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Research Output 1999 2019

2019

A rare missense mutation in GJB3 (Cx31G45E) is associated with a unique cellular phenotype resulting in necrotic cell death

Easton, J. A., Albuloushi, A. K., Kamps, M. A. F., Brouns, G. H. M. R., Broers, J. L., Coull, B. J., Oji, V., van Geel, M., van Steensel, M. A. M. & Martin, P. E., Oct 2019, In : Experimental Dermatology. 28, 10, p. 1106-1113 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Assessment of fibroblast nuclear morphology aids interpretation of LMNA variants

van Tienen, F., Lindsey, P., Kamps, M., Krapels, I., Ramaekers, F., Brunner, H., van den Wijngaard, A. & Broers, J., Mar 2019, In : European Journal of Human Genetics. 27, 3, p. 389–399 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fluorescent labelling of membrane fatty acid transporter CD36 (SR-B2) in the extracellular loop

Liu, Y., Rodriguez-Calvo, R., Wang, S., Zhu, X., Broers, J. L. V., Glatz, J. F. C., Luiken, J. J. F. P. & Neumann, D., 23 Jan 2019, In : PLOS ONE. 14, 1, 14 p., 0210704.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

The 180 splice variant of NCAM-containing exon 18-is specifically expressed in small cell lung cancer cells

Vander Borght, A., Duysinx, M., Broers, J. L. V., Ummelen, M., Falkenberg, F. W., Hahnel, C. & van der Zeijst, B. A. M., 1 Jun 2018, In : Translational Lung Cancer Research. 7, 3, p. 376-388 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Cellular strain avoidance is mediated by a functional actin cap - observations in an Lmna-deficient cell model

Tamiello, C., Halder, M., Kamps, M. A. F., Baaijens, F. P. T., Broers, J. L. V. & Bouten, C. V. C., 15 Feb 2017, In : Journal of Cell Science. 130, 4, p. 779-790 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Lamin A/C-Related Cardiac Disease Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation

Hoorntje, E. T., Bollen, I. A., Barge-Schaapveld, D. Q., van Tienen, F. H., te Meerman, G. J., Jansweijer, J. A., van Essen, A. J., Volders, P. G., Constantinescu, A. A., van den Akker, P. C., van Spaendonck-Zwarts, K. Y., Oldenburg, R. A., Marcelis, C. L., van der Smagt, J. J., Hennekam, E. A., Vink, A., Bootsma, M., Aten, E., Wilde, A. A., van den Wijngaard, A. & 5 others, Broers, J. L., Jongbloed, J. D., van der Velden, J., van den Berg, M. P. & van Tintelen, J. P., Aug 2017, In : Circulation : Cardiovascular Genetics. 10, 4, 36 p., 001631.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts

van Loosdregt, I. A. E. W., Kamps, M. A. F., Oomens, C. W. J., Loerakker, S., Broers, J. L. V. & Bouten, C. V. C., 1 Aug 2017, In : Integrative Biology. 9, 8, p. 709-721 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
4 Citations (Scopus)

Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments

Tamiello, C., Buskermolen, A. B. C., Baaijens, F. P. T., Broers, J. L. V. & Bouten, C. V. C., Mar 2016, In : Cellular and Molecular Bioengineering. 9, 1, p. 12-37

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
7 Citations (Scopus)

Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

Sieprath, T., Corne, T. D. J., Nooteboom, M., Grootaert, C., Rajkovic, A., Buysschaert, B., Robijns, J., Broers, J. L. V., Ramaekers, F. C. S., Koopman, W. J. H., Willems, P. H. G. M. & De Vos, W. H., 2015, In : Nucleus-austin. 6, 3, p. 236-246

Research output: Contribution to journalArticleAcademicpeer-review

2014

The role of the nuclear lamina in cancer and apoptosis

Broers, J. & Ramaekers, F., 2014, Cancer Biology and the nuclear envelope. Advances in experimental medicine and biology .

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2013
33 Citations (Scopus)

Birt-Hogg-Dube syndrome is a novel ciliopathy

Luijten, M. N. H., Basten, S. G., Claessens, T., Vernooij, M., Scott, C. L., Janssen, R., Easton, J. A., Kamps, M. A. F., Vreeburg, M., Broers, J. L. V., van Geel, M., Menko, F. H., Harbottle, R. P., Nookala, R. K., Tee, A. R., Land, S. C., Giles, R. H., Coull, B. J. & van Steensel, M. A. M., 1 Nov 2013, In : Human Molecular Genetics. 22, 21, p. 4383-4397

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Cytoplasmic localization of PML particles in laminopathies

Houben, F., De Vos, W. H., Krapels, I. P. C., Coorens, M., Kierkels, G. J. J., Kamps, M. A. F., Verstraeten, V. L. R. M., Marcelis, C. L. M., van den Wijngaard, A., Ramaekers, F. C. S. & Broers, J. L. V., Jan 2013, In : Histochemistry and Cell Biology. 139, 1, p. 119-134

Research output: Contribution to journalArticleAcademicpeer-review

2012

Overexpression of Vesicle-associated Membrane Protein (VAMP) 3, but Not VAMP2, Protects Glucose Transporter (GLUT) 4 Protein Translocation in an in Vitro Model of Cardiac Insulin Resistance

Schwenk, R. W., Angin, Y., Steinbusch, L. K. M., Dirkx, E., Hoebers, N., Coumans, W. A., Bonen, A., Broers, J. L. V., van Eys, G. J. J. M., Glatz, J. F. C. & Luiken, J. J. F. P., 26 Oct 2012, In : Journal of Biological Chemistry. 287, 44, p. 37530-37539

Research output: Contribution to journalArticleAcademicpeer-review

2011

Multiplexed profiling of secreted proteins for the detection of potential space biomarkers

Dieriks, B., De Vos, W. H., Moreels, M., Ghardi, M., Hennekam, R. C., Broers, J. L. V., Baatout, S. & Van Oostveldt, P., 2011, In : Molecular Medicine Reports. 4, 1, p. 17-23

Research output: Contribution to journalArticleAcademicpeer-review

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

De Vos, W. H., Houben, F., Kamps, M., Malhas, A., Verheyen, F., Cox, J., Manders, E. M. M., Verstraeten, V. L. R. M., van Steensel, M. A. M., Marcelis, C. L. M., van den Wijngaard, A., Vaux, D. J., Ramaekers, F. C. S. & Broers, J. L. V., 1 Nov 2011, In : Human Molecular Genetics. 20, 21, p. 4175-4186

Research output: Contribution to journalArticleAcademicpeer-review

2010

Electrical signals affect the cardiomyocyte transcriptome independently of contraction

Martherus, R. S. R. M., Vanherle, S. J. V., Timmer, E. D. J., Zeijlemaker, V. A., Broers, J. L., Smeets, H. J. T., Geraedts, J. P. & Ayoubi, T. A. Y., Nov 2010, In : Physiological genomics. 42A, 4, p. 283-289

Research output: Contribution to journalArticleAcademicpeer-review

Increased plasticity of the nuclear envelope and hypermobility of telomeres due to the loss of A-type lamins

De Vos, W. H., Houben, F., Hoebe, R. A., Hennekam, R. C., van Engelen, B. G. M., Manders, E. M. M., Ramaekers, F. C. S., Broers, J. L. V. & Van Oostveldt, P., Apr 2010, In : Biochimica et Biophysica Acta-general Subjects. 1800, 4, p. 448-458

Research output: Contribution to journalArticleAcademicpeer-review

2006

Keratin.

Randell, S. H., Broers, J. L. V. & Ramaekers, F. C. S., 1 Jan 2006, Encyclopedia of Respiratory Medicine. Laurent GJ, Shapiro SD (Eds).. Laurent, G. J. & Shapiro, S. D. (eds.). Oxford: Elsevier, p. 493-497

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2005
88 Citations (Scopus)
98 Downloads (Pure)

A-type lamins are essential for TGF-beta1 induced PP2A to dephosphorylate transcription factors.

Van Berlo, J. H., Voncken, M. J. W. M., Kubben, N., Broers, J. L. V., Duisters, R. F. J. J., van Leeuwen, R. E., Crijns, H. J. G. M., Ramaekers, F. C. S., Hutchison, C. J. & Pinto, Y. M., 1 Jan 2005, In : Human Molecular Genetics. 14, 19, p. 2839-2849

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
60 Citations (Scopus)
209 Downloads (Pure)

Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization.

Broers, J. L. V., Kuijpers, H. J. H., Ostlund, C., Worman, H. J., Endert, J. M. & Ramaekers, F. C. S., 1 Jan 2005, In : Experimental Cell Research. 304, p. 582-592

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2002
58 Citations (Scopus)
142 Downloads (Pure)

Discrimination of DNA and RNA in cells by a vital fluorescent probe: Lifetime imaging of SYTO13 in healthy and apoptotic cells.

van Zandvoort, M. A. M. J., de Grauw, C. J. ., Gerritsen, H. C., Broers, J. L. V., Oude Egbrink, M. G. A., Ramaekers, F. C. S. & Slaaf, D. W., 1 Jan 2002, In : Cytometry. 47, p. 226-235

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
21 Citations (Scopus)

Glutathione oxidation in calcium- and p38 MAPK-dependent membrane blebbing of endothelial cells

van Gorp Beisser, R. M. A., Heeneman, S., Broers, J. L. V., Bronnenberg, N. M. H. J., Mieras-van Dam, M. C. E. & Heemskerk, J. W. M., 1 Jan 2002, In : Biochimica et Biophysica Acta. 19, 1591 (1-3), p. 129-138 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
129 Downloads (Pure)

Quantification of cytoskeletal deformation in living cells based on hierarchical feature vector matching.

Delhaas, T., van Engeland, S., Broers, J. L. V., Bouten, C., Kuijpers, N., Ramaekers, F. C. S. & Snoeckx, L. H. E. M., 1 Jan 2002, In : American Journal of Physiology-Cell Physiology. 283, p. C639-C645

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2001
146 Citations (Scopus)
96 Downloads (Pure)

Both emerin and lamin C depend on lamin A for localization at the nuclear envelope.

Vaughan, O. A., Alvarez-Reyes, M., Bridger, J. M., Broers, J. L. V., Ramaekers, F. C. S., Wehnert, M., Morris, G. E., Whitfield, W. G. F. & Hutchison, C. J., 1 Jan 2001, In : Journal of Cell Science. 114, p. 2577-2590

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1999
35 Citations (Scopus)

Peroxide-induced membrane blebbing in endothelial cells associated with glutathione oxidation but not apoptosis.

van Gorp Beisser, R. M. A., Broers, J. L. V., Reutelingsperger, C. P. M., Bronnenberg, N. M. H. J., Hornstra, G., Mieras-van Dam, M. C. E. & Heemskerk, J. W. M., 1 Jan 1999, In : American Journal of Physiology (Consolidated). 277, 1 Pt 1, p. C20-C28 9 p.

Research output: Contribution to journalArticleAcademicpeer-review