19952020

Research output per year

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Research Output

Article

Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress

Behan, A. T., Van den Hove, D. L. A., Mueller, L., Jetten, M. J. A., Steinbusch, H. W. M., Cotter, D. R. & Prickaerts, J., Jan 2011, In : European Neuropsychopharmacology. 21, 1, p. 71-79

Research output: Contribution to journalArticleAcademicpeer-review

EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors

Prickaerts, J., van Goethem, N. P., Chesworth, R., Shapiro, G., Boess, F. G., Methfessel, C., Reneerkens, O. A. H., Flood, D. G., Hilt, D., Gawryl, M., Bertrand, S., Bertrand, D. & Koenig, G., Feb 2012, In : Neuropharmacology. 62, 2, p. 1099-1110

Research output: Contribution to journalArticleAcademicpeer-review

Fetal asphyctic preconditioning protects against perinatal asphyxia-induced behavioral consequences in adulthood

Strackx, E., Van den Hove, D. L. A., Prickaerts, J., Zimmermann, L., Steinbusch, H. W. M., Blanco, C. E., Gavilanes, D. A. W. & Vles, J. S. H., 2 Apr 2010, In : Behavioural Brain Research. 208, 2, p. 343-351

Research output: Contribution to journalArticleAcademicpeer-review

Fluoxetine during Development Reverses the Effects of Prenatal Stress on Depressive-Like Behavior and Hippocampal Neurogenesis in Adolescence

Rayen, I., van den Hove, D. L., Prickaerts, J., Steinbusch, H. W. & Pawluski, J. L., 1 Sep 2011, In : PLOS ONE. 6, 9, p. 9

Research output: Contribution to journalArticleAcademicpeer-review

Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice

Sierksma, A. S. R., de Nijs, L., Hoogland, G., Vanmierlo, T., van Leeuwen, F. W., Rutten, B. P. F., Steinbusch, H. W. M., Prickaerts, J. & van den Hove, D. L. A., 2016, In : Journal of Alzheimer's Disease. 51, 3, p. 677-682

Research output: Contribution to journalArticleAcademicpeer-review

Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-hydroxydopamine lesioned rats

Scholtissen, B., Deumens, R., Leentjens, A. F. G., Schmitz, C., Blokland, A., Steinbusch, H. W. M. & Prickaerts, J. H. H. J., 1 Jan 2006, In : Pharmacology, Biochemistry and Behavior. 83, p. 175-85

Research output: Contribution to journalArticleAcademicpeer-review

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

Bruno, O., Fedele, E., Prickaerts, J., Parker, L. A., Canepa, E., Brullo, C., Cavallero, A., Gardella, E., Balbi, A., Domenicotti, C., Bollen, E., Gijselaers, H. J. M., Vanmierlo, T., Erb, K., Limebeer, C. L., Argellati, F., Marinari, U. M., Pronzato, M. A. & Ricciarelli, R., Dec 2011, In : British Journal of Pharmacology. 164, 8, p. 2054-2063

Research output: Contribution to journalArticleAcademicpeer-review

Gender specific associations of serum levels of brain-derived neurotrophic factor in anxiety

Molendijk, M. L., Bus, B. A. A., Spinhoven, P., Penninx, B. W. J. H., Prickaerts, J., Voshaar, R. C. O. & Elzinga, B. M., Oct 2012, In : World Journal of Biological Psychiatry. 13, 7, p. 535-543

Research output: Contribution to journalArticleAcademicpeer-review

Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels

Vanmierlo, T., De Vry, J., Nelissen, E., Sierksma, A., Roumans, N., Steinbusch, H. W. M., Wennogle, L. P., van den Hove, D. & Prickaerts, J., 1 Apr 2018, In : Molecular and Cellular Neuroscience. 88, p. 292-299 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

How the COVID-19 pandemic highlights the necessity of animal research

Genzel, L., Adan, R., Berns, A., van den Beucken, J., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., Dam, A-M. V., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., Fentener van Vlissingen, J. M. & 62 others, la Fleur, S., Fouchier, R., Fitzsimons, C. P., Frieling, W., Haagmans, B., Heesters, B. A., Henckens, M., Herfst, S., Hol, E., van den Hove, D., de Jonge, M. I., Jonkers, J., Joosten, L. A. B., Kalsbeek, A., Kamermans, M., Kampinga, H. H., Kas, M. J., Keijer, J., Kersten, S., Kiliaan, A. J., Kooij, T. W. A., Kooijman, S., Koopman, W. J. H., Korosi, A., Krugers, H. J., Kuiken, T., Kushner, S. A., Langermans, J. A. M., Lesscher, H., Lucassen, P. J., Lutgens, E., Netea, M. G., Noldus, L. P. J. J., van der Meer, J. W. M., Meye, F. J., Mul, J. D., van Oers, K., Olivier, J. D. A., Pasterkamp, R. J., Philippens, I. H. C. H. M., Prickaerts, J., Pullox, B. J. A., Rensen, P. C. N., van Rheenen, J., van Rij, R. P., Ritsma, L., Rockx, B. H. G., Roozendaal, B., van Schothorst, E. M., Stittelaar, K., Stockhofe, N., Swaab, D. F., de Swart, R. L., Vanderschuren, L. J. M. J., de Vries, T., de Vrij, F., van Wezel, R., Wierenga, C. J., Wiesmann, M., Willuhn, I., de Zeeuw, C. I. & Homberg, J. R., 21 Sep 2020, In : Current Biology. 30, 18, p. R1014-R1018

Research output: Contribution to journalArticleAcademicpeer-review

Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice

Foulquier, S., Namsolleck, P., Van Hagen, B. T., Milanova, I., Post, M. J., Blankesteijn, W. M., Rutten, B. P., Prickaerts, J., Van Oostenbrugge, R. J. & Unger, T., Oct 2018, In : Hypertension Research. 41, 10, p. 817-827 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling

Bollen, E., Puzzo, D., Rutten, K., Privitera, L., De Vry, J., Vanmierlo, T., Kenis, G., Palmeri, A., D'Hooge, R., Balschun, D., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J., 12 May 2014, In : Neuropsychopharmacology. 39, p. 2497-2505

Research output: Contribution to journalArticleAcademicpeer-review

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

Sierksma, A. S. R., van den Hove, D. L. A., Pfau, F., Philippens, M., Bruno, O., Fedele, E., Ricciarelli, R., Steinbusch, H. W. M., Vanmierlo, T. & Prickaerts, J., Feb 2014, In : Neuropharmacology. 77, p. 120-130

Research output: Contribution to journalArticleAcademicpeer-review

Improving memory: a role for phosphodiesterases

Blokland, A., Schreiber, R. & Prickaerts, J. H. H. J., 1 Jan 2006, In : Current Pharmaceutical Design. 12, p. 2511-2523

Research output: Contribution to journalArticleAcademicpeer-review

Increase in Serum Brain-Derived Neurotrophic Factor in Met Allele Carriers of the BDNF Val66Met Polymorphism Is Specific to Males

Bus, B. A. A., Arias-Vasquez, A., Franke, B., Prickaerts, J., de Graaf, J. & Voshaar, R. C. O., 2012, In : Neuropsychobiology. 65, 4, p. 183-187

Research output: Contribution to journalArticleAcademicpeer-review

Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801

Reneerkens, O. A. H., Rutten, K., Bollen, E., Hage, T., Blokland, A., Steinbusch, H. W. M. & Prickaerts, J., 1 Jan 2013, In : Behavioural Brain Research. 236, p. 16-22 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inhibition of phosphodiesterase 2 increases nuronal cGMP, synaptic plasticity and memory performance

Boess, F. G., Hendrix, M., van der Staay, F. J., Erb, C., Schreiber, R., van Staveren, W. C. G., de Vente, J., Prickaerts, J., Blokland, A. & Koenig, G., 1 Jan 2004, In : Neuropharmacology. 47, 7, p. 1081-1092

Research output: Contribution to journalArticleAcademicpeer-review

Interactions between CRF and acetylcholine in the modulation of cognitive behaviour

Warnock, G., Prickaerts, J. H. H. J. & Steckler, T., 1 Jan 2006, In : EXS. 98, p. 41-63

Research output: Contribution to journalArticleAcademicpeer-review

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease

Prickaerts, J., Heckman, P. R. A. & Blokland, A., 9 Aug 2017, In : Expert Opinion on Investigational Drugs. 26, 9, p. 1033-1048 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In vivo electroporation of the central nervous system: A non-viral approach for targeted gene delivery

De Vry, J., Martinez-Martinez, P., Losen, M., Temel, Y., Steckler, T., Steinbusch, H. W. M., De Baets, M. H. & Prickaerts, J., Nov 2010, In : Progress in Neurobiology. 92, 3, p. 227-244

Research output: Contribution to journalArticleAcademicpeer-review

LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus

Mulder, M. T., Koopmans, G., Wassink, G., Al Mansouri, G., Simard, M. L., Havekes, L. M., Prickaerts, J. H. H. J. & Blokland, A., 1 Jan 2007, In : Neuroscience Research. 59, 3

Research output: Contribution to journalArticleAcademicpeer-review

Learning and adult neurogenesis: survival with or without proliferation?

Prickaerts, J., Koopmans, G., Blokland, A. & Scheepens, A., 1 Jan 2004, In : Neurobiology of Learning and Memory. 81, 1, p. 1-11

Research output: Contribution to journalArticleAcademicpeer-review

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

Vanmierlo, T., Rutten, K., Dederen, J., Bloks, V. W., Vark-van der Zee, L. C., Kuipers, F., Kiliaan, A., Blokland, A., Sijbrands, E. J. G., Steinbusch, H., Prickaerts, J., Lütjohann, D. & Mulder, M., 1 Jan 2011, In : Neurobiology of Aging. 32, 7, p. 1262-1272

Research output: Contribution to journalArticleAcademicpeer-review

Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets

Prickaerts, J., Gieling, E. T., Bruder, A. K., van der Staay, F. J. & Vanmierlo, T., Apr 2014, In : International Journal of Developmental Neuroscience. 33, p. 29-32

Research output: Contribution to journalArticleAcademicpeer-review

Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain

De Vry, J., Martinez-Martinez, P., Losen, M., Bode, G. H., Temel, Y., Steckler, T., Steinbusch, H. W. M., De Baets, M. & Prickaerts, J., Jun 2010, In : Molecular Therapy. 18, 6, p. 1183-1191

Research output: Contribution to journalArticleAcademicpeer-review

Low serum BDNF levels in depressed patients cannot be attributed to individual depressive symptoms or symptom cluster

Bus, B. A. A., Molendijk, M. L., Penninx, B. W. J. H., Buitelaar, J. K., Prickaerts, J., Elzinga, B. M. & Voshaar, R. C. O., Sep 2014, In : World Journal of Biological Psychiatry. 15, 7, p. 561-569

Research output: Contribution to journalArticleAcademicpeer-review

Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link?

Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M. & Prickaerts, J., 10 Jan 2010, In : European Journal of Pharmacology. 626, 1, p. 72-82

Research output: Contribution to journalArticleAcademicpeer-review

Maternal stress-induced reduction in birth weight as a marker for adult affective state

van den Hove, D. L. A., Kenis, G., Steinbusch, H. W. M., Blanco, C. E. & Prickaerts, J., 1 Jan 2010, In : Frontiers in Bioscience, Elite edition. 2, p. 43-6 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Memory deficits in the transgenic rat model of Huntington's disease

Zeef, D. H., van Goethem, N. P., Vlamings, R., Schaper, F., Jahanshahi, A., Hescham, S., von Hoersten, S., Prickaerts, J. & Temel, Y., 1 Feb 2012, In : Behavioural Brain Research. 227, 1, p. 194-198

Research output: Contribution to journalArticleAcademicpeer-review

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease

Ricciarelli, R., Brullo, C., Prickaerts, J., Arancio, O., Villa, C., Rebosio, C., Calcagno, E., Balbi, M., van Hagen, B. T. J., Argyrousi, E. K., Zhang, H., Pronzato, M. A., Bruno, O. & Fedele, E., 12 Apr 2017, In : Scientific Reports. 7, 14 p., 46320.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task

Steckler, T., Oliveira, A. F., van Dyck, C., van Craenendonck, H., Mateus, A. M., Langlois, X., Lesage, A. S. & Prickaerts, J. H. H. J., 1 Jan 2005, In : Behavioural Brain Research. 164, p. 52-60

Research output: Contribution to journalArticleAcademicpeer-review

Mind the gap: Delayed manifestation of long-term object memory improvement by phosphodiesterase inhibitors

Akkerman, S., Blokland, A. & Prickaerts, J., 1 Jan 2014, In : Neurobiology of Learning and Memory. 109, p. 139-143

Research output: Contribution to journalArticleAcademicpeer-review

Motor and non-motor behaviour in experimental Huntington's disease

Zeef, D. H., Vlamings, R., Lim, L. W., Tan, S., Janssen, M. L. F., Jahanshahi, A., Hoogland, G., Prickaerts, J., Steinbusch, H. W. M. & Temel, Y., 15 Jan 2012, In : Behavioural Brain Research. 226, 2, p. 435-439

Research output: Contribution to journalArticleAcademicpeer-review

Neurocognition in bipolar disorders-A closer look at comorbidities and medications

Balanza-Martinez, V., Selva, G., Martinez-Aran, A., Prickaerts, J., Salazar, J., Gonzalez-Pinto, A., Vieta, E. & Tabares-Seisdedos, R., 10 Jan 2010, In : European Journal of Pharmacology. 626, 1, p. 87-96

Research output: Contribution to journalArticleAcademicpeer-review

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Brullo, C., Ricciarelli, R., Prickaerts, J., Arancio, O., Massa, M., Rotolo, C., Romussi, A., Rebosio, C., Marengo, B., Pronzato, M. A., van Hagen, B. T. J., van Goethem, N. P., D'Ursi, P., Orro, A., Milanesi, L., Guariento, S., Cichero, E., Fossa, P., Fedele, E. & Bruno, O., 29 Nov 2016, In : European Journal of Medicinal Chemistry. 124, p. 82-102

Research output: Contribution to journalArticleAcademicpeer-review

No effect of acute tryptophan depletion on phosphodiesterase inhibition-related improvements of short-term object memory in male Wistar rats

van Donkelaar, E. L., Prickaerts, J., Akkerman, S., Rutten, K., Steinbusch, H. & Blokland, A., Aug 2013, In : Acta Psychiatrica Scandinavica. 128, 2, p. 107-113 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M. O., van Hoof, S. J., Groot, A. J., Habets, R., Prickaerts, J., Chalmers, A. J., Eekers, D. B. P., Theys, J., Short, S. C., Verhaegen, F. & Vooijs, M., 5 Jul 2016, In : Oncotarget. 7, 27, p. 41251-41264

Research output: Contribution to journalArticleAcademicpeer-review

Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors

Bollen, E., Akkerman, S., Puzzo, D., Gulisano, W., Palmeri, A., D'Hooge, R., Balschun, D., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J., 17 Apr 2015, In : Neuropharmacology. 95, p. 361-366

Research output: Contribution to journalArticleAcademicpeer-review

Object recognition testing: methodological considerations on exploration and discrimination measures

Akkerman, S., Blokland, A., Reneerkens, O., Goethem, N. P., Bollen, E., Gijselaers, H. J. M., Lieben, C. K. J., Steinbusch, H. W. M. & Prickaerts, J., 1 Jan 2012, In : Behavioural Brain Research. 232, 2, p. 335-347

Research output: Contribution to journalArticleAcademicpeer-review

Object recognition testing: Rodent species, strains, housing conditions, and estrous cycle

van Goethem, M., Rutten, K., van der Staay, F. J., Jans, L. A. W., Akkerman, S., Steinbusch, H. W. M., Blokland, A., van 't Klooster, J. & Prickaerts, J., 1 Jan 2012, In : Behavioural Brain Research. 232, 2, p. 323-334

Research output: Contribution to journalArticleAcademicpeer-review

Object recognition testing: statistical considerations

Akkerman, S., Prickaerts, J. H. H. J., Steinbusch, H. W. M. & Blokland, A., 1 Jan 2012, In : Behavioural Brain Research. 232, 2, p. 317-322

Research output: Contribution to journalArticleAcademicpeer-review

PDE2 and PDE10, but not PDE5, inhibition affect basic auditory information processing in rats

Reneerkens, O. A. H., Sambeth, A., Blokland, A. & Prickaerts, J., 1 Aug 2013, In : Behavioural Brain Research. 250, p. 251-256 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

PDE4D inhibitors: A potential strategy for the treatment of memory impairment?

Bruno, O., Ricciarelli, R., Prickaerts, J., Parker, L. & Fedele, E., Oct 2014, In : Neuropharmacology. 85, p. 290-292

Research output: Contribution to journalArticleAcademicpeer-review

PDE5 inhibition improves acquisition processes after learning via a central mechanism

Akkerman, S., Blokland, A., van Goethem, N. P., Cremers, P., Shaffer, C. L., Osgood, S. M., Steinbusch, H. W. M. & Prickaerts, J., Oct 2015, In : Neuropharmacology. 97, p. 233-239 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

PDE5 inhibition improves object memory in standard housed rats but not in rats housed in an enriched environment : implications for memory models?

Akkerman, S., Prickaerts, J., Bruder, A. K., Wolfs, K. H. M., De Vry, J., Vanmierlo, T. & Blokland, A., 1 Jan 2014, In : PLOS ONE. 9, 11, e111692.

Research output: Contribution to journalArticleAcademicpeer-review

PDE and cognitive processing : beyond the memory domain

Heckman, P., Blokland, A., Ramaekers, J. & Prickaerts, J., Mar 2015, In : Neurobiology of Learning and Memory. 119, p. 108-122 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

PDE Inhibition and cognition enhancement

Blokland, A., Menniti, F. S. & Prickaerts, J., Apr 2012, In : Expert Opinion on Therapeutic Patents. 22, 4, p. 349-354 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Persistence of the extinction of fear memory requires late-phase cAMP/PKA signaling in the infralimbic cortex

Batista Sohn, J. M., Furtado de Souza, S. T., Raymundi, A. M., Bonato, J., Weffort de Oliveira, R. M., Prickaerts, J. & Stern, C. A., Jul 2020, In : Neurobiology of Learning and Memory. 172, 14 p., 107244.

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension

Kerkhofs, D., van Hagen, B. T., Milanova, I. V., Schell, K. J., van Essen, H., Wijnands, E., Goossens, P., Blankesteijn, W. M., Unger, T., Prickaerts, J., Biessen, E. A., van Oostenbrugge, R. J. & Foulquier, S., 25 Jul 2020, In : Theranostics. 10, 21, p. 9512-9527 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion

van Donkelaar, E. L., Rutten, K., Blokland, A., Akkerman, S., Steinbusch, H. P. & Prickaerts, J. H. H. J., 1 Jan 2008, In : European Journal of Pharmacology. 600, 1-3, p. 98-104

Research output: Contribution to journalArticleAcademicpeer-review