, A. M. & Lenaerts, K., Apr 2017, In : Nutrition Reviews. 75, 4, p. 286-305 20 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals

Canfora, E. E., van der Beek, C. M., Hermes, G. D. A., Goossens, G. H., Jocken, J. W. E., Holst, J. J., van Eijk, H. M., Venema, K., Smidt, H., Zoetendal, E. G., Dejong, C. H. C., Lenaerts, K. & Blaak, E. E., Jul 2017, In : Gastroenterology. 153, 1, p. 87-97.e3 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
10 Citations (Scopus)

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

Reijnders, D., Goossens, G. H., Hermes, G. D. A., Neis, E. P. J. G., van der Beek, K., Most, J., Holst, J. J., Lenaerts, K., Kootte, R. S., Nieuwdorp, M., Groen, A. K., Olde Damink, S., Boekschoten, M. V., Smidt, H., Zoetendal, E. G., Dejong, C. H. C. & Blaak, E. E., 12 Jul 2016, In : Cell Metabolism. 24, 1, p. 63-74

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion

Grootjans, J., Lenaerts, K., Buurman, W. A., Dejong, K. & Derikx, J. P. M., 7 Mar 2016, In : World Journal of Gastroenterology. 22, 9, p. 2760-2770

Research output: Contribution to journalArticleAcademicpeer-review

Plasma intestinal fatty acid-binding protein fails to predict endoscopic disease activity in inflammatory bowel disease patients

Bodelier, A. G., Pierik, M. J., Lenaerts, K., de Boer, E., Olde Damink, S., Hameeteman, W., Masclee, A. A. M. & Jonkers, D. M. A. E., Jul 2016, In : European Journal of Gastroenterology & Hepatology. 28, 7, p. 807-813 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

The effect of endurance exercise on intestinal integrity in well-trained healthy men

JanssenDuijghuijsen, L. M., Mensink, M., Lenaerts, K., Fiedorowicz, E., van Dartel, D. A. M., Mes, J. J., Luiking, Y. C., Keijer, J., Wichers, H. J., Witkamp, R. F. & van Norren, K., Oct 2016, In : Physiological Reports. 4, 20, e12994.

Research output: Contribution to journalArticleAcademicpeer-review

2015
9 Citations (Scopus)

Hepatic Uptake of Rectally Administered Butyrate Prevents an Increase in Systemic Butyrate Concentrations in Humans

van der Beek, C. M., Bloemen, J. G., van den Broek, M. A., Lenaerts, K., Venema, K., Buurman, W. A. & Dejong, C. H., 1 Jan 2015, In : Journal of Nutrition. 145, 9, p. 2019-2024

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

The Human Colon Is More Resistant to Ischemia-reperfusion-induced Tissue Damage Than the Small Intestine An Observational Study

Hundscheid, I. H., Grootjans, J., Lenaerts, K., Schellekens, D. H., Derikx, J. P., Boonen, B. T., von Meyenfeldt, M. F., Beets, G. L., Buurman, W. A. & Dejong, C. H., Aug 2015, In : Annals of Surgery. 262, 2, p. 304-311

Research output: Contribution to journalArticleAcademicpeer-review

2014
25 Citations (Scopus)

Disturbed Intestinal Integrity in Patients With COPD: Effects of Activities of Daily Living

Rutten, E. P. A., Lenaerts, K., Buurman, W. A. & Wouters, E. F. M., 1 Jan 2014, In : Chest. 145, 2, p. 245-252

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

GI Symptoms in Patients With COPD

Rutten, E. P. A., Spruit, M. A., Franssen, F. M. E., Buurman, W. A., Wouters, E. F. M. & Lenaerts, K., 1 Jan 2014, In : Chest. 145, 6, p. 1437-1438

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

6 Citations (Scopus)

Integrated visualization of a multi-omics study of starvation in mouse intestine

van Iersel, M. P., Sokolovic, M., Lenaerts, K., Kutmon, M., Bouwman, F. G., Lamers, W. H., Mariman, E. C. & Evelo, C. T., 1 Jan 2014, In : Journal of integrative bioinformatics. 11, 1, 235.

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

L-Citrulline Improves Splanchnic Perfusion and Reduces Gut Injury during Exercise

van Wijck, K., Wijnands, K. A., Meesters, D. M., Boonen, B. T. C., van Loon, L. J., Buurman, W. A., Dejong, C. H., Lenaerts, K. & Poeze, M., 1 Jan 2014, In : Medicine and Science in Sports and Exercise. 46, 11, p. 2039-2046

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)
2013
8 Citations (Scopus)

Dietary protein digestion and absorption are impaired during acute postexercise recovery in young men.

van Wijck, K., Pennings, B., van Bijnen, A. A., Senden, J. M., Buurman, W. A., Dejong, C. H. C., van Loon, L. J. C. & Lenaerts, K., Mar 2013, In : American Journal of Physiology-regulatory Integrative and Comparative Physiology. 304, 5, p. R356-R361 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

Ischaemia-induced mucus barrier loss and bacterial penetration are counteracted by increased goblet cell secretory activity in human and rat colon.

Grootjans, J., Hundscheid, I. H., Lenaerts, K., Boonen, B., Renes, I. B., Verheyen, F. K., Dejong, C. H. C., von Meyenfeldt, M. F., Beets, G. L. & Buurman, W. A., 1 Jan 2013, In : Gut. 62, 2, p. 250-258

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Lipid-rich enteral nutrition regulates mucosal mast cell activation via the vagal anti-inflammatory reflex.

de Haan, J., Hadfoune, M., Lubbers, T., Hodin, C. M. I., Lenaerts, K., Ito, A., Verbaeys, I. Y., Skynner, M. J., Cailotto, C., van der Vliet, J., de Jonge, W. J., Greve, J. W. & Buurman, W. A., 1 Jan 2013, In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 305, 5, p. G383-G391

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

New insights in intestinal ischemia-reperfusion injury: implications for intestinal transplantation.

Lenaerts, K., Ceulemans, L. J., Hundscheid, I. H., Grootjans, J., Dejong, C. H. C. & Olde Damink, S., Jun 2013, In : Current Opinion in Organ Transplantation. 18, 3, p. 298-303 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: A randomized controlled crossover trial.

van Wijck, K., Verlinden, T. J., van Eijk, H. M. H., Dekker, J., Buurman, W. A., Dejong, C. H. C. & Lenaerts, K., Apr 2013, In : Clinical Nutrition. 32, 2, p. 245-251 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012
19 Citations (Scopus)

Aggravation of exercise-induced intestinal injury by Ibuprofen in athletes.

van Wijck, K., Lenaerts, K., van Bijnen, A. A., Boonen, B. T. C., van Loon, L. J. C., Dejong, C. H. C. & Buurman, W. A., 1 Jan 2012, In : Medicine and Science in Sports and Exercise. 44, 12, p. 2257-2262

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)

Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention.

van Wijck, K., Lenaerts, K., Grootjans, J., Wijnands, K. A., Poeze, M., van Loon, L. J. C., Dejong, C. H. C. & Buurman, W. A., Jul 2012, In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 303, 2, p. G155-G168 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Polyethylene glycol versus dual sugar assay for gastrointestinal permeability analysis: is it time to choose?

van Wijck, K., Bessems, B. A., van Eijk, H. M. H., Buurman, W. A., Dejong, C. H. C. & Lenaerts, K., 1 Jan 2012, In : Clinical and experimental gastroenterology. 5, p. 139-50

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Total parenteral nutrition induces a shift in the firmicutes to bacteroidetes ratio in association with paneth cell activation in rats.

Hodin, C. M. I., Visschers, R. G. J., Rensen, S. S. M., Boonen, B., Olde Damink, S., Lenaerts, K. & Buurman, W. A., 1 Jan 2012, In : Journal of Nutrition. 142, 12, p. 2141-2147

Research output: Contribution to journalArticleAcademicpeer-review

2011
66 Citations (Scopus)
123 Downloads (Pure)

Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men

van Wijck, K., Lenaerts, K., van Loon, L. J. C., Peters, W. H., Buurman, W. A. & Dejong, C. H. C., 21 Jul 2011, In : PLOS ONE. 6, 7, 9 p., 22366.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
50 Citations (Scopus)

Level of activation of the unfolded protein response correlates with paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion.

Grootjans, J., Hodin, C. M. I., de Haan, J., Derikx, J. P. M., Rouschop, K. M. A., Verheyen, F. K., van Dam, R. M., Dejong, C. H. C., Buurman, W. A. & Lenaerts, K., Feb 2011, In : Gastroenterology. 140, 2, p. 529-539 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Novel analytical approach to a multi-sugar whole gut permeability assay

van Wijck, K., van Eijk, H. M. H., Buurman, W. A., Dejong, C. H. C. & Lenaerts, K., 15 Sep 2011, In : Journal of Chromatography B. 879, 26, p. 2794-2801 8 p.

Research output: Contribution to journalArticleAcademicpeer-review