19952020

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2020

Activation of 5-HT1A postsynaptic receptors by NLX-101 results in functional recovery and an increase in neuroplasticity in mice with brain ischemia

Aguiar, R. P., Soares, L. M., Meyer, E., da Silveira, F. C., Milani, H., Newman-Tancredi, A., Varney, M., Prickaerts, J. & Weffort Oliveira, R. M., 20 Apr 2020, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. 99, 12 p., 109832.

Research output: Contribution to journalArticleAcademicpeer-review

Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease[S]

dos Reis, I. M., Houben, T., Oligschlager, Y., Bucken, L., Steinbusch, H., Cassiman, D., Luetjohann, D., Westerterp, M., Prickaerts, J., Plat, J. & Shiri-Sverdlov, R., Jun 2020, In : Journal of Lipid Research. 61, 6, p. 830-839 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Persistence of the extinction of fear memory requires late-phase cAMP/PKA signaling in the infralimbic cortex

Batista Sohn, J. M., Furtado de Souza, S. T., Raymundi, A. M., Bonato, J., Weffort de Oliveira, R. M., Prickaerts, J. & Stern, C. A., Jul 2020, In : Neurobiology of Learning and Memory. 172, 14 p., 107244.

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension

Kerkhofs, D., van Hagen, B. T., Milanova, I. V., Schell, K. J., van Essen, H., Wijnands, E., Goossens, P., Blankesteijn, W. M., Unger, T., Prickaerts, J., Biessen, E. A., van Oostenbrugge, R. J. & Foulquier, S., 25 Jul 2020, In : Theranostics. 10, 21, p. 9512-9527 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation

Heckman, P. R. A., Roig Kuhn, F., Raven, F., Bolsius, Y. G., Prickaerts, J., Meerlo, P. & Havekes, R., Jun 2020, In : Synapse. 74, 6, 6 p., 22150.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study

Blokland, A., Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Tsai, M., Lahu, G., Uz, T. & Prickaerts, J., May 2019, In : Neurobiology of Aging. 77, p. 37-43 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Antagonizing alpha 7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition

van Goethem, N. P., Paes, D., Puzzo, D., Fedele, E., Rebosio, C., Gulisano, W., Palmeri, A., Wennogle, L. P., Peng, Y., Bertrand, D. & Prickaerts, J., Oct 2019, In : Cellular Signalling. 62, p. 1-8 8 p., 109338.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of DNA methyltransferase inhibition on pattern separation performance in mice

Argyrousi, E. K., de Nijs, L., Lagatta, D. C., Schlütter, A., Weidner, M. T., Zoeller, J., van Goethem, N. P., Joca, S. R. L., van den Hove, D. L. A. & Prickaerts, J., Mar 2019, In : Neurobiology of Learning and Memory. 159, p. 6-15 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease

Houben, T., dos Reis, I. M., Oligschlaeger, Y., Steinbusch, H., Gijbels, M. J. J., Hendrikx, T., Binder, C. J., Cassiman, D., Westerterp, M., Prickaerts, J. & Shiri-Sverdlov, R., 7 Jan 2019, In : Frontiers in Immunology. 9, p. 1-13 13 p., 3089.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats

Nelissen, E., van Goethem, N. P., Bonassoli, V. T., Heckman, P. R. A., van Hagen, B. T. J., Suay, D., Wouters, C. & Prickaerts, J., 23 Apr 2019, In : Neuroscience Letters. 699, p. 41-46 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults

Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Smit, S., Tsai, M., Lahu, G., Uz, T., Blokland, A. & Prickaerts, J., 15 Mar 2018, In : Neuropharmacology. 131, p. 31-38 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial

Heckman, P. R. A., Van Duinen, M. A., Blokland, A., Uz, T., Prickaerts, J. & Sambeth, A., Jan 2018, In : Psychopharmacology. 235, 1, p. 301–308 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessing spatial pattern separation in rodents using the object pattern separation task

van Goethem, N. P., van Hagen, B. T. J. & Prickaerts, J., 1 Aug 2018, In : Nature Protocols. 13, 8, p. 1763-1792 30 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels

Vanmierlo, T., De Vry, J., Nelissen, E., Sierksma, A., Roumans, N., Steinbusch, H. W. M., Wennogle, L. P., van den Hove, D. & Prickaerts, J., 1 Apr 2018, In : Molecular and Cellular Neuroscience. 88, p. 292-299 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice

Foulquier, S., Namsolleck, P., Van Hagen, B. T., Milanova, I., Post, M. J., Blankesteijn, W. M., Rutten, B. P., Prickaerts, J., Van Oostenbrugge, R. J. & Unger, T., Oct 2018, In : Hypertension Research. 41, 10, p. 817-827 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata

Heckman, P. R. A., Schweimer, J. V., Sharp, T., Prickaerts, J. & Blokland, A., Mar 2018, In : Brain Structure & Function. 223, 2, p. 739-748 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

Santiago, A., Soares, L. M., Schepers, M., Milani, H., Vanmierlo, T., Prickaerts, J. & de Oliveira, R. M., 1 Aug 2018, In : Neuropharmacology. 138, p. 360-370 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment

Borghans, L. G. J. M., Sambeth, A., Prickaerts, J., Ramaekers, J. G. & Blokland, A., Aug 2018, In : Psychopharmacology. 235, 8, p. 2407-2416 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The mediating role of phosphodiesterase type 4 in the dopaminergic modulation of motor impulsivity

Heckman, P. R. A., Blokland, A., Van Goethem, N. P., Van Hagen, B. T. J. & Prickaerts, J., 17 Sep 2018, In : Behavioural Brain Research. 350, p. 16-22 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Early-postnatal iron deficiency impacts plasticity in the dorsal and ventral hippocampus in piglets

Nelissen, E., De Vry, J., Antonides, A., Paes, D., Schepers, M., van der Staay, F. J., Prickaerts, J. & Vanmierlo, T., Jun 2017, In : International Journal of Developmental Neuroscience. 59, p. 47-51 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease

Prickaerts, J., Heckman, P. R. A. & Blokland, A., 9 Aug 2017, In : Expert Opinion on Investigational Drugs. 26, 9, p. 1033-1048 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease

Ricciarelli, R., Brullo, C., Prickaerts, J., Arancio, O., Villa, C., Rebosio, C., Calcagno, E., Balbi, M., van Hagen, B. T. J., Argyrousi, E. K., Zhang, H., Pronzato, M. A., Bruno, O. & Fedele, E., 12 Apr 2017, In : Scientific Reports. 7, 14 p., 46320.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve

Prickaerts, J., Van Goethem, N. P., Gulisano, W., Argyrousi, E. K., Palmeri, A. & Puzzo, D., 15 Dec 2017, In : European Journal of Pharmacology. 817, p. 59-70 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity

Soares, L. M., Meyer, E., Milani, H., Steinbusch, H. W. M., Prickaerts, J. & de Oliveira, R. M. W., Feb 2017, In : European Journal of Neuroscience. 45, 4, p. 510-520 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice

Sierksma, A. S. R., de Nijs, L., Hoogland, G., Vanmierlo, T., van Leeuwen, F. W., Rutten, B. P. F., Steinbusch, H. W. M., Prickaerts, J. & van den Hove, D. L. A., 2016, In : Journal of Alzheimer's Disease. 51, 3, p. 677-682

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Brullo, C., Ricciarelli, R., Prickaerts, J., Arancio, O., Massa, M., Rotolo, C., Romussi, A., Rebosio, C., Marengo, B., Pronzato, M. A., van Hagen, B. T. J., van Goethem, N. P., D'Ursi, P., Orro, A., Milanesi, L., Guariento, S., Cichero, E., Fossa, P., Fedele, E. & Bruno, O., 29 Nov 2016, In : European Journal of Medicinal Chemistry. 124, p. 82-102

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M. O., van Hoof, S. J., Groot, A. J., Habets, R., Prickaerts, J., Chalmers, A. J., Eekers, D. B. P., Theys, J., Short, S. C., Verhaegen, F. & Vooijs, M., 5 Jul 2016, In : Oncotarget. 7, 27, p. 41251-41264

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications

Heckman, P. R. A., van Duinen, M. A., Bollen, E. P. P., Nishi, A., Wennogle, L. P., Blokland, A. & Prickaerts, J., Oct 2016, In : International Journal of Neuropsychopharmacology. 19, 10, 16 p., pyw030.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
193 Downloads (Pure)

Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach

Akkerman, S., Blokland, A. & Prickaerts, J., 1 Jan 2016, In : Learning & Memory. 23, 1, p. 29-37 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
186 Downloads (Pure)

Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

Snyder, G. L., Prickaerts, J., Wadenberg, M-L., Zhang, L., Zheng, H., Yao, W., Akkerman, S., Zhu, H., Hendrick, J. P., Vanover, K. E., Davis, R., Li, P., Mates, S. & Wennogle, L. P., Sep 2016, In : Psychopharmacology. 233, 17, p. 3113-3124

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

ROLIPRAM IMPROVES COGNITION, REDUCES ANXIETY- AND DESPAIR-LIKE BEHAVIORS AND IMPACTS HIPPOCAMPAL NEUROPLASTICITY AFTER TRANSIENT GLOBAL CEREBRAL ISCHEMIA

Soares, L. M., De Vry, J., Steinbusch, H. W. M., Milani, H., Prickaerts, J. & Weffort De Oliveira, R. M., 21 Jun 2016, In : Neuroscience. 326, p. 69-83

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

Vanmierlo, T., Creemers, P., Akkerman, S., van Duinen, M., Sambeth, A., De Vry, J., Uz, T., Blokland, A. & Prickaerts, J., 15 Apr 2016, In : Behavioural Brain Research. 303, p. 26-33 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment

de Bruin, N. M. W. J., van Loevezijn, A., Wicke, K. M., de Haan, M., Venhorst, J., Lange, J. H. M., de Groote, L., van der Neut, M. A. W., Prickaerts, J., Andriambeloson, E., Foley, A. G., van Drimmelen, M., van der Wetering, M. & Kruse, C. G., Sep 2016, In : Neurobiology of Learning and Memory. 133, p. 100-117

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice

De Vry, J., Vanmierlo, T., Martinez-Martinez, P., Losen, M., Temel, Y., Boere, J., Kenis, G., Steckler, T., Steinbusch, H. W. M., De Baets, M. & Prickaerts, J., 1 Jan 2016, In : Behavioural Brain Research. 296, p. 15-25

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Why an M1 Antagonist Could Be a More Selective Model for Memory Impairment than Scopolamine

Blokland, A., Sambeth, A., Prickaerts, J. & Riedel, W. J., 30 Sep 2016, In : Frontiers in Neurology. 7, 4 p., 167.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
168 Downloads (Pure)
2015

Changes in voiding behavior in a mouse model of Alzheimer's disease

Biallosterski, B. T., Prickaerts, J., Rahnama'i, M. S., de Wachter, S., van Koeveringe, G. A. & Meriaux, C., 25 Aug 2015, In : Frontiers in Aging Neuroscience. 7, 160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time

Bus, B. A. A., Molendijk, M. L., Tendolkar, I., Penninx, B. W. J. H., Prickaerts, J., Elzinga, B. M. & Voshaar, R. C. O., May 2015, In : Molecular Psychiatry. 20, 5, p. 602-608

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Continuous infusion of the alpha 7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study

van Goethem, N. P., Prickaerts, J., Welty, D., Flood, D. G. & Koenig, G., Jun 2015, In : Behavioural Pharmacology. 26, 4, p. 403-406

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Defeat stress in rodents: From behavior to molecules

Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J-P., Lesch, K-P., Daskalakis, N. P., Steinbusch, H. W. M., van Os, J., Kenis, G. & Rutten, B. P. F., Dec 2015, In : Neuroscience and Biobehavioral Reviews. 59, p. 111-40 30 p.

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)
5 Citations (Scopus)

Divergent effects of the 'biased' 5-HT1A receptor agonists F15599 and F13714 in a novel object pattern separation task

van Goethem, N. P., Schreiber, R., Newman-Tancredi, A., Varney, M. & Prickaerts, J., May 2015, In : British Journal of Pharmacology. 172, 10, p. 2532-2543

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms

Lim, L. W., Prickaerts, J., Huguet, G., Kadar, E., Hartung, H., Sharp, T. & Temel, Y., 31 Mar 2015, In : Translational Psychiatry. 5, e535.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors

Bollen, E., Akkerman, S., Puzzo, D., Gulisano, W., Palmeri, A., D'Hooge, R., Balschun, D., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J., 17 Apr 2015, In : Neuropharmacology. 95, p. 361-366

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

PDE5 inhibition improves acquisition processes after learning via a central mechanism

Akkerman, S., Blokland, A., van Goethem, N. P., Cremers, P., Shaffer, C. L., Osgood, S. M., Steinbusch, H. W. M. & Prickaerts, J., Oct 2015, In : Neuropharmacology. 97, p. 233-239 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

PDE and cognitive processing : beyond the memory domain

Heckman, P., Blokland, A., Ramaekers, J. & Prickaerts, J., Mar 2015, In : Neurobiology of Learning and Memory. 119, p. 108-122 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Phosphodiesterase Inhibition as a Therapeutic Target for Brain Ischemia

Soares, L. M., Prickaerts, J., Milani, H., Del Bel, E., Steinbusch, H. W. M. & Weffort de Oliveira, R. M., 2015, In : Cns & Neurological Disorders-Drug Targets. 14, 8, p. 1012-1023

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer's Disease: A Translational Overview

Heckman, P. R. A., Wouters, C. & Prickaerts, J., 2015, In : Current Pharmaceutical Design. 21, 3, p. 317-331

Research output: Contribution to journalArticleAcademicpeer-review

Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans

Theunissen, E. L., Heckman, P., de Sousa Fernandes Perna, E. B., Kuypers, K. P. C., Sambeth, A., Blokland, A., Prickaerts, J., Toennes, S. W. & Ramaekers, J. G., 1 Jan 2015, In : Psychopharmacology. 232, 2, p. 343-353 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

The object pattern separation (OPS) task: A behavioral paradigm derived from the object recognition task

van Hagen, B. T. J., van Goethem, N. P., Lagatta, D. C. & Prickaerts, J., 15 May 2015, In : Behavioural Brain Research. 285, p. 44-52

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)