19952020

Research output per year

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Research Output

Article
Open Access

Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications

Heckman, P. R. A., van Duinen, M. A., Bollen, E. P. P., Nishi, A., Wennogle, L. P., Blokland, A. & Prickaerts, J., Oct 2016, In : International Journal of Neuropsychopharmacology. 19, 10, 16 p., pyw030.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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197 Downloads (Pure)

Phosphodiesterase Inhibition as a Therapeutic Target for Brain Ischemia

Soares, L. M., Prickaerts, J., Milani, H., Del Bel, E., Steinbusch, H. W. M. & Weffort de Oliveira, R. M., 2015, In : Cns & Neurological Disorders-Drug Targets. 14, 8, p. 1012-1023

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer's Disease: A Translational Overview

Heckman, P. R. A., Wouters, C. & Prickaerts, J., 2015, In : Current Pharmaceutical Design. 21, 3, p. 317-331

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats

Rutten, K., van Donkelaar, E. L., Ferrington, L., Blokland, A., Bollen, E., Steinbusch, H. W. M., Kelly, P. A. & Prickaerts, J. H. H. J., 1 Jan 2009, In : Neuropsychopharmacology. 34, 8, p. 1914-1925

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation

Heckman, P. R. A., Roig Kuhn, F., Raven, F., Bolsius, Y. G., Prickaerts, J., Meerlo, P. & Havekes, R., Jun 2020, In : Synapse. 74, 6, 6 p., 22150.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Phosphodiesterases in neurodegenerative disorders

Bollen, E. & Prickaerts, J., Dec 2012, In : Iubmb Life. 64, 12, p. 965-970

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: Indications for central and peripheral mechanisms

Reneerkens, O. A. H., Rutten, K., Akkerman, S., Blokland, A., Shaffer, C. L., Menniti, F. S., Steinbusch, H. W. M. & Prickaerts, J., May 2012, In : Neurobiology of Learning and Memory. 97, 4, p. 370-379 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve

Prickaerts, J., Van Goethem, N. P., Gulisano, W., Argyrousi, E. K., Palmeri, A. & Puzzo, D., 15 Dec 2017, In : European Journal of Pharmacology. 817, p. 59-70 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Plasma corticosterone manipulations in mice affect brain cell proliferation, but only partly affect BDNF protein levels

Prickaerts, J. H. H. J., van den Hove, D. L. A., Fierens, F. L. P., Kia, H. K., Lenaerts, I. & Steckler, T., 1 Jan 2006, In : Neuroscience Letters. 396, p. 1-2016

Research output: Contribution to journalArticleAcademicpeer-review

Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease

Houben, T., dos Reis, I. M., Oligschlaeger, Y., Steinbusch, H., Gijbels, M. J. J., Hendrikx, T., Binder, C. J., Cassiman, D., Westerterp, M., Prickaerts, J. & Shiri-Sverdlov, R., 7 Jan 2019, In : Frontiers in Immunology. 9, p. 1-13 13 p., 3089.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach

Akkerman, S., Blokland, A. & Prickaerts, J., 1 Jan 2016, In : Learning & Memory. 23, 1, p. 29-37 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
189 Downloads (Pure)

Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

Snyder, G. L., Prickaerts, J., Wadenberg, M-L., Zhang, L., Zheng, H., Yao, W., Akkerman, S., Zhu, H., Hendrick, J. P., Vanover, K. E., Davis, R., Li, P., Mates, S. & Wennogle, L. P., Sep 2016, In : Psychopharmacology. 233, 17, p. 3113-3124

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prenatal maternal paroxetine treatment and neonatal mortality in the rat: a preliminary study

van den Hove, D. L., Blanco, C. E., Scheepens, A., Desbonnet, L., Myint, A. M., Leonard, B. E., Prickaerts, J. H. H. J. & Steinbusch, H. W. M., 1 Jan 2008, In : Neonatology. 93, 1, p. 52-55

Research output: Contribution to journalArticleAcademicpeer-review

Prenatal restraint stress and long-term affective consequences

van den Hove, D. L. A., Blanco, C. E., Aendekerk, B., Desbonnet, L., Bruschettini, M., Steinbusch, H. P. J., Prickaerts, J. H. H. J. & Steinbusch, H. W. M., 1 Jan 2005, In : Developmental Neuroscience. 27, 5, p. 313-320

Research output: Contribution to journalArticleAcademicpeer-review

Prenatal stress and neonatal rat brain development

van den Hove, D. L. A., Steinbusch, H. W. M., Scheepens, A., van de Berg, W. D. J., Kooiman, L. A. M., Boosten, B. J. G., Prickaerts, J. H. H. J. & Blanco, C. E., 1 Jan 2006, In : Neuroscience. 137, 1, p. 145-155

Research output: Contribution to journalArticleAcademicpeer-review

Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex

Michelsen, K. A., van den Hove, D. L., Schmitz, C., Segers, O., Prickaerts, J. H. H. J. & Steinbusch, H. W. M., 1 Jan 2007, In : BMC Neuroscience. 8, 1, p. 107-107

Research output: Contribution to journalArticleAcademicpeer-review

Prenatal stress in the rat alters 5-HT1A receptor binding in the ventral hippocampus

van den Hove, D. L., Lauder, J. M., Scheepens, A., Prickaerts, J. H. H. J., Blanco, C. E. & Steinbusch, H. W. M., 1 Jan 2006, In : Brain Research. 1090, 1, p. 29-34

Research output: Contribution to journalArticleAcademicpeer-review

Prenatal stress reduces S100B in the neonatal rat hippocampus

van den Hove, D. L., Steinbusch, H. W. M., Bruschettini, M., Gazzolo, D., Frulio, R., Scheepens, A., Prickaerts, J. H. H. J. & Blanco, C. E., 1 Jan 2006, In : Neuroreport. 17, 10, p. 1077-1080

Research output: Contribution to journalArticleAcademicpeer-review

Proteomic Investigation of the Hippocampus in Prenatally Stressed Mice Implicates Changes in Membrane Trafficking, Cytoskeletal, and Metabolic Function

Foecking, M., Opstelten, R., Prickaerts, J., Steinbusch, H. W. M., Dunn, M. J., van den Hove, D. L. A. & Cotter, D. R., 2014, In : Developmental Neuroscience. 36, 5, p. 432-442

Research output: Contribution to journalArticleAcademicpeer-review

Purinergic signaling and hippocampal long-term potentiation

Duster, R., Prickaerts, J. & Blokland, A., 1 Jan 2014, In : Current Neuropharmacology. 12, 1, p. 37-43

Research output: Contribution to journalArticleAcademicpeer-review

Recurrent long-lasting tethering reduces BDNF protein levels in the dorsal hippocampus and frontal cortex in pigs

De Vry, J., Prickaerts, J., Jetten, M., Hulst, M., Steinbusch, H. W. M., van den Hove, D. L. A., Schuurman, T. & van der Staay, F. J., Jun 2012, In : Hormones and Behavior. 62, 1, p. 10-17

Research output: Contribution to journalArticleAcademicpeer-review

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

Santiago, A., Soares, L. M., Schepers, M., Milani, H., Vanmierlo, T., Prickaerts, J. & de Oliveira, R. M., 1 Aug 2018, In : Neuropharmacology. 138, p. 360-370 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

ROLIPRAM IMPROVES COGNITION, REDUCES ANXIETY- AND DESPAIR-LIKE BEHAVIORS AND IMPACTS HIPPOCAMPAL NEUROPLASTICITY AFTER TRANSIENT GLOBAL CEREBRAL ISCHEMIA

Soares, L. M., De Vry, J., Steinbusch, H. W. M., Milani, H., Prickaerts, J. & Weffort De Oliveira, R. M., 21 Jun 2016, In : Neuroscience. 326, p. 69-83

Research output: Contribution to journalArticleAcademicpeer-review

Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action

Rutten, K., Prickaerts, J. H. H. J. & Blokland, A., 1 Jan 2006, In : Neurobiology of Learning and Memory. 85, 2, p. 132-138

Research output: Contribution to journalArticleAcademicpeer-review

Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques

Rutten, K., Basile, J. L., Prickaerts, J. H. H. J., Blokland, A. & Vivian, J., 1 Jan 2008, In : Psychopharmacology. 196, 4, p. 643-648

Research output: Contribution to journalArticleAcademicpeer-review

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

Reneerkens, O. A. H., Rutten, K., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J. H. H. J., 1 Jan 2009, In : Psychopharmacology. 202, 1-3, p. 419-443

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight

Molendijk, M. L., Haffmans, J. P. M., Bus, B. A. A., Spinhoven, P., Penninx, B. W. J. H., Prickaerts, J., Voshaar, R. C. O. & Elzinga, B. M., 2 Nov 2012, In : PLOS ONE. 7, 11, e48046.

Research output: Contribution to journalArticleAcademicpeer-review

Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment

Molendijk, M. L., Bus, B. A. A., Spinhoven, P., Penninx, B. W. J. H., Kenis, G., Prickaerts, J., Voshaar, R. C. O. & Elzinga, B. M., Nov 2011, In : Molecular Psychiatry. 16, 11, p. 1088-1095

Research output: Contribution to journalArticleAcademicpeer-review

SLV330, a cannabinoid CB1 receptor antagonist, ameliorates deficits in the T-maze, object recognition and Social Recognition Tasks in rodents

de Bruin, N. M. W. J., Prickaerts, J., Lange, J. H. M., Akkerman, S., Andriambeloson, E., de Haan, M., Wijnen, E. J., van Drimmelen, M., Hissink, E., Heijink, L. & Kruse, C. G., May 2010, In : Neurobiology of Learning and Memory. 93, 4, p. 522-531

Research output: Contribution to journalArticleAcademicpeer-review

Spatial discrimination learning and choline acetyltransferase activity in streptozotocin-treated rats: effects of chronic treatment with acetyl-L-carnitine

Prickaerts, J., Blokland, A., Honig, W., Meng, F. & Jolles, J., 1 Jan 1995, In : Brain Research. 674, 1, p. 142-146 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stress and the pregnant female: Impact on hippocampal cell proliferation, but not affective-like behaviors

Pawluski, J. L., van den Hove, D. L. A., Rayen, I., Prickaerts, J. & Steinbusch, H. W. M., Apr 2011, In : Hormones and Behavior. 59, 4, p. 572-580

Research output: Contribution to journalArticleAcademicpeer-review

Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats

Rutten, K., Prickaerts, J. H. H. J., Schaenzle, G., Rosenbrock, H. & Blokland, A., 1 Jan 2008, In : Neurobiology of Learning and Memory. 90, 3, p. 569-575

Research output: Contribution to journalArticleAcademicpeer-review

The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease.

Michelsen, K. A. P., Prickaerts, J. H. H. J. & Steinbusch, H. P. J., 1 Jan 2008, In : Progress in Brain Research. 172, p. 233-264

Research output: Contribution to journalArticleAcademicpeer-review

The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment

Borghans, L. G. J. M., Sambeth, A., Prickaerts, J., Ramaekers, J. G. & Blokland, A., Aug 2018, In : Psychopharmacology. 235, 8, p. 2407-2416 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val(66)Met

Elzinga, B. M., Molendijk, M. L., Voshaar, R. C. O., Bus, B. A. A., Prickaerts, J., Spinhoven, P. & Penninx, B. W. J. H., Mar 2011, In : Psychopharmacology. 214, 1, p. 319-328

Research output: Contribution to journalArticleAcademicpeer-review

The mediating role of phosphodiesterase type 4 in the dopaminergic modulation of motor impulsivity

Heckman, P. R. A., Blokland, A., Van Goethem, N. P., Van Hagen, B. T. J. & Prickaerts, J., 17 Sep 2018, In : Behavioural Brain Research. 350, p. 16-22 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents

van der Staay, F. J., Rutten, K., Barfacker, L., Devry, J., Erb, C., Heckroth, H., Karthaus, D., Tersteegen, A., van Kampen, M., Blokland, A., Prickaerts, J. H. H. J., Reymann, K. G., Schroder, U. H. & Hendrix, M., 1 Jan 2008, In : Neuropharmacology. 55, 5, p. 908-918

Research output: Contribution to journalArticleAcademicpeer-review

The object pattern separation (OPS) task: A behavioral paradigm derived from the object recognition task

van Hagen, B. T. J., van Goethem, N. P., Lagatta, D. C. & Prickaerts, J., 15 May 2015, In : Behavioural Brain Research. 285, p. 44-52

Research output: Contribution to journalArticleAcademicpeer-review

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

Vanmierlo, T., Creemers, P., Akkerman, S., van Duinen, M., Sambeth, A., De Vry, J., Uz, T., Blokland, A. & Prickaerts, J., 15 Apr 2016, In : Behavioural Brain Research. 303, p. 26-33 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The PDE5 inhibitor vardenafil does not affect auditory sensory gating in rats and humans

Reneerkens, O. A. H., Sambeth, A., van Duinen, M. A., Blokland, A., Steinbusch, H. W. M. & Prickaerts, J., 1 Jan 2013, In : Psychopharmacology. 225, 2, p. 303-312 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity

Soares, L. M., Meyer, E., Milani, H., Steinbusch, H. W. M., Prickaerts, J. & de Oliveira, R. M. W., Feb 2017, In : European Journal of Neuroscience. 45, 4, p. 510-520 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment

de Bruin, N. M. W. J., van Loevezijn, A., Wicke, K. M., de Haan, M., Venhorst, J., Lange, J. H. M., de Groote, L., van der Neut, M. A. W., Prickaerts, J., Andriambeloson, E., Foley, A. G., van Drimmelen, M., van der Wetering, M. & Kruse, C. G., Sep 2016, In : Neurobiology of Learning and Memory. 133, p. 100-117

Research output: Contribution to journalArticleAcademicpeer-review

The selective PDE5 inhibitor, sildenafil, improves object memory in Swiss mice and increases cGMP levels in hippocampal slices

Rutten, K., Vente, J. D., Sik, A., van Markerink, M., Prickaerts, J. H. H. J. & Blokland, A., 1 Jan 2005, In : Behavioural Brain Research. 164, 1, p. 11-6

Research output: Contribution to journalArticleAcademicpeer-review

The use of EEG parameters as predictors of drug effects on cognition

Blokland, A., Prickaerts, J., van Duinen, M. & Sambeth, A., 15 Jul 2015, In : European Journal of Pharmacology. 759, p. 163-168 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Time-dependent involvement of cAMP and cGMP in consolidation of object memory: Studies using selective phosphodiesterase type 2, 4 and 5 inhibitors

Rutten, K., Prickaerts, J. H. H. J., Hendrix, M., van der Staay, F. J., Sik, A. & Blokland, A., 1 Jan 2007, In : European Journal of Pharmacology. 558, 1-3, p. 107-112

Research output: Contribution to journalArticleAcademicpeer-review

Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania

Prickaerts, J. H. H. J., Moechars, D., Cryns, K., Lenaerts, I., van Craenendonck, H., Goris, I., Daneels, G., Bouwknecht, J. A. & Steckler, T., 1 Jan 2006, In : Journal of Neuroscience. 26, p. 9022-9

Research output: Contribution to journalArticleAcademicpeer-review