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Research Output

2020

Bile acids drive the newborn's gut microbiota maturation

van Best, N., Rolle-Kampczyk, U., Schaap, F. G., Basic, M., Damink, S. W. M. O., Bleich, A., Savelkoul, P. H. M., von Bergen, M., Penders, J. & Hornef, M. W., 23 Jul 2020, In : Nature Communications. 11, 1, 13 p., 3692.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gut microbiota in wheezing preschool children and the association with childhood asthma

Bannier, M. A. G. E., van Best, N., Bervoets, L., Savelkoul, P. H. M., Hornef, M. W., van de Kant, K. D. G., Jobsis, Q., Dompeling, E. & Penders, J., Jun 2020, In : Allergy. 75, 6, p. 1473-1476 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Open Access

How to Count Our Microbes? The Effect of Different Quantitative Microbiome Profiling Approaches

Galazzo, G., van Best, N., Benedikter, B. J., Janssen, K., Bervoets, L., Driessen, C., Oomen, M., Lucchesi, M., van Eijck, P. H., Becker, H. E. F., Hornef, M. W., Savelkoul, P. H., Stassen, F. R. M., Wolffs, P. F. & Penders, J., 7 Aug 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 10 p., 403.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prevalence and risk factors for carriage of ESBL-producing Enterobacteriaceae in a population of Dutch travellers: A cross-sectional study

Arcilla, M. S., Van Hattem, J. M., Bootsma, M. C. J., van Genderen, P. J. J., Goorhuis, A., Grobusch, M. P., Klaassen, C. H. W., Oude Lashof, A. M., Schultsz, C., Stobberingh, E. E., de Jong, M. D., Penders, J., Verbrugh, H. A. & Melles, D. C., 2020, In : Travel Medicine and Infectious Disease. 33, 7 p., 101547.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

An exploration of the gut and environmental resistome in a community in northern Vietnam in relation to antibiotic use

Vu Thi Ngoc Bich, Le Viet Thanh, Pham Duy Thai, Tran Thi Van Phuong, Oomen, M., Driessen, C., Beuken, E., Tran Huy Hoang, van Doorn, H. R., Penders, J. & Wertheim, H. F. L., 28 Nov 2019, In : Antimicrobial Resistance and Infection Control. 8, 1, 10 p., 194.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Carriage of Blastocystis spp. in travellers - A prospective longitudinal study

van Hattem, J. M., Arcilla, M. S., Schultsz, C., Bootsma, M. C., Verhaar, N., Rebers, S. P., Goorhuis, A., Grobusch, M. P., Penders, J., de Jong, M. D., van Gool, T., Bart, A., van Genderen, P. J., Melles, D. C., Molhoek, N., Lashof, A. M. O., Stobberingh, E. E., Verbrugh, H. A. & COMBAT Consortium, 2019, In : Travel Medicine and Infectious Disease. 27, p. 87-91 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Correlating Infant Fecal Microbiota Composition and Human Milk Oligosaccharide Consumption by Microbiota of 1-Month-Old Breastfed Infants

Borewicz, K., Gu, F., Saccenti, E., Arts, I. C. W., Penders, J., Thijs, C., van Leeuwen, S. S., Lindner, C., Nauta, A., van Leusen, E., Schols, H. A. & Smidt, H., Jul 2019, In : Molecular Nutrition & Food Research. 63, 13, p. 1-13 13 p., 1801214.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Faecal Microbiota Dynamics and their Relation to Disease Course in Crohn's Disease

Galazzo, G., Tedjo, D. I., Wintjens, D. S. J., Savelkoul, P. H. M., Masclee, A. A. M., Bodelier, A. G. L., Pierik, M. J., Jonkers, D. M. A. E. & Penders, J., Oct 2019, In : Journal of Crohn's & Colitis. 13, 10, p. 1273-1282 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hematopoietic Npc1 mutation shifts gut microbiota composition in Ldlr(-/-) mice on a high-fat, high-cholesterol diet

Houben, T., Penders, J., Oligschlaeger, Y., dos Reis, I. A. M., Bonder, M-J., Koonen, D. P., Fu, J., Hofker, M. H. & Shiri-Sverdlov, R., 18 Oct 2019, In : Scientific Reports. 9, 11 p., 14956.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children

Zhong, H., Penders, J., Shi, Z., Ren, H., Cai, K., Fang, C., Ding, Q., Thijs, C., Blaak, E. E., Stehouwer, C. D. A., Xu, X., Yang, H., Wang, J., Wang, J., Jonkers, D. M. A. E., Masclee, A. A. M., Brix, S., Li, J., Arts, I. C. W. & Kristiansen, K., 4 Jan 2019, In : Microbiome. 7, 14 p., 2.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intestinal archaea inversely associated with childhood asthma

Barnett, D., Mommers, M., Penders, J., Arts, I. & Thijs, C., Jun 2019, In : Journal of Allergy and Clinical Immunology. 143, 6, p. 2305-2307 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis

Schneider, K. M., Mohs, A., Kilic, K., Candels, L. S., Elfers, C., Bennek, E., Ben Schneider, L., Heymann, F., Gassler, N., Penders, J. & Trautwein, C., 2 Jan 2019, In : International journal of molecular sciences. 20, 2, p. 1-14 14 p., 308.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Risk of acquisition of human diarrhoeagenic Escherichia coli virulence genes in intercontinental travellers: A prospective, multi-centre study

van Hattem, J. M., Cabal, A., Arcilla, M. S., Alvarez, J., de Jong, M. D., Melles, D. C., Penders, J., Bootsma, M. C. J., van Genderen, P. J., Goorhuis, A., Grobusch, M., Molhoek, N., Lashof, A. M. L. O., Stobberingh, E. E., Verbrugh, H. A., Gortazar Schmidt, C., Schultsz, C. & COMBAT Consortium, 2019, In : Travel Medicine and Infectious Disease. 31, 8 p., 101362.

Research output: Contribution to journalArticleAcademicpeer-review

Stool Consistency: Looking Beyond the Bristol Stool Form Scale

Vork, L., Wilms, E., Penders, J. & Jonkers, D. M. A. E., Oct 2019, In : Journal of Neurogastroenterology and Motility. 25, 4, p. 625-625 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Open Access

The Clinical Link between Human Intestinal Microbiota and Systemic Cancer Therapy

Aarnoutse, R., Ziemons, J., Penders, J., Rensen, S. S., de Vos-Geelen, J. & Smidt, M. L., 1 Sep 2019, In : International journal of molecular sciences. 20, 17, 34 p., 4145.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The effect of prebiotic fortified infant formulas on microbiota composition and dynamics in early life

Borewicz, K., Suarez-Diez, M., Hechler, C., Beijers, R., de Weerth, C., Arts, I., Penders, J., Thijs, C., Nauta, A., Lindner, C., Van Leusen, E., Vaughan, E. E. & Smidt, H., 21 Feb 2019, In : Scientific Reports. 9, 13 p., 2434.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The fecal and mucosal microbiome in acute appendicitis patients: an observational study

Peeters, T., Penders, J., Smeekens, S. P., Galazzo, G., Houben, B., Netea, M. G., Savelkoul, P. H. M. & Gyssens, I. C., Jan 2019, In : Future Microbiology. 14, 2, p. 111-127 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gut Microbiota and Body Weight in School-Aged Children: The KOALA Birth Cohort Study

Mbakwa, C. A., Hermes, G. D. A., Penders, J., Savelkoul, P. H. M., Thijs, C., Dagnelie, P. C., Mommers, M., Zoetendal, E. G., Smidt, H. & Arts, I. C. W., Nov 2018, In : Obesity. 26, 11, p. 1767-1776 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Is the Impact of Starvation on the Gut Microbiota Specific or Unspecific to Anorexia Nervosa? A Narrative Review Based on a Systematic Literature Search

Mack, I., Penders, J., Cook, J., Dugmore, J., Mazurak, N. & Enck, P., 1 Jan 2018, In : Current Neuropharmacology. 16, 8, p. 1131-1149 19 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The neonatal window of opportunity-early priming for life

Renz, H., Adkins, B. D., Bartfeld, S., Blumberg, R. S., Farber, D. L., Garssen, J., Ghazal, P., Hackam, D. J., Marsland, B. J., McCoy, K. D., Penders, J., Prinz, I., Verhasselt, V., von Mutius, E., Weiser, J. N., Wesemann, D. R. & Hornef, M. W., Apr 2018, In : Journal of Allergy and Clinical Immunology. 141, 4, p. 1212-1214 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Volatile metabolites in breath strongly correlate with gut microbiome in CD patients

Smolinska, A., Tedjo, D. I., Blanchet, L., Bodelier, A., Pierik, M. J., Masclee, A. A. M., Dallinga, J., Savelkoul, P. H. M., Jonkers, D. M. A. E., Penders, J. & van Schooten, F-J., 26 Sep 2018, In : Analytica Chimica Acta. 1025, p. 1-11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Does a prenatal bacterial microbiota exist?

Hornef, M. & Penders, J., May 2017, In : Mucosal Immunology. 10, 3, p. 598-601 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Global phylogenetic analysis of Escherichia coli and plasmids carrying the mcr-1 gene indicates bacterial diversity but plasmid restriction

Matamoros, S., van Hattem, J. M., Arcilla, M. S., Willemse, N., Melles, D. C., Penders, J., Trung Nguyen Vinh, Ngo Thi Hoa, de Jong, M. D., Schultsz, C. & COMBAT Consortium, 10 Nov 2017, In : Scientific Reports. 7, 10 p., 15364.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gut Colonization by Methanogenic Archaea Is Associated with Organic Dairy Consumption in Children

van de Pol, J. A. A., van Best, N., Mbakwa, C. A., Thijs, C., Savelkoul, P. H., Arts, I. C. W., Hornef, M. W., Mommers, M. & Penders, J., 10 Mar 2017, In : Frontiers in microbiology. 8, 10 p., 355.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women

Most, J., Penders, J., Lucchesi, M., Goossens, G. H. & Blaak, E. E., Sep 2017, In : European Journal of Clinical Nutrition. 71, 9, p. 1040-1045 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gut microbiota composition strongly correlates to peripheral insulin sensitivity in obese men but not in women

Most, J., Goossens, G. H., Reijnders, D., Canfora, E. E., Penders, J. & Blaak, E. E., 2017, In : Beneficial Microbes. 8, 4, p. 557-562 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Import and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae by international travellers (COMBAT study): a prospective, multicentre cohort study

Arcilla, M. S., van Hattem, J. M., Haverkate, M. R., Bootsma, M. C. J., van Genderen, P. J. J., Goorhuis, A., Grobusch, M. P., Oude Lashof, A., Molhoek, N., Schultsz, C., Stobberingh, E. E., Verbrugh, H. A., de Jong, M. D., Melles, D. C. & Penders, J., Jan 2017, In : Lancet Infectious Diseases. 17, 1, p. 78-85

Research output: Contribution to journalArticleAcademicpeer-review

Influence of vitamin D on key bacterial taxa in infant microbiota in the KOALA Birth Cohort Study

Talsness, C. E., Penders, J., Jansen, E. H. J. M., Damoiseaux, J., Thijsl, C. & Mommers, M., 9 Nov 2017, In : PLOS ONE. 12, 11, 15 p., e0188011.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mode of Delivery and Asthma at School Age in 9 European Birth Cohorts

Rusconi, F., Zugna, D., Annesi-Maesano, I., Baiz, N., Barros, H., Correia, S., Duijts, L., Forastiere, F., Inskip, H., Kelleher, C. C., Larsen, P. S., Mommers, M., Andersen, A-M. N., Penders, J., Pike, K., Porta, D., Sonnenschein-van der Voort, A., Sunyer, J., Torrent, M., Viljoen, K. & 3 others, Vrijheid, M., Richiardi, L. & Galassi, C., 15 Mar 2017, In : American Journal of Epidemiology. 185, 6, p. 465-473 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Study protocol on the role of intestinal microbiota in colorectal cancer treatment: a pathway to personalized medicine 2.0

Aarnoutse, R., de Vos-Geelen, J. M. P. G. M., Penders, J., Boerma, E. G., Warmerdam, F. A. R. M., Goorts, B., Damink, S. W. M. O., Soons, Z., Rensen, S. S. M. & Smidt, M. L., Jul 2017, In : International Journal of Colorectal Disease. 32, 7, p. 1077-1084 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Towards standards for human fecal sample processing in metagenomic studies

Costea, P. I., Zeller, G., Sunagawa, S., Pelletier, E., Alberti, A., Levenez, F., Tramontano, M., Driessen, M., Hercog, R., Jung, F-E., Kultima, J. R., Hayward, M. R., Coelho, L. P., Allen-Vercoe, E., Bertrand, L., Blaut, M., Brown, J. R. M., Carton, T., Cools-Portier, S., Daigneault, M. & 38 others, Derrien, M., Druesne, A., de Vos, W. M., Finlay, B. B., Flint, H. J., Guarner, F., Hattori, M., Heilig, H., Luna, R. A., Vlieg, J. V. H., Junick, J., Klymiuk, I., Langella, P., Le Chatelier, E., Mai, V., Manichanh, C., Martin, J. C., Mery, C., Morita, H., O'Toole, P. W., Orvain, C., Patil, K. R., Penders, J., Persson, S., Pons, N., Popova, M., Salonen, A., Saulnier, D., Scott, K. P., Singh, B., Slezak, K., Veiga, P., Versalovic, J., Zhao, L., Zoetendal, E. G., Ehrlich, S. D., Dore, J. & Bork, P., Nov 2017, In : Nature Biotechnology. 35, 11, p. 1069-1076 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers

van Hattem, J. M., Arcilla, M. S., Grobusch, M. P., Bart, A., Bootsma, M. C., van Genderen, P. J., van Gool, T., Goorhuis, A., van Hellemond, J. J., Molenkamp, R., Molhoek, N., lashof, A. M. O., Stobberingh, E. E., de Wever, B., Verbrugh, H. A., Melles, D. C., Penders, J., Schultsz, C. & de Jong, M. D., Sep 2017, In : Travel Medicine and Infectious Disease. 19, p. 33-36 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Advantages and Limitations of Direct PCR Amplification of Bacterial 16S-rDNA from Resected Heart Tissue or Swabs Followed by Direct Sequencing for Diagnosing Infective Endocarditis: A Retrospective Analysis in the Routine Clinical Setting

Maneg, D., Sponsel, J., Mueller, I., Lohr, B., Penders, J., Madlener, K. & Hunfeld, K-P., 2016, In : BioMed Research International. 2016, 10 p., 7923874.

Research output: Contribution to journalArticleAcademicpeer-review

Can the composition of the intestinal microbiota predict the development of urinary tract infections?

den Heijer, C. D. J., Geerlings, S. E., Prins, J. M., Beerepoot, M. A. J., Stobberingh, E. E. & Penders, J., Oct 2016, In : Future Microbiology. 11, 11, p. 1394-1404

Research output: Contribution to journalArticleAcademicpeer-review

Composition and stability of intestinal microbiota of healthy children within a Dutch population

de Meij, T. G., Budding, A. E., de Groot, E. F., Jansen, F. M., Kneepkens, C. M., Benninga, M. A., Penders, J., van Bodegraven, A. A. & Savelkoul, P. H., Apr 2016, In : Faseb Journal. 30, 4, p. 1512-1522 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer

von Wintersdorff, C., Penders, J., van Niekerk, J., Mills, N. D., Majumder, S., van Alphen, L., Savelkoul, P. H. M. & Wolffs, P. F. G., 19 Feb 2016, In : Frontiers in microbiology. 7, 10 p., 173.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dissemination of the mcr-1 colistin resistance gene

Arcilla, M. S., van Hattem, J. M., Matamoros, S., Melles, D. C., Penders, J., de Jong, M. D. & Schultsz, C., 1 Jan 2016, In : Lancet Infectious Diseases. 16, 2, p. 147-149

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children

den Dekker, H. T., Sonnenschein-va Voort, A. M., de Jongste, J. C., Anessi-Maesano, I., Arshad, S. H., Barros, H., Beardsmore, C. S., Bisgaard, H., Phar, S. C., Craig, L., Devereux, G., van der Ent, C. K., Esplugues, A., Fantini, M. P., Flexeder, C., Frey, U., Forastiere, F., Gehring, U., Gori, D., van der Gugten, A. C. & 27 others, Henderson, A. J., Heude, B., Ibarluzea, J., Inskip, H. M., Keil, T., Kogevinas, M., Kreiner-Moller, E., Kuehni, C. E., Lau, S., Melen, E., Mommers, M., Morales, E., Penders, J., Pike, K. C., Porta, D., Reiss, I. K., Roberts, G., Schmidt, A., Schultz, E. S., Schulz, H., Sunyer, J., Torrent, M., Vassilaki, M., Wijga, A. H., Zabaleta, C., Jaddoe, V. W. & Duijts, L., Apr 2016, In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1026-1035 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Early Life Antibiotic Exposure and Weight Development in Children

Mbakwa, C. A., Scheres, L., Penders, J., Mommers, M., Thijs, C. & Arts, I. C. W., Sep 2016, In : The Journal of Pediatrics. 176, p. 105-113.e2 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Long-Term Green Tea Supplementation Does Not Change the Human Gut Microbiota

Janssens, P. L. H. R., Penders, J., Hursel, R., Budding, A. E., Savelkoul, P. H. M. & Westerterp-Plantenga, M. S., 7 Apr 2016, In : PLOS ONE. 11, 4, 15 p., e0153134.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers

van Hattem, J. M., Arcilla, M. S., Bootsma, M. C. J., van Genderen, P. J., Goorhuis, A., Grobusch, M. P., Molhoek, N., Oude Lashof, A., Schultsz, C., Stobberingh, E. E., Verbrugh, H. A., de Jong, M. D., Melles, D. C. & Penders, J., Jul 2016, In : Future Microbiology. 11, 7, p. 857-864 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The fecal microbiota as a biomarker for disease activity in Crohn's disease

Tedjo, D. I., Blanchet - Smolinska, A., Savelkoul, P. H., Masclee, A. A., van Schooten, F. J., Pierik, M. J., Penders, J. & Jonkers, D. M. A. E., 13 Oct 2016, In : Scientific Reports. 6, 10 p., 35216.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The gut resistome is highly dynamic during the first months of life

von Wintersdorff, C. J. H., Wolffs, P. F. G., Savelkoul, P. H. M., Nijsen, R. R. R., Lau, S., Gerhold, K., Hamelmann, E. & Penders, J., 2016, In : Future Microbiology. 11, 4, p. 501-510 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Weight gain in anorexia nervosa does not ameliorate the faecal microbiota, branched chain fatty acid profiles, and gastrointestinal complaints

Mack, I., Cuntz, U., Graemer, C., Niedermaier, S., Pohl, C., Schwiertz, A., Zimmermann, K., Zipfel, S., Enck, P. & Penders, J., 27 May 2016, In : Scientific Reports. 6, 16 p., 26752.

Research output: Contribution to journalArticleAcademicpeer-review

2015

An ADAM33 Polymorphism Associates with Progression of Preschool Wheeze into Childhood Asthma: A Prospective Case-Control Study with Replication in a Birth Cohort Study

Klaassen, E. M. M., Penders, J., Jöbsis, Q., van de Kant, K. D. G., Thijs, C., Mommers, M., van Schayck, C. P., van Eys, G., Koppelman, G. H. & Dompeling, E., 1 Jan 2015, In : PLOS ONE. 10, 3, e0119349.

Research output: Contribution to journalArticleAcademicpeer-review

A new poly(1,3-trimethylene carbonate) film provides effective adhesion reduction after major abdominal surgery in a rat model

Vogels, R. R. M., Bosmans, J. W. A. M., van Barneveld, K. W. Y., Verdoold, V., van Rijn, S., Gijbels, M. J. J., Penders, J., Breukink, S. O., Grijpma, D. W. & Bouvy, N. D., 1 Jan 2015, In : Surgery. 157, 6, p. 1113-1120

Research output: Contribution to journalArticleAcademicpeer-review

CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis.

Schneider, K. M., Bieghs, V., Heymann, F., Hu, W., Dreymueller, D., Liao, L., Frissen, M., Ludwig, A., Gassler, N., Pabst, O., Latz, E., Selige, G., Penders, J., Tacke, F. & Trautwein, C., Nov 2015, In : Hepatology. 62, 5, p. 1405-1416 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gut colonization with methanobrevibacter smithii is associated with childhood weight development

Mbakwa, C. A., Penders, J., Savelkoul, P. H., Thijs, C., Dagnelie, P. C., Mommers, M. & Arts, I. C. W., 2 Nov 2015, In : Obesity. 23, 12, p. 2508-2516

Research output: Contribution to journalArticleAcademicpeer-review