If you made any changes in Pure these will be visible here soon.

Research Output

2019

Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis

Govers-Riemslag, J. W. P., Konings, J., Cosemans, J. M. E. M., van Geffen, J. P., de Laat, B., Heemskerk, J. W. M., Dargaud, Y. & Ten Cate, H., Jul 2019, In : TH open : companion journal to thrombosis and haemostasis. 3, 3, p. e273-e285 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MYELOID PHD2 KNOCKDOWN DRIVES MACROPHAGE APOPTOSIS AND PARACRINE FIBROBLAST/SMOOTH MUSCLE CELL COLLAGEN SECRETION LEADING TO ATHEROSCLEROTIC PLAQUE FIBROSIS

Van Kuijk, K., Theelen, T., Demandt, J., Marsch, E., Gijbels, M., Jin, H., Reutelingsperger, C., Cosemans, J., Schurgers, L., Carmeliet, P., Biessen, E., Daemen, M. & Sluimer, J., Aug 2019, In : Atherosclerosis. 287, p. E10-E10 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

2018

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding

Baaten, C. C. F. M. J., Meacham, S., de Witt, S. M., Feijge, M. A. H., Adams, D. J., Akkerman, J-W. N., Cosemans, J. M. E. M., Grassi, L., Jupe, S., Kostadima, M., Mattheij, N. J. A., Prins, M. H., Ramirez-Solis, R., Soehnlein, O., Swieringa, F., Weber, C., White, J. K., Ouwehand, W. H. & Heemskerk, J. W. M., 13 Dec 2018, In : Blood. 132, 24, p. E35-E46 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

At the MERcy of platelet primers

Cosemans, J. M. E. M., 1 Feb 2018, In : Journal of Thrombosis and Haemostasis. 16, 2, p. 349-351 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Suppressive Role of Tissue Factor Pathway Inhibitor-alpha in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength

Thomassen, S., Mastenbroek, T. G., Swieringa, F., Winckers, K., Feijge, M. A. H., Schrijver, R., Cosemans, J. M. E. M., Maroney, S. A., Mast, A. E., Hackeng, T. M. & Heemskerk, J. W. M., 1 Mar 2018, In : Thrombosis and Haemostasis. 118, 3, p. 502-513 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

Nagy, M., Mastenbroek, T. G., Mattheij, N. J. A., de Witt, S., Clemetson, K. J., Kirschner, J., Schulz, A. S., Vraetz, T., Speckmann, C., Braun, A., Cosemans, J. M. E. M., Zieger, B. & Heemskerk, J. W. M., 28 Feb 2018, In : Haematologica-the Hematology Journal. 103, 3, p. 540-549 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Platelet interaction with activated endothelium: mechanistic insights from microfluidics

Coenen, D. M., Mastenbroek, T. G. & Cosemans, J. M. E. M., 28 Dec 2017, In : Blood. 130, 26, p. 2819-2828 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

Coated platelets function in platelet-dependent fibrin formation via integrin alpha(IIb)beta(3) and transglutaminase factor XIII

Mattheij, N. J. A., Swieringa, F., Mastenbroek, T. G., Berny-Lang, M. A., May, F., Baaten, C. C. F. M. J., van der Meijden, P. E. J., Henskens, Y. M. C., Beckers, E. A. M., Suylen, D. P. L., Nolte, M. W., Hackeng, T. M., McCarty, O. J. T., Heemskerk, J. W. M. & Cosemans, J. M. E. M., Apr 2016, In : Haematologica-the Hematology Journal. 101, 4, p. 427-436

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome

Solari, F. A., Mattheij, N. J. A., Burkhart, J. M., Swieringa, F., Collins, P. W., Cosemans, J. M. E. M., Sickmann, A., Heemskerk, J. W. M. & Zahedi, R. P., Oct 2016, In : Molecular & Cellular Proteomics. 15, 10, p. 3154-3169

Research output: Contribution to journalArticleAcademicpeer-review

Dimensional analysis and scaling relevant to flow models of thrombus formation: communication from the SSC of the ISTH

McCarty, O. J. T., Ku, D., Sugimoto, M., King, M. R., Cosemans, J. M. E. M. & Neeves, K. B., Mar 2016, In : Journal of Thrombosis and Haemostasis. 14, 3, p. 619-622

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow

Swieringa, F., Baaten, C. C. F. M. J., Verdoold, R., Mastenbroek, T. G., Rijnveld, N., van der Laan, K. O., Breel, E. J., Collins, P. W., Lance, M. D., Henskens, Y. M. C., Cosemans, J. M. E. M., Heemskerk, J. W. M. & van der Meijden, P. E. J., Apr 2016, In : Arteriosclerosis Thrombosis and Vascular Biology. 36, 4, p. 692-699

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage

Mattheij, N. J. A., Braun, A., van Kruchten, R., Castoldi, E., Pircher, J., Baaten, C. C. F. M. J., Wuelling, M., Kuijpers, M. J. E., Koehler, R., Poole, A. W., Schreiber, R., Vortkamp, A., Collins, P. W., Nieswandt, B., Kunzelmann, K., Cosemans, J. M. E. M. & Heemskerk, J. W. M., Feb 2016, In : Faseb Journal. 30, 2, p. 727-737

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling and swelling

Mattheij, N., Braun, A., van Kruchten, R., Castoldi, E., PIRCHER, J., Baaten, C., WÜLLING, M., Kuijpers, M., KÖHLER, R., POOLE, A. W., Schreiber, R., VORTKAMP, A., COLLINS, P. W., Nieswandt, B., KUNZELMANN, K., Cosemans, J. & Heemskerk, J., 2016, In : Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde. 41, p. 207-208

Research output: Contribution to journalArticleAcademicpeer-review

2015

Acute and persistent platelet and coagulant activities in atherothrombosis

Mastenbroek, T. G., Van Geffen, J. P., Heemskerk, J. W. M. & Cosemans, J. M. E. M., Jun 2015, In : Journal of Thrombosis and Haemostasis. 13, p. S272-S280

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Coordinated Membrane Ballooning and Procoagulant Spreading in Human Platelets

Agbani, E. O., van den Bosch, M. T. J., Brown, E., Williams, C. M., Mattheij, N. J. A., Cosemans, J. M. E. M., Collins, P. W., Heemskerk, J. W. M., Hers, I. & Poole, A. W., 13 Oct 2015, In : Circulation. 132, 15, p. 1414-1424

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Hyperreactivity of Junctional Adhesion Molecule A-Deficient Platelets Accelerates Atherosclerosis in Hyperlipidemic Mice

Karshovska, E., Zhao, Z., Blanchet, X., Schmitt, M. M. N., Bidzhekov, K., Soehnlein, O., von Hundelshausen, P., Mattheij, N. J., Cosemans, J. M. E. M., Megens, R. T. A., Koeppel, T. A., Schober, A., Hackeng, T. M., Weber, C. & Koenen, R. R., 13 Feb 2015, In : Circulation Research. 116, 4, p. 587-599

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Normal Platelet Activation Profile in Patients with Peripheral Arterial Disease on Aspirin

van Geffen, J. P., Kleinegris, M-C., Verdoold, R., Baaten, C. C. F. M. J., Cosemans, J. M. E. M., Clemetson, K. J., ten Cate, H., Roest, M., de Laat, B. & Heemskerk, J. W. M., Mar 2015, In : Thrombosis Research. 135, 3, p. 513-520

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity

Mastenbroek, T. G., Feijge, M. A. H., Kremers, R. M. W., van den Bosch, M. T. J., Swieringa, F., De Groef, L., Moons, L., Bennett, C., Ghevaert, C., Johnson, J. L., van der Meijden, P. E. J. & Cosemans, J. M. E. M., Dec 2015, In : Arteriosclerosis Thrombosis and Vascular Biology. 35, 12, p. 2554-2561

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase beta, and Not Via CD40 and I kappa B Kinase alpha

Kuijpers, M. J. E., Mattheij, N. J. A., Cipolla, L., van Geffen, J. P., Lawrence, T., Donners, M. M. P. C., Boon, L., Lievens, D., Torti, M., Noels, H., Gerdes, N., Cosemans, J. M. E. M., Lutgens, E. & Heemskerk, J. W. M., Jun 2015, In : Arteriosclerosis Thrombosis and Vascular Biology. 35, 6, p. 1374-1381

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
2014

Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation

Muenzer, P., Borst, O., Walker, B., Schmid, E., Feijge, M. A. H., Cosemans, J. M. E. M., Chatterjee, M., Schmidt, E-M., Schmidt, S., Towhid, S. T., Leibrock, C., Elvers, M., Schaller, M., Seizer, P., Ferlinz, K., May, A. E., Gulbins, E., Heemskerk, J. W. M., Gawaz, M. & Lang, F., Jan 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 1, p. 61-+

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
13 Citations (Scopus)

Factor XII Regulates the Pathological Process of Thrombus Formation on Ruptured Plaques

Kuijpers, M. J. E., van der Meijden, P. E. J., Feijge, M. A. H., Mattheij, N. J. A., May, F., Govers-Riemslag, J., Meijers, J. C. M., Heemskerk, J. W. M., Renne, T. & Cosemans, J. M. E. M., Aug 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 8, p. 1674-+

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Identification of platelet function defects by multi-parameter assessment of thrombus formation

de Witt, S. M., Swieringa, F., Cavill, R., Lamers, M. M., van Kruchten, R., Mastenbroek, T., Baaten, C., Coort, S., Pugh, N., Schulz, A., Scharrer, I., Jurk, K., Zieger, B., Clemetson, K. J., Farndale, R. W., Heemskerk, J. W. & Cosemans, J. M., Jul 2014, In : Nature Communications. 5, 13 p., 4257.

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)

Insights into platelet-based control of coagulation

de Witt, S. M., Verdoold, R., Cosemans, J. M. E. M. & Heemskerk, J. W. M., May 2014, In : Thrombosis Research. 133, p. S139-S148

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

Supporting Roles of Platelet Thrombospondin-1 and CD36 in Thrombus Formation on Collagen

Kuijpers, M. J. E., de Witt, S., Nergiz-Unal, R., van Kruchten, R., Korporaal, S. J. A., Verhamme, P., Febbraio, M., Tjwa, M., Voshol, P. J., Hoylaerts, M. F., Cosemans, J. M. E. M. & Heemskerk, J. W. M., Jun 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 6, p. 1187-1192

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
2013

Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors.

Nergiz-Unal, R., Kuijpers, M. J. E., de Witt, S. M., Heeneman, S., Feijge, M. A. H., Garcia Caraballo, S., Biessen, E. A., Haenen, G. R. M. M., Cosemans, J. M. & Heemskerk, J. W., 1 Jan 2013, In : Thrombosis Research. 131, 5, p. 411-417

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Distinct Role of von Willebrand Factor Triplet Bands in Glycoprotein Ib-Dependent Platelet Adhesion and Thrombus Formation under Flow

Fuchs, B., de Witt, S., Solecka, B. A., Kroening, M., Obser, T., Cosemans, J. M. E. M., Schneppenheim, R., Heemskerk, J. W. M. & Kannicht, C., Apr 2013, In : Seminars in Thrombosis and Hemostasis. 39, 3, p. 306-314

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Dual Mechanism of Integrin alpha(IIb)beta(3) Closure in Procoagulant Platelets

Mattheij, N. J. A., Gilio, K., van Kruchten, R., Jobe, S. M., Wieschhaus, A. J., Chishti, A. H., Collins, P., Heemskerk, J. W. M. & Cosemans, J. M. E. M., 10 May 2013, In : Journal of Biological Chemistry. 288, 19, p. 13325-13336

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Platelet-based coagulation: different populations, different functions

Heemskerk, J. W. M., Mattheij, N. J. A. & Cosemans, J. M. E. M., Jan 2013, In : Journal of Thrombosis and Haemostasis. 11, 1, p. 2-16

Research output: Contribution to journalArticleAcademicpeer-review

The effects of arterial flow on platelet activation, thrombus growth, and stabilization

Cosemans, J. M. E. M., Angelillo-Scherrer, A., Mattheij, N. J. A. & Heemskerk, J. W. M., 15 Jul 2013, In : Cardiovascular Research. 99, 2, p. 342-352

Research output: Contribution to journalArticleAcademicpeer-review

2012

Measurement of whole blood thrombus formation using parallel-plate flow chambers - a practical guide

Van Kruchten, R., Cosemans, J. M. E. M. & Heemskerk, J. W. M., 2012, In : Platelets. 23, 3, p. 229-242

Research output: Contribution to journalArticleAcademicpeer-review

Monitoring in vitro thrombus formation with novel microfluidic devices

Westein, E., de Witt, S., Lamers, M., Cosemans, J. M. E. M. & Heemskerk, J. W. M., 2012, In : Platelets. 23, 7, p. 501-509

Research output: Contribution to journalArticleAcademicpeer-review

2011

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow

Cosemans, J. M. E. M., Schols, S. E. M., Stefanini, L., de Witt, S., Feijge, M. A. H., Hamulyak, K., Deckmyn, H., Bergmeier, W. & Heemskerk, J. W. M., 13 Jan 2011, In : Blood. 117, 2, p. 651-660

Research output: Contribution to journalArticleAcademicpeer-review

Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2

Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M. E. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W. M., Leitges, M., Cantrell, D. & Poole, A. W., 14 Jul 2011, In : Blood. 118, 2, p. 416-424

Research output: Contribution to journalArticleAcademicpeer-review

Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoprotein

Nergiz-Unal, R., Lamers, M. M. E., Van Kruchten, R., Luiken, J. J., Cosemans, J. M. E. M., Glatz, J. F. C., Kuijpers, M. J. E. & Heemskerk, J. W. M., Sep 2011, In : Journal of Thrombosis and Haemostasis. 9, 9, p. 1835-1846

Research output: Contribution to journalArticleAcademicpeer-review

Unravelling the different functions of protein kinase C isoforms in platelets

Heemskerk, J. W. M., Harper, M. T., Cosemans, J. M. E. M. & Poole, A. W., 23 Jun 2011, In : Febs Letters. 585, 12, p. 1711-1716

Research output: Contribution to journalArticleAcademicpeer-review

2010

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen

Gilio, K., Harper, M. T., Cosemans, J. M. E. M., Konopatskaya, O., Munnix, I. C. A., Prinzen, L., Leitges, M., Liu, Q., Molkentin, J. D., Heemskerk, J. W. M. & Poole, A. W., 23 Jul 2010, In : Journal of Biological Chemistry. 285, 30, p. 23408-23417

Research output: Contribution to journalArticleAcademicpeer-review

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization

Cosemans, J. M. E. M., Van Kruchten, R., Olieslagers, S., Schurgers, L. J., Verheyen, F. K., Munnix, I. C. A., Waltenberger, J., Angelillo-Scherrer, A., Hoylaerts, M. F., Carmeliet, P. & Heemskerk, J. W. M., Aug 2010, In : Journal of Thrombosis and Haemostasis. 8, 8, p. 1797-1808

Research output: Contribution to journalArticleAcademicpeer-review

Spatial Distribution of Factor Xa, Thrombin, and Fibrin(ogen) on Thrombi at Venous Shear

Berny, M. A., Munnix, I. C. A., Auger, J. M., Schols, S. E. M., Cosemans, J. M. E. M., Panizzi, P., Bock, P. E., Watson, S. P., McCarty, O. J. T. & Heemskerk, J. W. M., 29 Apr 2010, In : PLOS ONE. 5, 4, p. 8

Research output: Contribution to journalArticleAcademicpeer-review

Stabilizing Role of Platelet P2Y(12) Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques

Nergiz-Unal, R., Cosemans, J. M. E. M., Feijge, M. A. H., van der Meijden, P. E. J., Storey, R. F., van Giezen, J. J. J., Egbrink, M. G. A. O., Heemskerk, J. W. M. & Kuijpers, M. J. E., 12 Apr 2010, In : PLOS ONE. 5, 4, p. 13

Research output: Contribution to journalArticleAcademicpeer-review

2009
Open Access
File
360 Downloads (Pure)