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Research Output

2019

AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism

Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M. & Schroen, B., 1 Mar 2019, In : Molecular Therapy - Nucleic Acids. 14, p. 424-437 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Augmentation index is not a proxy for wave reflection magnitude: mechanistic analysis using a computational model

Heusinkveld, M. H. G., Delhaas, ET., Lumens, J., Huberts, W., Spronck, B., Hughes, A. D. & Reesink, K. D., Aug 2019, In : Journal of Applied Physiology. 127, 2, p. 491-500 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Computational models in cardiology

Niederer, S. A., Lumens, J. & Trayanova, N. A., Feb 2019, In : Nature Reviews Cardiology. 16, 2, p. 100-111 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Impact of abrupt versus gradual correction of mitral and tricuspid regurgitation: a modelling study

Walmsley, J., Squara, P., Wolfhard, U., Cornelussen, R. & Lumens, J., Nov 2019, In : Eurointervention. 15, 10, p. 902-911 24 p.

Research output: Contribution to journalArticleAcademicpeer-review

Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction

Heusinkveld, M. H. G., Huberts, W., Lumens, J., Arts, T., Delhaas, T. & Reesink, K. D., Jul 2019, In : PLoS Computational Biology. 15, 7, 21 p., 1007173.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

LBBB and High Afterload A Dangerous Liaison?

Prinzen, F. W., Willemen, E. & Lumens, J., Jun 2019, In : JACC-Cardiovascular Imaging. 12, 6, p. 978-980 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Opposing Wall Pushing and Stretching: Response to Cardiac Resynchronization Therapy Requires Electrical Delay and Viability

Gorcsan, J. & Lumens, J., Dec 2019, In : JACC-Cardiovascular Imaging. 12, 12, p. 2414-2416 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update

Noordegraaf, A. V., Chin, K. M., Haddad, F., Hassoun, P. M., Hemnes, A. R., Hopkins, S. R., Kawut, S. M., Langleben, D., Lumens, J. & Naeije, R., 1 Jan 2019, In : European Respiratory Journal. 53, 1, 13 p., 1801900.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Relative Impact of Right Ventricular Electromechanical Dyssynchrony Versus Pulmonary Regurgitation on Right Ventricular Dysfunction and Exercise Intolerance in Patients After Repair of Tetralogy of Fallot

Lumens, J., Fan, C-P. S., Walmsley, J., Yim, D., Manlhiot, C., Dragulescu, A., Grosse-Wortmann, L., Mertens, L., Prinzen, F. W., Delhaas, T. & Friedberg, M. K., 22 Jan 2019, In : Journal of the American Heart Association. 8, 2, 27 p., 010903.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systolic Stretch Characterizes the Electromechanical Substrate Responsive to Cardiac Resynchronization Therapy

Gorcsan, J., Anderson, C. P., Tayal, B., Sugahara, M., Walmsley, J., Starling, R. C. & Lumens, J., Sep 2019, In : JACC-Cardiovascular Imaging. 12, 9, p. 1741-1752 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Left and Right Ventricles Respond Differently to Variation of Pacing Delays in Cardiac Resynchronization Therapy: A Combined Experimental- Computational Approach

Willemen, E., Schreurs, R., Huntjens, P. R., Strik, M., Plank, G., Vigmond, E., Walmsley, J., Vernooy, K., Delhaas, T., Prinzen, F. W. & Lumens, J., 1 Feb 2019, In : Frontiers in physiology. 10, p. 1-13 13 p., 17.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Prognostic Value of Right Ventricular Deformation Imaging in Early Arrhythmogenic Right Ventricular Cardiomyopathy

Mast, T. P., Taha, K., Cramer, M. J., Lumens, J., van der Heijden, J. F., Bouma, B. J., van den Berg, M. P., Asselbergs, F. W., Doevendans, P. A. & Teske, A. J., Mar 2019, In : JACC-Cardiovascular Imaging. 12, 3, p. 446-455 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Clinical Applications of Patient-Specific Models: The Case for a Simple Approach

Holmes, J. W. & Lumens, J., 1 Apr 2018, In : Journal of Cardiovascular Translational Research. 11, 2, p. 71-79 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Electrical Substrates Driving Response to Cardiac Resynchronization Therapy: A Combined Clinical–Computational Evaluation

Huntjens, P. R., Ploux, S., Strik, M., Walmsley, J., Ritter, P., Haissaguerre, M., Prinzen, F. W., Delhaas, T., Lumens, J. & Bordachar, P., 1 Apr 2018, In : Circulation-Arrhythmia and Electrophysiology. 11, 4, 12 p., e005647.

Research output: Contribution to journalArticleAcademicpeer-review

Heart Failure With Recovered Ejection Fraction

Merken, J., Brunner-La Rocca, H-P., Weerts, J., Verdonschot, J., Hazebroek, M., Schummers, G., Schreckenberg, M., Lumens, J., Heymans, S. & Knackstedt, C., 25 Sep 2018, In : Journal of the American College of Cardiology. 72, 13, p. 1556-1557 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

High tension in sarcomeres hinders myocardial relaxation: A computational study

Dupuis, L. J., Lumens, J., Arts, T. & Delhaas, T., 4 Oct 2018, In : PLOS ONE. 13, 10, 13 p., e0204642.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Innovation in cardiovascular disease in Europe with focus on arrhythmias: current status, opportunities, roadblocks, and the role of multiple stakeholders

Prinzen, F. W., Dagres, N., Bollmann, A., Arnar, D. O., Bove, S., Camm, J., Casadei, B., Kirchhof, P., Kuck, K-H., Lumens, J., Michel, M. C., Schwartz, P. J., Van Vleymen, B., Vardas, P. & Hindricks, G., 1 May 2018, In : EP Europace. 20, 5, p. 733-738 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Linking cross-bridge cycling kinetics to response to cardiac resynchronization therapy: a multiscale modelling study

Dupuis, L. J., Arts, T., Prinzen, F. W., Delhaas, T. & Lumens, J., Nov 2018, In : EP Europace. 20, p. 87-93 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Uniqueness of local myocardial strain patterns with respect to activation time and contractility of the failing heart: a computational study

Kirn, B., Walmsley, J. & Lumens, J., 5 Dec 2018, In : Biomedical Engineering Online. 17, 18 p., 182.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function

Jones, S., Lumens, J., Sohaib, S. M. A., Finegold, J. A., Kanagaratnam, P., Tanner, M., Duncan, E., Moore, P., Leyva, F., Frenneaux, M., Mason, M., Hughes, A. D., Francis, D. P., Whinnett, Z. I. & BRAVO Investigators, Jul 2017, In : EP Europace. 19, 7, p. 1178-1186 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Combining computer modelling and cardiac imaging to understand right ventricular pump function

Walmsley, J., van Everdingen, W., Cramer, M. J., Prinzen, F. W., Delhaas, T. & Lumens, J., 1 Oct 2017, In : Cardiovascular Research. 113, 12, p. 1486-1498 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Distinctive Left Ventricular Activations Associated With ECG Pattern in Heart Failure Patients

Derval, N., Duchateau, J., Mahida, S., Eschalier, R., Sacher, F., Lumens, J., Cochet, H., Denis, A., Pillois, X., Yamashita, S., Komatsu, Y., Ploux, S., Amraoui, S., Zemmoura, A., Ritter, P., Hocini, M., Haissaguerre, M., Jais, P. & Bordachar, P., Jun 2017, In : Circulation-Arrhythmia and Electrophysiology. 10, 6, 10 p., e005073.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Echocardiographic Prediction of Cardiac Resynchronization Therapy Response Requires Analysis of Both Mechanical Dyssynchrony and Right Ventricular Function: A Combined Analysis of Patient Data and Computer Simulations

van Everdingen, W. M., Walmsley, J., Cramer, M. J., van Hagen, I., De Boeck, B. W. L., Meine, M., Delhaas, T., Doevendans, P. A., Prinzen, F. W., Lumens, J. & Leenders, G. E., Oct 2017, In : Journal of the American Society of Echocardiography. 30, 10, p. 1012-1020 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary Right Ventricular Resynchronization in Congenital Heart Disease Acute Improvement in Right Ventricular Mechanics and Contraction Efficiency

Janousek, J., Kovanda, J., Lozek, M., Tomek, V., Vojtovic, P., Gebauer, R., Kubus, P., Krejcir, M., Lumens, J., Delhaas, T. & Prinzen, F., Sep 2017, In : Circulation-Cardiovascular Imaging. 10, 9, 10 p., 006424.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Rocking and Flashing With RV Pacing Implications for Resynchronization Therapy

Gorcsan, J. & Lumens, J., Oct 2017, In : JACC-Cardiovascular Imaging. 10, 10, p. 1100-1102 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model

Palau-Caballero, G., Walmsley, J., Van Empel, V., Lumens, J. & Delhaas, T., Apr 2017, In : American Journal of Physiology-heart and Circulatory Physiology. 312, 4, p. H691-H700 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Abnormal Ventricular and Aortic Wall Properties Can Cause Inconsistencies in Grading Aortic Regurgitation Severity: A Computer Simulation Study

Palau-Caballero, G., Walmsley, J., Gorcsan, J. III., Lumens, J. & Delhaas, T., Nov 2016, In : Journal of the American Society of Echocardiography. 29, 11, p. 1122-1130.e4

Research output: Contribution to journalArticleAcademicpeer-review

Mechano-chemical Interactions in Cardiac Sarcomere Contraction: A Computational Modeling Study

Dupuis, L. J., Lumens, J., Arts, T. & Delhaas, T., Oct 2016, In : PLoS Computational Biology. 12, 10

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

New insights from a computational model on the relation between pacing site and CRT response

Pluijmert, M., Bovendeerd, P. H. M., Lumens, J., Vernooy, K., Prinzen, F. & Delhaas, T., Dec 2016, In : EP Europace. 18, Suppl_4, p. iv94–iv103 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Physiology of Cardiac Pacing and Resynchronization

Prinzen, F., Vernooy, K., Lumens, J. & Auricchio, A., 2016, Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy. 5 ed. Elsevier Canada, p. 213-248

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Right Ventricular Imaging and Computer Simulation for Electromechanical Substrate Characterization in Arrhythmogenic Right Ventricular Cardiomyopathy

Mast, T. P., Teske, A. J., Walmsley, J., van der Heijden, J. F., van Es, R., Prinzen, F. W., Delhaas, T., van Veen, T. A., Loh, P., Doevendans, P. A., Cramer, M. J. & Lumens, J., 15 Nov 2016, In : Journal of the American College of Cardiology. 68, 20, p. 2185-2197

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Septal flash and septal rebound stretch have different underlying mechanisms

Walmsley, J., Huntjens, P. R., Prinzen, F. W., Delhaas, T. & Lumens, J., 1 Feb 2016, In : American Journal of Physiology-heart and Circulatory Physiology. 310, 3, p. H394-H403

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
2015

Assessment of septal motion abnormalities in left bundle branch block patients using computer simulations

Huntjens, P. R., Walmsley, J., Wu, V., Delhaas, T., Axel, L. & Lumens, J., 2015, Functional Imaging and Modeling of the Heart 2015. Berlin Heidelberg: Springer Verlag, p. 40-47

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

1 Citation (Scopus)

Better understanding before implanting

Lumens, J. & Vernooy, K., 1 Apr 2015, In : International Journal of Cardiology. 184, p. 6-8

Research output: Contribution to journalArticleAcademicpeer-review

Computer modelling for better diagnosis and therapy of patients by cardiac resynchronisation therapy

Pluijmert, M., Lumens, J., Potse, M., Delhaas, T., Auricchio, A. & Prinzen, F. W., 2015, In : Arrhythmia & Electrophysiology Review. 4, 1, p. 62-67 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Detailed analysis of ventricular activation sequences during right ventricular apical pacing and left bundle branch block and the potential implications for cardiac resynchronization therapy

Eschalier, R., Ploux, S., Lumens, J., Whinnett, Z., Varma, N., Meillet, V., Ritter, P., Jais, P., Haissaguerre, M. & Bordachar, P., Jan 2015, In : Heart Rhythm. 12, 1, p. 137-143

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Differentiating Electromechanical From Non-Electrical Substrates of Mechanical Discoordination to Identify Responders to Cardiac Resynchronization Therapy

Lumens, J., Tayal, B., Walmsley, J., Delgado-Montero, A., Huntjens, P. R., Schwartzman, D., Althouse, A. D., Delhaas, T., Prinzen, F. W. & Gorcsan, J., Sep 2015, In : Circulation-Cardiovascular Imaging. 8, 9, e003744.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Electrical dyssynchrony induced by biventricular pacing: Implications for patient selection and therapy improvement

Ploux, S., Eschalier, R., Whinnett, Z. I., Lumens, J., Derval, N., Sacher, F., Hocini, M., Jais, P., Dubois, R., Ritter, P., Haissaguerre, M., Wilkoff, B. L., Francis, D. P. & Bordachar, P., Apr 2015, In : Heart Rhythm. 12, 4, p. 782-791

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module

Walmsley, J., Arts, T., Derval, N., Bordachar, P., Cochet, H., Ploux, S., Prinzen, F. W., Delhaas, T. & Lumens, J., Jul 2015, In : PLoS Computational Biology. 11, 7, e1004284.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Hemodynamics in aortic regurgitation simulated using a computational cardiovascular system model

Palau Caballero, G., Walmsley, J., Rudenick, P., Evangelista, A., Lumens, J. & Delhaas, T., 2015, Functional Imaging and Modeling of the Heart 2015. Berlin Heidelberg: Springer Verlag, p. 364-372

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

1 Citation (Scopus)

In vivo electromechanical assessment of heart failure patients with prolonged QRS duration

Kroon, W., Lumens, J., Potse, M., Suerder, D., Klersy, C., Regoli, F., Murzilli, R., Moccetti, T., Delhaas, T., Krause, R., Prinzen, F. W. & Auricchio, A., Jun 2015, In : Heart Rhythm. 12, 6, p. 1259-1267

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Longitudinal Strain "Think Globally, Track Locally"

Lumens, J., Prinzen, F. W. & Delhaas, T., Dec 2015, In : JACC-Cardiovascular Imaging. 8, 12, p. 1360-1363

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
2014

Creating your own virtual patient with CircAdapt Simulator

Lumens, J., Feb 2014, In : European Heart Journal. 35, 6, p. 335-337

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Influence of left ventricular lead position relative to scar location on response to cardiac resynchronization therapy: a model study

Huntjens, P. R., Walmsley, J., Ploux, S., Bordachar, P., Prinzen, F. W., Delhaas, T. & Lumens, J., Nov 2014, In : EP Europace. 16 Suppl 4, p. iv62-iv68

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Mechano-electrical coupling as framework for understanding functional remodeling during LBBB and CRT

Kuijpers, N. H. L., Hermeling, E., Lumens, J., ten Eikelder, H. M. M., Delhaas, T. & Prinzen, F. W., 15 Jun 2014, In : American Journal of Physiology-heart and Circulatory Physiology. 306, 12, p. H1644-H1659

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Optimal Strategies on Avoiding CRT Nonresponse

Bordachar, P., Eschalier, R., Lumens, J. & Ploux, S., May 2014, In : Current treatment options in cardiovascular medicine. 16, 5, 299.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Acute hemodynamic benefits of biventricular and single-site systemic ventricular pacing in patients with a systemic right ventricle

van Geldorp, I. E., Bordachar, P., Lumens, J., de Guillebon, M., Whinnett, Z. I., Prinzen, F. W., Haissaguerre, M., Delhaas, T. & Thambo, J-B., May 2013, In : Heart Rhythm. 10, 5, p. 676-682

Research output: Contribution to journalArticleAcademicpeer-review

Comparative Electromechanical and Hemodynamic Effects of Left Ventricular and Biventricular Pacing in Dyssynchronous Heart Failure Electrical Resynchronization Versus Left-Right Ventricular Interaction

Lumens, J., Ploux, S., Strik, M., Gorcsan, J. III., Cochet, H., Derval, N., Strom, M., Ramanathan, C., Ritter, P., Haissaguerre, M., Jais, P., Arts, T., Delhaas, T., Prinzen, F. W. & Bordachar, P., 24 Dec 2013, In : Journal of the American College of Cardiology. 62, 25, p. 2395-2403

Research output: Contribution to journalArticleAcademicpeer-review