1983 …2020
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Research Output 1983 2020

2020
Open Access
2019

Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease

Bohler, S., Liu, X., Krauskopf, J., Gaiment, F., Aubrecht, J., Nicolaes, G. A. F., Kleinjans, J. C. S. & Briede, J. J., Oct 2019, In : Clinical Pharmacology & Therapeutics. 106, 4, p. 696-696 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure

Lewalle, A., Land, S., Merken, J. J., Raafs, A., Sepulveda, P., Heymans, S., Kleinjans, J. & Niederer, S. A., 17 Dec 2019, In : Biophysical Journal. 117, 12, p. 2337-2348 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cell-free, circulating microRNAs reflect air pollution-induced environmental health risks

Krauskopf, J., van Veldhoven, K., Chadeau-Hyam, M., Vermeulen, R., Carrasco-Turigas, G., Nieuwenhuijsen, M., Vineis, P., de Kok, T. M. & Kleinjans, J. C. S., 15 Oct 2019, In : Toxicology Letters. 314, p. S68-S68 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Circulating Serum MicroRNAs as Potential Diagnostic Biomarkers of Posttraumatic Stress Disorder: A Pilot Study

Snijders, C., Krauskopf, J., Pishva, E., Eijssen, L., Machiels, B., Kleinjans, J., Kenis, G., van den Hove, D., Kim, M. O., Boks, M. P. M., Vinkers, C. H., Vermetten, E., Geuze, E., Rutten, B. P. F. & de Nijs, L., 22 Nov 2019, In : Frontiers in Genetics. 10, 10 p., 1042.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro

Verheijen, M., Lienhard, M., Schrooders, Y., Clayton, O., Nudischer, R., Boerno, S., Timmermann, B., Selevsek, N., Schlapbach, R., Gmuender, H., Gotta, S., Geraedts, J., Herwig, R., Kleinjans, J. & Caiment, F., 15 Mar 2019, In : Scientific Reports. 9, p. 1-12 12 p., 4641.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches

Rodrigues, D., Souza, T., Jennen, D. G. J., Lemmens, L., Kleinjans, J. C. S. & de Kok, T. M., Jul 2019, In : Cancer Treatment Reviews. 77, p. 57-66 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access

High information content assays for genetic toxicology testing: A report the International Workshops on Genotoxicity Testing (IWGT)

Dertinger, S. D., Totsuka, Y., Bielas, J. H., Doherty, A. T., Kleinjans, J., Honma, M., Marchetti, F., Schuler, M. J., Thybaud, V., White, P. & Yauk, C. L., Nov 2019, In : Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 847, 13 p., 403022.

Research output: Contribution to journalArticleAcademicpeer-review

Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

Jiang, J., Messner, S., Kelm, J. M., van Herwijnen, M., Jennen, D. G. J., Kleinjans, J. C. & de Kok, T. M., 15 Sep 2019, In : Toxicology Letters. 312, p. 34-44 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of key transcription factor networks mediating valproic acid-induced mitochondrial dysfunctioning in primary human hepatocytes

Caiment, F., Wolters, J., Smit, E., Schrooders, Y., Kleinjans, J. C. S. & van den Beucken, T., 15 Oct 2019, In : Toxicology Letters. 314, p. S162-S162 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs)

Espin-Perez, A., Hebels, D. G. A. J., Kiviranta, H., Rantakokko, P., Georgiadis, P., Botsivali, M., Bergdahl, I. A., Palli, D., Spath, F., Johansson, A., Chadeau-Hyam, M., Kyrtopoulos, S. A., Kleinjans, J. C. S. & de Kok, T. M. C. M., 24 Jan 2019, In : Scientific Reports. 9, p. 1-12 12 p., 746.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integration of extracellular metabolomics and intracellular transcriptomics to unravel the mechanisms of 5-FU-induced gastrointestinal toxicity

Souza, T., Rodrigues, D. F., Schrooders, Y., Coyle, L., Vappiani, J., Sevin, D., Jennen, D., Kleinjans, J. C. S. & de Kok, T. M., 15 Oct 2019, In : Toxicology Letters. 314, p. S148-S149 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Optimization of a 5-Fluorouracil-induced intestinal injury model in mice to construct a multi-scale predictive model of drug-induced intestinal toxicity

Jardi, F., Van Heerden, M., Vereyken, L., Erkens, T., Rodrigues, D. F., Kleinjans, J. C. S., de Kok, T. M., Ferreria, S., Gardner, I., Fisher, C., Pritchard, M., Lynch, A., Sevin, D., Beattie, K., Pin, C., Lammens, L. & de Jonghe, S., 15 Oct 2019, In : Toxicology Letters. 314, p. S73-S74 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Phosphorylation of eIF2 alpha promotes cell survival in response to benzo[a]pyrene exposure

Smit, E., Kleinjans, J. C. S. & van den Beucken, T., Feb 2019, In : Toxicology in Vitro. 54, p. 330-337 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks

Krauskopf, J., van Veldhoven, K., Chadeau-Hyam, M., Vermeulen, R., Carrasco-Turigas, G., Nieuwenhuijsen, M., Vineis, P., de Kok, T. M. & Kleinjans, J. C., Jul 2019, In : Environment International. 128, p. 193-200 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Transcriptomic approach to improve the understanding of 5-fluorouracil (5-FU) induced intestinal toxicity in vitro and in vivo

Rodrigues, D. F., de Souza, T., Coyle, L., Schrooders, Y., Jardi, F., de Jonghe, S., van Heerden, M., Lammens, L., Jennen, D., Kleinjans, J. C. & de Kok, T. M., 15 Oct 2019, In : Toxicology Letters. 314, p. S88-S89 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Acute changes in DNA methylation in relation to 24 h personal air pollution exposure measurements: A panel study in four European countries

Mostafavi, N., Vermeulen, R., Ghantous, A., Hoek, G., Probst-Hensch, N., Herceg, Z., Tarallo, S., Naccarati, A., Kleinjans, J. C. S., Imboden, M., Jeong, A., Morley, D., Amaral, A. F. S., van Nunen, E., Gulliver, J., Chadeau-Hyam, M., Vineis, P. & Vlaanderen, J., Nov 2018, In : Environment International. 120, p. 11-21 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity

Kuepfer, L., Clayton, O., Thiel, C., Cordes, H., Nudischer, R., Blank, L. M., Baier, V., Heymans, S., Caiment, F., Roth, A., Fluri, D. A., Kelm, J. M., Castell, J., Selevsek, N., Schlapbach, R., Keun, H., Hynes, J., Sarkans, U., Gmuender, H., Herwig, R. & 4 others, Niederer, S., Schuchhardt, J., Segall, M. & Kleinjans, J., 1 Jan 2018, In : Archives of Toxicology. 92, 1, p. 553-555 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Open Access

Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool

Espin-Perez, A., Font-Ribera, L., van Veldhoven, K., Krauskopf, J., Portengen, L., Chadeau-Hyam, M., Vermeulen, R., Grimalt, J. O., Villanueva, C. M., Vineis, P., Kogevinas, M., Kleinjans, J. C. & de Kok, T. M., 1 Jan 2018, In : Environment International. 110, p. 42-50 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling

Verheijen, M., Schrooders, Y., Gmuender, H., Nudischer, R., Clayton, O., Hynes, J., Niederer, S., Cordes, H., Kuepfer, L., Kleinjans, J. & Caiment, F., 15 Sep 2018, In : Toxicology Letters. 294, p. 184-192 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comparison of statistical methods and the use of quality control samples for batch effect correction in human transcriptome data

Espin-Perez, A., Portier, C., Chadeau-Hyam, M., van Veldhoven, K., Kleinjans, J. C. S. & de Kok, T. M. C. M., 30 Aug 2018, In : PLOS ONE. 13, 8, 19 p., 0202947.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Data on novel DNA methylation changes induced by valproic acid in human hepatocytes

Wolters, JJ., van Breda, SJ., Claessen, S., de Kok, TCM. & Kleinjans, JS., Feb 2018, In : Data in brief. 16, p. 161-171 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury

Souza, T., Trairatphisan, P., Pinero, J., Furlong, L., Saez-Rodriguez, J., Kleinjans, J. & Jennen, D., 20 Nov 2018, In : Frontiers in Genetics. 9, 12 p., 527.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Epigenome-wide association study of adiposity and future risk of obesity-related diseases

Campanella, G., Gunter, M. J., Polidoro, S., Krogh, V., Palli, D., Panico, S., Sacerdote, C., Tumino, R., Fiorito, G., Guarrera, S., Iacoviello, L., Bergdahl, I. A., Melin, B., Lenner, P., de Kok, T. M. C. M., Georgiadis, P., Kleinjans, J. C. S., Kyrtopoulos, S. A., Bueno-de-Mesquita, H. B., Lillycrop, K. A. & 15 others, May, A. M., Onland-Moret, N. C., Murray, R., Riboli, E., Verschuren, M., Lund, E., Mode, N., Sandanger, T. M., Fiano, V., Trevisan, M., Matullo, G., Froguel, P., Elliott, P., Vineis, P. & Chadeau-Hyam, M., Dec 2018, In : International Journal of Obesity. 42, 12, p. 2022-2035 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes

Wolters, J. E. J., van Breda, S. G. J., Grossmann, J., Fortes, C., Caiment, F. & Kleinjans, J. C. S., 1 Jun 2018, In : Toxicology Letters. 289, p. 1-13 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Takeuchi, F., Akiyama, M., Matoba, N., Katsuya, T., Nakatochi, M., Tabara, Y., Narita, A., Saw, W-Y., Moon, S., Spracklen, C. N., Chai, J-F., Kim, Y-J., Zhang, L., Wang, C., Li, H., Li, H., Wu, J-Y., Dorajoo, R., Nierenberg, J. L., Wang, Y. X. & 31 others, He, J., Bennett, D. A., Takahashi, A., Momozawa, Y., Hirata, M., Matsuda, K., Rakugi, H., Nakashima, E., Isono, M., Shirota, M., Hozawa, A., Ichihara, S., Matsubara, T., Yamamoto, K., Kohara, K., Igase, M., Han, S., Gordon-Larsen, P., Huang, W., Lee, N. R., Adair, L. S., Hwang, M. Y., Lee, J., Chee, M. L., Sabanayagam, C., Zhao, W., Liu, J., Reilly, D. F., Sun, L., Huo, S. & Kleinjans, J., 28 Nov 2018, In : Nature Communications. 9, p. 1-16 16 p., 5052.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)

O'Callaghan-Gordo, C., Kogevinas, M., Pedersen, M., Fthenou, E., Espinosa, A., Tsiapa, X., Chalkiadaki, G., Daraki, V., Dermitzaki, E., Decordier, I., Farmer, P. B., Georgiadis, P., Georgiou, V., Kyrtopoulos, S. A., Merlo, D. F., Romaguera, D., Roumeliotaki, T., Sarri, K., Tornqvist, M., Vande Loock, K. & 4 others, von Stedingk, H., Kleinjans, J., Kirsch-Volders, M. & Chatzi, L., 1 Feb 2018, In : European Journal of Nutrition. 57, 1, p. 209-218 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

Limonciel, A., van Breda, S. G., Jiang, X., Tredwell, G. D., Wilmes, A., Aschauer, L., Siskos, A. P., Sachinidis, A., Keun, H. C., Kopp-Schneider, A., de Kok, T. M., Kleinjans, J. C. S. & Jennings, P., 3 Dec 2018, In : Frontiers in Genetics. 9, 15 p., 558.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses

Vermeulen, R., Hosnijeh, F. S., Bodinier, B., Portengen, L., Liquet, B., Garrido-Manriquez, J., Lokhorst, H., Bergdahl, I. A., Kyrtopoulos, S. A., Johansson, A-S., Georgiadis, P., Melin, B., Palli, D., Krogh, V., Panico, S., Sacerdote, C., Tumino, R., Vineis, P., Castagne, R., Chadeau-Hyam, M. & 30 others, Botsivali, M., Chatziioannou, A., Valavanis, I., Kleinjans, J. C. S., de Kok, T. M. C. M., Keun, H. C., Athersuch, T. J., Kelly, R., Lenner, P., Hallmans, G., Stephanou, E. G., Myridakis, A., Kogevinas, M., Fazzo, L., De Santis, M., Comba, P., Bendinelli, B., Kiviranta, H., Rantakokko, P., Airaksinen, R., Ruokojarvi, P., Gilthorpe, M., Fleming, S., Fleming, T., Tu, Y-K., Lundh, T., Chien, K-L., Chen, W. J., Lee, W-C. & Hsiao, C. K., 15 Sep 2018, In : International Journal of Cancer. 143, 6, p. 1335-1347 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Rationale for Environmental Hygiene towards global protection of fetuses and young children from adverse lifestyle factors

Bourguignon, J-P., Parent, A-S., Kleinjans, J. C. S., Nawrot, T. S., Schoeters, G. & Van Larebeke, N., 23 Apr 2018, In : Environmental Health. 17, 11 p., 42.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Short-term exposure to ambient motor vehicle emissions perturb the human circulating miRNA genome

Krauskopf, J., Caiment, F., van Veldhoven, K., Chadeau-Hyam, M., Sinharay, R., Chung, K. F., Cullinan, P., Collins, P., Barratt, B., Kelly, F. J., Vermeulen, R., de Kok, T. M. & Kleinjans, J. C. S., 10 Oct 2018, In : Toxicology Letters. 295, p. S85-S85 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Short-term transcriptome and microRNAs responses to exposure to different air pollutants in two population studies

Espin-Perez, A., Krauskopf, J., Chadeau-Hyam, M., van Veldhoven, K., Chung, F., Cullinan, P., Piepers, J., van Herwijnen, M., Kubesch, N., Carrasco-Turigas, G., Nieuwenhuijsen, M., Vineis, P., Kleinjans, J. C. S. & de Kok, T. M. C. M., Nov 2018, In : Environmental Pollution. 242, p. 182-190 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution

Krauskopf, J., Caiment, F., van Veldhoven, K., Chadeau-Hyam, M., Sinharay, R., Chung, K. F., Cullinan, P., Collins, P., Barratt, B., Kelly, F. J., Vermeulen, R., Vineis, P., de Kok, T. M. & Kleinjans, J. C., 1 Apr 2018, In : Environment International. 113, p. 26-34 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Translational regulation is a key determinant of the cellular response to benzo[a]pyrene

Smit, E., Caiment, F., Piepers, J., Kleinjans, J. C. S. & van den Beucken, T., 1 Oct 2018, In : Toxicology Letters. 295, p. 144-152 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides

Mostafavi, N., Vlaanderen, J., Portengen, L., Chadeau-Hyam, M., Modig, L., Palli, D., Bergdahl, I. A., Brunekreef, B., Vineis, P., Hebels, D. G. A. J., Kleinjans, J. C. S., Krogh, V., Hoek, G., Georgiadis, P., Kyrtopoulos, S. A. & Vermeulen, R., May 2017, In : Epidemiology. 28, 3, p. 320-328 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Chatziioannou, A., Georgiadis, P., Hebels, D. G., Liampa, I., Valavanis, I., Bergdahl, I. A., Johansson, A., Palli, D., Chadeau-Hyam, M., Siskos, A. P., Keun, H., Botsivali, M., de Kok, T. M. C. M., Perez, A. E., Kleinjans, J. C. S., Vineis, P. & Kyrtopoulos, S. A., 22 Feb 2017, In : Scientific Reports. 7, 13 p., 42870.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

DNA methylation and exposure to ambient air pollution in two prospective cohorts

Plusquin, M., Guida, F., Polidoro, S., Vermeulen, R., Raaschou-Nielsen, O., Campanella, G., Hoek, G., Kyrtopoulos, S. A., Georgiadis, P., Naccarati, A., Sacerdote, C., Krogh, V., Bueno-de-Mesquita, H. B., Verschuren, W. M. M., Sayols-Baixeras, S., Panni, T., Peters, A., Hebels, D. G. A. J., Kleinjans, J., Vineis, P. & 1 others, Chadeau-Hyam, M., Nov 2017, In : Environment International. 108, p. 127-136 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds

Hendrickx, D. M., Souza, T., Jennen, D. G. J. & Kleinjans, J. C. S., Jun 2017, In : Archives of Toxicology. 91, 6, p. 2343-2352 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

Georgiadis, P., Liampa, I., Hebels, D. G., Krauskopf, J., Chatziioannou, A., Valavanis, I., de Kok, T. M. C. M., Kleinjans, J. C. S., Bergdahl, I. A., Melin, B., Spaeth, F., Palli, D., Vermeulen, R. C. H., Vlaanderen, J., Chadeau-Hyam, M., Vineis, P. & Kyrtopoulos, S. A., 13 Sep 2017, In : BMC Genomics. 18, 15 p., 728.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

From the exposome to mechanistic understanding of chemical-induced adverse effects

Escher, B. I., Hackermuller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Boehme, A., Bopp, S. K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisentraeger, A., Galligan, J. J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J. & 16 others, Kluever, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G. W., Mueller, A., Phillips, D. H., Reemtsma, T., Rolle-Kampczyk, U., Schueuermann, G., Schwikowski, B., Tan, Y-M., Trump, S., Walter-Rohde, S. & Wambaugh, J. F., Feb 2017, In : Environment International. 99, p. 97-106 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Inferring transcription factor activity from microarray data reveals novel targets for toxicological investigations

Souza, T. M., van den Beucken, T., Kleinjans, J. C. S. & Jennen, D. G. J., 15 Aug 2017, In : Toxicology. 389, p. 101-107 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery

Krauskopf, J., de Kok, T. M., Hebels, D. G., Bergdahl, I. A., Johansson, A., Spaeth, F., Kiviranta, H., Rantakokko, P., Kyrtopoulos, S. A. & Kleinjans, J. C., 23 Aug 2017, In : Scientific Reports. 7, 9 p., 9262.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

Corvi, R., Madia, F., Guyton, K. Z., Kasper, P., Rudel, R., Colacci, A., Kleinjans, J. & Jennings, P., Dec 2017, In : Toxicology in Vitro. 45, p. 278-286 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort

Winckelmans, E., Vrijens, K., Tsamou, M., Janssen, B. G., Saenen, N. D., Roels, H. A., Kleinjans, J., Lefebvre, W., Vanpoucke, C., de Kok, T. M. & Nawrot, T. S., 5 Jun 2017, In : Environmental Health. 16, 17 p., 52.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access