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Research Output 1998 2019

2019

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study

Blokland, A., Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Tsai, M., Lahu, G., Uz, T. & Prickaerts, J., May 2019, In : Neurobiology of Aging. 77, p. 37-43 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Antagonizing alpha 7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition

van Goethem, N. P., Paes, D., Puzzo, D., Fedele, E., Rebosio, C., Gulisano, W., Palmeri, A., Wennogle, L. P., Peng, Y., Bertrand, D. & Prickaerts, J., Oct 2019, In : Cellular Signalling. 62, p. 1-8 8 p., 109338.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of DNA methyltransferase inhibition on pattern separation performance in mice

Argyrousi, E. K., de Nijs, L., Lagatta, D. C., Schlütter, A., Weidner, M. T., Zoeller, J., van Goethem, N. P., Joca, S. R. L., van den Hove, D. L. A. & Prickaerts, J., Mar 2019, In : Neurobiology of Learning and Memory. 159, p. 6-15 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

From OPC to Oligodendrocyte: An Epigenetic Journey

Tiane, A., Schepers, M., Rombaut, B., Hupperts, R., Prickaerts, J., Hellings, N., van den Hove, D. & Vanmierlo, T., Oct 2019, In : Cells. 8, 10, 19 p., 1236.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Phosphodiesterase Type 4 Inhibition in CNS Diseases

Blokland, A., Heckman, P., Vanmierlo, T., Schreiber, R., Paes, D. & Prickaerts, J., Dec 2019, In : Trends in Pharmacological Sciences. 40, 12, p. 971-985 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease

Houben, T., dos Reis, I. M., Oligschlaeger, Y., Steinbusch, H., Gijbels, M. J. J., Hendrikx, T., Binder, C. J., Cassiman, D., Westerterp, M., Prickaerts, J. & Shiri-Sverdlov, R., 7 Jan 2019, In : Frontiers in Immunology. 9, p. 1-13 13 p., 3089.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment

Schepers, M., Tiane, A., Paes, D., Sanchez, S., Rombaut, B., Piccart, E., Rutten, B. P. F., Brone, B., Hellings, N., Prickaerts, J. & Vanmierlo, T., 24 Jul 2019, In : Frontiers in Immunology. 10, p. 1-17 17 p., 1727.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies

Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J. & Vingerhoets, C., 15 Dec 2019, In : Brain Research. 1725, 14 p., 146476.

Research output: Contribution to journalReview articleAcademicpeer-review

Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats

Nelissen, E., van Goethem, N. P., Bonassoli, V. T., Heckman, P. R. A., van Hagen, B. T. J., Suay, D., Wouters, C. & Prickaerts, J., 23 Apr 2019, In : Neuroscience Letters. 699, p. 41-46 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults

Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Smit, S., Tsai, M., Lahu, G., Uz, T., Blokland, A. & Prickaerts, J., 15 Mar 2018, In : Neuropharmacology. 131, p. 31-38 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial

Heckman, P. R. A., Van Duinen, M. A., Blokland, A., Uz, T., Prickaerts, J. & Sambeth, A., Jan 2018, In : Psychopharmacology. 235, 1, p. 301–308 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessing spatial pattern separation in rodents using the object pattern separation task

van Goethem, N. P., van Hagen, B. T. J. & Prickaerts, J., 1 Aug 2018, In : Nature Protocols. 13, 8, p. 1763-1792 30 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels

Vanmierlo, T., De Vry, J., Nelissen, E., Sierksma, A., Roumans, N., Steinbusch, H. W. M., Wennogle, L. P., van den Hove, D. & Prickaerts, J., 1 Apr 2018, In : Molecular and Cellular Neuroscience. 88, p. 292-299 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice

Foulquier, S., Namsolleck, P., Van Hagen, B. T., Milanova, I., Post, M. J., Blankesteijn, W. M., Rutten, B. P., Prickaerts, J., Van Oostenbrugge, R. J. & Unger, T., Oct 2018, In : Hypertension Research. 41, 10, p. 817-827 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Neuropsychofarmacologie in Translatie

Prickaerts, J., 16 Nov 2018

Research output: Book/ReportInaugural speechPopular

Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata

Heckman, P. R. A., Schweimer, J. V., Sharp, T., Prickaerts, J. & Blokland, A., Mar 2018, In : Brain Structure & Function. 223, 2, p. 739-748 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations

Heckman, P. R. A., Blokland, A., Bollen, E. P. P. & Prickaerts, J., Apr 2018, In : Neuroscience and Biobehavioral Reviews. 87, p. 233-254 22 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

Santiago, A., Soares, L. M., Schepers, M., Milani, H., Vanmierlo, T., Prickaerts, J. & de Oliveira, R. M., 1 Aug 2018, In : Neuropharmacology. 138, p. 360-370 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment

Borghans, L. G. J. M., Sambeth, A., Prickaerts, J., Ramaekers, J. G. & Blokland, A., Aug 2018, In : Psychopharmacology. 235, 8, p. 2407-2416 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The mediating role of phosphodiesterase type 4 in the dopaminergic modulation of motor impulsivity

Heckman, P. R. A., Blokland, A., Van Goethem, N. P., Van Hagen, B. T. J. & Prickaerts, J., 17 Sep 2018, In : Behavioural Brain Research. 350, p. 16-22 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Early-postnatal iron deficiency impacts plasticity in the dorsal and ventral hippocampus in piglets

Nelissen, E., De Vry, J., Antonides, A., Paes, D., Schepers, M., van der Staay, F. J., Prickaerts, J. & Vanmierlo, T., Jun 2017, In : International Journal of Developmental Neuroscience. 59, p. 47-51 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of riociguat and biperiden on memory

Borghans, L. G. J. M., Sambeth, A., Prickaerts, J. H. H. J., Ramaekers, J. G. & Blokland, A., Oct 2017, p. S645-S645.

Research output: Contribution to conferencePosterAcademic

From Age-Related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential Role for Phosphodiesterases

Heckman, P. R. A., Blokland, A. & Prickaerts, J., 2017, Phosphodiesterases: CNS Functions and Diseases. Zhang, H-T., Xu, Y. & O'Donnell, J. M. (eds.). Springer, p. 135-168 34 p. (Advances in Neurobiology, Vol. 17).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

From age-related cognitive decline to Alzheimer’s disease: a translational overview of the potential role for phosphodiesterases

Heckman, P., Blokland, A. & Prickaerts, J., 2017, Phosphodiesterases: CNS Functions and Diseases. . Zhang, H-T., Xu, Y. & O'Donnell, J. M. (eds.). Berlin: Springer Verlag, p. 217-221 4 p. (Advances in Neurobiology, Vol. 17).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease

Prickaerts, J., Heckman, P. R. A. & Blokland, A., 9 Aug 2017, In : Expert Opinion on Investigational Drugs. 26, 9, p. 1033-1048 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease

Ricciarelli, R., Brullo, C., Prickaerts, J., Arancio, O., Villa, C., Rebosio, C., Calcagno, E., Balbi, M., van Hagen, B. T. J., Argyrousi, E. K., Zhang, H., Pronzato, M. A., Bruno, O. & Fedele, E., 12 Apr 2017, In : Scientific Reports. 7, 14 p., 46320.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve

Prickaerts, J., Van Goethem, N. P., Gulisano, W., Argyrousi, E. K., Palmeri, A. & Puzzo, D., 15 Dec 2017, In : European Journal of Pharmacology. 817, p. 59-70 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The PDE4-inhibitor roflumilast improves memory: findings from a translational perspective

Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Tsai, M., Lahu, G., Uz, T., Blokland, A. & Prickaerts, J., Oct 2017, In : European Neuropsychopharmacology. 27, Suppl 4, p. S1024-S1025

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity

Soares, L. M., Meyer, E., Milani, H., Steinbusch, H. W. M., Prickaerts, J. & de Oliveira, R. M. W., Feb 2017, In : European Journal of Neuroscience. 45, 4, p. 510-520 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016
1 Citation (Scopus)

Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice

Sierksma, A. S. R., de Nijs, L., Hoogland, G., Vanmierlo, T., van Leeuwen, F. W., Rutten, B. P. F., Steinbusch, H. W. M., Prickaerts, J. & van den Hove, D. L. A., 2016, In : Journal of Alzheimer's Disease. 51, 3, p. 677-682

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Brullo, C., Ricciarelli, R., Prickaerts, J., Arancio, O., Massa, M., Rotolo, C., Romussi, A., Rebosio, C., Marengo, B., Pronzato, M. A., van Hagen, B. T. J., van Goethem, N. P., D'Ursi, P., Orro, A., Milanesi, L., Guariento, S., Cichero, E., Fossa, P., Fedele, E. & Bruno, O., 29 Nov 2016, In : European Journal of Medicinal Chemistry. 124, p. 82-102

Research output: Contribution to journalArticleAcademicpeer-review

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M. O., van Hoof, S. J., Groot, A. J., Habets, R., Prickaerts, J., Chalmers, A. J., Eekers, D. B. P., Theys, J., Short, S. C., Verhaegen, F. & Vooijs, M., 5 Jul 2016, In : Oncotarget. 7, 27, p. 41251-41264

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
143 Downloads (Pure)

Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications

Heckman, P. R. A., van Duinen, M. A., Bollen, E. P. P., Nishi, A., Wennogle, L. P., Blokland, A. & Prickaerts, J., Oct 2016, In : International Journal of Neuropsychopharmacology. 19, 10, 16 p., pyw030.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
138 Downloads (Pure)

Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach

Akkerman, S., Blokland, A. & Prickaerts, J., 1 Jan 2016, In : Learning & Memory. 23, 1, p. 29-37 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)

Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

Snyder, G. L., Prickaerts, J., Wadenberg, M-L., Zhang, L., Zheng, H., Yao, W., Akkerman, S., Zhu, H., Hendrick, J. P., Vanover, K. E., Davis, R., Li, P., Mates, S. & Wennogle, L. P., Sep 2016, In : Psychopharmacology. 233, 17, p. 3113-3124

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)

ROLIPRAM IMPROVES COGNITION, REDUCES ANXIETY- AND DESPAIR-LIKE BEHAVIORS AND IMPACTS HIPPOCAMPAL NEUROPLASTICITY AFTER TRANSIENT GLOBAL CEREBRAL ISCHEMIA

Soares, L. M., De Vry, J., Steinbusch, H. W. M., Milani, H., Prickaerts, J. & Weffort De Oliveira, R. M., 21 Jun 2016, In : Neuroscience. 326, p. 69-83

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

Vanmierlo, T., Creemers, P., Akkerman, S., van Duinen, M., Sambeth, A., De Vry, J., Uz, T., Blokland, A. & Prickaerts, J., 15 Apr 2016, In : Behavioural Brain Research. 303, p. 26-33 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment

de Bruin, N. M. W. J., van Loevezijn, A., Wicke, K. M., de Haan, M., Venhorst, J., Lange, J. H. M., de Groote, L., van der Neut, M. A. W., Prickaerts, J., Andriambeloson, E., Foley, A. G., van Drimmelen, M., van der Wetering, M. & Kruse, C. G., Sep 2016, In : Neurobiology of Learning and Memory. 133, p. 100-117

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice

De Vry, J., Vanmierlo, T., Martinez-Martinez, P., Losen, M., Temel, Y., Boere, J., Kenis, G., Steckler, T., Steinbusch, H. W. M., De Baets, M. & Prickaerts, J., 1 Jan 2016, In : Behavioural Brain Research. 296, p. 15-25

Research output: Contribution to journalArticleAcademicpeer-review

117 Downloads (Pure)

Why an M1 Antagonist Could Be a More Selective Model for Memory Impairment than Scopolamine

Blokland, A., Sambeth, A., Prickaerts, J. & Riedel, W. J., 30 Sep 2016, In : Frontiers in Neurology. 7, 4 p., 167.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2015
3 Citations (Scopus)

Changes in voiding behavior in a mouse model of Alzheimer's disease

Biallosterski, B. T., Prickaerts, J., Rahnama'i, M. S., de Wachter, S., van Koeveringe, G. A. & Meriaux, C., 25 Aug 2015, In : Frontiers in Aging Neuroscience. 7, 160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time

Bus, B. A. A., Molendijk, M. L., Tendolkar, I., Penninx, B. W. J. H., Prickaerts, J., Elzinga, B. M. & Voshaar, R. C. O., May 2015, In : Molecular Psychiatry. 20, 5, p. 602-608

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Continuous infusion of the alpha 7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study

van Goethem, N. P., Prickaerts, J., Welty, D., Flood, D. G. & Koenig, G., Jun 2015, In : Behavioural Pharmacology. 26, 4, p. 403-406

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Defeat stress in rodents: From behavior to molecules

Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J-P., Lesch, K-P., Daskalakis, N. P., Steinbusch, H. W. M., van Os, J., Kenis, G. & Rutten, B. P. F., Dec 2015, In : Neuroscience and Biobehavioral Reviews. 59, p. 111-40 30 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
6 Citations (Scopus)

Divergent effects of the 'biased' 5-HT1A receptor agonists F15599 and F13714 in a novel object pattern separation task

van Goethem, N. P., Schreiber, R., Newman-Tancredi, A., Varney, M. & Prickaerts, J., May 2015, In : British Journal of Pharmacology. 172, 10, p. 2532-2543

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms

Lim, L. W., Prickaerts, J., Huguet, G., Kadar, E., Hartung, H., Sharp, T. & Temel, Y., 31 Mar 2015, In : Translational Psychiatry. 5, e535.

Research output: Contribution to journalArticleAcademicpeer-review

Episodic memory and the medial temporal lobe: towards a unifying framework of recognition and recall

Berkers, R., van Goethem, N., Rutten, K., Blokland, A. & Prickaerts, J., 2015, Episodic Memory: Formation, Clinical Disorders and Role of Aging. . Edison, K. (ed.). New York: Nova Science Publishers, p. 85-134 49 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

6 Citations (Scopus)

Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors

Bollen, E., Akkerman, S., Puzzo, D., Gulisano, W., Palmeri, A., D'Hooge, R., Balschun, D., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J., 17 Apr 2015, In : Neuropharmacology. 95, p. 361-366

Research output: Contribution to journalArticleAcademicpeer-review