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2019

AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism

Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M. & Schroen, B., 1 Mar 2019, In : Molecular Therapy - Nucleic Acids. 14, p. 424-437 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Augmentation index is not a proxy for wave reflection magnitude: mechanistic analysis using a computational model

Heusinkveld, M. H. G., Delhaas, ET., Lumens, J., Huberts, W., Spronck, B., Hughes, A. D. & Reesink, K. D., Aug 2019, In : Journal of Applied Physiology. 127, 2, p. 491-500 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impact of abrupt versus gradual correction of mitral and tricuspid regurgitation: a modelling study

Walmsley, J., Squara, P., Wolfhard, U., Cornelussen, R. & Lumens, J., Nov 2019, In : Eurointervention. 15, 10, p. 902-911 24 p.

Research output: Contribution to journalArticleAcademicpeer-review

Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction

Heusinkveld, M. H. G., Huberts, W., Lumens, J., Arts, T., Delhaas, T. & Reesink, K. D., Jul 2019, In : PLoS Computational Biology. 15, 7, 21 p., 1007173.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update

Noordegraaf, A. V., Chin, K. M., Haddad, F., Hassoun, P. M., Hemnes, A. R., Hopkins, S. R., Kawut, S. M., Langleben, D., Lumens, J. & Naeije, R., 1 Jan 2019, In : European Respiratory Journal. 53, 1, 13 p., 1801900.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Relative Impact of Right Ventricular Electromechanical Dyssynchrony Versus Pulmonary Regurgitation on Right Ventricular Dysfunction and Exercise Intolerance in Patients After Repair of Tetralogy of Fallot

Lumens, J., Fan, C-P. S., Walmsley, J., Yim, D., Manlhiot, C., Dragulescu, A., Grosse-Wortmann, L., Mertens, L., Prinzen, F. W., Delhaas, T. & Friedberg, M. K., 22 Jan 2019, In : Journal of the American Heart Association. 8, 2, 27 p., 010903.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systolic Stretch Characterizes the Electromechanical Substrate Responsive to Cardiac Resynchronization Therapy

Gorcsan, J., Anderson, C. P., Tayal, B., Sugahara, M., Walmsley, J., Starling, R. C. & Lumens, J., Sep 2019, In : JACC-Cardiovascular Imaging. 12, 9, p. 1741-1752 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Left and Right Ventricles Respond Differently to Variation of Pacing Delays in Cardiac Resynchronization Therapy: A Combined Experimental- Computational Approach

Willemen, E., Schreurs, R., Huntjens, P. R., Strik, M., Plank, G., Vigmond, E., Walmsley, J., Vernooy, K., Delhaas, T., Prinzen, F. W. & Lumens, J., 1 Feb 2019, In : Frontiers in physiology. 10, p. 1-13 13 p., 17.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Prognostic Value of Right Ventricular Deformation Imaging in Early Arrhythmogenic Right Ventricular Cardiomyopathy

Mast, T. P., Taha, K., Cramer, M. J., Lumens, J., van der Heijden, J. F., Bouma, B. J., van den Berg, M. P., Asselbergs, F. W., Doevendans, P. A. & Teske, A. J., Mar 2019, In : JACC-Cardiovascular Imaging. 12, 3, p. 446-455 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Electrical Substrates Driving Response to Cardiac Resynchronization Therapy: A Combined Clinical–Computational Evaluation

Huntjens, P. R., Ploux, S., Strik, M., Walmsley, J., Ritter, P., Haissaguerre, M., Prinzen, F. W., Delhaas, T., Lumens, J. & Bordachar, P., 1 Apr 2018, In : Circulation-Arrhythmia and Electrophysiology. 11, 4, 12 p., e005647.

Research output: Contribution to journalArticleAcademicpeer-review

High tension in sarcomeres hinders myocardial relaxation: A computational study

Dupuis, L. J., Lumens, J., Arts, T. & Delhaas, T., 4 Oct 2018, In : PLOS ONE. 13, 10, 13 p., e0204642.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Innovation in cardiovascular disease in Europe with focus on arrhythmias: current status, opportunities, roadblocks, and the role of multiple stakeholders

Prinzen, F. W., Dagres, N., Bollmann, A., Arnar, D. O., Bove, S., Camm, J., Casadei, B., Kirchhof, P., Kuck, K-H., Lumens, J., Michel, M. C., Schwartz, P. J., Van Vleymen, B., Vardas, P. & Hindricks, G., 1 May 2018, In : EP Europace. 20, 5, p. 733-738 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Linking cross-bridge cycling kinetics to response to cardiac resynchronization therapy: a multiscale modelling study

Dupuis, L. J., Arts, T., Prinzen, F. W., Delhaas, T. & Lumens, J., Nov 2018, In : EP Europace. 20, p. 87-93 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Uniqueness of local myocardial strain patterns with respect to activation time and contractility of the failing heart: a computational study

Kirn, B., Walmsley, J. & Lumens, J., 5 Dec 2018, In : Biomedical Engineering Online. 17, 18 p., 182.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function

Jones, S., Lumens, J., Sohaib, S. M. A., Finegold, J. A., Kanagaratnam, P., Tanner, M., Duncan, E., Moore, P., Leyva, F., Frenneaux, M., Mason, M., Hughes, A. D., Francis, D. P., Whinnett, Z. I. & BRAVO Investigators, Jul 2017, In : EP Europace. 19, 7, p. 1178-1186 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Distinctive Left Ventricular Activations Associated With ECG Pattern in Heart Failure Patients

Derval, N., Duchateau, J., Mahida, S., Eschalier, R., Sacher, F., Lumens, J., Cochet, H., Denis, A., Pillois, X., Yamashita, S., Komatsu, Y., Ploux, S., Amraoui, S., Zemmoura, A., Ritter, P., Hocini, M., Haissaguerre, M., Jais, P. & Bordachar, P., Jun 2017, In : Circulation-Arrhythmia and Electrophysiology. 10, 6, 10 p., e005073.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Echocardiographic Prediction of Cardiac Resynchronization Therapy Response Requires Analysis of Both Mechanical Dyssynchrony and Right Ventricular Function: A Combined Analysis of Patient Data and Computer Simulations

van Everdingen, W. M., Walmsley, J., Cramer, M. J., van Hagen, I., De Boeck, B. W. L., Meine, M., Delhaas, T., Doevendans, P. A., Prinzen, F. W., Lumens, J. & Leenders, G. E., Oct 2017, In : Journal of the American Society of Echocardiography. 30, 10, p. 1012-1020 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary Right Ventricular Resynchronization in Congenital Heart Disease Acute Improvement in Right Ventricular Mechanics and Contraction Efficiency

Janousek, J., Kovanda, J., Lozek, M., Tomek, V., Vojtovic, P., Gebauer, R., Kubus, P., Krejcir, M., Lumens, J., Delhaas, T. & Prinzen, F., Sep 2017, In : Circulation-Cardiovascular Imaging. 10, 9, 10 p., 006424.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model

Palau-Caballero, G., Walmsley, J., Van Empel, V., Lumens, J. & Delhaas, T., Apr 2017, In : American Journal of Physiology-heart and Circulatory Physiology. 312, 4, p. H691-H700 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Abnormal Ventricular and Aortic Wall Properties Can Cause Inconsistencies in Grading Aortic Regurgitation Severity: A Computer Simulation Study

Palau-Caballero, G., Walmsley, J., Gorcsan, J. III., Lumens, J. & Delhaas, T., Nov 2016, In : Journal of the American Society of Echocardiography. 29, 11, p. 1122-1130.e4

Research output: Contribution to journalArticleAcademicpeer-review

Mechano-chemical Interactions in Cardiac Sarcomere Contraction: A Computational Modeling Study

Dupuis, L. J., Lumens, J., Arts, T. & Delhaas, T., Oct 2016, In : PLoS Computational Biology. 12, 10

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

New insights from a computational model on the relation between pacing site and CRT response

Pluijmert, M., Bovendeerd, P. H. M., Lumens, J., Vernooy, K., Prinzen, F. & Delhaas, T., Dec 2016, In : EP Europace. 18, Suppl_4, p. iv94–iv103 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Right Ventricular Imaging and Computer Simulation for Electromechanical Substrate Characterization in Arrhythmogenic Right Ventricular Cardiomyopathy

Mast, T. P., Teske, A. J., Walmsley, J., van der Heijden, J. F., van Es, R., Prinzen, F. W., Delhaas, T., van Veen, T. A., Loh, P., Doevendans, P. A., Cramer, M. J. & Lumens, J., 15 Nov 2016, In : Journal of the American College of Cardiology. 68, 20, p. 2185-2197

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Septal flash and septal rebound stretch have different underlying mechanisms

Walmsley, J., Huntjens, P. R., Prinzen, F. W., Delhaas, T. & Lumens, J., 1 Feb 2016, In : American Journal of Physiology-heart and Circulatory Physiology. 310, 3, p. H394-H403

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
2015

Better understanding before implanting

Lumens, J. & Vernooy, K., 1 Apr 2015, In : International Journal of Cardiology. 184, p. 6-8

Research output: Contribution to journalArticleAcademicpeer-review

Computer modelling for better diagnosis and therapy of patients by cardiac resynchronisation therapy

Pluijmert, M., Lumens, J., Potse, M., Delhaas, T., Auricchio, A. & Prinzen, F. W., 2015, In : Arrhythmia & Electrophysiology Review. 4, 1, p. 62-67 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Detailed analysis of ventricular activation sequences during right ventricular apical pacing and left bundle branch block and the potential implications for cardiac resynchronization therapy

Eschalier, R., Ploux, S., Lumens, J., Whinnett, Z., Varma, N., Meillet, V., Ritter, P., Jais, P., Haissaguerre, M. & Bordachar, P., Jan 2015, In : Heart Rhythm. 12, 1, p. 137-143

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Differentiating Electromechanical From Non-Electrical Substrates of Mechanical Discoordination to Identify Responders to Cardiac Resynchronization Therapy

Lumens, J., Tayal, B., Walmsley, J., Delgado-Montero, A., Huntjens, P. R., Schwartzman, D., Althouse, A. D., Delhaas, T., Prinzen, F. W. & Gorcsan, J., Sep 2015, In : Circulation-Cardiovascular Imaging. 8, 9, e003744.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Electrical dyssynchrony induced by biventricular pacing: Implications for patient selection and therapy improvement

Ploux, S., Eschalier, R., Whinnett, Z. I., Lumens, J., Derval, N., Sacher, F., Hocini, M., Jais, P., Dubois, R., Ritter, P., Haissaguerre, M., Wilkoff, B. L., Francis, D. P. & Bordachar, P., Apr 2015, In : Heart Rhythm. 12, 4, p. 782-791

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module

Walmsley, J., Arts, T., Derval, N., Bordachar, P., Cochet, H., Ploux, S., Prinzen, F. W., Delhaas, T. & Lumens, J., Jul 2015, In : PLoS Computational Biology. 11, 7, e1004284.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

In vivo electromechanical assessment of heart failure patients with prolonged QRS duration

Kroon, W., Lumens, J., Potse, M., Suerder, D., Klersy, C., Regoli, F., Murzilli, R., Moccetti, T., Delhaas, T., Krause, R., Prinzen, F. W. & Auricchio, A., Jun 2015, In : Heart Rhythm. 12, 6, p. 1259-1267

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Longitudinal Strain "Think Globally, Track Locally"

Lumens, J., Prinzen, F. W. & Delhaas, T., Dec 2015, In : JACC-Cardiovascular Imaging. 8, 12, p. 1360-1363

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
2014

Creating your own virtual patient with CircAdapt Simulator

Lumens, J., Feb 2014, In : European Heart Journal. 35, 6, p. 335-337

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Influence of left ventricular lead position relative to scar location on response to cardiac resynchronization therapy: a model study

Huntjens, P. R., Walmsley, J., Ploux, S., Bordachar, P., Prinzen, F. W., Delhaas, T. & Lumens, J., Nov 2014, In : EP Europace. 16 Suppl 4, p. iv62-iv68

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Mechano-electrical coupling as framework for understanding functional remodeling during LBBB and CRT

Kuijpers, N. H. L., Hermeling, E., Lumens, J., ten Eikelder, H. M. M., Delhaas, T. & Prinzen, F. W., 15 Jun 2014, In : American Journal of Physiology-heart and Circulatory Physiology. 306, 12, p. H1644-H1659

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Optimal Strategies on Avoiding CRT Nonresponse

Bordachar, P., Eschalier, R., Lumens, J. & Ploux, S., May 2014, In : Current treatment options in cardiovascular medicine. 16, 5, 299.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Acute hemodynamic benefits of biventricular and single-site systemic ventricular pacing in patients with a systemic right ventricle

van Geldorp, I. E., Bordachar, P., Lumens, J., de Guillebon, M., Whinnett, Z. I., Prinzen, F. W., Haissaguerre, M., Delhaas, T. & Thambo, J-B., May 2013, In : Heart Rhythm. 10, 5, p. 676-682

Research output: Contribution to journalArticleAcademicpeer-review

Comparative Electromechanical and Hemodynamic Effects of Left Ventricular and Biventricular Pacing in Dyssynchronous Heart Failure Electrical Resynchronization Versus Left-Right Ventricular Interaction

Lumens, J., Ploux, S., Strik, M., Gorcsan, J. III., Cochet, H., Derval, N., Strom, M., Ramanathan, C., Ritter, P., Haissaguerre, M., Jais, P., Arts, T., Delhaas, T., Prinzen, F. W. & Bordachar, P., 24 Dec 2013, In : Journal of the American College of Cardiology. 62, 25, p. 2395-2403

Research output: Contribution to journalArticleAcademicpeer-review

Noninvasive Electrocardiographic Mapping to Improve Patient Selection for Cardiac Resynchronization Therapy Beyond QRS Duration and Left Bundle Branch Block Morphology

Ploux, S., Lumens, J., Whinnett, Z., Montaudon, M., Strom, M., Ramanathan, C., Derval, N., Zemmoura, A., Denis, A., De Guillebon, M., Shah, A., Hocini, M., Jais, P., Ritter, P., Haissaguerre, M., Wilkoff, B. L. & Bordachar, P., 18 Jun 2013, In : Journal of the American College of Cardiology. 61, 24, p. 2435-2443

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

Pre- and Intra-Procedural Predictors of Reverse Remodeling After Cardiac Resynchronization Therapy: An MRI Study

Cochet, H., Denis, A., Ploux, S., Lumens, J., Amraoui, S., Derval, N., Sacher, F., Reant, P., Lafitte, S., Jais, P., Laurent, F., Ritter, P., Montaudon, M. & Bordachar, P., Jun 2013, In : Journal of Cardiovascular Electrophysiology. 24, 6, p. 682-691

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology

Vonk-Noordegraaf, A., Haddad, F., Chin, K. M., Forfia, P. R., Kawut, S. M., Lumens, J., Naeije, R., Newman, J., Oudiz, R. J., Provencher, S., Torbicki, A., Voelkel, N. F. & Hassoun, P. M., 24 Dec 2013, In : Journal of the American College of Cardiology. 62, 25 Suppl, p. D22-33

Research output: Contribution to journalArticleAcademicpeer-review

2012

Acute hemodynamic response to biventricular pacing in heart failure patients with narrow, moderately, and severely prolonged QRS duration

Ploux, S., Whinnett, Z., Lumens, J., Denis, A., Zemmoura, A., De Guillebon, M., Ramoul, K., Ritter, P., Jais, P., Clementy, J., Haissaguerre, M. & Bordachar, P., Aug 2012, In : Heart Rhythm. 9, 8, p. 1247-1250

Research output: Contribution to journalArticleAcademicpeer-review

Atrial septostomy benefits severe pulmonary hypertension patients by increase of left ventricular preload reserve

Koeken, Y., Kuijpers, N. H. L., Lumens, J., Arts, T. & Delhaas, T., Jun 2012, In : American Journal of Physiology-heart and Circulatory Physiology. 302, 12, p. H2654-H2662

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)
5 Citations (Scopus)

Control of Whole Heart Geometry by Intramyocardial Mechano-Feedback: A Model Study

Arts, T., Lumens, J., Kroon, W. & Delhaas, T., Feb 2012, In : PLoS Computational Biology. 8, 2

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Early-diastolic left ventricular lengthening implies pulmonary hypertension-induced right ventricular decompensation

Lumens, J., Arts, T., Marcus, J. T., Vonk-Noordegraaf, A. & Delhaas, T., 1 Nov 2012, In : Cardiovascular Research. 96, 2, p. 286-295

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Mechanistic Evaluation of Echocardiographic Dyssynchrony Indices Patient Data Combined With Multiscale Computer Simulations

Lumens, J., Leenders, G. E., Cramer, M. J., De Boeck, B. W. L., Doevendans, P. A., Prinzen, F. W. & Delhaas, T., Jul 2012, In : Circulation-Cardiovascular Imaging. 5, 4, p. 491-499

Research output: Contribution to journalArticleAcademicpeer-review

Septal Deformation Patterns Delineate Mechanical Dyssynchrony and Regional Differences in Contractility Analysis of Patient Data Using a Computer Model

Leenders, G. E., Lumens, J., Cramer, M. J., De Boeck, B. W. L., Doevendans, P. A., Delhaas, T. & Prinzen, F. W., Jan 2012, In : Circulation-Heart Failure. 5, 1, p. 87-96

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)