19952020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2015

Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time

Bus, B. A. A., Molendijk, M. L., Tendolkar, I., Penninx, B. W. J. H., Prickaerts, J., Elzinga, B. M. & Voshaar, R. C. O., May 2015, In : Molecular Psychiatry. 20, 5, p. 602-608

Research output: Contribution to journalArticleAcademicpeer-review

Continuous infusion of the alpha 7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study

van Goethem, N. P., Prickaerts, J., Welty, D., Flood, D. G. & Koenig, G., Jun 2015, In : Behavioural Pharmacology. 26, 4, p. 403-406

Research output: Contribution to journalArticleAcademicpeer-review

Defeat stress in rodents: From behavior to molecules

Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J-P., Lesch, K-P., Daskalakis, N. P., Steinbusch, H. W. M., van Os, J., Kenis, G. & Rutten, B. P. F., Dec 2015, In : Neuroscience and Biobehavioral Reviews. 59, p. 111-40 30 p.

Research output: Contribution to journalArticleAcademicpeer-review

Divergent effects of the 'biased' 5-HT1A receptor agonists F15599 and F13714 in a novel object pattern separation task

van Goethem, N. P., Schreiber, R., Newman-Tancredi, A., Varney, M. & Prickaerts, J., May 2015, In : British Journal of Pharmacology. 172, 10, p. 2532-2543

Research output: Contribution to journalArticleAcademicpeer-review

Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms

Lim, L. W., Prickaerts, J., Huguet, G., Kadar, E., Hartung, H., Sharp, T. & Temel, Y., 31 Mar 2015, In : Translational Psychiatry. 5, e535.

Research output: Contribution to journalArticleAcademicpeer-review

Episodic memory and the medial temporal lobe: towards a unifying framework of recognition and recall

Berkers, R., van Goethem, N., Rutten, K., Blokland, A. & Prickaerts, J., 2015, Episodic Memory: Formation, Clinical Disorders and Role of Aging. . Edison, K. (ed.). New York: Nova Science Publishers, p. 85-134 49 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors

Bollen, E., Akkerman, S., Puzzo, D., Gulisano, W., Palmeri, A., D'Hooge, R., Balschun, D., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J., 17 Apr 2015, In : Neuropharmacology. 95, p. 361-366

Research output: Contribution to journalArticleAcademicpeer-review

PDE5 inhibition improves acquisition processes after learning via a central mechanism

Akkerman, S., Blokland, A., van Goethem, N. P., Cremers, P., Shaffer, C. L., Osgood, S. M., Steinbusch, H. W. M. & Prickaerts, J., Oct 2015, In : Neuropharmacology. 97, p. 233-239 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

PDE and cognitive processing : beyond the memory domain

Heckman, P., Blokland, A., Ramaekers, J. & Prickaerts, J., Mar 2015, In : Neurobiology of Learning and Memory. 119, p. 108-122 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase 2A inhibition and impulsivity

Heckman, P. R. A., Van Duinen, M., Blokland, A., Ramaekers, J. & Prickaerts, J., Mar 2015, p. S31-S31.

Research output: Contribution to conferenceAbstractAcademic

Phosphodiesterase Inhibition as a Therapeutic Target for Brain Ischemia

Soares, L. M., Prickaerts, J., Milani, H., Del Bel, E., Steinbusch, H. W. M. & Weffort de Oliveira, R. M., 2015, In : Cns & Neurological Disorders-Drug Targets. 14, 8, p. 1012-1023

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase Inhibitors

Prickaerts, J., 2015, Encyclopedia of Psychopharmacology .

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer's Disease: A Translational Overview

Heckman, P. R. A., Wouters, C. & Prickaerts, J., 2015, In : Current Pharmaceutical Design. 21, 3, p. 317-331

Research output: Contribution to journalArticleAcademicpeer-review

Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans

Theunissen, E. L., Heckman, P., de Sousa Fernandes Perna, E. B., Kuypers, K. P. C., Sambeth, A., Blokland, A., Prickaerts, J., Toennes, S. W. & Ramaekers, J. G., 1 Jan 2015, In : Psychopharmacology. 232, 2, p. 343-353 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Impact of Fluoxetine Treatment on BDNF Signaling and Cellular Plasticity in the Brain

de Vry, J., Boulle, F., Rutten, B., van den Hove, D. & Prickaerts, J., 2015, Fluoxetine: Pharmacology, Mechanisms of Action and Potential Side Effects .

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

The object pattern separation (OPS) task: A behavioral paradigm derived from the object recognition task

van Hagen, B. T. J., van Goethem, N. P., Lagatta, D. C. & Prickaerts, J., 15 May 2015, In : Behavioural Brain Research. 285, p. 44-52

Research output: Contribution to journalArticleAcademicpeer-review

The use of EEG parameters as predictors of drug effects on cognition

Blokland, A., Prickaerts, J., van Duinen, M. & Sambeth, A., 15 Jul 2015, In : European Journal of Pharmacology. 759, p. 163-168 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Treatment of cognitive impairment in schizophrenia: potential value of phosphodiesterase inhibitors in prefrontal dysfunction

van Duinen, M., Reneerkens, O. A. H., Lambrecht, L., Sambeth, A., Rutten, B. P. F., van Os, J., Blokland, A. & Prickaerts, J., 1 Jan 2015, In : Current Pharmaceutical Design. 21, 26, p. 3813-3828 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Delivery of DNA into the central nervous system via electroporation

De Vry, J., Vanmierlo, T., Martínez-Martínez, P., Losen, M., Temel, Y., Steinbusch, H., De Baets, M. & Prickaerts, J., 2014, Methods in molecular biology. Vol. 1121. p. 157-63 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse modet of cognitive impairment in schizophrenia

Karamihalev, S., Prickaerts, J. & van Goethem, N. P., 1 Oct 2014, In : Behavioural Brain Research. 272, p. 248-251

Research output: Contribution to journalArticleAcademicpeer-review

Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling

Bollen, E., Puzzo, D., Rutten, K., Privitera, L., De Vry, J., Vanmierlo, T., Kenis, G., Palmeri, A., D'Hooge, R., Balschun, D., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J., 12 May 2014, In : Neuropsychopharmacology. 39, p. 2497-2505

Research output: Contribution to journalArticleAcademicpeer-review

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

Sierksma, A. S. R., van den Hove, D. L. A., Pfau, F., Philippens, M., Bruno, O., Fedele, E., Ricciarelli, R., Steinbusch, H. W. M., Vanmierlo, T. & Prickaerts, J., Feb 2014, In : Neuropharmacology. 77, p. 120-130

Research output: Contribution to journalArticleAcademicpeer-review

Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

Prickaerts, J., Gieling, E. T., Bruder, A. K., van der Staay, F. J. & Vanmierlo, T., Apr 2014, In : International Journal of Developmental Neuroscience. 33, p. 29-32

Research output: Contribution to journalArticleAcademicpeer-review

Low serum BDNF levels in depressed patients cannot be attributed to individual depressive symptoms or symptom cluster

Bus, B. A. A., Molendijk, M. L., Penninx, B. W. J. H., Buitelaar, J. K., Prickaerts, J., Elzinga, B. M. & Voshaar, R. C. O., Sep 2014, In : World Journal of Biological Psychiatry. 15, 7, p. 561-569

Research output: Contribution to journalArticleAcademicpeer-review

Mind the gap: Delayed manifestation of long-term object memory improvement by phosphodiesterase inhibitors

Akkerman, S., Blokland, A. & Prickaerts, J., 1 Jan 2014, In : Neurobiology of Learning and Memory. 109, p. 139-143

Research output: Contribution to journalArticleAcademicpeer-review

PDE4D inhibitors: A potential strategy for the treatment of memory impairment?

Bruno, O., Ricciarelli, R., Prickaerts, J., Parker, L. & Fedele, E., Oct 2014, In : Neuropharmacology. 85, p. 290-292

Research output: Contribution to journalArticleAcademicpeer-review

PDE5 inhibition improves object memory in standard housed rats but not in rats housed in an enriched environment : implications for memory models?

Akkerman, S., Prickaerts, J., Bruder, A. K., Wolfs, K. H. M., De Vry, J., Vanmierlo, T. & Blokland, A., 1 Jan 2014, In : PLOS ONE. 9, 11, e111692.

Research output: Contribution to journalArticleAcademicpeer-review

Proteomic Investigation of the Hippocampus in Prenatally Stressed Mice Implicates Changes in Membrane Trafficking, Cytoskeletal, and Metabolic Function

Foecking, M., Opstelten, R., Prickaerts, J., Steinbusch, H. W. M., Dunn, M. J., van den Hove, D. L. A. & Cotter, D. R., 2014, In : Developmental Neuroscience. 36, 5, p. 432-442

Research output: Contribution to journalArticleAcademicpeer-review

Purinergic signaling and hippocampal long-term potentiation

Duster, R., Prickaerts, J. & Blokland, A., 1 Jan 2014, In : Current Neuropharmacology. 12, 1, p. 37-43

Research output: Contribution to journalArticleAcademicpeer-review

Translational issues with the development of cognition enhancing drugs

Blokland, A., van Goethem, N., Heckman, P., Schreiber, R. & Prickaerts, J., 1 Jan 2014, In : Frontiers in Neurology. 5, 190.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2013

7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice

Bollen, E., Vanmierlo, T., Akkerman, S., Wouters, C., Steinbusch, H. M. W. & Prickaerts, J., 15 Nov 2013, In : Behavioural Brain Research. 257, p. 8-12

Research output: Contribution to journalArticleAcademicpeer-review

Adrenalectomy and corticosterone replacement differentially alter CA3 dendritic morphology and new cell survival in the adult rat hippocampus

Martinez-Claros, M., Steinbusch, H. W. M., van Selm, A., van den Hove, D. L. A., Prickaerts, J. & Pawluski, J. L., Mar 2013, In : Journal of Chemical Neuroanatomy. 48-49, p. 23-28

Research output: Contribution to journalArticleAcademicpeer-review

Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice

Sierksma, A. S. R., Prickaerts, J., Chouliaras, L., Rostamian, S., Delbroek, L., Rutten, B. P. F., Steinbusch, H. W. M. & van den Hove, D. L. A., Jan 2013, In : Neurobiology of Aging. 34, 1, p. 319-337

Research output: Contribution to journalArticleAcademicpeer-review

Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease

Sierksma, A. S. R., Rutten, K., Sydlik, S., Rostamian, S., Steinbusch, H. W. M., van den Hove, D. L. A. & Prickaerts, J., Jan 2013, In : Neuropharmacology. 64, p. 124-136

Research output: Contribution to journalArticleAcademicpeer-review

Deep brain stimulation of the forniceal area enhances memory functions in experimental dementia: The role of stimulation parameters

Hescham, S., Lim, L. W., Jahanshahi, A., Steinbusch, H. W. M., Prickaerts, J., Blokland, A. & Temel, Y., 1 Jan 2013, In : Brain stimulation. 6, 1, p. 72-77 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801

Reneerkens, O. A. H., Rutten, K., Bollen, E., Hage, T., Blokland, A., Steinbusch, H. W. M. & Prickaerts, J., 1 Jan 2013, In : Behavioural Brain Research. 236, p. 16-22 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

No effect of acute tryptophan depletion on phosphodiesterase inhibition-related improvements of short-term object memory in male Wistar rats

van Donkelaar, E. L., Prickaerts, J., Akkerman, S., Rutten, K., Steinbusch, H. & Blokland, A., Aug 2013, In : Acta Psychiatrica Scandinavica. 128, 2, p. 107-113 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

PDE2 and PDE10, but not PDE5, inhibition affect basic auditory information processing in rats

Reneerkens, O. A. H., Sambeth, A., Blokland, A. & Prickaerts, J., 1 Aug 2013, In : Behavioural Brain Research. 250, p. 251-256 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The PDE5 inhibitor vardenafil does not affect auditory sensory gating in rats and humans

Reneerkens, O. A. H., Sambeth, A., van Duinen, M. A., Blokland, A., Steinbusch, H. W. M. & Prickaerts, J., 1 Jan 2013, In : Psychopharmacology. 225, 2, p. 303-312 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Vulnerability versus resilience to prenatal stress in male and female rats; Implications from gene expression profiles in the hippocampus and frontal cortex

Van den Hove, D. L. A., Kenis, G., Brass, A., Opstelten, R., Rutten, B. P. F., Bruschettini, M., Blanco, C. E., Lesch, K. P., Steinbusch, H. W. M. & Prickaerts, J., Oct 2013, In : European Neuropsychopharmacology. 23, 10, p. 1226-1246

Research output: Contribution to journalArticleAcademicpeer-review

2012

Differential BDNF Responses of Triple Versus Dual Reuptake Inhibition in Neuronal and Astrocytoma Cells as well as in Rat Hippocampus and Prefrontal Cortex

Prickaerts, J., De Vry, J., Boere, J., Kenis, G., Quinton, M. S., Engel, S., Melnick, L. & Schreiber, R., Sep 2012, In : Journal of Molecular Neuroscience. 48, 1, p. 167-175

Research output: Contribution to journalArticleAcademicpeer-review

Effects of protein kinase A and G inhibitors on hippocampal cholinergic markers expressions in rolipram- and sildenafil-induced spatial memory improvement

Hosseini-Sharifabad, A., Ghahremani, M. H., Sabzevari, O., Naghdi, N., Abdollahi, M., Beyer, C., Bollen, E., Prickaerts, J., Roghani, A. & Sharifzadeh, M., May 2012, In : Pharmacology, Biochemistry and Behavior. 101, 3, p. 311-319

Research output: Contribution to journalArticleAcademicpeer-review

EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors

Prickaerts, J., van Goethem, N. P., Chesworth, R., Shapiro, G., Boess, F. G., Methfessel, C., Reneerkens, O. A. H., Flood, D. G., Hilt, D., Gawryl, M., Bertrand, S., Bertrand, D. & Koenig, G., Feb 2012, In : Neuropharmacology. 62, 2, p. 1099-1110

Research output: Contribution to journalArticleAcademicpeer-review

Gender specific associations of serum levels of brain-derived neurotrophic factor in anxiety

Molendijk, M. L., Bus, B. A. A., Spinhoven, P., Penninx, B. W. J. H., Prickaerts, J., Voshaar, R. C. O. & Elzinga, B. M., Oct 2012, In : World Journal of Biological Psychiatry. 13, 7, p. 535-543

Research output: Contribution to journalArticleAcademicpeer-review

Increase in Serum Brain-Derived Neurotrophic Factor in Met Allele Carriers of the BDNF Val66Met Polymorphism Is Specific to Males

Bus, B. A. A., Arias-Vasquez, A., Franke, B., Prickaerts, J., de Graaf, J. & Voshaar, R. C. O., 2012, In : Neuropsychobiology. 65, 4, p. 183-187

Research output: Contribution to journalArticleAcademicpeer-review

Memory deficits in the transgenic rat model of Huntington's disease

Zeef, D. H., van Goethem, N. P., Vlamings, R., Schaper, F., Jahanshahi, A., Hescham, S., von Hoersten, S., Prickaerts, J. & Temel, Y., 1 Feb 2012, In : Behavioural Brain Research. 227, 1, p. 194-198

Research output: Contribution to journalArticleAcademicpeer-review

Motor and non-motor behaviour in experimental Huntington's disease

Zeef, D. H., Vlamings, R., Lim, L. W., Tan, S., Janssen, M. L. F., Jahanshahi, A., Hoogland, G., Prickaerts, J., Steinbusch, H. W. M. & Temel, Y., 15 Jan 2012, In : Behavioural Brain Research. 226, 2, p. 435-439

Research output: Contribution to journalArticleAcademicpeer-review